During the first Biosphere 2 mission, crew members lost 16% of their body weight

As an experiment, the first B2 mission highlighted the challenges of isolated systems

Some argue that isolation from the outside world was compromised—making the experiment a failure—when a crew member was taken from Biosphere 2 for surgery and returned hours later. This position was strengthened when it was revealed that oxygen had been pumped into the facility.

Before Biosphere 2, the Soviet BIOS-3 system tested semi-closed ecosystems

Built from 1965 to 1972, the habitat hosted 10 experiments with crews ranging from one to three individuals who had their air recycled by algae and grew their own wheat and vegetables. However, dried meats were routinely brought into the facility to balance crew members’ diets.

Read a firsthand account of a participant in the first Biosphere 2 mission

The first crew of “Biospherians” spent four months growing their own wheat and awaiting the ripening of tomatoes, onions, and peppers to make their own pizza. They also raised their own livestock, including chickens, pigs, and two goats named Milky Way and Stardust.

Exposed concrete led to oxygen depletion within Biosphere 2

Instead of being absorbed by plants through photosynthesis to produce oxygen, significant amounts of carbon dioxide were taken up by the calcium hydroxide in the concrete, trapping the oxygen in calcium carbonate and water. This concrete was sealed before the start of the second B2 mission.

Biosphere 2 revealed limitations in maintaining wildlife in unfamiliar environments

Trees appeared to become weak and more prone to breaking because a lack of wind caused them to no longer need to develop stress wood. The extinction of pollinators—potentially due to an explosion in the population of longhorn crazy ants—was also unexpected.

An artificial ‘lung’ protects the glass structures making up Biosphere 2

Although confined from much of the surrounding environment, B2 allows sunlight to enter, enabling its plants to engage in photosynthesis. Expansion chambers were built to protect the facility's integrity by managing changes in gas pressure resulting from temperature fluctuations.

Prolonged space travel significantly impacts multiple human body systems

Astronauts can lose 20% of their muscle mass after two weeks and 10% of their bone mass after six months in space. Decreased sharpness of eyesight and changes in neural connectivity, brain structure and gut bacteria have also been observed.

The setting of the comedy film ‘Bio-Dome’ was inspired by Biosphere 2

The film features characters played by Pauly Shore and Stephen Baldwin who accidentally lock themselves inside an experimental biosphere, mistaking it for a shopping mall, while searching for a bathroom. With a Rotten Tomatoes score of 4%, it is considered one of the best-worst movies of all time.

Steve Bannon was made CEO of the company in charge of Biosphere 2 in 1994

After providing $200M to launch and upgrade B2 before its second mission, billionaire philanthropist Ed Bass appointed the future political strategist and then financial consultant to help find new investments and bring costs under control. Fearing interference from non-science experts, Biospherians from the first mission vandalized the project.

The story of the 1945 Minnesota Starvation Experiment

Amid the severe conditions of World War II, researchers were eager to learn the effects of starvation in a controlled study. This podcast dives into a yearlong study of 36 men at a Minneapolis college who endured a six-month period of semi-starvation, where their caloric intake was halved. Results from the experiment became a landmark study in human starvation.

Depending on environment, aliens' bodies would have wide-ranging possibilities

Humans tend to imagine aliens as humanlike, but that's probably unlikely. From small space spiders to metallic carnivores, life on other planets—and how we could interact with it—is difficult to imagine.

Researchers think most of its residents escaped with their lives—but how?

With only a few hundred bodies recovered, evidence suggests most Pompeiians fled. This TED-Ed animation follows the stories of three hypothetical residents—one who stayed inside, one who ran, and one who fled by sea—to illustrate how their survival ultimately depended on the choices they made.

Butterfly populations have declined by 22% from 2000 to 2020

Research suggests that one in every five butterflies is lost due to pesticide use, habitat loss, and climate change. Playing a vital role in pollination, their declining populations threaten plant reproduction and the health of ecosystems.

The crew of the ISS creates unique memorials for deceased colleagues

The continued human occupancy of the International Space Station since 2000 has led to the development of social and cultural elements by crew members, which the ISS Archaeology Project has catalogued. Records of handmade cakes, decorations, and memorabilia highlight the human aspect of living in space.

What it's like to live with insomnia

The biological process Shakespeare referred to as the chief nourisher of life's feast is necessary for the body and mind to rest and repair from the activities of daily life. As sleep evades the exhausted, sufferers also lose emotional stability, mental clarity, social connections, and more while simultaneously gaining waves of interrupted biological processes that can lead to disease and death.

When people stopped using GLP-1, they regained two-thirds of the weight back

Research from 2022 found that when people stopped using the injectable form of the medication, they regained up to two-thirds of lost weight within a year. The finding suggests ongoing treatment will be required for weight loss.

Why does the body have a stress response?

When encountering a stressful situation, the human body typically goes into what is known as "fight-or-flight" mode. Because it evolved as a survival mechanism, the biochemical response enables people and other mammals to react quickly to life-threatening situations. The carefully orchestrated yet near-instantaneous sequence of hormonal changes and physiological responses helps someone to fight the threat off or flee to safety.

Watch how coral bleaching resembles an organism's immune system attacking itself

Microorganisms called zooxanthellae are in a symbiotic relationship with coral polyps and provide them with food created through photosynthesis. When ocean temperatures or sunlight exceed an optimal range, zooxanthellae release harmful chemicals that irritate coral cells. To protect themselves, corals sacrifice their food source and expel the colorful microorganisms, becoming white.

Why 'spacing out' or dissociating may help reduce trauma awareness

Dissociation may have developed as a defense mechanism in the brain to help navigate intense emotional or physical situations by providing out-of-body experiences that put distance between the mind and the environment. However, in about 1.1% and 1.5% percent of the general population, a severe form of this separation can produce alternate identities, or alters.

My experience with biohacking

A general approach that employs technology to enhance the functioning of the human body, biohacking enthusiasts are continuously seeking new ways to optimize their performance. Martin Kremmer, an entrepreneur who became interested in the topic after experiencing burnout, explores his own experiences in biohacking his own diet and lifestyle in pursuit of a longer, healthier life.

Tidally locked exoplanets experience extreme atmospheric temperatures

On worlds like WASP 76b, which orbits its host star approximately 3% the Earth-sun distance, temperatures on its day side can vaporize iron. Winds more than 14 times the speed of sound blow this material to its night side, where it condenses and falls as liquid metal.

Twin studies helped scientists understand why mosquitoes like some of us more than others

A combination of carbon dioxide output, skin chemistry, genetic factors, hormones, and clothing choice can make us particularly vulnerable to mosquito bites. Watch how mosquitoes responded to one man in the video versus his wife, a research approach typically conducted with identical and fraternal twins to test mosquito attractiveness.

Body horror is a subgenre that uses anxieties about appearance

Made popular in the 1980s through films like “The Fly,” the body horror subgenre focuses on physical transformation and violence. It gained significant attention in 2024, thanks to the critical attention “The Substance” received, including an Academy Award nomination for best picture.

Explore the complex relationship between calories and weight

What if you found out that weight loss is actually much more complex than "calories in, calories out" and that the 2,000 calorie-a-day recommendation may not actually be accurate?

A flood left 2023 Burning Man attendees stuck in the desert

During Burning Man 2023, unexpected heavy rainfall and road closures in the desert led to thousands of attendees becoming trapped in the mud with limited resources. The parties and rituals prevailed, but burners also suffered serious consequences with injuries, lost and damaged supplies, and one death.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Apollo astronauts left items in the moon's 'toss zone,' including golf balls, family photos, and bags of human waste, to make room for lunar rocks.

After NASA's Voyager 1 captured Earth as a single pixel as it left the solar system in 1990, astronomer Carl Sagan used the image to reflect on humanity's fragility and the responsibility to protect 'the only world we've ever known.'

Explore what it's like inside a patient isolation unit, used in situations such as treating a patient or suspected patient with Ebola.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Scientists testing how climate change affects plants found, in a years-long simulation study, that poison ivy grew 70% faster with the resulting extra carbon dioxide.

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

Fish populations in the Great Barrier Reef have increased after installing waterproof speakers on the ocean floor that played recordings of sounds from healthy coral reefs.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

While the sun's gravity keeps the planets in orbit, their gravity also pulls on the sun, causing it and everything else in the solar system to orbit around a mutual balance point called the barycenter—the true center of the solar system.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

In 1984, Operation Smash Hit intentionally crashed a 239-ton train into a nuclear waste canister at 100 miles per hour to prove the canister's safety, which remained completely intact and lost just 0.29 of its 100 pounds of pressure.

Double world record holder Hunter Ewen helped conquer his fear of balloons, called globophobia, by training to win Guinness World Record titles for balloon inflation.

Use this calculator to find the dollar value of your mental load, from meal planning to coordinating after-school care for your children.

A 2019 Facebook event called on attendees to "Storm Area 51, They Can't Stop All of Us," resulting in countless memes, the creation of a music festival, and eventually the arrests of those who did try to approach the area.

American short story writer Flannery O'Connor raised 40 peacocks, which became potent symbols for her fiction's elegant violence

US housing costs have risen by roughly 175% between 1991 and 2026—but a growing number of Gen Zers are becoming homeowners anyway. In 2025, 4% of homebuyers were Gen Z, up from 3% the year before.