Wet macular degeneration affects 10%-15% of those with macular degeneration

As deposits build up under the eye, the retina bends with macular degeneration

The retina bends due to the accumulation of proteins and other materials beneath it. That's considered the milder "dry" form of macular degeneration. Another form, called "wet" macular degeneration, is caused by abnormal blood vessels leaking fluid into the eye, which can rapidly affect central vision.

The macula is a small area in the center of the retina

This part of the eye—roughly the bullseye of the back of the eye—is responsible for processing the central vision of the eye. Degradation of the macula, formally called macular degeneration, leads to symptoms including blurred vision, the need for brighter lighting, and difficulty recognizing faces. The condition doesn't affect peripheral vision, but if you lose central vision, you can still be considered blind.

Drusen are bumps under the retina that distort the vision of most macular degeneration patients

These yellow deposits are made up of proteins and lipids and come in a variety of sizes. They're common in people aged 50 and older, but amassing many of them is often a symptom of age-related macular degeneration—the most prevalent type of macular degeneration.

Age-related macular degeneration is the primary cause of blindness in older Americans

Around 20 million Americans suffer from macular degeneration, and it's the leading cause of blindness in older Americans. Risk factors for age-related macular degeneration include aging, genetics, smoking, hypertension, obesity, and diet.

Photodynamic therapy is one current treatment for age-related macular degeneration

This laser-based treatment is used on advanced "wet" age-related macular degeneration patients, but it's now used less often than in the past because there are newer injection-based drugs to decrease abnormal blood vessel growth.

US macular degeneration burden is based on statistical modeling and Medicare claims

Prevalence estimates for age-related macular degeneration in the US are usually based on the Vision and Eye Health Surveillance System. Disease numbers are generated using Bayesian meta-regression (a type of statistical modeling), which pulls together information from multiple sources, including Medicare claims.

LIghter-colored eyes have heightened risks for macular degeneration

People with blue eyes appear to be at elevated risk of developing the disorder, perhaps because more light can penetrate their eyes. But the most significant modifiable factor heightening the risk for macular degeneration is smoking.

Vitamins can slow macular degeneration

Research published in 2022 affirmed that vitamin formulations containing vitamins C and E, copper, zinc, lutein, and zeaxanthin—but no beta carotene—can enhance eye health and slow the progression of macular degeneration.

Targeting cholesterol metabolism may help address macular degeneration

Research published in 2025, based on human plasma samples and mouse models, indicates that boosting the levels of a molecule called apolipoprotein M in the blood can improve cholesterol processing, helping prevent some cellular damage that contributes to age-related macular degeneration.

There are more than 1,400 listed clinical trials for macular degeneration

The US database of clinical trials listed more than 1,400 macular degeneration trials in early 2026. That doesn't mean every trial is recruiting, but it does indicate there is significant interest in this medical condition.

Watch patient stories describing life with macular degeneration

This video series features patients discussing their experiences with the disorder, family members describing caregiving, and other insights about the disease.

Caucasians are at the greatest risk of developing macular degeneration

A 2016 analysis across ethnic groups found, among other things, that white participants had the highest incidence of the disease, followed by Chinese, Hispanic, and Black participants. This study did not answer why that may be the case.

World health experts expect more than 240 million global cases of AMD in 2030

The World Health Organization estimated in 2019 that by 2020 there would be roughly 195.6 million cases of age-related macular degeneration and projected that the number would continue to grow. (Some users may experience a paywall.)

In a first, eye prosthesis has restored sight to macular generation patients

In a clinical trial, 27 of 32 participants with advanced macular degeneration regained enough vision to read books, food labels, and subway signs about a year after receiving a prosthetic retina device. This is the first device to restore functional vision to patients with incurable vision loss, though in this case they can only see in black and white, with no shades in between.

Why vascular dementia develops

This type of dementia, the second most common form after Alzheimer's, develops due to microscopic bleeds and blood vessel blockages in the brain. The condition isn't curable but medications to help with blood clotting and high blood pressure are part of a suite of interventions designed to minimize damage to the brain.

Changes in vision or eye pain can be early MS symptoms

This occurs due to myelin degradation around the optic nerve, impairing its ability to transmit visual information to the brain. Individuals may especially experience eye symptoms after exercising or taking a hot shower because boosted body temperatures slow down nerve function in nerves already damaged by MS.

Usher Syndrome, a rare genetic disorder, causes progressive hearing and vision loss

People with one of the subtypes of this condition have a genetic mutation that starves cells in the inner ear and the retina of proteins required for detecting sound and light. Gene therapy in animals has seemed like a promising treatment for the condition.

Rheumatoid arthritis affects about 1% of the population

Rheumatoid arthritis is an autoimmune condition leading to breakdown and inflammation of multiple joints throughout the body. This academic article provides an updated deep dive into our current cellular understanding of rheumatoid arthritis, how it is diagnosed, and the variety of medications available for treating this painful condition.

Hemorrhagic strokes make up roughly 13% of stroke events

A hemorrhagic stroke occurs when a faulty blood vessel within the brain bleeds. Though this is less common than an ischemic stroke, it is often far more deadly. This in-depth resource from the American Stroke Association provides a comprehensive overview of the two main subtypes of hemorrhagic stroke along with a useful animation of the condition.

20% of patients with migraines may also experience vertigo

Vestibular migraine is a common cause of vertigo, affecting approximately 20% of patients with migraine. It's the most common cause of recurrent, sudden-onset vertigo.

Multiple sclerosis means 'many scars'

That's a reference to the scarring or lesions that occur in the brain, spinal cord, and elsewhere whenever the immune system has a flare-up. The immune system attacks the myelin because it incorrectly responds as if it's a threat, damaging the body's ability to transmit electrical signals effectively from areas of the body to the brain.

Tattoos remain visible on your skin thanks to immune cells called macrophages

Tattoos remain visible thanks to immune cells called macrophages

Macrophages are a robust part of the human immune system. These large cells engulf invading particles, like viruses and bacteria, and use enzymes to break them apart. They perceive ink as a foreign body but can't digest them. Macrophages hold on to the ink, helping maintain the tattoo pattern.

View the transition from laminar to turbulent flow

Using a dye released in the water, streamlines, which are parallel to one another and consistent at low flow velocities, become visible. As the water moves more quickly, viscosity cannot suppress the velocity change, and streamlines become chaotic, creating turbulence.

Fear or disgust related to clusters of holes and cracks, called trypophobia, may stem from evolutionary processes to help us avoid pathogens.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Delirium tremens is the most severe form of alcohol withdrawal

Due to the impact of alcohol on the central nervous system, withdrawal from the drug can cause severe effects. Roughly 1% to 1.5% of heavy drinkers will experience delirium tremens, which includes tremors, seizures, hallucinations, and more. Onset typically occurs 48-72 hours after the last drink.

Breaking down various tongue disorders, from infections to genetics

Taste is one of our fundamental senses, but can be impeded by a wide variety of conditions including glossitis, angioedema, and black hairy tongue. Most are characterized by their color, shape, and sometimes change in function. Causes range from vitamin or mineral deficiencies to fluid accumulation, fungal infection, or more.

All rainbows are 'raincircles' caused by water droplets separating white sunlight into a spectrum of colors, but Earth's surface blocks the bottom half of the circle from our line of sight.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Marburg virus, related to Ebola, is also extremely deadly, and has no available vaccine.

Planarian flatworms are small, aquatic worms with exceptional regenerative capabilities. When cut, the worms can regenerate multiple bodies in a matter of weeks.

Radioactive elements can introduce software errors because the ionizing radiation they produce can detach electrons from atoms, and computer code relies on the distribution of electrons.

Firework or sparkler burns, even if they cover a relatively small area of skin, can significantly affect our range of motion.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Power lines are dotted with large, brightly colored balls to improve the visibility of these thin wires to helicopters and small planes and help prevent potential crashes.

When caught in the mouths of cardinal fish, seed shrimp release glowing, bioluminescent chemicals, which alert predators of the cardinal fish, prompting the shrimp's ejection.

The boiling temperature of water decreases with increasing elevation because the molecules need less energy to overcome the lower atmospheric pressure associated with thinner air.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.

Some coin denominations have ridges etched on their sides, partly to prevent counterfeiting, in a practice called 'reeding.'

See 33 images that became central to huge scandals, including a young Charles and Camilla, Michael Jackson's baby on a hotel balcony, and Hugh Grant's mugshot.

Explore the known asteroids, comets, and spacecraft involved in asteroid studies within our solar system with 'Eyes on Asteroids,' a 3D visualization from NASA.

'Grand Canyon of the Yellowstone,' a work by American painter Thomas Moran, inspired Congress to establish Yellowstone National Park.

US consumers collectively owe more than $1T to credit card companies—almost as much as they owe in auto loans.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

Poison ivy's characteristic rash is caused by an allergic response to an oily compound in the plant called urushiol.

Venture capital is a form of funding provided to early-stage companies with high growth potential, typically in exchange for an equity (or ownership) stake