Delirium tremens is the most severe form of alcohol withdrawal

How alcohol rewires your brain

Alcohol doesn't just make you tipsy—it rewires your brain chemistry in real time. It slows your brain with GABA, spikes dopamine to make you feel unstoppable, and blocks glutamate so you can't form memories. That mix explains everything from slurred speech to blackouts … and brutal hangovers.

Alcohol use disorder is the most common addiction in the US

This comprehensive overview from the Addiction Center uses recent data from SAMHSA’s National Survey to examine the 10 most common substance dependencies in the United States. It ranks addictions from alcohol (affecting 28.3 million Americans) to barbiturates, while highlighting key trends, risks, and societal impacts.

Drug tolerance and withdrawals are consequences of overloading dopamine circuits

Addictive substances or behaviors will typically flood our brains with more dopamine than usual. In response to the overstimulation, our brains will decrease the number of available dopamine receptors. This results in the need for more stimulus for the same response (tolerance) and a rise in negative feelings when the stimulus is absent (withdrawal).

How seizures (potentially) alter consciousness

Seizures occur when intense electrical activity floods the brain, prompting significant loss of self-control and a variety of sensory disruptions and hallucinations. Cultures interpret the episodes differently, with many contemporary norms viewing them as negative while others characterize them as intense spiritual occasions. Author Fyodor Dostoyevsky viewed his seizures this way, as well as cultures in Mongolia, some Shamanic indigenous religions, and others.

Vertigo can last for minutes—or months—and may occur periodically

Vertigo can be caused by a variety of conditions, including as a side effect of medication, but if it comes on suddenly and is accompanied by other symptoms including difficulty with speech or weakness on one side of the body it's important to go to the emergency room to get checked for a stroke. For recurring vertigo, care teams can teach patients exercises to limit panic, lessen nausea and teach the brain to better tolerate head movements.

Gibberish, urine, and utter chaos: what happens when you sleepwalk

Sleepwalking, or somnambulism, occurs most frequently in children who are in the deepest stages of sleep. REM, the sleep stage in which most people dream, often causes temporary muscle paralysis, so it’s only when sleepers pass to the deeper stages of sleep that sleepwalking—and sleep talking—can occur.

Naltrexone blocks the reward effects of alcohol and opioids

Naltrexone is used to treat alcohol and opioid dependence, blocking opioid receptors in the brain, reducing cravings, and preventing the euphoric effects of alcohol or opioids. It is nonaddictive and works best as part of a comprehensive treatment plan, including counseling or therapy, to support long-term recovery.

American medical organizations rescind recognition of diagnosis cited in police custody deaths

American medical organizations have rescinded their recognition of a syndrome whose theory stemmed from discredited research. This article explores the history and implications of "excited delirium syndrome," a medical condition that can reportedly...

Terminal lucidity is the phenomenon of sudden, heightened mental clarity when on the verge of death

The "Let's Talk Near Death" podcast explores phenomena around the end of life, inviting guests to recount their own experiences. This episode focuses on the phenomenon known as "terminal lucidity," where patients experience clarity, vivid memory recall, and more, typically following a heart attack, stroke, or other trauma.

Long-term memory issues among West Nile survivors may be from immune response, not virus

Rodent research suggests that long-term neurological complications such as fatigue, weakness, difficulty walking, and memory loss, may be due to the immune system systematically destroying parts of neurons in the brain in response to the infection, rather than due to viral infection itself.

Bipolar disorder, which is characterized by extreme mood swings, affects nearly 3% of the US population

There are two types of this disorder. Bipolar 1 features a significant manic episode—abnormally elevated mood and frantic energy—followed by repeated depression, while Bipolar 2 vacillates between depressive episodes and hypomania, a milder form of mania, but not a full mania. Listen to this podcast as experts explain the condition.

Schizophrenia symptoms often appear suddenly

Schizophrenia is a particularly shocking mental illness because its symptoms may appear seemingly without any prior signs of illness after a person has had no symptoms for the first couple of decades of their life. Among teens, symptoms may look like typical adolescent behaviors—withdrawal, being irritable, and having trouble sleeping.

How Alzheimer’s disease becomes fatal

Despite more than 100,000 people with Alzheimer's dying each year, the specific cause of death is not the disease itself. Often, secondary diseases arise from complications with the disease, including pneumonia, severe falls, malnutrition, or infection. Read more about the range of complications caused by Alzheimer’s here.

'Blackout challenge' can cause brain damage or death in under 5 minutes

A social media trend that encourages viewers to asphyxiate themselves until they lose consciousness in the hopes of feeling "high" or euphoric has garnered the interest of teens and adolescents, with dangerous results. Variations of this deadly challenge have been adolescent trends every few years.

Heat exhaustion is the most likely diagnosis if someone is talking clearly

Heatstroke, true to its name, looks more like a stroke. Its symptoms include severe disorientation, irritability, and seizures, among others. A patient does not need to have collapsed in order to have exertional heatstroke, but if someone is talking clearly, they likely have heat exhaustion, and it hasn't progressed to heatstroke.

Veterans reported single dose of ibogaine improved TBI, PTSD, anxiety, and depression

Research published in 2024 on the Central African plant-derived drug included 30 male combat vets who received ibogaine treatment in Mexico. It reported significant reductions in multiple mental health conditions and no serious side effects. Other work, however, has shown the substance can cause fatal cardiac arrhythmias, killing at least 19 people between 1990 and 2008. (Some users may encounter a paywall.)

How frontotemporal dementia changes your personality

Significant changes in personality later in life are often attributed to psychological factors. But Dr. Bruce Miller, long-time researcher of FTD, argues this shift is most often attributable to changes in the brain.

Wet macular degeneration affects 10%-15% of those with macular degeneration

This form of molecular degeneration refers to when excess blood vessels form in the back of the eye and damage the macula. If someone with this condition looks at straight lines, they will typically appear wavy or crooked.

Prolonged Grief Disorder has certain recognizable risk factors

This official diagnosis is characterized by intense, daily symptoms of grief a year after the loss of a loved one among adults and faster—around at least six months—for kids and teens. Factors that put people at increased risk of this disorder include being single, attachment anxiety, violent or unnatural death, low education, low income, and multiple losses, among others.

The temperance movement loathed toasting

The 19th- and 20th-century groups opposed to drinking alcohol viewed toasting as a vile practice that encouraged excess and debauchery. One reverend wrote in 1881 that "toasting is a relic of the vile custom of drinking to the honour, applause and commemoration of depraved men and women, whose persons should have been despised, and whose memories should be perished."

About 20% of people infected with cholera have severe symptoms

That's according to studies from outbreaks in Bangladesh. Most people who contract the disease have mild or moderate symptoms, or none at all. Yet anyone infected with the disease-causing bacteria can shed the pathogens in their feces for a few days, or even up to around 10, seeding the environment with bacteria.

The stages of fasting

What happens to the body when it goes without caloric intake? This article overviews the immediate physical effects of fasting. Within a day of going without food, the body will have used up its glucose stores and ordered the liver and muscles to convert their glycogen (glucose storage) into usable glucose. By the second day, glycogen stores will run out, forcing the body to use fat as energy. This process is known as ketosis.

Tannins contribute to a wine's composition

Tannins are compounds found in many different types of food, including grape skins. When consumed, they produce a noticeable drying effect in the mouth. Because of the difference in production methods, red wines typically have tannins while white wines do not.

The 1975 sinking of the Edmund Fitzgerald spurred a number of maritime changes

One of the worst Great Lakes shipwrecks in modern history, the freighter sank during an intense storm on Lake Superior that reportedly produced 50-foot waves. The exact cause remains unknown, and the disaster remains in public consciousness today.

Certain medications can make tinnitus worse

Certain antidepressants, antimalarial medications, antibiotics, ibuprofen, and cancer drugs have been linked with the condition. At higher doses, particularly, it seems they can trigger or worsen tinnitus in some individuals.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

About 12.5% of US adults experience a phobia in their lifetime, a diagnosis that hinges on the intense fear interfering with daily life and persisting for at least six months.

The Dracula character, now seen as the vampire archetype, was inspired by a seafood-induced nightmare its creator experienced.

This real-time tracking of the hantavirus cruise ship outbreak in May 2026 offers a unique glimpse into the global reach of the outbreak and whether the virus sickened passengers and their communities around the world.

Three Ebola species are responsible for most large outbreaks of the disease, yet the only approved Ebola vaccine is known to work against just one of them.

Dirty lightning is a thunderstorm created from friction between rising and falling flows of ash and smoke during volcanic eruptions.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

For centuries, Niagara Falls has been a magnet for daredevils seeking to conquer one of nature's most powerful wonders, with its 200-foot drop and water rushing at 32 feet per second with 280 tons of force.

Firework or sparkler burns, even if they cover a relatively small area of skin, can significantly affect our range of motion.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

In 1945, Surrealist artist Salvador Dalí and legendary animator Walt Disney began collaborating on a short film that was not completed until 2003, years after both men had died.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

A small portion of The Winstons' 'Amen, Brother,' an obscure '60s gospel record, is the basis for thousands of hip-hop tracks, making it one of the most sampled records ever that's informally known as 'the Amen break.'

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

Poison ivy's characteristic rash is caused by an allergic response to an oily compound in the plant called urushiol.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.

Explore chaos in this simulation of two double pendulums, where small differences in the release angles produce wildly different outcomes.

See 33 images that became central to huge scandals, including a young Charles and Camilla, Michael Jackson's baby on a hotel balcony, and Hugh Grant's mugshot.

44% of Americans say they pray at least once a day—discover how your state's religiosity stacks up against the rest of the country.

The rivalry between Alexander Hamilton and Thomas Jefferson centered on federalism—the question of how much power the federal government should hold relative to the states.

Roughly 43 million US borrowers owe roughly $1.7T in student debt, the second-largest source of consumer debt behind mortgages.

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.