What is the most painful thing in the world?

What's the point of pain?

It's notoriously hard to define pain, though everyone knows what it is. From day to day aches to the worst pains imaginable, this video goes into what researchers know about the purpose of pain. An estimated quarter of all adults live with chronic pain, which is defined as at least three months of pain.

The benefits of extreme pain rituals, explained

We naturally avoid pain and see it as a negative experience. But many traditional cultures incorporate extremely painful rituals into their religious ceremonies, claiming they, in fact, provide ample benefits. Researchers were able to observe boosts in happiness and a sense of belonging in a tribe of Mauritians after they undertook a rigorously painful religious ritual. Read about the study here.

Opioids are a class of drugs including fentanyl, heroin, oxycodone, and more

Since the dawn of pain, living things have sought ways to mitigate this evolutionary warning signal. One of nature's most effective painkillers is opium, a highly addictive, milky latex extracted from poppy plants. This forms the basis of one of the most prescribed classes of modern drugs.

Dengue is sometimes called 'breakbone fever' because it's so painful

Though this mosquito-transmitted disease can be asymptomatic, in more severe cases patients experience high fever, muscle spasms, and joint pain. The experience can be so excruciating that it feels like the patient's bones are broken, thus the nickname of breakbone fever. It's the world's fastest spreading tropical disease.

Breaking down the knee's anatomy

The human knee is a remarkably complex structure carrying the full weight of the body throughout a person’s life while allowing a number of complex twists, flexes, and extensions. It's also one of the body's biggest weaknesses—the location of chronic pain and replacement surgeries for millions of Americans.

Doctors ignored women's pain as a nurse replaced their fentanyl with saline

This five-part podcast series, produced by Serial Productions, focuses on the experiences of women undergoing fertility treatments at a Yale clinic where a nurse secretly replaced pain medication with saline solution. This led to women experiencing excruciating pain during procedures, but the clinic downplayed or ignored their complaints.

The most challenging marathons in the world

Even on a flat course, the event is a taxing ordeal. Now imagine those 26.2 miles climbing some of the world’s highest mountains (via the Tenzing Hillary Everest Marathon or the Kilimanjaro Trail Marathon), across the Great Wall of China, or trekking up the Inca Trail. These races won’t earn you a PR, but they will make for good stories.

View the most expensive materials on Earth, led by those forged in particle accelerators

Californium-252—valued at $27.8M per gram, as of 2025—is far rarer and more valuable than gold, silver, or diamonds due to production and transportation costs. The most expensive substance ever found or created is antimatter, costing approximately $62.5T per gram.

The neuroscience of heartbreak

An analysis of functional MRIs revealed a difficult fact: the active brain areas of people experiencing heartbreak were very similar to those actively in love. This is a major reason why people in the middle of rejection can't accept the reality of their loss. This article breaks down the various changes in neurotransmitters and neural pathways for those enduring that universal experience, heartbreak.

Animal phobias are likely the most common type of phobias, followed by an extreme fear of heights.

Animal phobias are likely the most common type of phobias, followed by an extreme fear of heights

Dr. Martin Antony, a Canadian expert on phobias and anxiety, says that fears of creepy, crawly animals like snakes, spiders, and mice are particularly common.

A 101 on the 'Death Cap,' the world's deadliest mushroom

The Death Cap, also known as amanita phalloides, is the most fatal mushroom on the planet, responsible for roughly 90% of the world's mushroom deaths per year. Ingestion of the mushroom wreaks havoc on the liver and kidneys, frequently leading to...

Where you fall on the sports misery index

Only one team can win it all each season, which means the majority of fans are disappointed. This bot mines the data on how your teams have performed in recent years and measures your misery index (the higher, the more miserable).

Which organs can you live without?

While there are some organs (such as the heart) that people simply can’t live without, there are other organs that can be removed without a huge impact. Patients who have their appendix removed, for example, experience no changes to their daily...

Explore the gap in what Americans die from versus news coverage on death causes

Top killers like heart disease, stroke, and liver disease, though they represent a significant burden nationally, are not often extensively covered in the media.

Food poisoning can sometimes cause serious long-term health issues

Although foodborne illness can be relatively mild and cause short-term discomfort, more rarely it can also cause long-term severe health consequences, depending on your individual risk factors, the severity of your sickness, and the care you receive. Kidney failure is one serious complication associated with certain types of food poisoning. Meningitis, hepatitis, arthritis, and pancreatitis are also rare and serious foodborne illness complications. If a pregnant person gets food poisoning, it can cause health issues for the fetus.

The world's most (and least) corrupt countries

The annual index measuring every country's relative levels of corruption. In 2022, Denmark earned the top spot for transparency, with Sudan, Syria, and Somalia identified as having the highest levels of corruption in the public sector. The rankings...

The most common birthdays

Nine of the top 10 most common birthdays fall in September, with Sept. 9 being the most common. However, August is the most common birth month, followed by July and December. On the flip side, the least common birthdays are around major holidays, with Christmas Day being the rarest—probably due to doctors scheduling fewer inductions and C-sections on those days. Find out more birthday surprises here.

Here's why weddings are so expensive

Anyone who has planned a wedding knows firsthand how shockingly expensive things like flowers or a live band can be. This article from the wedding experts at The Knot breaks down why, exactly, weddings cost so much. Plus, it explains the truth behind the so-called “wedding tax.” Read the article to learn more.

Extreme heat puts people at risk of developing kidney stones

It's essential to remain hydrated in summer weather to keep your body healthy, but one reason is to help dilute minerals that naturally build up if they aren't excreted in our water-fueled urine. Doctors recommend people generally drink 64 ounces of water a day and also eat foods with salt to help ward off dehydration.

The world’s oldest tattoos belong to 'Iceman' Ötzi

Ötzi is the corpse of "the Iceman" found in the Alps along the Italian and Austrian border in 1991. His mummified body was covered with lines and crosses along the “hard-working” areas of his body, signifying their potential application for therapeutic pain management.

The 30 most important performance artists

Through centering on the human body, performance art can surprise and shock us. This rundown of 30 of its practitioners highlights their individual art and selects an image to showcase their specific style. While some are more clever or conceptual, many are viscerally shocking, including artistic nudity and, in some cases, graphic violence.

Does minimum wage hurt workers?

Many economists traditionally believed raising the minimum wage hurt workers more than helped them. They argued that doing so would lead to job losses believing that if something is more expensive (like labor), people (like business owners) would want to buy less of it. However, recent research suggests otherwise.

Ludwig van Beethoven suffered from tinnitus

Historical figures that reportedly had the condition include Charles Darwin and Beethoven. Both men wrote letters about the frustrations and pain they experienced from the condition. (Some users may experience a paywall.)

Blood pressure readings correspond to the peaks and valleys of heart beats

Pushing 2,000 gallons of blood through the body every day exerts a force known as blood pressure. Blood pressure is highest during the heart's contractile phase, known as systole, which forces blood through the circulatory system, and lowest during the heart's resting phase between beats, known as diastole.

The evidence for the best sleep positions

For a behavior so crucial to human health, sleep positions are reportedly understudied by researchers. This article summarizes some of the more recent studies, taking into account the various forms of problems encountered during sleep: neck and back pain, snoring, acid reflux, and facial skin damage. Most studies point to side-sleeping as the most optimal, with sleeping on one's front as the least helpful. Read the piece to see which position is best for you.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

See images of medical cases of firework injuries shared on this 'Instagram for doctors.' (Warning: Graphic content)

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

The Russia-Ukraine conflict is the largest ground war in Europe since World War II in terms of casualties, forces mobilized, and displacement of civilians.

The deadliest aspect of volcanic eruptions is often not lava, but pyroclastic flows—avalanches of ash, gas, and rock that can move more than half the speed of sound.

Existentialist writer Jean-Paul Sartre coined the famous phrase 'Hell is—other people' in his play 'No Exit'

A pickleball's loud 'pop' sound can reach 120 decibels, which is equivalent to a hammer hitting a nail

Art theft is the third-largest source of criminal revenues worldwide, thanks in part to the subjective nature of valuing a work of art.

Neutron stars, the remains of some massive stars after they explode in a supernova, are the densest directly observable objects in the universe.

Poison ivy is in the same family as mangoes, cashews, and pistachios—and they all produce oily urushiol in their raw, unprocessed state—but they are typically prepared in ways to avoid causing human discomfort.

Use this tool to calculate the dollar value of your parental mental load, from meal planning to coordinating after-school care, then see resources that help generate solutions.

The price of gas is a composite made up of several different factors, with the federal gas tax making up less than 20% of what drivers pay at the pump.

For centuries, Niagara Falls has been a magnet for daredevils seeking to conquer one of nature's most powerful wonders, with its 200-foot drop and water rushing at 32 feet per second with 280 tons of force.

Three Ebola species are responsible for most large outbreaks of the disease, yet the only approved Ebola vaccine is known to work against just one of them.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Explore a list of the 100 best novels of all time, compiled by some of the world's best living writers, including Salman Rushdie, Stephen King, and Jennifer Egan.

The most expensive ad of all time was for Chanel No. 5 perfume and cost roughly $33M to produce in 2004—about $57M in today's dollars.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

The US first hosted the World Cup in 1994, a tournament that lives in soccer infamy for its poor planning and the murder of Colombian player Andres Escobar, who'd accidentally scored on his own net.

The US Constitution is widely regarded as the longest-standing written national constitution still in force—see how it has influenced rights worldwide.

See a ranking of the best (and worst) Federal Reserve Chairs since 1914 out of the 16 men and women who have held the office since.

Take a 3D tour of the Hajj, Islam's annual pilgrimage to Mecca, undertaken by over 1.5 million Muslims.

A small portion of The Winstons' 'Amen, Brother,' an obscure '60s gospel record, is the basis for thousands of hip-hop tracks, making it one of the most sampled records ever that's informally known as 'the Amen break.'

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.