Antibiotic resistance is a growing global health problem

Drug-resistant infections worldwide have increased by about 65% since 2000

Since 1990, antibiotic resistance has claimed at least one million lives annually and is projected to account for 39 million deaths between now and 2050 if current trends continue. The expanded use of antibiotics, particularly in agriculture, combined with a slowing pipeline of new drugs has led to the crisis.

Antimicrobial resistance is responsible for 1.3 million deaths each year

Antimicrobial resistance is a global health threat, driven by the misuse and overuse of antimicrobials in humans, animals, and more. Estimates suggest superbugs could lead to $1T in healthcare costs by 2050, and the world faces a shortage of new drug development to meet the challenge.

Superbugs could claim 1.9 million lives per year by 2050

The increased use of antibiotics combined with an aging population, is projected to result in an almost 50% increase in global deaths from antimicrobial resistance each year. At the same time, antibiotic use for livestock is expected to increase by 30% over the same time frame.

Overuse of antibiotics gives bacteria more opportunity to evolve their defenses

The overuse and misuse of antibiotics are significant contributors to the rise of antibiotic resistant bacteria. Experts say antibiotics should only be used for specific medical problems, and patients need to be sure to take antibiotics exactly as prescribed in order to reduce the risk of antibiotic resistance.

Resistant infections are no longer isolated and can spread worldwide

What does the rise of antibiotic resistance mean in practical terms? Maryn McKenna is a journalist at the forefront of covering antibiotic resistance since 2007. In this TED talk, McKenna lays out the very real consequences of antibiotic resistance—and what needs to be done to address the problem.

Superbugs are bacteria and pathogens that rapidly evolve defenses against medication

Superbugs, or antibiotic-resistant bacteria, infect millions and pose a threat to global health. Developing new antibiotics is costly, offers limited profits, and struggles to outpace bacteria’s rapid evolution.

The international agreement to address antimicrobial resistance

Antimicrobial resistance has become an increasingly glaring problem for both health and agriculture. In 2024, the United Nations announced a new suite of clear actions and targets that—taken together with existing efforts—can help address superbugs in a meaningful way and on a global scale. This page from the UN lays out these efforts, with links to additional information on the many aspects of the initiative.

Drug-resistant staph infection is one of the deadliest superbugs

Methicillin-resistant Staphylococcus aureus (MRSA)—the superbug version of staph infection—is responsible for more deaths than any other superbug, killing more than 120,000 people globally each year. The bug is leading cause of hospital infections, and is harmless on the skin but causes severe symptoms once inside the body.

COVID accelerated antibiotic resistance

The COVID-19 pandemic was caused by a virus, and viruses can’t be treated with antibiotics. But recent research finds that COVID patients were given a tremendous amount of antibiotics, contributing to the problem of antibiotic-resistant bacteria. Why? This NPR feature sheds light on an unexpected side effect of the pandemic.

The most critical superbug strains (as of 2024)

The World Health Organization updated its list of the highest priority pathogens known to have developed antimicrobial resistance. Topping the 2024 update is Acinetobacter baumannii, carbapenem-resistant ("CRAB"), which has a mortality rate close to 50% and has evolved defenses against last-line medications. Download the full report here.

Tips for reducing the risk of antimicrobial resistance

Antimicrobial resistance is bad news. But there are lots of things you can do to both protect yourself from superbugs and help keep the problem of antimicrobial resistance from getting worse. This page from the CDC offers clear, straightforward guidelines that can help keep you—and your loved ones—healthy.

It can take 10 to 15 years and more than $1B to develop a new antibiotic.

Why don't we just develop new antibiotics? In part, it's a complex scientific challenge, but market incentives also play a significant role. It can be time consuming, expensive, and most notably, we should use as little as possible to avoid driving further antibiotic resistance.

Pneumonia was once a leading killer before penicillin treatments

In the early 20th century, pneumonia was a top cause of death worldwide, often fatal without effective treatment. Penicillin turned a once deadly infection into one of the most treatable bacterial diseases.

Vector-borne diseases kill more than 700,000 people globally each year—and are growing

The diseases with the greatest potential to spread widely aren't the ones that quickly kill human hosts. Instead, the best hosts or reservoirs for vector-borne diseases would be chronically ill over the long term, increasing the likelihood that the pathogen could be transmitted to others.

Explore the history of antibiotics with 'This Podcast Will Kill You'

The show blends medical history with storytelling and science. In Episode 50, the hosts trace the dramatic origins of antibiotics—from Fleming’s moldy petri dish to Florey’s wartime labs—and explore their lasting impact on health.

Most penicillin allergy diagnoses are wrong

A Freakonomics Radio episode investigates why so many people mistakenly believe they’re allergic to penicillin. This widespread misdiagnosis leads to costlier, less effective treatments and contributes to the growing problem of antibiotic resistance.

19 fungal pathogens are of key concern to world health officials

In 2022, this global health body issued its first-ever list of top fungal threats to human health. It said fungal threats are spreading and occurring more frequently. The WHO’s list included 19 fungal pathogens to watch, and said that the most dangerous ones to public health are Cryptococcus neoformans, Aspergillus fumigatus, Candida albicans, and Candida auris. There are only a handful of classes of medication currently available to combat fungal pathogens, with few others in the pipeline even though antimicrobial resistance is growing.

An estimated 1% of DNA mutations in bacteria can produce more dangerous strains

Researchers have developed a technique to monitor these mutations in real time. Using this technology, scientists found that mutations occur at a steady rate, with 1% leading to potentially deadly changes.

Sepsis is the leading cause of death in hospitals

Sepsis is the result of an overly aggressive immune system trying to combat infection, triggering inflammation throughout the body. After it begins, each passing hour increases the risk of death by 4% to 9%, and an estimated 350,000 people die from the condition in the US each year.

There are between 10 and 100 trillion bacteria in the gut

The composition of our microbiome is essential to overall health. Anything that disrupts the balance of the trillions of bacteria may be harmful—even treatments meant to fight infection, like antibiotics.

1 in 4 people around the world don't have access to clean water

Poor water sanitation puts people at risk of acquiring this diarrheal infection. Cholera infections are on the rise due to extreme weather events and conflict. In recent years there have been cholera outbreaks in locations that hadn't seen the disease in many years, including Haiti.

Influenza infects up to a billion people worldwide each year

The World Health Organization estimates that seasonal influenza causes about 1B cases annually, including 3 to 5M severe illnesses and between 290,000 to 650,000 deaths.

Anopheles mosquitoes are developing resistance to insecticides

The malaria-transmitting mosquito species is developing resistance to the insecticides used in insecticide-treated bed nets and in indoor spraying in people's homes and communities. Malaria parasites are also developing resistance to antimalarial drugs.

Overwork contributes to thousands of worker deaths

Can work really kill you? The World Health Organization and the International Labor Organization have estimated that long work hours contribute to thousands of death from strokes and heart attacks each year. This BBC article argues that the culture of overwork and burnout is leading to a public health crisis in desperate need of solutions.

Most of the world’s population has difficulty processing lactose—but that’s not an allergy

Lactose intolerance is a digestive condition that occurs when the small intestine has difficulty breaking down lactose, a sugar found in products like milk or cheese, leading to symptoms such as diarrhea or bloating. Almost 70% of the world’s population may have lactose processing issues, particularly in Asia and Africa. This is different from a condition called cow's milk protein allergy—an immune system disorder that can cause hives and anaphylaxis.

See how Ebola tore through Guinea, Sierra Leone, and Liberia in 2014-2016.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

11 people died from firework injuries in the US in 2024.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Human-to-human transmission of hantavirus remains extremely rare, so the 2026 hantavirus cruise ship outbreak doesn't mean we're facing a COVID-style pandemic risk.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Some researchers have labeled nomophobia, the fear of being without your phone, as 'the phobia of the 21st century.'

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

An investigation suggests a Scottish island became awash in forever chemicals via seafoam and seaspray—raising questions about what that means for the safety of other coastal areas.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Double world record holder Hunter Ewen helped conquer his fear of balloons, called globophobia, by training to win Guinness World Record titles for balloon inflation.

The US dollar is the most widely circulated currency in the world, and is involved in nearly 90% of global transactions

During the French Revolution, a botanist's letter asking about "dear Rhus" (poison ivy) was intercepted, leading authorities to suspect he was conspiring with the Russians.

The Russia-Ukraine conflict is the largest ground war in Europe since World War II in terms of casualties, forces mobilized, and displacement of civilians.

In 2019, a laptop loaded with six of the worst malware in history and described as 'an exhibit of historical weaponry' sold for $1.3M.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

The tragic Pulitzer Prize-winning image 'The Vulture and the Little Girl' (1993) generated controversy, raised concerns about ethics in photography, and eventually led to the photographer's death.

Some renewable energy sources may weaken the resiliency of electric grids by removing outage buffers provided by coal- and natural gas-fired plants, which provide the system with more time to find a new power source if a plant goes down.

20,000 letters to the advice columnist 'Dear Abby' provide insight into prevailing sex, religion, and LGBTQ fears, anxieties, and concerns from the 1950s onward.

Explore a list of the 100 best novels of all time, compiled by some of the world's best living writers, including Salman Rushdie, Stephen King, and Jennifer Egan.