Is conventional wisdom about amyloid plaques wrong?

Scientists are reevaluating the causes of Alzheimer's beyond the amyloid hypothesis

The cause of Alzheimer's disease has been debated for decades. The amyloid cascade hypothesis—where plaques build up in the brain, triggering neurodegeneration—has long been the leading theory. But after a number of failed drug trials, researchers are beginning to reevaluate various culprits. [Untreated hearing loss is linked with dementia risk](https://www.thelancet.com/article/S0140-6736(20)30367-6/fulltext) Hearing loss does not cause dementia, but it does increase the risk of developing dementia and research suggests that people who wear hearing aids for age-related hearing loss also maintain better brain function than those who don't.

"Plaques" and "tangles" are top potential causes of Alzheimer's—but questions remain

The exact causes of Alzheimer's—and how to treat it—continue to be the subject of intense research. Two leading factors are amyloid beta plaques and tau protein tangles, which effectively pile up in the brain and interfere with neurons and cause cell death, which manifests as memory loss and other symptoms.

A top Alzheimer's researcher was accused of faking results

In 2021, an investigation revealed photo manipulation in images from a seminal 2006 paper by researcher Sylvain Lesné on the role of amyloid plaques in progressive Alzheimer's disease. The revelation rocked the field, leaving many wondering whether they had tried to build on fabricated results. (Some users may experience a paywall.)

More than 200 drug trials for Alzheimer's have failed or been abandoned since 2010

The complexity of Alzheimer's disease, coupled with decades of underfunded research efforts, has left patients with little in the way of effective treatments. In recent years, scientists have synthesized several drugs that studies show can slow the progression of Alzheimer's—though the disease itself remains incurable.

Early-onset Alzheimer's can appear as early as age 30

Drugs recently approved to slow the progression of Alzheimer's appear to work best when administered as early as possible. Early stages are marked by a low buildup of tau, a protein experts believe clumps into misfolded, neuron-disrupting tangles once clusters of another protein—amyloid beta—have already started causing damage.

Why genetic testing for Alzheimer's risk may not be right for you

Medical experts warn that completing Alzheimer's testing for late-onset versions of the disease can be fraught, in part because there's a shortage of genetic counselors to help navigate the findings and their potential implications, including for one's finances. Learning you have one or two copies of the APOE4 gene variant, which elevates Alzheimer's risk, can be panic-inducing, but an elevated risk for the disease is not the same as saying it definitely will develop.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Does our fear of Alzheimer's create stigma around its treatment?

Surveys suggest our fear of Alzheimer's as a disease outranks that of heart disease and cancer. This piece argues our fear of aging and the slipping away of our mental capacities make it more difficult to treat Alzheimer's compassionately.

These areas of the brain are hard-hit in depression—but the changes are reversible

Depressed brains can have certain characteristic changes, including an overactive amygdala, reduced hippocampus size, and changes to the thalamus and neuromodulating chemicals in the brain.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Remylination is a huge focus for treatment—especially among older adults

Our ability to build new myelin sheaths for nerves degrades with age. There have been research advances boosting cells that support these processes and clear away debris from degraded myelin, but not yet any medications to boost myelination itself, which would aid nerve signaling and preserve nerve function.

The brain doesn't seem to massively rewire following amputation—upending earlier beliefs about phantom pain

The findings, published in 2025, traced three amputees' brain-body maps and how they respond to body part movements—both before and after scheduled arm amputations. The unexpected neural stability suggests that the unchanged pathways for the missing limbs may explain why people continue to feel them so acutely.

Most penicillin allergy diagnoses are wrong

A Freakonomics Radio episode investigates why so many people mistakenly believe they’re allergic to penicillin. This widespread misdiagnosis leads to costlier, less effective treatments and contributes to the growing problem of antibiotic resistance.

Long-term memory formation may not need short-term memory

New research shows that long-term memories can still develop even when short-term memory formation is blocked, suggesting the brain uses separate pathways for short- and long-term memory. This discovery could help scientists open new avenues for treating memory loss in diseases like Alzheimer’s.

Critics say Nobel Prizes need updating to reflect how science and society work today

The rules still favor individuals over teams and may reflect outdated views on who does science. In 2013, the Nobel Prize in physics went to two theorists, even though over 5,000 scientists helped confirm the Higgs boson.

Neanderthal stereotypes fall flat in the face of evidence, advocates argue

Picture a Neanderthal in all their knuckle-dragging, loin cloth-wearing glory. Now, throw that picture away. This article dives into the rising tide of academic advocates for Neanderthals, a human ancestor that went extinct about 40,000 years ago.

How psychedelics can potentially reinvent learning

Critical periods, discovered in the early 20th century, describe a period when someone is incredibly sensitive to their environment, and any information learned can stick with them for life. Some researchers argue these states can be "reopened" via psychedelics, which put the mind into a malleable state that can potentially be used to treat conditions ranging from lazy eyes to PTSD.

The myth of multitasking's prestige

In this article, renowned neurologist Richard Cytowic seeks to expose multitasking as a fool’s errand. Cytowic explains how the brain, like a computer, switches between tasks rather than handling multiple tasks at once. He shares that attempting to focus on multiple activities at the same time consequentially decreases the brain's ability to ignore distractions, maintain focus, and organize information. Instead, he suggests, try to focus on completing one thing at a time.

American medical organizations rescind recognition of diagnosis cited in police custody deaths

American medical organizations have rescinded their recognition of a syndrome whose theory stemmed from discredited research. This article explores the history and implications of "excited delirium syndrome," a medical condition that can reportedly...

How Nobel Prize-winning research unraveled why the immune system doesn't always attack itself

The 2025 Nobel Prize was awarded to scientists who discovered how immune system soldiers are typically stopped from attacking healthy tissue. The work furthered autoimmune understanding and cancer therapies.

This Harvard philosophy professor suggests we should rethink our relationship with animals

Christine Korsgaard, a professor of philosophy at Harvard, wrote a book arguing that humans are not more important than other animals and that we should improve our treatment of them. In her view, we have a duty to value the life of our fellow creatures not just for their utility, but for their existence as sentient and conscious beings.

Anthropic's interpretability team discusses how AI models' thinking mimics biology

Just as humans engage in complex behaviors to survive and reproduce, teams of experts in neuroscience, virology, mathematics, and other disciplines argue that large language models develop complex mechanisms to achieve their goals. These mechanisms can be manipulated to assess how they modify outputs—much like stimulating individual neurons—to uncover how LLMs "think."

How the placebo effect became mainstream

Contemporary patients and medical students take the placebo effect for granted, as its a standard element in most drug trials. But the concept was only first debated and standardized in the 1950s after a ground-breaking 1955 paper by medical...

Déjà vu is a memory illusion involving brain regions correcting inaccurate memories

Neuroscientists suggest the phenomenon is your brain recognizing that this feeling of familiarity is incorrect, showing off the brain's internal fact-checking system. Younger people experience déjà vu more often because their brains have higher excitatory activity and stronger memory monitoring systems.

Everything you know about Phineas Gage is wrong

A stray spark sent a 3.5-foot-long, 1.25-inch thick iron rod through the brain of foreman Phineas Gage in 1848, creating a scientific case that has attracted onlookers for nearly two centuries. His life reportedly soon spiraled out of control, with his behavior tending toward selfishness and chaos. Evidence of these changes is far less common, with Gage's story bloated by fabrication, scientific prejudice, and artistic license.

CBT helps rewire the brain's false beliefs by challenging negative thoughts

Cognitive behavioral therapy identifies how specific situations can trigger distorted core beliefs—often formed early in life—that negatively shape thoughts and behavior. It frequently uses structured questioning that promotes self-reflection to uncover distorted thinking and guide people toward more balanced perspectives.

The belief that classical music enhances intelligence is mostly incorrect

"The Mozart Effect" was based on a 1993 study by psychologist Francis Rauscher. Rauscher played a Mozart Piano Sonata for college students and then assessed their spatial reasoning, finding it improved for 10 to 15 minutes. The media ran with a simpler story: listening to classical music made you smarter.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

How the most famous Ebola book, The Hot Zone, which sold 3.5 million copies and was translated into 30 languages, got aspects of the disease so wrong.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

SpongeBob exemplifies Aristotle's philosophy for living well because he understands that happiness doesn't come from external factors like money, recognition, or power.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

The Mona Lisa's celebrity status and repeated restorations have obscured what made the painting so revolutionary for its time

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

Warren Buffett's former professor Benjamin Graham is known as the 'father of value investing,' a strategy in which investors seek to buy stocks trading below their intrinsic worth.

Search a massive database of over 4 decades of clues from the TV quiz show 'Jeopardy!'

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

The name 'Silicon Valley' arose from the founding of Shockley Semiconductor Laboratory in Fairchild Semiconductor in 1956-57, founded near Stanford University in Palo Alto

Famed poet TS Eliot rejected the manuscript for George Orwell's political fable 'Animal Farm,' writing that its criticism of authoritarianism was not 'the right point of view.'

Legendary architect Frank Lloyd Wright designed the SC Johnson headquarters in Wisconsin, aiming to make a cathedral-like workplace

The power and influence of the American presidency have expanded significantly over time—far beyond what the founders envisioned.