What happens in a dying brain?

Brain activity goes into overdrive around the point of death

Recent studies suggest increased electrical activity in the brain during and after clinical death could be responsible for near-death experiences. Both high-frequency gamma waves (linked to perception and attention) and low-frequency beta waves (related to focus and concentration) increased and became more synchronized across multiple brain regions, potentially resulting in a near-death state of heightened consciousness.

Around 5% of people report memories of a near-death experience

Near-death experiences are moments reported by people who’ve come close to death, often associated with bright lights, out-of-body sensations, or encounters with otherworldly beings. While scientific research offers theories ranging from brain chemistry to psychological coping mechanisms, no single explanation fully captures the mystery of these experiences.

Some scientists argue NDEs are constructed by the brain, not actually experienced

Despite the powerful memories associated with NDEs, scientists question the idea that the experiences prove consciousness endures after death, opting instead to find physiological explanations for common reports of out-of-body experiences, euphoric and lucid thinking, and more.

Scientists are studying dying patients' brain activity in the final moments of life

In the final moments of life there are distinctive bursts of coordinated neural activity. Researchers are interested in parsing that data to better understand the dying process and also exploring how this data relates to our understanding of consciousness.

The body's response to cardiac arrest has been linked to near-death experiences

Most people who report near‑death experiences experience events like out‑of‑body sensations, altered cognition, emotional and spiritual shifts, or even supernatural phenomena, particularly during cardiac arrest. Research suggests many such experiences may be linked to brain-generated sensory distortions that can be experimentally replicated, suggesting a physiological rather than mystical cause.

NDEs typically change people's outlooks drastically and can prompt depression

The phenomena are regularly categorized as hallucinations, but some specialists are interested in their psychological nuances. Many survivors report feeling less anxiety about death, though some surveys show the experiences can increase physiological sensitivities.

Dr. Bruce Greyson on what we know, and how to study, near-death experiences

Considered one of the premier researchers on near-death studies, Dr. Bruce Greyson discusses what researchers know (and don't know) about what happens as we near death, and recounts his decades of observations on the phenomenon.

Watch this 2021 video demonstrating a full brain death examination

This video and accompanying article in the peer-reviewed New England Journal of Medicine show the then-standard steps of a full brain death examination—demonstrating the process on a medical dummy to search for pain, blinking, eye movement, cough, gagging, or other forms of responsiveness. (May need to sign up for a free account to view.)

When is someone actually dead?

Death is a process, not a sudden flip of a switch. Technology can now interrupt this process at various stages, begging the question of when exactly death happens in the dying process. This 33-minute podcast episode explores this question and the...

Terminal lucidity is the phenomenon of sudden, heightened mental clarity when on the verge of death

The "Let's Talk Near Death" podcast explores phenomena around the end of life, inviting guests to recount their own experiences. This episode focuses on the phenomenon known as "terminal lucidity," where patients experience clarity, vivid memory recall, and more, typically following a heart attack, stroke, or other trauma.

An avowed rationalist discusses his near-death experience

Documentarian Sebastian Junger, a veteran reporter and skeptic discusses his experiences—in particular, a frightening vision—after an aneurysm and internal hemorrhaging left him nearly dead. Junger talks about his NDE, the possible scientific explanations, and how that day changed his fundamental worldview.

What happens to your brain when you burn out?

You've probably heard of burnout, also known as the feeling of exhaustion that happens after a long period of being overwhelmed or stressed. It's often associated with work and careers, but other parts of life, like parenting, can cause burnout, too. Scientists are figuring out what happens, biochemically speaking, in the brain when burnout hits—and spoiler alert, it includes a neurotransmitter called glutamate. Watch this video to learn more.

Brain death is very rare—only 2% of hospital patients have brain death in the US

A peer-reviewed analysis examining US hospital billing code data from 2012 to 2016 concluded that the incidence of brain death is about 2% in the country. There was no available information indicating what proportion of those patients underwent organ donation.

A brain scientist's experience with a stroke

What happens when a leading brain scientist has a stroke of her own? Dr. Jill Bolte Taylor recounts moment by moment watching her brain function slow and then cease, followed by a prolonged recovery. Through this experience, she details what she learned about the phenomenon of stroke and how it has impacted her research ever since.

What happens to the brain during migraine?

Migraine is a neurological condition that can cause debilitating symptoms across various bodily functions. So, what exactly is happening in the brain during these attacks? This five-minute video briefly overviews the internal machinations behind the painful episodes. An incapacitating headache is a common symptom of migraine, though migraine can occur without any headache.

The neuroscience of heartbreak

An analysis of functional MRIs revealed a difficult fact: the active brain areas of people experiencing heartbreak were very similar to those actively in love. This is a major reason why people in the middle of rejection can't accept the reality of their loss. This article breaks down the various changes in neurotransmitters and neural pathways for those enduring that universal experience, heartbreak.

How science explains déjà vu

Take a fun look at the science explaining the odd experience of déjà vu, which some theories suggest is actually a sign of a healthy brain.

Your brain appears to age in five distinct stages

Analysis of brain scans from about 4,000 people has helped scientists identify five major stages of our brain's maturation from birth to death. The pattern of connections inside our brains seem to shift, on average, at ages 9, 32, 66 and 83. (Some readers may experience a paywall.)

The human body relaxes upon death, including the bowel and bladder, expelling urine and feces

Watch a hospice nurse walk through how death affects the human body and what to expect in the hours and days following the death of a loved one as the body breaks down.

How neurodegeneration happens, the underlying disease process of dementia

Dementia symptoms may vary between individuals, and may include mood changes, difficulty walking, speaking, and memory problems. It can progress over many years, occurring due to progressive damage to nerve cells in the brain. This degradation may happen for myriad reasons, and its triggers are under investigation.

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Necrosis is the unplanned death of cells and the tissue they comprise

If cells die prematurely due to a lack of blood flow, injury, or disease, they and their organelles can swell, leading to rupture of the surrounding cell membrane. This releases the cell's contents into the surrounding tissue, causing inflammation and damage to neighboring cells.

While dreaming, the brain connects new information with already-stored memories

During dream sleep, the brain makes connections between new information learned during the day and information already stored in the mind, creating a revised mind-wide web of associations. The dreamer also temporarily becomes confused about time and place and is subjected to a pendulum of strong emotions.

Organ donation isn't usually logistically possible if you die at home

Since organs need to be well-preserved for organ donation, with oxygen flowing through the body, internal organs often aren't viable for organ donation if someone dies at home. But some tissues—like eye corneas and skin tissue—may still be donated since they remain usable for a longer period without oxygen flow.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

The neuroscience of REM atonia disorders, where patients act out dreams

What prevents the typical person from acting out their dreams? Temporary paralysis of skeletal muscles, usually leading up to, and during, REM sleep. This academic article and related graphics explore what happens when this process doesn't go as planned, leading to REM sleep behavior disorder.

Take a deep dive into the neuron

Neurons are the basic unit of the brain and nervous system—electrically excitable cells that sends signals throughout the body. They can communicate with each other, fire in sequence, and conspire to do everything from drive body movement to help form memories. Check out this intro-level overview to learn more about their structure and how they work.

Watch what the Ebola virus does inside our cells and organs in order to spread and survive.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

According to the physics of black holes, our 4D reality may be a hologram—a projection of information coded on a 2D surface on the edge of the universe.

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

Learn how your body is, scientifically, like a firework with its own slow, controlled burn.

Volcanoes 'die' when their supply of magma runs out, if they are shifted away from their underlying magma reservoir, or if they get clogged by collapsing or their magma cooling back into rock.

Neutron stars, the remains of some massive stars after they explode in a supernova, are the densest directly observable objects in the universe.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

Salvador Dalí believed he was his own dead brother, who had died nine months before he was born

Massive blooms of microscopic plankton called dinoflagellates produce the neon blue light seen in glowing tides.

For centuries, Niagara Falls has been a magnet for daredevils seeking to conquer one of nature's most powerful wonders, with its 200-foot drop and water rushing at 32 feet per second with 280 tons of force.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

A Yale student wrote a profound essay about the consulting industry's influence on elite college students that was published in a book of her writing after she died in a post-graduation car accident.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Netflix profits when you're not watching, and its movies are designed that way—read a detail-rich critical essay exposing lesser-known Netflix takes

El Niño, Spanish for 'the boy,' was named after Jesus Christ because the phenomenon resembled the weather changes observed around Christmastime.

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Explore the known asteroids, comets, and spacecraft involved in asteroid studies within our solar system with 'Eyes on Asteroids,' a 3D visualization from NASA.

The 1987 Nintendo video game 'Stadium Events' isn't known for being particularly fun, but its scarcity has made it a highly sought-after item that has sold for up to $35K at auction.