Before Biosphere 2, the Soviet BIOS-3 system tested semi-closed ecosystems

Biosphere 2 is the largest Earth science experiment ever built

The vivarium—an enclosed system including animals and plants—is sealed from below with 454 metric tons of stainless steel liner and includes an ocean habitat with more than 700,000 gallons of seawater. B2 is visited by 100,000 people yearly, including more than 10,000 K-12 students.

Biosphere 2 gradually transformed into a lab modeling environmental disasters

Built to establish a self-sustaining habitat, the privately funded facility was taken over by Columbia University in 1995. Closed-system experiments were halted in favor of investigations focused on the effects of climate change, which continued after B2 was donated to the University of Arizona in 2011.

As an experiment, the first B2 mission highlighted the challenges of isolated systems

Some argue that isolation from the outside world was compromised—making the experiment a failure—when a crew member was taken from Biosphere 2 for surgery and returned hours later. This position was strengthened when it was revealed that oxygen had been pumped into the facility.

During the first Biosphere 2 mission, crew members lost 16% of their body weight

Food and oxygen shortages drove the “Biospherians” to split into two factions—one seeking to bring in outside resources and another aiming to maintain isolation for the experiment’s integrity. Psychological stress was exacerbated further by the increasing prevalence of insect pests.

Read a firsthand account of a participant in the first Biosphere 2 mission

The first crew of “Biospherians” spent four months growing their own wheat and awaiting the ripening of tomatoes, onions, and peppers to make their own pizza. They also raised their own livestock, including chickens, pigs, and two goats named Milky Way and Stardust.

Biological terraforming studies have been conducted at Biosphere 2

The experiments involve populating barren hillslopes within the Landscape Evolution Observatory with microbes that react with air and rock to produce molecules needed by more complex organisms. Mosses and other simple plants can then grow in these spaces, gradually making them more hospitable to humans.

An artificial ‘lung’ protects the glass structures making up Biosphere 2

Although confined from much of the surrounding environment, B2 allows sunlight to enter, enabling its plants to engage in photosynthesis. Expansion chambers were built to protect the facility's integrity by managing changes in gas pressure resulting from temperature fluctuations.

A prototype greenhouse for Biosphere 2 is now part of a test habitat for Mars

The Space Analog for the Moon and Mars combines the Test Module greenhouse with a workshop, kitchen, common area, sleeping quarters, and a yard that mimics lunar and Martian surfaces. A blind crew member in SAM’s first mission, Inclusion I, helped assess accessibility in potential future space habitats.

A basement of mechanical systems—collectively called the technosphere—supports B2

Twenty-six underground air handlers heat, cool, filter and manage the humidity of the air across the biomes of Biosphere 2. The above-ground Energy Center complex provides continuous power to these and other systems, including heating and cooling water for laboratory experiments and personal use.

Biosphere 2 revealed limitations in maintaining wildlife in unfamiliar environments

Trees appeared to become weak and more prone to breaking because a lack of wind caused them to no longer need to develop stress wood. The extinction of pollinators—potentially due to an explosion in the population of longhorn crazy ants—was also unexpected.

As of 2025, scientists at B2 study the heat tolerance of cacao and coffee trees

The research at Biosphere 2 has led to the development of low-cost plant monitors, which can be provided to farmers worldwide to enable more precise monitoring of crops. Geodesic domes built within the ocean biome are used to investigate the best architectural structures for repopulating degraded reefs.

China developed an artificial closed ecosystem in preparation for a future lunar base

Yuegong-1, also known as Moon Palace 1, was a Beijing facility where volunteers simulated life on a colony and conducted experiments on bioregenerative life support systems to assess their viability in an off-Earth environment. The longest experiment at the 0.04-acre facility lasted 370 days.

The setting of the comedy film ‘Bio-Dome’ was inspired by Biosphere 2

The film features characters played by Pauly Shore and Stephen Baldwin who accidentally lock themselves inside an experimental biosphere, mistaking it for a shopping mall, while searching for a bathroom. With a Rotten Tomatoes score of 4%, it is considered one of the best-worst movies of all time.

Steve Bannon was made CEO of the company in charge of Biosphere 2 in 1994

After providing $200M to launch and upgrade B2 before its second mission, billionaire philanthropist Ed Bass appointed the future political strategist and then financial consultant to help find new investments and bring costs under control. Fearing interference from non-science experts, Biospherians from the first mission vandalized the project.

Read the NASA overview of the results of Viking’s biological experiments on Mars

Three experiments on the Viking 1 and 2 landers searched for signs of metabolic activity in soil samples, indicating the presence of microorganisms. No definitive evidence of life was found in any experiment or lander imaging.

How spoiled meat helped uncover a bacterium that can survive the vacuum of space

When a can of ground beef and pork spoiled despite attempts to sterilize it with gamma radiation, researcher Arthur Anderson isolated the bacteria in the food and discovered Deinococcus radiodurans. The polyextremophile has since been found on the walls of nuclear reactors and overcomes radiation damage through highly optimized DNA repair mechanisms.

The USSR’s Venera program made the only successful landings on Venus

While the Soviet space program is famous for launching the first satellite and human into orbit, its most extraordinary feat was the Venera missions—probes that captured data, images, and audio from Venus’s brutal surface. No other nation has repeated the achievement.

Inside the community movement behind DIY synthetic biology

Margaret Talbot spotlights the rise of DIY biology in community labs, where amateur scientists—often outside formal institutions—create everything from insulin to prosthetic prototypes. These grassroots biohackers challenge traditional science by pursuing open, accessible innovation, raising questions about credibility, ethical oversight, and acceptance by mainstream researchers.

The origin of atmospheric science while testing nuclear weapons during the Cold War

The arms race between the US and the Soviet Union saw both countries stockpiling and detonating hundreds of bombs underground, underwater, and in the atmosphere. To better predict where nuclear fallout would travel after these tests, scientists developed models that would serve as a foundation for those used to explain atmospheric circulation.

During the Cold War, the Soviet Union created a Eurovision competitor

The Soviet Union was not a member of the European Broadcasting Union, so it couldn't compete in Eurovision. In 1977, it turned a preexisting Polish-language singing competition into one that more closely resembled Eurovision and renamed it Intervision. The competition was open to countries from across the globe, regardless of their form of government, though most entrants were from communist countries.

A 36-year-old Russian physicist survived a particle accelerator beam to the head

Several safety mechanisms failed during Anatoli Bugorski's inspection of malfunctioning equipment at the U-70 synchrotron, the Soviet Union's largest particle accelerator. Despite receiving as much as 600 times the lethal dose of radiation to the brain, he has shown no intellectual damage and worked until the age of 77.

Single-cell organisms have circadian clocks that direct daily biochemical routines

Cyanobacteria, a type of light-sensitive bacteria, use this clock to signal when to alternate between making organic compounds through photosynthesis and when to convert atmospheric nitrogen into usable ammonia. Upregulating photosynthetic machinery before dawn helps ensure efficient photosynthesis.

Before humans, the Soviet Union and the United States sent animals—including apes, dogs, and cats—to space during the Space Race.

The Chernobyl exclusion zone remains a region restricted to public access

It now spans beyond the initial 30-kilometer radius around the nuclear plant to include surrounding areas found to have significant radioactive contamination. Aside from a handful of elderly self-settlers, permanent residency is banned, and access remains tightly controlled due to lingering radioactive contamination.

The common 'Three Sisters' mound-planting system used by natives

In the 17th century, Native Americans cultivated a three-plant combination of corn, beans, and squash—a symbiotic tradition dating back hundreds of years. The corn allowed the beans to climb, the beans fertilized the plants by extracting nitrogen from the air, and the squash leaves protected the soil and preserved moisture. Learn more about the tradition here.

The most common spacewalk spacesuits are over four decades old

NASA's Extravehicular Mobility Unit has been in use since the 1980s, with 11 units of the model in existence and four in active use on the ISS at any given time. It consists of 11 layers, a primary life support system (which resembles a backpack), a drinking bag, and more.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Scientists testing how climate change affects plants found, in a years-long simulation study, that poison ivy grew 70% faster with the resulting extra carbon dioxide.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

Explore what it's like inside a patient isolation unit, used in situations such as treating a patient or suspected patient with Ebola.

Artificial coral reefs have been 3D printed from nontoxic, biodegradable terracotta clay, which coral polyps have used as a foundation for rebuilding marine ecosystems.

In 1963, a basement renovation in Turkey revealed a passageway to a hidden, multilevel underground city that once housed as many as 20,000 people

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

See how Budweiser's famous Clydesdales spend their days at Warm Springs Ranch, where roughly 70 to 80 of the beer brand's giant horses can be found at any given time.

In 1984, Operation Smash Hit intentionally crashed a 239-ton train into a nuclear waste canister at 100 miles per hour to prove the canister's safety, which remained completely intact and lost just 0.29 of its 100 pounds of pressure.

Legendary architect Frank Lloyd Wright designed the SC Johnson headquarters in Wisconsin, aiming to make a cathedral-like workplace

In its famous catalog, Sears sold $600 DIY house kits from 1908 through the 1940s, resulting in an estimated 100,000 'Sears and Roebuck homes.'

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

The 1987 Nintendo video game 'Stadium Events' isn't known for being particularly fun, but its scarcity has made it a highly sought-after item that has sold for up to $35K at auction.

US intelligence allegedly pursued more than 600 schemes to assassinate Cuban revolutionary Fidel Castro.

NBA superstar Victor Wembanyama spent the 2025 summer training with monks in central China to enhance his body and mind.

Planeterrellas create artificial auroras that mimic the atmospheric displays of light by setting up an electric field between two metal balls in a jar filled with a small amount of air.

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

When you complete a CAPTCHA on a website to prove you are human, you may be unknowingly training algorithms for self-driving cars, whose systems require training data to help identify crosswalks, bicycles, and other outdoor objects.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.