Coffee gives you energy, but it ultimately makes you more tired.

Coffee is addictive, and those going through withdrawal often experience headaches and fatigue.

The American Heart Association says adults can safely drink up to five cups of coffee per day and regular consumption may improve cardiovascular health.

Coffee contains an average of 15mg of caffeine per fluid ounce, which is significantly more than most sodas.

Muscles fatigue due to the loss of energy like ATP and glycogen

Adenosine triphosphate fuels muscle contraction, and with each contraction (like during exercise), the amount of ATP reduces. ATP helps potassium and sodium move across muscle membranes, generating ions and helping to contract the muscle.

The brain will attempt to rest itself in periods of chronic sleep deprivation

Skimping on sleep lengthens reaction times and blunts decision-making skills. At a certain point, the brain will try to sneak sleep where it can, shifting sections offline even as you remain awake. Going without sleep raises blood pressure, undermines the immune system, and increases one's risk of dementia.

The benefits of power napping

Research shows it may not be beneficial to fight that mid-afternoon drowsiness: Power naps can make you more alert, reduce stress, and improve your cognitive function.

Your DNA may determine whether you like coffee or tea

Whether people prefer coffee or tea may boil down to a matter of taste genetics. People with a version of a gene that increases sensitivity to the bitter flavor of caffeine tend to be coffee drinkers, according to a report. Read on for more.

Up to 400 milligrams of caffeine a day is considered safe

Small, frequent doses can be more effective than large amounts, though caffeine can raise blood pressure and heart rate, especially in people with hypertension. While low doses of caffeine may help with depression by stimulating dopamine, excessive caffeine, particularly from energy drinks, can lead to anxiety and heart issues.

Bees are more likely to remember a flower if its nectar contains caffeine

Plants want pollinators to keep coming back, so the finding suggests that some plants, such as Citrus and Coffea species, have evolved to include caffeine in their nectar. Researchers suggest the findings could help develop methods to reinvigorate pollinator populations.

Before it was a drink, coffee was used for handwashing.

Listen to a '1440 Explores' podcast episode on the surprising story of how a humble Ethiopian berry reshaped religion, commerce, social life, slavery, and more.

Coffee was put on trial in Mecca in 1511, and its eventual acceptance helped coffee spread beyond religious use and into the world's first public coffeehouses, which ultimately gave birth to the London Stock Exchange.

Understand distinctions between coffee types and other popular cafe beverages with this visual guide.

Prolonged stress impairs the prefrontal cortex

Burnout isn't just a feeling—it physically affects the brain. Prolonged stress impairs regions of the brain responsible for decision-making, emotional control, memory, and more. It can also lead to chemical imbalances, like reduced dopamine and norepinephrine levels, that worsen these effects.

Why death is caused by a dearth of ATP

Though people die from many causes, this video makes the case that a lack of adenosine triphosphate production in the body is what kills almost all of us. Without ATP, physiological processes grind to a halt, and organs stop functioning.

What happens to your brain when you burn out?

You've probably heard of burnout, also known as the feeling of exhaustion that happens after a long period of being overwhelmed or stressed. It's often associated with work and careers, but other parts of life, like parenting, can cause burnout, too. Scientists are figuring out what happens, biochemically speaking, in the brain when burnout hits—and spoiler alert, it includes a neurotransmitter called glutamate. Watch this video to learn more.

Distinct plant species evolved to produce caffeine as a pesticide

Although it provides a defense against insects trying to eat caffeine-bearing plants, the molecule is an example of exaptation, where its original function was repurposed over time. Studies show that some plants now produce caffeine-laced nectar to help pollinators move more quickly and pollinate more efficiently.

Determine the right amount of daily caffeine for you with this calculator.

Most coffee is grown within the coffee belt, a geographic region characterized by mild climates, regular rainfall, and higher altitudes.

How alcohol rewires your brain

Alcohol doesn't just make you tipsy—it rewires your brain chemistry in real time. It slows your brain with GABA, spikes dopamine to make you feel unstoppable, and blocks glutamate so you can't form memories. That mix explains everything from slurred speech to blackouts … and brutal hangovers.

Beanless 'coffee' is an eco-friendly alternative

As we consider the role of agriculture in climate change, many people are seeking alternatives to the most resource-hungry crops—coffee included. Are new synthetic alternatives the answer? Startups are exploring beanless “coffee” made in a variety of ways.

How does your body turn food into energy?

Cells get energy via a process known as cellular respiration, which involves turning glucose into ATP or adenosine triphosphate. Breaking the phosphate bonds of ATP results in usable energy being released into cells, which can then use that energy to power biological processes. This 10-minute video explains how glucose turns into ATP, giving the body the energy it needs to survive.

Emerging research suggests that cannabis, used by about 9% of American adults as a sleep aid, may suppress rapid eye movement and lead to worse quality sleep and fewer remembered dreams.

The history of coffee

From its likely origins in what is now Ethiopia to today's worldwide consumption, this video uses a map to show how coffee conquered the world. Follow along and see how pilgrimages and centuries of trade influenced the spread of the beverage we all know so well.

The depression paradox refers to a lack of energy to take action to help alleviate it

Activities like exercise, even at low levels, have been shown to alleviate some of depression's symptoms for some people. However, depression saps energy levels, making it particularly difficult to motivate oneself to take helpful action.

Sleep deprivation may slow metabolism

This article explains that, according to research from Penn State, restricting sleep for just a few days can affect how the human body metabolizes fats and change how satisfied people feel after a meal. The study found that people who don’t get...

Temperature and certain medications can also affect your circadian rhythms

Although light and dark have the largest influence on circadian rhythms, temperature, stress, and certain medications are among the factors that also play a role. Persistent trouble sleeping or staying asleep may signal it’s time to see your doctor to get a better sleep-wake schedule.

People are experiencing AI 'brain fry' at work

Workers, particularly in marketing, are experiencing mental fatigue in the workplace due to expectations—often unspoken—that they should use AI to multitask beyond their comfort levels. Many feel they are underperforming if they don't embrace this technology. This situation differs from typical burnout. This podcast discussion suggests that this "brain fry" tends to intensify when employees are required to use more than three AI tools.

As coffee became popular in Europe, colonial powers began to spread the drink around the globe.

Sleep deprivation leads to the buildup of dangerous molecules in the gut.

Poor sleep increases the risk of developing Alzheimer's, and a main reason appears to be that the brain disposes of toxic protein buildup during high-quality sleep.

The myth of sugar rushes vs. the reality of sugar crashes

It's generally accepted that sugar rushes are a myth, and that hyperactivity is a more psychological experience. However, there is real science behind the rare sugar crash that primarily impacts those with diabetes. Read this article to understand how historical and cultural factors have shaped sugar perceptions, and how low blood sugar can trigger shakiness, fatigue, weakness, and more in diabetes patients.

What it's like to live with insomnia

The biological process Shakespeare referred to as the chief nourisher of life's feast is necessary for the body and mind to rest and repair from the activities of daily life. As sleep evades the exhausted, sufferers also lose emotional stability, mental clarity, social connections, and more while simultaneously gaining waves of interrupted biological processes that can lead to disease and death.

Stress activates the "fight-or-flight" response when we face threats, a reaction that can help keep us alive.

After the Boston Tea Party, colonists switched to coffee, which became the main morning drink for revolutionaries.

After the Boston Tea Party (1773), colonists boycotted tea and turned to coffee, with coffeehouses becoming hubs for revolutionary discussions. The stimulating import from the Caribbean helped shape the nascent American taste.

Narcolepsy occurs when the brain loses its ability to control its sleep-wake cycle.

How to end bedtime procrastination

Finally done with external obligations, you might plop onto the sofa and dive into a hobby or bit of media, pushing past sleepiness to have some time to yourself and enjoy doing what you want. This is known as "revenge bedtime procrastination," a behavior that feels relaxing but impairs sleep hygiene.

Key symptoms of burnout can be both mental and physical

Burnout can be accompanied by several symptoms, including low energy and chronic fatigue, trouble concentrating, difficulty sleeping, and depression. It may even manifest physically as musculoskeletal pain, headaches, stomach and intestinal pain, and more. More intense cases have been linked to cardiovascular and mental health disorders.

External factors, not aging itself, lead to sleep loss in older adults

Though it is often believed that people need less sleep as they age, the recommended sleep guidelines for all adult age groups are almost identical. However, factors such as medication use, lack of physical activity, and loneliness can lead to sleep problems, and thereby lead older people to believe that they actually need less sleep than they do.

Continual sitting harms your health in a variety of ways

Prolonged inactivity, like sitting for long periods, slows metabolism, weakens muscles and bones, and impairs insulin function. When these negative changes persist over time, the cumulative result is an increased risk of cardiovascular disease, diabetes, and many cancers.

Watch Danish coffee expert Asser Christensen explain the best way to grind coffee.

Diabetes 101: Insulin deficiency leads to high glucose levels in the blood

Glucose, the brain's preferred energy source, enters the bloodstream when the body breaks down consumed carbohydrates. To manage this increase in readily available energy, the body releases the hormone insulin, which allows glucose to enter and fuel our cells. Without insulin, glucose remains in the blood, causing health issues.

The stages of fasting

What happens to the body when it goes without caloric intake? This article overviews the immediate physical effects of fasting. Within a day of going without food, the body will have used up its glucose stores and ordered the liver and muscles to convert their glycogen (glucose storage) into usable glucose. By the second day, glycogen stores will run out, forcing the body to use fat as energy. This process is known as ketosis.

The human brain only uses 5% more energy during active tasks versus resting

Despite only being 2% of the weight of a human body, the average adult brain consumes 20% of its energy, with the majority of it spent on maintaining homeostasis—the stable equilibrium conditions of temperature, acidity, blood sugar, and other properties in the body. For infants, the consumption is closer to 50%.

Exercise improves brain blood flow, stimulates neural growth, and more.

Anesthetics slow brain activity by promoting inhibitory neurotransmitters

Drugs like propofol and isoflurane increase activity at the GABA receptor, which opens chloride channels. These ions enter neurons and hyperpolarize them, making them less likely to fire. Dexmedetomidine instead blocks norepinephrine receptors in the brainstem to sedate patients.

How dreams affect your memory

In 1999, scientists conducted a study in which participants were asked to recall images flashed before them for milliseconds. They found that participants who slept before recalling the information performed better than those who had been asked to recall the same information that same day. This was some of the earliest convincing evidence of how crucial sleep is for learning and memory, findings that current research continues to strengthen.

Exercise releases chemicals that enhance cognitive function

Neurotransmitters like dopamine, serotonin, and norepinephrine, along with increased brain-derived neurotrophic factor levels, enhance a wide range of brain functions. New research demonstrates a direct link between movement and numerous cognitive benefits, including memory, learning, and stress resilience.

Slow pour-over coffee resists the haste of 'espresso' and commodification of drip

Pour-over coffee involves what its name suggests: slowly pouring hot water from a gooseneck kettle over a funnel of ground coffee, usually requiring at least 3 minutes. This trend developed in the 1970s in opposition to on-demand drip coffee and "espresso," literally invented as an "express" option to save time.

Studies suggest when you sleep is as important as how much you get.

How burnout alters your brain

Stress is a normal part of everyday life, and it’s not necessarily all bad. But chronic stress—the kind that leads to burnout—can change the size and functioning of parts of your brain. It can alter the ability to make new brain cells and memories and even potentially modify your DNA.