FDA has removed black box warnings from HRT for menopause

27% of US menopausal women used estrogen in 1999, but by 2020 that number was under 5%

The fallout of studies in the early 2000s linking hormone therapy for menopause and elevated cancer, stroke, and other health risks meant that even decades later—yet before the FDA removed its black box warning in 2025—use of HRT remained extremely uncommon. (Some users may experience a paywall.)

Within months of a landmark 2002 study that indicated HRT harms, sales dropped by about half

In the early 2000s, Women's Health Initiative studies indicated HRT increased risk of breast cancer, heart disease, and stroke in some women—so many physicians stopped prescribing it to help with menopause symptoms. But further research has concluded that much of the elevated risk was overblown and that it was also disproportionately seen in women in their 70s who had been taking an older HRT formulation.

FDA removed its cardiovascular risk warning on testosterone products in 2025

The change came a decade after the FDA added the label. Recent work, including a gold-standard randomized trial, found that men receiving the products had similar cardiovascular risk levels as men taking placebo products. Testosterone, however, may hold other health risks, including infertility.

America doesn't have enough estradiol patches for menopause and perimenopause demand

Fueled in part by the lifting of the FDA's black box warning about HRT risks, sales of estradiol patches in the US have shot upward. More than 142 million units of the patches were sold in 2025 versus 46.5 million in 2020. Suppliers are failing to keep up with demand—11 patch products were in short supply in early 2026. (Some users may experience a paywall.)

HRT for menopause may not help with mental health or sleep says a large 2026 analysis

A recent analysis investigating the effects of menopause and HRT use on mental health, cognition, and brain health suggested HRT did little or nothing to aid with mental health and sleep. But the researchers caution that, among other data gaps, they didn't have information on which HRT formulations were used among their nearly 125,000 participants, so results may have varied by drug treatment.

HRT patches are popular partly because they have lower blood clotting risks than oral estradiol

Women taking estradiol for menopause or perimenopause are sometimes told oral HRT is not an option for them because it increases blood clot risks. But a large analysis in 2019 concluded that other forms of the HRT, such as the patch, creams, and gel, do not.

It's never too late to start hormone replacement therapy for menopause symptoms

This board-certified gynecologist discusses how it's ideal to start estradiol as soon as possible after menopause to maximize its benefits, but that if older women have healthy hearts they can still start these medications later, in consultation with their doctors, and the products could be useful if women are continuing to suffer from symptoms of menopause or want to fight bone loss.

There are multiple HRT options to treat menopause and perimenopause symptoms

This lengthy video features a board-certified OB/GYN based in Texas who provides a thorough overview of the different formulations for HRT, used to treat symptoms including hot flashes, vaginal dryness, and mood swings, and the pros and cons of each. She also discusses modern synthetic options versus the older formulation extracted from the urine of confined pregnant horses.

MS Drugs reduce inflammation, helping reduce relapses and slow disease progression

Disease-Modifying Drugs calm the body's inflammatory response to help stave off relapses—when new or existing MS symptoms show up for a day or longer. Avoiding smoking, exercising, reducing stress via mindfulness, checking for vitamin D deficiencies, drinking more water and eating well, all can slow disease progression. [The jury's still out on if HRT around the time of menopause may reduce dementia risk](https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(25)00122-9/fulltext) Estrogen can reduce inflammation and support neural growth in the brain, and some research has suggested that beginning hormone replacement therapy around menopause—versus later in life—reduces Alzheimer's disease risk. Still, a recent systematic review concluded that taking HRT didn't affect dementia risk, regardless of when women started taking it, so the science remains unsettled.

Gender-affirming hormone therapy cues changes similar to puberty

When HRT is part of gender affirmation care, people receive regular doses of estrogen or testosterone to alter hormone levels to more closely align with those of cis individuals of that biological sex. HRT may affect voice pitch, body hair, bone density, and more. Many of those changes are not reversible with the cessation of therapy, though the effects may diminish.

The US FDA considered mitochondrial replacement therapy during 2014 hearings

An agency committee assessed if this approach could have undesirable ripple effects across multiple generations and whether a clinical trial involving this approach would be appropriate. As of 2026, the US has continued to prohibit this procedure though it is legal in other settings including the UK and Australia.

The US FDA issued a 2025 warning about BPC-157 and other popular peptides

BPC-157, which mimics a naturally occurring gut peptide involved in soft tissue repair, has been marketed for various regenerative properties. But the FDA warned in July 2025 that it doesn't have enough data to assess its safety in humans and that such products may also pose risks related to contamination.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Kava, kratom, St. John's Wort, and green tea extract present health concerns

Consumer Reports, which tests supplements for safety, urges consumers to avoid these four supplements due to safety warnings from researchers and public health authorities.

Why we should care about renaming the hormonal disorder PCOS to PMOS

The new name, polyendocrine metabolic ovarian syndrome, nods to the hormonal disruptions that cause this condition, which affects roughly one in eight women. People with PMOS may have symptoms including irregular periods, trouble conceiving, weight gain, acne, undesired hair growth, and more. The earlier name, polycystic ovary syndrome, was a misnomer because women with the condition don't have cysts in their ovaries. Rather, they have masses that are actually immature follicles. World health experts think the condition often goes undiagnosed.

Peanut allergies dropped by 43% after doctors reversed avoidance guidance, but questions remain

The study’s data appear to confirm the policy shift. Still, since the study did not include an examination of infant diet, researchers can’t definitively say that the guideline shift led to dietary changes and thus directly caused the decline.

Yes, you can die from a broken heart

Researchers reviewed the health records of about 200,000 people diagnosed with broken heart syndrome from 2016 to 2020 and the death rate was 6.5%—with men's deaths roughly doubling that of women.

Saccharin was banned in Canada in the 1970s, but regulators may allow its use once again

The product, commonly known as Sweet'N Low, was banned in Canada in the late 1970s due to research indicating that the sweetener could cause cancer in lab rats. Subsequent studies have found that the rodent findings didn't hold true for humans, and so Canadian regulators state that they are considering updating their stance to allow the product to be added to certain foods (the product is currently allowed in the US).

American medical organizations rescind recognition of diagnosis cited in police custody deaths

American medical organizations have rescinded their recognition of a syndrome whose theory stemmed from discredited research. This article explores the history and implications of "excited delirium syndrome," a medical condition that can reportedly...

Learn why the Montreal Protocol may help prevent millions of cancer deaths

By restoring the ozone layer and reducing ultraviolet exposure, full implementation of the Montreal Protocol is expected to prevent about 443 million cases of skin cancer, 2.3 million skin cancer deaths, and 63 million cases of cataracts among Americans born from 1890 to 2100.

The WHO’s guidance on 5G, radiation, and health

5G is the latest wireless mobile phone technology, first widely deployed in 2019. 5G is expected to increase performance and a wide range of new applications, including strengthening e-Health (telemedicine, remote surveillance, and telesurgery).

Staying on standard time permanently would slightly reduce obesity and stroke risk

A 2025 study that examined time changes found that permanently changing to standard time would slightly reduce obesity and stroke risk more than switching to permanent daylight saving time.

Black women offer a solution to racial health disparities

Black women in the US face higher rates of obesity, heart disease and more diseases. This article explores the historical and systemic racism underpinning the disparity, and the solutions Black women are creating.

The FDA claims microplastics have not yet been shown to pose a health risk

Although microplastics and nanoplastics are found in many foods and environments, their presence does not violate regulations. Additionally, as of 2025, the administration believes evidence does not confirm that detected levels harm humans.

What employers can do about parental stress

The US Surgeon General recently released a formal warning deeming parental stress a public health issue. The advisory also included recommendations for how employers can mitigate the issue. Employers can help their employees access child care, for instance, or provide flexible working hours. To find out more about what the Surgeon General prescribes, read more here.

Remember: Not all fats are bad for you

Contrary to past dietary advice promoting low-fat diets, newer research shows that certain types of fats are both necessary and healthy. It all comes down to the type of fat you eat. Focus on getting "good" unsaturated fats from sources like nuts,...

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Human-to-human transmission of hantavirus remains extremely rare, so the 2026 hantavirus cruise ship outbreak doesn't mean we're facing a COVID-style pandemic risk.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

11 people died from firework injuries in the US in 2024.

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

70 years ago today, city officials in Santa Cruz, California, banned rock 'n' roll to protect its youth from corruption after witnessing a 'provocative' concert the night before.

While the first exchange-traded fund (a 'basket' of different assets that can be bought and sold on a stock exchange) in the US only launched in 1993, the global ETF market has grown to more than $10T in the short time since.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

20,000 letters to the advice columnist 'Dear Abby' provide insight into prevailing sex, religion, and LGBTQ fears, anxieties, and concerns from the 1950s onward.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Radioactive elements can introduce software errors because the ionizing radiation they produce can detach electrons from atoms, and computer code relies on the distribution of electrons.

The United States has had a tumultuous relationship with Cuba since its 1959 revolution, highlighted by a nuclear crisis and a decades-long trade embargo.

See a ranking of the best (and worst) Federal Reserve Chairs since 1914 out of the 16 men and women who have held the office since.

The American Society of Civil Engineers' infrastructure report card gave the US a C in 2025, its highest grade since the project launched in 1998.

Poison ivy can cause rashes year-round since all parts of the plant contain urushiol, the oil that triggers our allergic response.

Fish populations in the Great Barrier Reef have increased after installing waterproof speakers on the ocean floor that played recordings of sounds from healthy coral reefs.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Visualize the path of every solar eclipse from 1900 to 2099 and see what each looks like when observed from different locations on Earth.

Brandi Chastain, the star of the 1999 US victory over China in the 1999 Women's World Cup, was a last-second choice to take the penalty kick that sealed the victory.