The history of germ theory, which explains that illnesses are caused by microorganisms

An overview on germ theory, the crucial framework developed by Louis Pasteur

Germ theory of disease is based on the concept that many diseases are caused by infections with microorganisms, typically only visualized under high magnification. Read this general overview to understand the basic framework which allowed for development of vaccines.

The cholera bacteria was first isolated in 1854—but the discovery was largely ignored

The pathogen was isolated by the Italian physician Filippo Pacini in Florence, Italy, though his discovery was largely ignored in favor of the popular miasma—bad air—theory of disease at the time. The pathogen was separately isolated about three decades later by German microbiologist Robert Koch.

A list of five scientific theories that were accepted and later disproved

Humoral theory held that everyone's personality derived from different combinations of four bodily fluids: blood, phlegm, yellow bile, and black bile. The phlogiston theory stated that all combustible materials possessed a fire element—phlogiston—that was released and absorbed by the air during burning. When the air became saturated with phlogiston, the fire would go out.

Before discovering cells, life was believed to emerge suddenly from inorganic matter

Popularized by Aristotle in the 4th century BCE, spontaneous generation was used to explain phenomena like mice appearing in seemingly sealed grain storage. The invention of the compound microscope in the late 16th century led to the identification of cells as the basic unit of life, but it was not until 1855 that their origin from preexisting cells was established.

A 1954 outbreak at a Boston boarding school allowed scientists to isolate the measles virus

While measles was described as early as the 9th century, humanity lacked the medical technology to fight the disease until the mid-20th century. Vaccine development from the Boston outbreak in the 1960s and 1970s led to one of the most effective inoculation campaigns in history.

The mosquito's role in the transmission of malaria was confirmed in 1897

The British army doctor Ronald Ross, who later won the Nobel Prize for his work, was the first to describe the transmission of malarial parasites by mosquitoes. He had lab mosquitoes suck blood from malaria-infected people and separately found the malaria parasite inside a mosquito's gut, confirming the bug's role in malaria transmission.

Bacteria helped scientists realize that DNA was the hereditary molecule, not proteins

Until the mid-1900s, most scientists believed genes were made of proteins, which were known to act as enzymes, hormones, and other chemicals that mediated an organism's traits. The Avery-MacLeod-McCarty and that benign bacteria could be made lethal, where the inherited factor that caused bacterial transformation contained DNA.

Some dementia cases may be linked to microorganisms in the brain

Researchers now know that, much like the gut, the brain is home to an ecosystem of microorganisms—the brain microbiome. While this area of study is still new, some scientists believe 50% of bacteria-caused dementia cases could be treated. (Some users may encounter a paywall.)

Malaria comes from the Italian term 'mal'aria,' meaning 'bad air'

The term refers to marshy areas associated with the disease. An estimated 94% of malaria cases—215 million—occur in Africa.

One doctor argued vampires were based on a real disease

At a conference in 1985, Canadian biochemist David H. Dolphin posited that stories of vampires and werewolves had a real-world origin. He argued that porphyria could have caused sufferers to seek out blood, as well as experience light sensitivity and an aversion to garlic. More than one article in the 1990s discredited this take.

Watch how viruses like Ebola can spill over from animals to humans—and vice-versa

More than 70% of all new infectious diseases originate in animals. Referred to as zoonotic diseases, these are diseases that originate in animals and occasionally spill over or jump from animals to humans. Bats, mosquitoes, and primates have all been linked to spillover events. As human populations push further into previously uninhabited wilderness, animal-human contact increases, and disease spillover is inevitable.

Fungi make people sick when they invade and survive in otherwise healthy human tissue

We breathe in airborne spores frequently, but they often don't make us sick. This video details how certain concerning fungal changes can occur and discusses the role of mycologists—scientists who study fungi—in helping to improve human health.

The theory of chemtrails originated from misinterpreting a US Air Force paper

The document proposed a future weather modification system to achieve military objectives, but clarified that such a system "does not reflect current military policy, practice, or capability." Past testing of biological and chemical weapons has accelerated conspiracies about streaks of condensation trailing aircraft to be harmful chemical agents.

Pneumonia was once a leading killer before penicillin treatments

In the early 20th century, pneumonia was a top cause of death worldwide, often fatal without effective treatment. Penicillin turned a once deadly infection into one of the most treatable bacterial diseases.

Embracing poor hygiene in early life won't stave off allergies

The hygiene hypothesis, first proposed in 1989 by British immunologist David Strachan, suggests that early life exposure to microbes—like those from farm dust or pets—properly trains our immune systems to respond to threats. But sometimes the idea is misinterpreted: It doesn’t mean that poor hygiene—like failing to wash hands–will help ward off allergies; that type of behavior leads to infections and won’t help with allergy prevention.

Horror evolved from Gothic literature

Although creepy tales can be found in nearly every folk tradition, the roots of modern horror can be traced back to Gothic literature, which focused on the battle between humans and unnatural, evil forces.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

In 2019, videos on TikTok convinced children they had Tourette syndrome

Right before the COVID-19 pandemic, an "outbreak" of Tourette syndrome was attributed to videos from a German TikToker who documented his life with the condition. The children experiencing the symptoms all had the same tics, which experts say was a case of mass sociogenic illness, also referred to as mass hysteria.

Watch how viruses like Ebola can spill over from animals to humans—and vice-versa.

If you have a cold, the body produces excess mucus to trap germs

This process clogs up narrowed nasal airways, which results in congestion. This process is often accompanied or triggered by swelling of blood vessels in the nose.

'Mental hygiene' was the 1843 term for mental health

It was coined by American psychiatrist William Sweetzer to reference the same idea as personal hygiene. Mental hygiene, in Sweetzer's view, needed to be maintained in the same way people attend to their personal cleanliness, an idea that was supplanted by better understanding of the complexities of mental health disorder causes in the decades that followed.

The term 'cancer' is 3,000 years old

Around 400 BCE, Hippocrates is said to have named masses of cancerous cells "karkinos"—the Greek word for crab. Science and medical historian Dr. Howard Markel discusses a few hypotheses on why Hippocrates named the disease after a crab and how well cancer was understood in the ancient world.

Ménière's disease was first identified in 1861

This condition is named after the French clinician Prosper Ménière, who first identified it as being linked to the inner ear, noting it was a disorder of the semicircular canals. It tends to occur in people who are 40 years old or older.

The history of malware includes computer viruses, worms, trojans, and ransomware

Some of the earliest significant pieces of malware—the Creeper worm and the Elk Cloner virus—displayed silly messages to users without causing major harm. As computer science has advanced, malware has become more easily spread, incorporated social engineering to manipulate users, targeted infrastructure systems, and been used by governments for virtual espionage.

The history of Earth's breathable atmosphere, made possible by photosynthetic bacteria

Between 3.2 billion and 2.8 billion years ago, threadlike microorganisms called cyanobacteria began consuming available water vapor, carbon dioxide, and sunlight to produce oxygen. However, molecules released from Earth's interior by volcanoes consumed this oxygen via chemical reactions, preventing it from accumulating until volcanism had sufficiently decreased about 2.4 billion years ago.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

The theory of plate tectonics first emerged from the theory of continental drift

German meteorologist Alfred Wegener proposed that the continents were all one giant landmass in the past, which he named Pangaea. Despite geological and climate evidence suggesting continental movement, his theory was dismissed until the 1960s.

Play 17th-century death roulette

Before modern science and medicine, death was much harder to escape. Using real mortality records from London's Dreadful Visitation–a collection of all the Bills of Mortality from 1665–this interactive game gives you an idea of what may have possibly killed you during the Great Plague. Grow your appreciation for life today as you stumble upon causes of death like “livergrown” and “drowned at St. Katharine’s by the Tower”.

How the most famous Ebola book, The Hot Zone, which sold 3.5 million copies and was translated into 30 languages, got aspects of the disease so wrong.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

The first horror movie is believed to be George Méliès' 1986 short 'The Haunted Castle,' which pioneered the use of special effects

Chaos theory—informally known as the butterfly effect—is the reason why weather forecasts are presented with probabilities rather than certainties.

Learn more about the history of fireworks, which dates back to an accidental invention during an alchemist's quest for information about immortality.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

Human-to-human transmission of hantavirus remains extremely rare, so the 2026 hantavirus cruise ship outbreak doesn't mean we're facing a COVID-style pandemic risk.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

The Brothers Grimm were lawyers before they were storytellers, but became interested in fairy tales as they began investigating how rules and customs had been passed down through cultures.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Some researchers have labeled nomophobia, the fear of being without your phone, as 'the phobia of the 21st century.'

The word 'jazz' evolved from 'jasm,' 19th-century American slang for 'energy'

Poison ivy's characteristic rash is caused by an allergic response to an oily compound in the plant called urushiol.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

The term 'algorithm' originated from the Latinized name of al-Khwārizmī, a 9th-century mathematician whose works introduced Arabic numerals and the decimal-based numeral system to Europe and whose treatise 'Al-Jabr' gave algebra its name.

Famed poet TS Eliot rejected the manuscript for George Orwell's political fable 'Animal Farm,' writing that its criticism of authoritarianism was not 'the right point of view.'

Georgia O'Keeffe's flower paintings are often assumed to be sexual, though the artist claimed she was simply interested in highlighting the beauty of flowers that most people neglect