The neuroscience of heartbreak

Love and heartbreak trigger powerful, neurochemical-driven changes in the body

The feeling of falling in love floods the brain with dopamine, oxytocin and serotonin, which collectively dull pain and boost immunity. However, the loss of these chemicals during a break-up produces withdrawal-like symptoms and heart issues, such as high blood pressure.

Grief rewires the human brain

The human brain handles stress and emotional traumas similarly. In response to the emotional stress of a situation like the death of a loved one, divorce, or abuse, the brain may strengthen or weaken connections between nerves to form new neural connections. Over time, chronic stress can diminish brainpower, reducing overall nerve growth and memory to shift resources to enable elevated fear responses and enable humans to survive.

These areas of the brain are hard-hit in depression—but the changes are reversible

Depressed brains can have certain characteristic changes, including an overactive amygdala, reduced hippocampus size, and changes to the thalamus and neuromodulating chemicals in the brain.

'Susan's Brain': what happens to the brain during addiction

This engaging animation from Harvard Online breaks down the neuroscience of addiction through the story of “Susan’s brain,” demonstrating how addictive substances hijack normal reward pathways. Through clear visual metaphors and approachable narration, it explains complex brain chemistry in understandable terms.

The brain doesn't seem to massively rewire following amputation—upending earlier beliefs about phantom pain

The findings, published in 2025, traced three amputees' brain-body maps and how they respond to body part movements—both before and after scheduled arm amputations. The unexpected neural stability suggests that the unchanged pathways for the missing limbs may explain why people continue to feel them so acutely.

Yes, you can die from a broken heart

Researchers reviewed the health records of about 200,000 people diagnosed with broken heart syndrome from 2016 to 2020 and the death rate was 6.5%—with men's deaths roughly doubling that of women.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

What happens to your brain when you burn out?

You've probably heard of burnout, also known as the feeling of exhaustion that happens after a long period of being overwhelmed or stressed. It's often associated with work and careers, but other parts of life, like parenting, can cause burnout, too. Scientists are figuring out what happens, biochemically speaking, in the brain when burnout hits—and spoiler alert, it includes a neurotransmitter called glutamate. Watch this video to learn more.

The brains of people who experience frisson have unique neural pathways

A small 2016 study aimed to investigate the behavioral and neural differences between 10 individuals who experience goose bumps when listening to music and 10 who typically don’t. Scientists reported that individuals experiencing musical chills had greater white matter connectivity in specific auditory, emotional, and social processing areas of the brain.

Why the human brain loves opioids

When opioids enter the brain, they dock in receptors, blocking electrical pulses such as those that communicate pain. They also trigger the release of dopamine, a neurotransmitter tied to motivation and associated with stress relief.

What happens in a dying brain?

Near-death experiences usually happen during death or on the border of life and death when a person isn't understood to be conscious. This article details the science of what's going on with the brain during NDEs.

Emotional crying is an important and cathartic process

Though babies don't initially produce tears when they cry, this podcast discusses how humans are hardwired to cry throughout life. Most crying research relies on self-reporting of crying and emotions. This podcast notes that there aren't neuroimaging studies of crying—they're quite expensive to complete. As a result, the brain precursors and processes during a bout of crying remain understudied.

A brain scientist's experience with a stroke

What happens when a leading brain scientist has a stroke of her own? Dr. Jill Bolte Taylor recounts moment by moment watching her brain function slow and then cease, followed by a prolonged recovery. Through this experience, she details what she learned about the phenomenon of stroke and how it has impacted her research ever since.

What happens to the brain during migraine?

Migraine is a neurological condition that can cause debilitating symptoms across various bodily functions. So, what exactly is happening in the brain during these attacks? This five-minute video briefly overviews the internal machinations behind the painful episodes. An incapacitating headache is a common symptom of migraine, though migraine can occur without any headache.

Mixed reality technologies may help treat depression

A study led by a team from Stanford University showed that MR can help people with depression by providing pathways to engage in activities such as digital board games and dancing. Participants saw reduced symptoms of depression that made their overall treatment plans more successful.

Stress can be contagious—and scientists want to learn more about it

Researchers have shown that being around someone who is stressed can trigger a stress response in your body, such as elevated cortisol levels and elevated heart rate. One way this was recently studied was by having people watch stressful activities, like a recorded job interview or solving challenging math problems, and then sampling hormones in observers' spit.

How brain cells carry information

At any moment, there is an electrical storm coursing through your body. Discover how chemical reactions create an electric current that drives our responses to everything from hot pans to a mother’s caress.

Menopause affects the brain in complex ways

Lisa Mosconi, a neuroscientist studying the impact of menopause on the brain, explains in this video how menopause directly impacts a woman's brain health and explores why this is an important and often overlooked area in menopause and women's aging healthcare discussions.

How do brain scans work?

There’s only one thing in our solar system sophisticated enough to study itself: the human brain. But this self-investigation is challenging because a living brain is shielded by skull, swaddled in tissue, and made up of billions of tiny cells. How do we study living brains without harming their owners? Two experts explain how the various techniques like EEGs, fMRIs, and PETs work in this TedEd talk.

How science explains déjà vu

Take a fun look at the science explaining the odd experience of déjà vu, which some theories suggest is actually a sign of a healthy brain.

Neural replays in mice help explain food aversions

Princeton University scientists published research in 2025 analyzing how mice learn to associate certain foods or flavors with feeling ill—even when there’s a time gap between eating something and feeling sick. The work, performed with grape Kool-Aid and injections of a substance that made mice sick, traced the literal “gut reaction” of how gut distress signals are linked to neural replays of what the mouse ate.

When common sounds become disturbing

Misophonia causes certain sounds to feel violating, triggering a "very visceral kind of experience" filled with extremely unpleasant emotions, including annoyance, anger, and disgust. A 2017 study found that people with misophonia have elevated activity in the brain's anterior insula—a region associated with interoception, emotional processing, and behavioral responses—when exposed to trigger sounds. Ongoing research suggests trigger sound context affects the severity and manifestation of the condition.

What is the brain up to when the mind wanders?

As you stare into the distance while washing your home's seemingly never-ending pile of dishes, the brain activates its default mode network. This collection of "task-negative" brain regions associated with memory, reward, action consideration, and prediction alight with activity when humans mentally turn inward, possibly giving rise to the brain's ability to wander and humans' ability to construct internal narratives about the world.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Some bereavement support groups prohibit dating other members

This in-depth podcast covers many aspects of grieving and support. One aspect it discusses is that people may naturally feel a connection with others who are going through similar experiences and may want to build community that way, including pursuing romantic relationships. Such liaisons may be off-putting to some participants and that's why some groups prohibit dating other support group members.

Visualizing shifts in emotional performance in film

Computational scientists were curious: has the intensity of emotional expression in films changed over the decades? Using their sophisticated analytical models, the researchers discovered actors' emotional performance has declined in intensity over time. They believe the close-up shots common in contemporary film-making allows actors to be more subtle in their performance. Check out the main takeaways and charts with this unusual study.

How to repair a baby’s broken heart

A rare disorder that prevents some babies from getting enough oxygen to their organs can be repaired through a series of three intricate surgeries. This article and graphic explain the process behind correcting single-ventricle defects, also known as SVDs.This disorder happens when one of the heart's lower chambers doesn't work correctly, resulting in deoxygenated and oxygenated blood circulating the body rather than just the latter.

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

Learn how your body is, scientifically, like a firework with its own slow, controlled burn.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

Neutron stars, the remains of some massive stars after they explode in a supernova, are the densest directly observable objects in the universe.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Watch what the Ebola virus does inside our cells and organs in order to spread and survive.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

According to the physics of black holes, our 4D reality may be a hologram—a projection of information coded on a 2D surface on the edge of the universe.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

Existentialist writer Jean-Paul Sartre coined the famous phrase 'Hell is—other people' in his play 'No Exit'

Netflix profits when you're not watching, and its movies are designed that way—read a detail-rich critical essay exposing lesser-known Netflix takes

When you complete a CAPTCHA on a website to prove you are human, you may be unknowingly training algorithms for self-driving cars, whose systems require training data to help identify crosswalks, bicycles, and other outdoor objects.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

Art theft is the third-largest source of criminal revenues worldwide, thanks in part to the subjective nature of valuing a work of art.

A Yale student wrote a profound essay about the consulting industry's influence on elite college students that was published in a book of her writing after she died in a post-graduation car accident.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

Exploring the Larry Bird punch that almost changed March Madness

The first steps to rebuilding your credit score include getting to know exactly what's on your credit report and figuring out how far you are from the '700 club,' or 'good score' range.

The 19th-century painters of the Hudson River School were among the first American romantics, with portraits that displayed the natural beauty of the young country.

Hurricanes, which rely on air consistently spinning in the same direction, cannot cross the equator because air curves in opposite directions north and south of it.

Poison ivy's rash-causing compound is found in the plant's roots, stem, and leaves—so coming into contact with any part of the plant can lead to rashes for the 85% of people who are allergic to it.

Prince's sexually explicit 1984 track 'Darling Nikki' attracted the ire of the Parents Music Resource Center, an advocacy group that inspired the Parental Advisory sticker, even though the song ends with a Christian message.