Brain conditions and surgery can cause some individuals to feel no fear

Fearology, or the study of fear, explores the difference between stress and fear

Our brains involuntarily respond to our environment and signal alarm when that isn’t always needed, triggering responses that include goose bumps. But understanding fear and how to talk our brains into calming down can improve daily life.

Where do phobias come from?

Scientists say phobias are extreme version of a primitive evolutionary mechanism that tells us when danger is near or we are in a dangerous situation. A number of brain regions work in concert to trigger flight or fight responses, and with some...

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

Our ancient fight-or-flight response may contribute to modern ailments

Many common modern diseases humans struggle with may in fact have their origins in our ancient fight-or-flight stress response. Long-term effects of the stress hormones cortisol and adrenaline—in this case, triggered by things like workplace stressors—can wreak havoc on the delicate internal balance of our organ systems.

An intense fear must persist for at least six months to be diagnosed as a phobia

Research suggests that both environmental and genetic factors can contribute to the onset of these intense, irrational fears. Often, they can stem from an early traumatic experience, but not always.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

Why so many people love roller coasters even though they’re scary

When a threat arises, it triggers our bodies to go into fight-or-flight mode and prepare for danger. However, when no obvious threat to our safety is present, this natural high can become enjoyable. Some people are more likely to enjoy these thrills based on factors like individual brain chemistry or physical health.

Animal phobias are likely the most common type of phobias, followed by an extreme fear of heights.

Does our fear of Alzheimer's create stigma around its treatment?

Surveys suggest our fear of Alzheimer's as a disease outranks that of heart disease and cancer. This piece argues our fear of aging and the slipping away of our mental capacities make it more difficult to treat Alzheimer's compassionately.

How the feared self fuels OCD

Obsessive-compulsive disorder is characterized by intrusive thoughts that prompt people to enact compulsions—behaviors intended to relieve the anxiety or stress from the obsession. A significant intrusive thought OCD sufferers endure is the fear they will become a dangerous or immoral person. Therapeutic approaches try to show patients this is just a story that can be set aside.

Grief rewires the human brain

The human brain handles stress and emotional traumas similarly. In response to the emotional stress of a situation like the death of a loved one, divorce, or abuse, the brain may strengthen or weaken connections between nerves to form new neural connections. Over time, chronic stress can diminish brainpower, reducing overall nerve growth and memory to shift resources to enable elevated fear responses and enable humans to survive.

Fear or disgust related to clusters of holes and cracks, called trypophobia, may stem from evolutionary processes to help us avoid pathogens.

Panic attacks are intense fear episodes that often occur without a clear trigger

Unlike typical fear responses to real danger, panic attacks can mimic serious health problems, such as heart attacks. Sweating during a panic attack may seem random, but it's a leftover survival mechanism that made it easier for our ancestors to escape by slipping out of an attacker’s grasp.

Why 'spacing out' or dissociating may help reduce trauma awareness

Dissociation may have developed as a defense mechanism in the brain to help navigate intense emotional or physical situations by providing out-of-body experiences that put distance between the mind and the environment. However, in about 1.1% and 1.5% percent of the general population, a severe form of this separation can produce alternate identities, or alters.

Menopause can exacerbate anxiety

Some research shows that menopause can fuel anxiety and also that pre-existing anxiety can boost the chances of experiencing other menopause symptoms, including hot flashes, insomnia, and brain fog. But treatments including hormone replacement therapy, breathing exercises, and other forms of exercise can alleviate some of these symptoms.

The limbic system drives emotion, memory, and survival instincts in the brain.

This interconnected group of brain structures—including the amygdala, hippocampus, thalamus, and hypothalamus—processes emotional responses, regulates bodily functions, and plays a key role in memory and learning.

Surgery before the dawn of anesthesia

The arc toward anesthetics was painfully slow, with early pain mitigation offerings ranging from analgesics—drugs that dim pain but don't block it—and numbing surgical sites with cold water to gassing patients with carbon dioxide or bashing or bleeding them unconscious. Such treatments and the torturous surgery they preceded led many to avoid even life-saving procedures, and those who survived often kept silent about the trauma.

Some researchers have labeled nomophobia, the fear of being without your phone, as 'the phobia of the 21st century'

The phobia's name is short for "no-mobile-phone phobia" and was first recognized as a result of 2010 UK government study that found men, in particular, were uncomfortable and anxious being away from their devices.

Touch deprivation can heighten anxiety and depression

Pacinian Corpuscles are pressure receptors just under the skin that send signals to the vagus nerve in the brain—that's the cranial nerve which regulates involuntary actions like breathing, heart rate, and the general "fight or flight" response. Activating those receptors can slow the heart, decrease blood pressure, and lead to the release of oxytocin and cortisol. The absence of touch, conversely, can promote negative feelings.

An overview of modern clinical research on LSD

Researchers have determined that LSD, taken in a medical setting, decreases anxiety related to "life-threatening disease," reduces brain reactivity to fearful faces, increases the meaning and emotional response derived from music, and more. No complications of LSD administration have been observed in medical settings, though acute adverse effects, including exhaustion, nausea, and difficulty concentrating.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Losing a brain-computer interface can trigger lasting psychological distress

A clinical trial participant with severe epilepsy described becoming “one” with her implant after it gave her unprecedented control over her seizures. When the device was removed due to the company shutting down, she experienced deep emotional trauma and a sense of personal loss.

Sleep disorders can exacerbate neurological and other health conditions

Brain regions that control sleep sit adjacent to those that regulate the autonomic nervous system, which controls involuntary bodily functions like heart and breathing rates. These neighbors influence each other, meaning poor sleep can impair or negatively impact the ANS, further disturbing sleep.

Some researchers have labeled nomophobia, the fear of being without your phone, as 'the phobia of the 21st century.'

How depression affects the brain

Treatment for depression has historically hinged on the theory that the condition was caused by underactive or abnormal neurotransmitters, specifically serotonin and norepinephrine. This four-minute video by Yale Medicine details how these neurotransmitters didn't explain the symptoms of depression but, two other neurotransmitters involved in regulating mood and emotion did. GABA and glutamate, some of the brain's most plentiful neurotransmitters, may possibly be the source of depressive symptoms.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

Aphantasia involves a lack of mental images—but doesn't affect behavior

The condition, generally known about for over a century, first received its name in 2015 by researcher Adam Zeman. An estimated 4% of people lack this ability to perceive mental images, and research suggests this deficiency does not have any practical impact on behavior.

She can't feel pain, hunger, or danger

Olivia Farnsworth, born with a rare chromosome 6p deletion, may be the only person known to lack pain, hunger, and fear responses. This overview explores her unique condition, the incredible incidents that revealed it, and how scientists hope her case could unlock new insights into human survival and sensory systems.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Why do some people always get lost?

Using GPS, anthropological data, and VR, scientists have learned that one's sense of direction is largely influenced by upbringing. A person's wayfinding ability can be measured by how accurately they point toward an out-of-sight location, a challenge further complicated by imagining they're somewhere else and pointing toward a third location. Anxiety, safety concerns, and dislike of wandering can negatively impact one's sense of direction, which can improve with practice.

How humans breathe without thinking about it

We breathe without thinking about it thanks to the body’s respiratory system and autonomic nervous system, which controls vital functions. Breathing transports oxygen to the body’s cells to keep them working and clears the body of carbon...

What happens to the brain during migraine?

Migraine is a neurological condition that can cause debilitating symptoms across various bodily functions. So, what exactly is happening in the brain during these attacks? This five-minute video briefly overviews the internal machinations behind the painful episodes. An incapacitating headache is a common symptom of migraine, though migraine can occur without any headache.

Less than 1% of people globally have schizophrenia, a syndrome strongly linked to genetics

Schizophrenia's causes remain largely unknown, though scientists suggest it's caused by multiple factors. Its symptoms include disruption of thought processes rather than the exhibiting of multiple personalities. This brief video provides an overview of the condition.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

Chaos theory—informally known as the butterfly effect—is the reason why weather forecasts are presented with probabilities rather than certainties.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Human-to-human transmission of hantavirus remains extremely rare, so the 2026 hantavirus cruise ship outbreak doesn't mean we're facing a COVID-style pandemic risk.

Cultural norms about how to handle the bodies of loved ones in communities in West Africa have hampered Ebola responses.

Radioactive elements can introduce software errors because the ionizing radiation they produce can detach electrons from atoms, and computer code relies on the distribution of electrons.

The animatronic shark from Steven Spielberg's 'Jaws,' the first modern blockbuster, was a complex underwater apparatus called 'Bruce.'

When you complete a CAPTCHA on a website to prove you are human, you may be unknowingly training algorithms for self-driving cars, whose systems require training data to help identify crosswalks, bicycles, and other outdoor objects.

SpongeBob exemplifies Aristotle's philosophy for living well because he understands that happiness doesn't come from external factors like money, recognition, or power.

Fireworks-related ER visits are on the rise—in 2024, they increased by 52% as compared to the prior year.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

American dance legend Martha Graham, sometimes called 'the Picasso of dance,' refused to perform at the 1936 Olympics in Berlin and conceived the piece 'Chronicle' in response to the experience.

The power and influence of the American presidency have expanded significantly over time—far beyond what the founders envisioned.

Hedge funds, the private investment firms that trade a wide swath of financial assets, make money by imposing steep fees on investors and from the fund's investment performance.

Exploring the Larry Bird punch that almost changed March Madness