Poor sleep increases the risk of developing Alzheimer's

The brain will attempt to rest itself in periods of chronic sleep deprivation

Skimping on sleep lengthens reaction times and blunts decision-making skills. At a certain point, the brain will try to sneak sleep where it can, shifting sections offline even as you remain awake. Going without sleep raises blood pressure, undermines the immune system, and increases one's risk of dementia.

Listen to how one gene affects Alzheimer's risk

Multiple genes are associated with Alzheimer's risk, but one well-known disease-associated gene is the apolipoprotein E (APOE) gene, which is typically involved in making a protein that helps carry cholesterol and other fats in the bloodstream. Specific variants of this gene are associated with elevated disease risk, though even if someone has two copies of the disease, that doesn't mean they will definitely develop Alzheimer's.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

What sleep loss does to the brain

Proteins in the brain perform various critical functions, such as helping neurotransmitters function or enabling electrical activity in the organ. These proteins must fold in specific ways to perform their duties, similar to paper airplanes. Sleep deprivation contributes to the gathering of misfolded proteins that aren't shaped correctly for their roles and so accumulate in undesired spaces, such as in the gaps between neurons.

Alzheimer's disease is the leading cause of dementia and risks rise after age 65

Read this primer about Alzheimer's disease and learn what factors increase the risk of this form of dementia, including genetics, being a woman, and health conditions, including high blood pressure.

Alzheimer's brain changes may begin years before symptoms appear

The debilitating disorder degrades cognitive abilities. Its symptoms may start with subtle memory issues, but by the time patients notice any changes, neural changes may already be progressing, such as the accumulation of beta-amyloid plaques between neurons and tau protein tangles within them.

Sleep disorders can exacerbate neurological and other health conditions

Brain regions that control sleep sit adjacent to those that regulate the autonomic nervous system, which controls involuntary bodily functions like heart and breathing rates. These neighbors influence each other, meaning poor sleep can impair or negatively impact the ANS, further disturbing sleep.

High-quality sleep is effectively a superpower

Sleep is critical to maintaining healthy biological functions. From restoring energy to consolidating memories, aiding immune system functions and balancing hormone production, optimizing sleep habits are one of the most important ingredients to healthy living.

Sleep apnea explained

While sleep apnea is directly tied to an increased risk of cardiovascular and metabolic health problems, many affected people are unaware of their problem. Sleep apnea occurs when upper airway muscles relax during sleep and pinch off the airway, which can cause breathing to pause for 10 seconds or more at a time. Sleep partners (rather than those inflicted) are often the first to notice breathing pauses or loud snoring in their bedmates.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

How dreams affect your memory

In 1999, scientists conducted a study in which participants were asked to recall images flashed before them for milliseconds. They found that participants who slept before recalling the information performed better than those who had been asked to recall the same information that same day. This was some of the earliest convincing evidence of how crucial sleep is for learning and memory, findings that current research continues to strengthen.

Genetics play a role in the reliability of the body's biological clocks

Growing evidence suggests genetics influence when, how long, and how well one sleeps, meaning insomnia may have a genetic component. While exact insomnia biomarkers have yet to be determined, some genes, including those related to psychiatric disorders, have been implicated.

External factors, not aging itself, lead to sleep loss in older adults

Though it is often believed that people need less sleep as they age, the recommended sleep guidelines for all adult age groups are almost identical. However, factors such as medication use, lack of physical activity, and loneliness can lead to sleep problems, and thereby lead older people to believe that they actually need less sleep than they do.

What it's like to live with insomnia

The biological process Shakespeare referred to as the chief nourisher of life's feast is necessary for the body and mind to rest and repair from the activities of daily life. As sleep evades the exhausted, sufferers also lose emotional stability, mental clarity, social connections, and more while simultaneously gaining waves of interrupted biological processes that can lead to disease and death.

Obsessing over sleep metrics leads to worse sleep quality

Over one-third of Americans have used wearable technology to track their sleep, and the anxiety over having perfect sleep data, or orthosomnia, has made getting a good night's sleep more difficult. Experts agree that most devices cannot correctly assess sleep details, making the data unreliable.

Sitting 10+ hours per day increases dementia risk

People who sit for at least 10 hours per day are more likely to develop dementia, according to a study published in 2023. This article details the study on the murky relationship between brain health and prolonged sitting. This study involved...

Researchers are exploring neural links between Alzheimer's and autism

Recent DNA sequencing and molecular biology studies suggest that similarities in genes, neural circuitry and patterns of disease warrant further exploration to potentially better understand both conditions and how to treat them. (Some users may encounter a paywall.)

Resistance training is linked to better memory and cognitive function in older adults

Randomized control trials looking at structural neuroimaging and exercise suggest that resistance training in older adults induces structural brain changes that could reduce the risk of Alzheimer's Disease or mitigate its progression. The benefits have been documented when performed at least twice per week for at least six months.

A deeper walk through of the four stages of sleep

In this TED video, sleep expert Matthew Walker carefully breaks down the sleep stages along with a description of why each is important. He finishes the discussion by examining the consequences of altered or decreased sleep, and why seemingly small alterations in our sleep patterns can have outsized effects.

Smell is a robust memory cue for individuals with Alzheimer's disease

Odor is more effective than both visual and verbal cues for triggering autobiographical recall in Alzheimer's disease, according to 2021 research.

Face and neck massages improve the removal of brain cell waste products in mice

A study identified that massaging mice and monkeys' faces and necks enhanced the flow of cerebrospinal fluid. Because CSF has been shown to flush out proteins linked to Alzheimer's and Parkinson's, the research hints at non-invasive treatments to reduce the severity of these diseases.

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

Inflammaging is chronic low-level inflammation as we age, and it may be a key disease driver

The term refers to the idea that largely invisible but consistent low-level inflammation as humans age fuels chronic diseases and cellular aging. Inflammaging, this article says, is due to lifestyle factors like poor sleep, low levels of activity, and poor diet, acting in concert to cause cellular damage and trigger inflammation.

How the buildings you occupy may affect your brain health

Beautiful spaces filled with light and natural motifs aren't just aesthetic, but likely key to your health. Researchers had study participants view photographs of two distinct buildings, one designed with more natural elements while the other featured more abstract shapes and lines. Using electroencephalograph readings of each participant, they discovered participants had less brain inflammation while viewing the "biophilic," or natural, architecture. Learn more about the interdisciplinary framework of so-called neuroarchitecture here.

Hearing loss can affect balance and make falls more likely

For reasons that are not yet fully understood, hearing loss seems to increase the risk of falls. One explanation is that reduced environmental awareness due to hearing loss may put people at greater risk. Another theory is that the brain has to work harder to process sound with hearing loss and that cognitive load may also boost the chances of falls. One study found that for every 10 decibel increase in hearing loss, there was a 1.4 fold increased odds of falling in the preceding 12 months.

SAD uniquely affects people with attention-deficit hyperactivity disorder

Those with ADHD—chronic issues with attention and executive function—are primed for SAD. Many are disproportionately evening chronotypes (more awake in the evening), have a delayed sleep phase, and have low sensitivity to light in the morning. This podcast explores the overlap between these two groups.

Diabetes has downstream effects on the heart, eyes, kidneys, and more

High blood sugar levels in untreated diabetes roughen artery walls, increasing plaque buildup, heart disease, and high blood pressure risk. High levels also cause acid to build up in the bloodstream, potentially making the brain swell, the lungs fill with fluid, and the heart to beat arrhythmically—all fatal complications.

Menopause can exacerbate anxiety

Some research shows that menopause can fuel anxiety and also that pre-existing anxiety can boost the chances of experiencing other menopause symptoms, including hot flashes, insomnia, and brain fog. But treatments including hormone replacement therapy, breathing exercises, and other forms of exercise can alleviate some of these symptoms.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Radioactive elements can introduce software errors because the ionizing radiation they produce can detach electrons from atoms, and computer code relies on the distribution of electrons.

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Scientists can determine Earth's past climate conditions by analyzing air trapped in microscopic bubbles within ice cores—columns of compressed snow layers that build up over hundreds of thousands of years.

Massive 3D printers have been used to build homes by stacking layers of 'concrete toothpaste,' a fire-resistant material that effectively insulates against outside noise.

Apollo astronauts left items in the moon's 'toss zone,' including golf balls, family photos, and bags of human waste, to make room for lunar rocks.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

A 2019 Facebook event called on attendees to "Storm Area 51, They Can't Stop All of Us," resulting in countless memes, the creation of a music festival, and eventually the arrests of those who did try to approach the area.

US consumers collectively owe more than $1T to credit card companies—almost as much as they owe in auto loans.

In 2026, Finland was named the world's happiest country for the ninth consecutive year based on its wealth, social safety network, and high life expectancy, among other factors.

Art theft is the third-largest source of criminal revenues worldwide, thanks in part to the subjective nature of valuing a work of art.

A small portion of The Winstons' 'Amen, Brother,' an obscure '60s gospel record, is the basis for thousands of hip-hop tracks, making it one of the most sampled records ever that's informally known as 'the Amen break.'

Learn how to read a prospectus, the juicy document that any company must file with the SEC before going public.

Abraham Lincoln was almost assassinated weeks before his inauguration as he traveled from Illinois to DC through Baltimore in 1861; it took two independent claims for Lincoln to be convinced the threat was real