The macula is a small area in the center of the retina

As deposits build up under the eye, the retina bends with macular degeneration

The retina bends due to the accumulation of proteins and other materials beneath it. That's considered the milder "dry" form of macular degeneration. Another form, called "wet" macular degeneration, is caused by abnormal blood vessels leaking fluid into the eye, which can rapidly affect central vision.

Wet macular degeneration affects 10%-15% of those with macular degeneration

This form of molecular degeneration refers to when excess blood vessels form in the back of the eye and damage the macula. If someone with this condition looks at straight lines, they will typically appear wavy or crooked.

Age-related macular degeneration is the primary cause of blindness in older Americans

Around 20 million Americans suffer from macular degeneration, and it's the leading cause of blindness in older Americans. Risk factors for age-related macular degeneration include aging, genetics, smoking, hypertension, obesity, and diet.

Drusen are bumps under the retina that distort the vision of most macular degeneration patients

These yellow deposits are made up of proteins and lipids and come in a variety of sizes. They're common in people aged 50 and older, but amassing many of them is often a symptom of age-related macular degeneration—the most prevalent type of macular degeneration.

In a first, eye prosthesis has restored sight to macular generation patients

In a clinical trial, 27 of 32 participants with advanced macular degeneration regained enough vision to read books, food labels, and subway signs about a year after receiving a prosthetic retina device. This is the first device to restore functional vision to patients with incurable vision loss, though in this case they can only see in black and white, with no shades in between.

LIghter-colored eyes have heightened risks for macular degeneration

People with blue eyes appear to be at elevated risk of developing the disorder, perhaps because more light can penetrate their eyes. But the most significant modifiable factor heightening the risk for macular degeneration is smoking.

Vitamins can slow macular degeneration

Research published in 2022 affirmed that vitamin formulations containing vitamins C and E, copper, zinc, lutein, and zeaxanthin—but no beta carotene—can enhance eye health and slow the progression of macular degeneration.

There are more than 1,400 listed clinical trials for macular degeneration

The US database of clinical trials listed more than 1,400 macular degeneration trials in early 2026. That doesn't mean every trial is recruiting, but it does indicate there is significant interest in this medical condition.

Watch patient stories describing life with macular degeneration

This video series features patients discussing their experiences with the disorder, family members describing caregiving, and other insights about the disease.

Changes in vision or eye pain can be early MS symptoms

This occurs due to myelin degradation around the optic nerve, impairing its ability to transmit visual information to the brain. Individuals may especially experience eye symptoms after exercising or taking a hot shower because boosted body temperatures slow down nerve function in nerves already damaged by MS.

One theory claims the retinae of SAD patients may fail to adjust to less light in winter

Most people’s eyes become more sensitive to light in the winter months, but some do not. This failure to adjust causes ripple effects on those individuals’ biological clocks. This Ted-ED video provides a clear, brief, narrative explanation of the condition in six minutes.

When processing light, the brain can perceive colors with no natural wavelength

While some animals are sensitive to many forms of light, humans possess receptors that are sensitive to red, green, and blue wavelengths. These receptors send signals to the brain, which are processed and mixed to produce the array of colors we observe, including magenta, pink, and "supercolors" that lack a corresponding natural wavelength in the visible spectrum.

During LASIK surgery, a laser removes microscopic amounts of tissue from the cornea

Before surgery, a patient’s vision needs are incorporated with measurements and mapping of their eye’s surface to identify corrections to refractive errors. This ensures light entering the eye correctly focuses onto the retina to produce a clear image.

Studying involuntary, rapid eye movements is a key part of vertigo diagnosis

A doctor will look at a vertigo patient's rapid, uncontrollable eye movements—formally called nystagmus—to better understand its causes. When a patient is lying down with their head turned and their eyes spin in a certain position and stop it's likely a peripheral cause, but if the spinning doesn't stop or it changes direction it's more likely a central nervous system issue.

Tattoos remain visible thanks to immune cells called macrophages

Macrophages are a robust part of the human immune system. These large cells engulf invading particles, like viruses and bacteria, and use enzymes to break them apart. They perceive ink as a foreign body but can't digest them. Macrophages hold on to the ink, helping maintain the tattoo pattern.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Tattoos remain visible on your skin thanks to immune cells called macrophages

What is the blood brain barrier?

Every blood vessel is lined with endothelial cells that act as filters between blood and the rest of the body. In the brain, these cells are tightly packed together to keep a close watch on what substances can access the vital organ. This protective measure poses an obstacle to drugmakers looking to deliver drugs to the well-defended brain for conditions like Alzheimer's. Watch a quick overview here.

An imperfection 1/50th the width of a human hair blurred Hubble's initial images

Not all parts of the space telescope's primary mirror focused incoming light to the same location, an effect known as spherical aberration. Because Hubble was designed to reside in low Earth orbit and be serviced by astronauts, service missions were deployed in the years after its launch to conduct repairs.

These areas of the brain are hard-hit in depression—but the changes are reversible

Depressed brains can have certain characteristic changes, including an overactive amygdala, reduced hippocampus size, and changes to the thalamus and neuromodulating chemicals in the brain.

Aphantasia involves a lack of mental images—but doesn't affect behavior

The condition, generally known about for over a century, first received its name in 2015 by researcher Adam Zeman. An estimated 4% of people lack this ability to perceive mental images, and research suggests this deficiency does not have any practical impact on behavior.

Mac settings have evolved from minimalism to chaotic clutter

The 1984 Mac control panel featured wordless icons, sliders, and desktop pattern editors, highlighting early experimentation in graphical user interface design. This software charm and personality gradually disappeared as Apple enforced visual and functional consistency over time.

All hurricanes have a central eye where no extreme weather phenomena take place

When standing in the eye of a hurricane, you're likely to experience sunny, cloudless skies surrounded by a wall of intense winds and thunderstorms. The physics behind this formation is the same as what causes water to spiral around a hollow cone as it goes down a drain.

Our brains trick us into seeing an enlarged Moon when on the horizon

Humans perceive the sky as a flattened bowl and judge the size of an object by accounting for its perceived distance away from us. Combined, studies have found that the Moon on the horizon is perceived to be larger because the terrain makes it seem like it is farther away, similar to the Ponzo illusion.

Erythema migrans rash is common in Lyme—but it often doesn't look like a bull's-eye

The US Centers for Disease Control and Prevention states that this rash occurs in roughly 70% or more of Lyme disease patients, and typically occurs at the site of a tick bite. The rash may expand slowly over several days and feel warm to the touch, but it's rarely itchy or painful. As it grows, areas of it may clear—creating a target or "bull's-eye" appearance.

Macy’s doesn’t own its flagship location because of the 'million dollar corner'

When Macy’s moved to the Herald Square location, it reached a verbal agreement to acquire that corner of land—but at the last minute, it was sold to a rival store for roughly $1M.

The edge of the Milky Way may be identified by its star-forming disk

Like Earth's atmosphere and its core, galaxies become more diffuse with increasing distance from their centers, making it hard to define where they end. However, one approach focuses on where gas concentrations are no longer dense enough to support measurable star formation.

Fear or disgust related to clusters of holes and cracks, called trypophobia, may stem from evolutionary processes to help us avoid pathogens.

All rainbows are 'raincircles' caused by water droplets separating white sunlight into a spectrum of colors, but Earth's surface blocks the bottom half of the circle from our line of sight.

Ebola infects and disables immune cells, triggering a cascade of events that leads to small blood clots throughout the body, weakening blood vessels and interrupting blood flow to key organs.

See 33 images that became central to huge scandals, including a young Charles and Camilla, Michael Jackson's baby on a hotel balcony, and Hugh Grant's mugshot.

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

Power lines are dotted with large, brightly colored balls to improve the visibility of these thin wires to helicopters and small planes and help prevent potential crashes.

When you complete a CAPTCHA on a website to prove you are human, you may be unknowingly training algorithms for self-driving cars, whose systems require training data to help identify crosswalks, bicycles, and other outdoor objects.

Explore the known asteroids, comets, and spacecraft involved in asteroid studies within our solar system with 'Eyes on Asteroids,' a 3D visualization from NASA.

Dorothy's famous entrance into Oz in 'The Wizard of Oz' relied on analog tricks, including a body double and sepia-toned paint, as much as it did on technology

When caught in the mouths of cardinal fish, seed shrimp release glowing, bioluminescent chemicals, which alert predators of the cardinal fish, prompting the shrimp's ejection.

Most of the observable universe's volume consists of voids and supervoids—enormous regions of space with little to no galaxies, stars, or light.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

The first steps to rebuilding your credit score include getting to know exactly what's on your credit report and figuring out how far you are from the '700 club,' or 'good score' range.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

Mid-century modern graphic designers, known for their bright colors and bold lines in advertising, also found success with children's books.

The Nasdaq's 'Magnificent 7' companies are responsible for roughly 40% of the Nasdaq 100 index's gains, while the remaining 93 companies account for the other 60%.

See a 3D reconstruction of Tenochtitlan, the Aztec capital that was home to an estimated population of 200,000 to 400,000.

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

'Grand Canyon of the Yellowstone,' a work by American painter Thomas Moran, inspired Congress to establish Yellowstone National Park.

See photos of Meteora, a mountainous site in central Greece, home to 14th-century monasteries perched atop soaring outcroppings.