The brain will attempt to rest itself in periods of chronic sleep deprivation

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Poor sleep increases the risk of developing Alzheimer's

Brain imaging studies reveal poor sleep leads to production of amyloid beta proteins—molecules linked to Alzheimer’s—which are cleaned from the brain during high-quality sleep. These findings suggest conditions like sleep apnea and insomnia increase the risk of developing the disease.

Studies suggest when you sleep is as important as how much you get

"Molecular clocks" made of timekeeping proteins and genes help regulate the body and its processes, meaning the disruption of one cog will impact another. Those who live in sync with their circadian rhythms report less fatigue, clearer thoughts, greater medication benefits, and better long-term health outcomes.

What sleep loss does to the brain

Proteins in the brain perform various critical functions, such as helping neurotransmitters function or enabling electrical activity in the organ. These proteins must fold in specific ways to perform their duties, similar to paper airplanes. Sleep deprivation contributes to the gathering of misfolded proteins that aren't shaped correctly for their roles and so accumulate in undesired spaces, such as in the gaps between neurons.

Sleep deprivation may slow metabolism

This article explains that, according to research from Penn State, restricting sleep for just a few days can affect how the human body metabolizes fats and change how satisfied people feel after a meal. The study found that people who don’t get...

Sleep disorders can exacerbate neurological and other health conditions

Brain regions that control sleep sit adjacent to those that regulate the autonomic nervous system, which controls involuntary bodily functions like heart and breathing rates. These neighbors influence each other, meaning poor sleep can impair or negatively impact the ANS, further disturbing sleep.

A sleep expert discusses the broad benefits of quality rest

In this three-part series, renowned sleep expert Matthew Walker and doctor Peter Attia explore the role of sleep in memory consolidation and mental health, and the detrimental effects of chronic lack of sleep. The latter has been linked to increased risk of dementia, hypertension, and more.

What it's like to live with insomnia

The biological process Shakespeare referred to as the chief nourisher of life's feast is necessary for the body and mind to rest and repair from the activities of daily life. As sleep evades the exhausted, sufferers also lose emotional stability, mental clarity, social connections, and more while simultaneously gaining waves of interrupted biological processes that can lead to disease and death.

Prolonged stress impairs the prefrontal cortex

Burnout isn't just a feeling—it physically affects the brain. Prolonged stress impairs regions of the brain responsible for decision-making, emotional control, memory, and more. It can also lead to chemical imbalances, like reduced dopamine and norepinephrine levels, that worsen these effects.

Sleep deprivation leads to buildup of danger molecules in the gut

Fruit flies genetically engineered to be awake for as long as they live tend to live half as long as their well-rested brethren. Analysis shows these modified flies suffer from a buildup of DNA-destroying reactive oxygen species in their guts. When enabled to sleep, the flies live as long as their counterparts.

How dreams affect your memory

In 1999, scientists conducted a study in which participants were asked to recall images flashed before them for milliseconds. They found that participants who slept before recalling the information performed better than those who had been asked to recall the same information that same day. This was some of the earliest convincing evidence of how crucial sleep is for learning and memory, findings that current research continues to strengthen.

External factors, not aging itself, lead to sleep loss in older adults

Though it is often believed that people need less sleep as they age, the recommended sleep guidelines for all adult age groups are almost identical. However, factors such as medication use, lack of physical activity, and loneliness can lead to sleep problems, and thereby lead older people to believe that they actually need less sleep than they do.

What happens when we sleep

Sleep is a highly specialized and complex process that begins via signals from a region of the brain called the hypothalamus. As explained in this overview video from The Economist, the hypothalamus maintains our circadian rhythm by using light cues from our environment to regulate sleep via a compound known as melatonin. Once asleep, the brain begins the "sleep cycle" and progresses through the four stages of sleep over and over again each night.

Cerebrospinal fluid flushes waste from your brain during sleep

Recent research suggests a nightly brain cleanup as an important purpose of sleep. Brain waves have been observed to work in lockstep with the brain’s blood flow and cerebrospinal fluid flow, allowing for a cleansing tide that washes away toxic waste.

Sitting 10+ hours per day increases dementia risk

People who sit for at least 10 hours per day are more likely to develop dementia, according to a study published in 2023. This article details the study on the murky relationship between brain health and prolonged sitting. This study involved...

Some animals seem to live well on little sleep

African bush elephants typically sleep for about 2 hours per 24-hour day, coming in well under a human's recommended seven-hour minimum. Other animals also appear to skimp on sleep, by human standards, without the consequences humans associate with being sleep deprived. This academic article details the sleeping habits of animals that appear to thrive on fewer than 40 winks and explores whether their sleep processes are just built different.

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

The US loses roughly $400B a year in productivity due to sleep deprivation

For an article about a woman who built a business empire telling bedtime stories, the Hustle created this graphic showing the estimated GDP loss associated with chronic insomnia. The United States had a much more significant loss than other countries.

Daylight Saving Time is linked to a rise in heart attacks and strokes

Losing an hour of sleep with seasonal time changes is not good for our health and it’s linked to risks for the first couple days of Daylight Saving Time, including a short-term rise in heart attacks and strokes. Scientists theorize these elevated risks are linked to the disruption to the body’s circadian rhythm.

Coffee gives you energy, but it ultimately makes you more tired

The caffeine in coffee delays your brain's fatigue signals. Caffeine blocks adenosine, a compound that builds up as you burn energy and signals rest. Once caffeine wears off, adenosine floods back, leaving you even more tired.

Forty to 110 minutes of deep sleep is recommended per night

Adults typically spend 10% to 20% of the night in deep sleep, also known as slow-wave sleep, with the rest of the night spent either in light sleep or REM states.

The benefits of power napping

Research shows it may not be beneficial to fight that mid-afternoon drowsiness: Power naps can make you more alert, reduce stress, and improve your cognitive function.

The human brain only uses 5% more energy during active tasks versus resting

Despite only being 2% of the weight of a human body, the average adult brain consumes 20% of its energy, with the majority of it spent on maintaining homeostasis—the stable equilibrium conditions of temperature, acidity, blood sugar, and other properties in the body. For infants, the consumption is closer to 50%.

How alcohol rewires your brain

Alcohol doesn't just make you tipsy—it rewires your brain chemistry in real time. It slows your brain with GABA, spikes dopamine to make you feel unstoppable, and blocks glutamate so you can't form memories. That mix explains everything from slurred speech to blackouts … and brutal hangovers.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Anesthetics slow brain activity by promoting inhibitory neurotransmitters

Drugs like propofol and isoflurane increase activity at the GABA receptor, which opens chloride channels. These ions enter neurons and hyperpolarize them, making them less likely to fire. Dexmedetomidine instead blocks norepinephrine receptors in the brainstem to sedate patients.

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

Prolonged space travel significantly impacts multiple human body systems

Astronauts can lose 20% of their muscle mass after two weeks and 10% of their bone mass after six months in space. Decreased sharpness of eyesight and changes in neural connectivity, brain structure and gut bacteria have also been observed.

Eliminating distractions is essential to improving one's attention span

Setting a baseline, removing distractions, establishing focus rituals, taking breaks, and finding purpose in your task are five science-backed practices that can help address a short attention span. Bestselling author Daniel Pink breaks down how to approach each part of the plan and introduce these habits to your life today.

Ebola infects and disables immune cells, triggering a cascade of events that leads to small blood clots throughout the body, weakening blood vessels and interrupting blood flow to key organs.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Netflix profits when you're not watching, and its movies are designed that way—read a detail-rich critical essay exposing lesser-known Netflix takes

Play the role of a student in a game where you try to navigate college and remain debt-free, selecting different income levels, high school experience, race, ethnicity, and more.

Use this calculator to find the dollar value of your mental load, from meal planning to coordinating after-school care for your children.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.

Chaos theory—informally known as the butterfly effect—is the reason why weather forecasts are presented with probabilities rather than certainties.

The Dracula character, now seen as the vampire archetype, was inspired by a seafood-induced nightmare its creator experienced.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

In 1945, Surrealist artist Salvador Dalí and legendary animator Walt Disney began collaborating on a short film that was not completed until 2003, years after both men had died.

The idea for the Federal Reserve was conceived in secret in 1910—with bankers donning duck hunt gear for disguise while traveling to a remote country club on Georgia's Jekyll Island

The US Constitution is widely regarded as the longest-standing written national constitution still in force—see how it has influenced rights worldwide.

Volcanoes 'die' when their supply of magma runs out, if they are shifted away from their underlying magma reservoir, or if they get clogged by collapsing or their magma cooling back into rock.

The USPS spent $3.97B in 2024, accounting for .058% of the federal budget.