When common sounds become disturbing

Misophonia is a neurological disorder where sounds trigger strong emotions

The phenomenon is characterized by decreased tolerance to specific sounds, such as heavy breathing, pen clicking, and water dripping, which trigger a fight-or-flight response. The resulting emotions, which can range from irritation and disgust to anxiety and fear, can be overwhelming and uncontrollable.

People with tinnitus should avoid silence—sound-rich environments distract the brain

This podcast from an audiologist discusses common questions about tinnitus. It notes that tinnitus could be described as a phantom sound associated with hyperactivity in the brain. It's linked with loud sound exposures above 85 decibels, hearing loss associated with aging and stress, among other factors.

Why you may hate the sound of your voice

It's a relatively common experience to cringe while listening to a recording of your own voice. This Popular Science article offers physiological explanations for the discrepancy between what we hear when we speak versus what others hear. The piece also expands on the psychology behind this discontent, and how our voices influence our self-perception and social interactions.

Misfired motor signals may explain why many people with schizophrenia hear voices

Up to 80% of schizophrenia patients may have auditory hallucinations. Recent research concluded that this symptom may be from misfired motor signals that feed into each other, essentially failing to suppress certain sensory neural activities and that resulting overexcitment fuels hallucinations. The finding suggests that, one day, magnetic pulses might be used to stimulate specific nerves to better regulate the errant signals and reduce or stop hallucinations. (Some users may encounter a paywall.)

Fear or disgust related to clusters of holes and cracks, called trypophobia, may stem from evolutionary processes to help us avoid pathogens

This type of extreme reaction to harmless holes, dots, cracks, and seed collections can be debilitating for those who have it, but it is not an officially recognized disorder in the DSM-5.

Fear or disgust related to clusters of holes and cracks, called trypophobia, may stem from evolutionary processes to help us avoid pathogens.

Individuals with synesthesia experience involuntarily overlapping sensations

Tasting words or seeing colors in music results from the brain retaining extrasensory connections from infancy. While most lose these neural pathways during development, about 4% of people are synesthetes, maintaining them without realizing it's unusual.

50 years of research has focused on unraveling the relationship between music and frisson

One insight reveals that musical passages with surprising volume changes or unexpected harmonies and beauty are more likely to trigger frisson, perhaps because they upend listeners' expectations.

Neural replays in mice help explain food aversions

Princeton University scientists published research in 2025 analyzing how mice learn to associate certain foods or flavors with feeling ill—even when there’s a time gap between eating something and feeling sick. The work, performed with grape Kool-Aid and injections of a substance that made mice sick, traced the literal “gut reaction” of how gut distress signals are linked to neural replays of what the mouse ate.

Touch deprivation can heighten anxiety and depression

Pacinian Corpuscles are pressure receptors just under the skin that send signals to the vagus nerve in the brain—that's the cranial nerve which regulates involuntary actions like breathing, heart rate, and the general "fight or flight" response. Activating those receptors can slow the heart, decrease blood pressure, and lead to the release of oxytocin and cortisol. The absence of touch, conversely, can promote negative feelings.

Anosmia is the total loss of the sense of smell

This type of loss—due to disease or trauma—has ripple effects, including an altered or limited sense of taste. This video details the anatomy and physiology of our sense of smell and taste and how these senses are interrelated.

Noise-canceling headphones cancel out environmental sounds with sound of its own

If sound waves are perfectly out of sync, they can undergo destructive interference, canceling each other out. A microphone in noise-canceling headphones picks up external sounds, and an out-of-sync version is emitted to cancel them out in your ears.

Over time, people develop a resistance to spicy foods

TRPV1 is a receptor in the body that detects potentially harmful things and responds in a variety of ways, including sweating, tearing up or a runny nose. Over time, more exposure to spicy foods can build up a resistance that minimizes these reactions.

Mapping hearing loss in the US

Nearly 10% of Americans suffer from some degree of hearing loss, measured as the inability to hear sounds lower than 25 decibels. The incidence of hearing loss increases with age and is typically higher among men. Recent analysis produced a puzzling observation researchers can't quite explain: There's a larger incidence of hearing loss among rural populations than in urban centers. Explore the data with this map and explainer.

Overuse of opioids can lead to hypersensitivity to pain

Opioid misuse can lead opioid-induced hyperalgesia, where the body becomes increasingly sensitive to pain. The body produces its own opioids as a way to temporarily block pain signals. When met with external opioid use, the body ratchets up pain sensitivity to ensure it senses the pain necessary to trigger its own response.

What happens to the brain during migraine?

Migraine is a neurological condition that can cause debilitating symptoms across various bodily functions. So, what exactly is happening in the brain during these attacks? This five-minute video briefly overviews the internal machinations behind the painful episodes. An incapacitating headache is a common symptom of migraine, though migraine can occur without any headache.

To get that song out of your head, try distracting yourself or playing a new song

Around 90% of people experience getting a snippet of a song stuck in their head, also known as an earworm. Researchers think they are linked to memory, repetition, and inner rehearsal. Before written language, music was used alongside rhyming in many cultures to help people preserve oral histories.

Sound can shatter glass if its frequency matches the material's natural vibrations

The sound made by an object when struck is its resonant frequency, which is the sound made when energy is dissipated. Providing energy at that frequency amplifies the vibrations, rather than allowing them to dissipate, which can deteriorate the object's structural integrity.

On average, people smell worse if they're sick

For a small 2014 research study, a panel was tasked with sniffing the smelly t-shirts of people who had been injected with a compound known to activate the immune system and those of controls without the shot. It found that those who were acting as if unwell (due to the injection) generally smelled worse. Subsequent work found that those who sniffed unpleasant odors had a mild immune response of their own—perhaps to protect them from disease. (Some users may experience a paywall.)

The word allergy is partly derived from the Greek word 'allos' for 'other'

For people with allergies, their immune systems recognize substances as a harmful "other"—cuing an inflammatory response. This podcast explores allergy details and related topics, including how scientists are interested in if the same allergic response mechanisms could underpin other health issues, including severe, painful symptoms around the time of menstrual cycles. Since estrogen acts on white blood cells called mast cells, which leads to the release of histamines—similar to what happens during allergic responses—an understudied question is whether the same process is fueling some of the uncomfortable symptoms around menstruation. An allergist guest notes this raises questions about if antihistamine medications like Pepsid might alleviate them, something that hasn't yet been explored in clinical trials.

What happens when the gut microbiome is out of whack?

An imbalance in gut microbiome flora can lead to a condition known as dysbiosis. This condition is typically characterized by a drop in microbiota diversity and an increase in harmful unicellular and acellular organisms, such as viruses, that can negatively impact the host's immune system and overall health. Genetics, infections, dietary choices, antibiotics, food additives, artificial sweeteners, and other lifestyle and environmental factors can cause dysbiosis.

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

Menopause and perimenopause symptoms may affect both the mind and body

Women going through these aging transitions may experience some common physical and mental symptoms to varying degrees, including hot flashes, bladder control issues, brain fog, and vaginal dryness. This article dives into some of the most common symptoms women might expect during perimenopause, plus what they can do to relieve them.

A licensed therapist shares advice for kindly addressing feelings of irritation in your relationship

All couples are bound to annoy each other, and it's often not caused by ill will. Reflecting on how and when to express pet peeves is important for ultimately building a connection and helping partners not feel attacked. While differences may not always be fully resolved, it can be helpful to discuss paths forward toward a compromise.

Anhedonia, which means 'without pleasure' in Greek, is typical in major depressive disorder

This common symptom—a flat affect—results in previously enjoyable hobbies no longer bringing pleasure. People with anhedonia may also avoid social situations because they anticipate they'll bring no joy, not because of anxiety or fear.

Losing a brain-computer interface can trigger lasting psychological distress

A clinical trial participant with severe epilepsy described becoming “one” with her implant after it gave her unprecedented control over her seizures. When the device was removed due to the company shutting down, she experienced deep emotional trauma and a sense of personal loss.

Emotional crying is an important and cathartic process

Though babies don't initially produce tears when they cry, this podcast discusses how humans are hardwired to cry throughout life. Most crying research relies on self-reporting of crying and emotions. This podcast notes that there aren't neuroimaging studies of crying—they're quite expensive to complete. As a result, the brain precursors and processes during a bout of crying remain understudied.

Some researchers have labeled nomophobia, the fear of being without your phone, as 'the phobia of the 21st century.'

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

A pickleball's loud 'pop' sound can reach 120 decibels, which is equivalent to a hammer hitting a nail

Fireworks make a loud booming sound after exploding due to air expanding faster than the speed of sound.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Poison ivy is in the same family as mangoes, cashews, and pistachios—and they all produce oily urushiol in their raw, unprocessed state—but they are typically prepared in ways to avoid causing human discomfort.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

A 2019 Facebook event called on attendees to "Storm Area 51, They Can't Stop All of Us," resulting in countless memes, the creation of a music festival, and eventually the arrests of those who did try to approach the area.

American short story writer Flannery O'Connor raised 40 peacocks, which became potent symbols for her fiction's elegant violence

Existentialist writer Jean-Paul Sartre coined the famous phrase 'Hell is—other people' in his play 'No Exit'

Prince's sexually explicit 1984 track 'Darling Nikki' attracted the ire of the Parents Music Resource Center, an advocacy group that inspired the Parental Advisory sticker, even though the song ends with a Christian message.

In 2019, a laptop loaded with six of the worst malware in history and described as 'an exhibit of historical weaponry' sold for $1.3M.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

Watch how deep-sea mining equipment collects and processes polymetallic nodules—metal-rich, potato-shaped rocks—from the ocean floor and creates environmentally damaging plumes of sediments.

Legendary architect Frank Lloyd Wright designed the SC Johnson headquarters in Wisconsin, aiming to make a cathedral-like workplace

Learn how to read a prospectus, the juicy document that any company must file with the SEC before going public.

See photos of Meteora, a mountainous site in central Greece, home to 14th-century monasteries perched atop soaring outcroppings.