Bipolar disorder, which is characterized by extreme mood swings, affects nearly 3% of the US population

35% of polled Americans said they'd view people differently if they knew they had a mental illness

In April 2025 polling, mental health remained highly stigmatized in the US. Though 88% of US adults say a mental health disorder is nothing to be ashamed about, 84% of them think the term "mental illness" carries a stigma and only about half of respondents said they'd feel comfortable sharing their mental health struggles with others.

Gene expression patterns are similar between ASD, schizophrenia, and bipolar disorder

Postmortem brain tissue analysis suggests there are genetic and epigenetic similarities between individuals with autism, schizophrenia and bipolar disorder. All three conditions appeared to have activation of genes in astrocytes and suppression of specific genes that function at the junction between neurons, called synapses. (Some users may encounter a paywall.)

Roughly 10% of the world has SSAD—SAD’s milder, nonclinical cousin

Subsyndromal affective disorder is diagnosed when someone exhibits two of the nine major criteria for depression (but not more than five) as a result of seasonal changes. While it is milder than primary SAD, SSAD is still significant and impacts millions.

Circadian rhythm disruption can influence various mental health disorders

This 2020 research overview surveys the relationship between disrupted circadian clocks and disorders including schizophrenia, anxiety, and bipolar disorder. It incorporates findings and therapeutic approaches drawing from human night shift studies and jet lag studies alongside animal research.

How menopause affects mental health

Menopause, a natural biological process, occurs in three stages: perimenopause (hormone fluctuations), menopause (end of menstrual cycles), and postmenopause (12 months without menstruation). Hormonal shifts during this time can affect neurotransmitters, increasing the risk of mood disorders.

Antidepressants alone may fail to help an estimated one-third to one-half of depressed patients

There are three major categories of antidepressants—tricyclic antidepressants, monoamine oxidate inhibitors, and selective serotonin reuptake inhibitors. This podcast notes these first-line depression drugs are not effective for many patients and may also come with concerning side effects. Other therapeutic approaches—either in combination with medication or as an alternative—include therapy, meditation, and consistent exercise.

Roughly 1 in every 4,300 individuals in the US has mitochondrial disease

Roughly 1,000 to 4,000 kids are born with these conditions each year in the US though many of the diseases are fatal. Mitochondrial disorders often affect the organs that require the most energy, including the heart, brain, and muscles.

Diabetes is a hormonal disorder

Hormones are naturally produced in the body in concert with cell receptors, influencing how cells behave, but diseases that affect hormonal production, including those produced by the pancreas or the thyroid, can upend those processes.

About 10%-15% of people experience chronic insomnia

How often would you say you struggle to stay or fall asleep? If it's more than three times per week (and has been going on for at least one month), then you might have one of the most common sleep disorders: insomnia.

About 12.5% of US adults experience a phobia in their lifetime, a diagnosis that hinges on the intense fear interfering with daily life and persisting for at least six months.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

What's the difference between a psychologist and a psychiatrist?

While both psychiatrists and psychologists are mental health professionals, the big difference is that psychiatrists are medical physicians (MD or DO) while psychologists are not. Learn what makes these two profession different with this brief explainer.

Obsessive compulsive disorder is a mental health disorder, not a personality quirk

In popular culture OCD has been incorrectly overused to describe neatness or perfectionistic behaviors, but the disorder involves intrusive thoughts and compulsive behaviors that take over a person's actions.

Key symptoms of burnout can be both mental and physical

Burnout can be accompanied by several symptoms, including low energy and chronic fatigue, trouble concentrating, difficulty sleeping, and depression. It may even manifest physically as musculoskeletal pain, headaches, stomach and intestinal pain, and more. More intense cases have been linked to cardiovascular and mental health disorders.

Rheumatoid arthritis affects about 1% of the population

Rheumatoid arthritis is an autoimmune condition leading to breakdown and inflammation of multiple joints throughout the body. This academic article provides an updated deep dive into our current cellular understanding of rheumatoid arthritis, how it is diagnosed, and the variety of medications available for treating this painful condition.

Schizophrenia literally means 'split mind'—a reference to patients' break with reality

Contrary to the name, patients do not have multiple personalities. Rather, the split mind refers to the sufferers' inability to distinguish reality from hallucinations when they are aware and awake. Cognitive difficulties, including challenges focusing and communicating are also common among those with schizophrenia, as well as auditory and visual hallucinations.

Vertigo is considered a subtype of dizziness

This two-minute video explains vertigo—a subtype of dizziness—and its many potential causes. It explores the vestibular system, the inner ear system, which typically governs our sense of stability, and details its anatomy.

The most common types of bankruptcy filings are Chapter 7, Chapter 11, and Chapter 13

However, there are actually six types in practice today. These less-common options can be lifelines for foreign businesses operating in the US, local governments, and farms and fisheries.

How public policy shapes demographic trends

This IMF podcast explores the population booms and busts throughout human history. According to Harvard economist and demographer David Bloom, it took more than 50,000 years for the world population to reach 1 billion. But since 1960, we have added...

Pulsatile tinnitus is when you hear thumping synchronized with your heartbeat

This rare type of tinnitus, which sounds like rhythmic thumping or whooshing, is often linked to blood vessel conditions or high blood pressure. Lowering blood pressure through exercise and food choices can help reduce the severity of this condition.

Ibogaine is being investigated for treating mental health issues and substance abuse

This compound, which is illegal to use in the US, has had promising results for patients who have tried it in other countries for substance abuse and mental health concerns. This psychoactive substance is not without risks, however; this TED talk points out it's also caused fatal cardiac arrhythmias and shouldn't be taken without medical supervision.

Bomb cyclones can produce heavy rain, blizzard conditions, and intense winds

Known as "bombogenesis" in meteorology, these systems get their colloquial name from their rapid intensification over a 24-hour period—a phenomenon seen in some tropical cyclones. They occur most commonly along the coasts of the Northeast and Northwest US when there is a severe temperature difference between colliding air masses.

Why Americans are drowning in credit card debt

Americans owe more than $1T to credit card companies. And with rising interest rates that prevent cardholders from paying down debt (not to mention the rising cost of living), that number is likely to keep growing. A podcast episode explains how the US got here, and what policymakers and individuals can do about it.

Headache disorders have historically been neglected and under-researched

Confusion between the variety of headaches—from mild discomfort to debilitating pain—and gender bias—migraines primarily affect women—have led to widespread misunderstandings of the medical issue. Medical students in the US may get as little as 30 minutes of instruction on the three major types: migraines, cluster headaches, and tension-type headaches.

The world is shifting from unipolarity toward a multipolar order

The post-Cold War world was briefly unipolar after 1991, with the US standing alone as a global superpower following decades of US-Soviet bipolarity. Analysts increasingly describe today's order as multipolar, with China, Russia, the US, and regional powers all competing for influence.

There are multiple types of multiple sclerosis—they differ by attack patterns

When your immune system targets the nervous system, this can cause new or worsening symptoms and the development of scarring or damage within the central nervous system. Relapsing-remitting MS is the most common type of the disease—it includes progressive bouts of attacks that occur months or years apart.

Delirium tremens is the most severe form of alcohol withdrawal

Due to the impact of alcohol on the central nervous system, withdrawal from the drug can cause severe effects. Roughly 1% to 1.5% of heavy drinkers will experience delirium tremens, which includes tremors, seizures, hallucinations, and more. Onset typically occurs 48-72 hours after the last drink.

The United States is one of only around two dozen countries with a fully federal system of government, in which power is divided between national and state governments.

US consumers collectively owe more than $1T to credit card companies—almost as much as they owe in auto loans.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

Three Ebola species are responsible for most large outbreaks of the disease, yet the only approved Ebola vaccine is known to work against just one of them.

Explore chaos in this simulation of two double pendulums, where small differences in the release angles produce wildly different outcomes.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Between 10 million and 50 million people in the US develop rashes from poison ivy, poison sumac, and poison oak each year.

An initial public offering or 'IPO' is the process of a private company becoming public by putting shares of the company on the stock market for purchase.

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

Use this calculator to find the dollar value of your mental load, from meal planning to coordinating after-school care for your children.

The United States has had a tumultuous relationship with Cuba since its 1959 revolution, highlighted by a nuclear crisis and a decades-long trade embargo.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Fireworks-related ER visits are on the rise—in 2024, they increased by 52% as compared to the prior year.

A century of Billboard issues documenting the evolution of popular music.

Coral polyps reproduce via broadcast spawning, where entire reefs simultaneously release reproductive cells for about one hour, once a year.

In 2026, Finland was named the world's happiest country for the ninth consecutive year based on its wealth, social safety network, and high life expectancy, among other factors.

While the sun's gravity keeps the planets in orbit, their gravity also pulls on the sun, causing it and everything else in the solar system to orbit around a mutual balance point called the barycenter—the true center of the solar system.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

While El Niño moves warm Pacific Ocean waters east along the equator, La Niña moves them west, shifting where rainfall will become more common for months.

A pickleball's loud 'pop' sound can reach 120 decibels, which is equivalent to a hammer hitting a nail

In 2009, the nation was gripped by the story of a missing young boy who was believed to be floating over Colorado in a homemade balloon, until it was revealed that he was at home the whole time.