Gender-affirming hormone therapy cues changes similar to puberty

There are multiple HRT options to treat menopause and perimenopause symptoms

This lengthy video features a board-certified OB/GYN based in Texas who provides a thorough overview of the different formulations for HRT, used to treat symptoms including hot flashes, vaginal dryness, and mood swings, and the pros and cons of each. She also discusses modern synthetic options versus the older formulation extracted from the urine of confined pregnant horses.

HRT for menopause may not help with mental health or sleep says a large 2026 analysis

A recent analysis investigating the effects of menopause and HRT use on mental health, cognition, and brain health suggested HRT did little or nothing to aid with mental health and sleep. But the researchers caution that, among other data gaps, they didn't have information on which HRT formulations were used among their nearly 125,000 participants, so results may have varied by drug treatment.

HRT patches are popular partly because they have lower blood clotting risks than oral estradiol

Women taking estradiol for menopause or perimenopause are sometimes told oral HRT is not an option for them because it increases blood clot risks. But a large analysis in 2019 concluded that other forms of the HRT, such as the patch, creams, and gel, do not.

FDA has removed black box warnings from HRT for menopause

The agency removed the label in 2025, reversing its 2003 decision to warn women about HRT's links to stroke risk, developing cancer, and heart disease. Years of accumulating research have found that the risks had been overstated and unnecessarily deterred hormone therapy use. The agency still warns against using certain estrogen-alone products, however, due to elevated endometrial cancer risk.

Testosterone therapy can cause infertility, and has been explored as a contraceptive

Augmenting testosterone with testosterone hormone therapy suppresses sperm production, and the resulting infertility is permanent in some men. Though a high level of testosterone inside the testicles is essential for fertility, testosterone supplements suppress the production of the pituitary hormones that leads to that natural testosterone production in the testicles—causing infertility.

Early 20th-century ID cards protected trans people in Germany using hormone therapy

A small number of passes were granted by the German police—with clinician support—between 1909 and 1933 that nominally allowed them to dress in ways that matched their gender identity, use experimental hormone therapies, and even receive early sex reassignment surgeries. At the time, individuals could be charged with "public nuisance" without the pass.

Estrogen is a really important hormone for men, too

Many people may be familiar with the idea that too much estrogen can cause infertility and other complications, including erectile dysfunction, but too little estrogen is also a significant medical concern because it can result in a reduced sex drive and limit overall growth.

Men are flocking to hundreds of new online testosterone clinics for low T prescriptions

Many primary care clinicians may not be familiar with testosterone testing protocols and treatments, but online testosterone clinics are proliferating, with names like DudeMeds. COVID-era restrictions loosened remote prescribing rules, allowing them to expand online widely, though those more lenient prescribing policies are slated to expire in December 2026 unless they're renewed. (Some users may experience a paywall.)

Treatment-induced menopause is menopause induced by surgery or medicine

Chemotherapy and radiation, as well as oophorectomy (a surgical procedure that removes the ovaries) and a radical hysterectomy can cause a woman to become menopausal. Women that go through medical menopause experience the same symptoms as women that experience menopause caused by natural hormonal cycles.

Women experience heightened bone loss after menopause

Both women and men begin to lose some bone density after age 35, on average, but for the first decade after menopause women lose bone more rapidly due to the significantly decreased levels of estrogen, putting women at heightened risk of osteoporosis and related bone fractures.

Girls are hitting puberty earlier than ever before

Around the world, there has been a spike in children—especially girls—experiencing early puberty and doctors are seeking to understand why. The rise has been particularly strong post-2020. Early-maturing girls are at a higher risk for developing...

Gene therapy is restoring hearing among kids with genetic deafness

Gene therapy for profound genetic deafness has been advancing in recent years, with multiple clinical trials enabling hearing at normal levels for the first time without hearing aids or cochlear implants. The therapies target hearing loss caused by mutations in the OTOF gene that codes for a protein called otoferlin. That protein normally plays a key role in relaying sound signals in synaptic transmission between the ear's inner hair cells and the auditory nerve.

The halting of human bone growth helps manage heat produced from metabolism

While fish, amphibians and reptiles get bigger throughout their lives until they die, their slower metabolisms allow their bodies to regulate the resulting smaller temperature increases. In humans, hormones triggered during puberty harden growth plates, ending bone lengthening.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Diabetes is a hormonal disorder

Hormones are naturally produced in the body in concert with cell receptors, influencing how cells behave, but diseases that affect hormonal production, including those produced by the pancreas or the thyroid, can upend those processes.

Strength training appears to make for a healthier, youthful-looking brain

A study from 2025 links having higher amounts of muscle with a more youthful-looking brain age. Scientists analyzed data from more than 1,100 healthy adults around their mid-50s after they underwent full-body MRIs, comparing muscle, fat, and brain age appearances from the scans.Their findings link strength training and controlling visceral fat with improved brain health. The research didn't tease apart why this benefit occurs.

Boy culture pressures teens to hide emotions, weakening their friendships over time

Cultural norms about masculinity teach boys to suppress vulnerability and prioritize independence over time, resulting in isolation. Given that humans are social creatures, mental health struggles gradually become more common through this abandonment of connection.

Biohacking: The effort to optimize health and extend life through technology

Biohacking seeks to optimize human health and performance through everything from simple lifestyle adjustments to more radical interventions like body modifications and experimental technology. At its core, biohacking covers a wide spectrum—ranging from improving sleep and focus to implanting devices that integrate technology with the human body.

Why breathing helium, sulfur hexafluoride, and other gases changes your voice

The speed of sound varies depending on the properties of the material it travels through, including its density. Because helium is less dense than air, sound travels faster, altering the timbre of one's voice to be squeakier by enhancing its higher frequencies. In molecules that are heavier than air, low-frequency sounds are enhanced, producing a deeper voice.

Becoming a man in ancient Rome

In ancient Rome, boys between the ages of 14 and 17 underwent a traditional ceremony marking their transition from childhood to adulthood. This article explores what we know about this common practice and its significance. Learn about the ritual celebration, which included a new white toga, sacrifices, and becoming registered as a citizen.

The government has said Title IX does not protect transgender athletes or apply to athlete pay

In early 2025, President Donald Trump signed an executive order banning transgender women from college athletics, suggesting the move was in line with Title IX compliance. A week later, the Department of Education said Title IX does not require equitable distribution of name, image, and likeness payments to athletes. Both instances reverse former President Joe Biden’s interpretations of the law.

Most things you would get tested for at the doctor’s office are influenced by circadian rhythm

In this video, a Salk Institute Researcher offers daily habit tips focused on aligning with your circadian rhythms. She notes heart rate and blood pressure are highest in the afternoon, for example, and there’s a triglyceride peak in the morning. Generally, she says, it’s a good idea to schedule your doctor’s checkups at the same time of day each year so there’s consistency across your data.

CBT helps rewire the brain's false beliefs by challenging negative thoughts

Cognitive behavioral therapy identifies how specific situations can trigger distorted core beliefs—often formed early in life—that negatively shape thoughts and behavior. It frequently uses structured questioning that promotes self-reflection to uncover distorted thinking and guide people toward more balanced perspectives.

Group therapy is not the same thing as a support group

Group therapy, facilitated by a licensed therapist, is typically covered by insurance or involves a fee. Support groups are often peer-led and usually come with no cost.

How race science influences breast cancer research

Despite researchers' and physicians' pushback, race is still used in studies and clinics to categorize human differences in health conditions and treatment responses. This article explores how race has influenced breast cancer research. Considering race as a factor in cancer research, diagnosis, and treatment can lead to racial inequalities. Sociocultural factors, including food access and air pollution, greatly influence health outcomes.

Can music alter your memories?

You’re familiar with music’s ability to transport you to a past experience, but new research suggests that music can even alter how you remember your past experiences. A team of psychology researchers and music experts recently published a study that demonstrates how music can help shift our emotional recollection of a memory. Read to learn more about the study’s findings and how it could influence therapy practices.

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

US housing costs have risen by roughly 175% between 1991 and 2026—but a growing number of Gen Zers are becoming homeowners anyway. In 2025, 4% of homebuyers were Gen Z, up from 3% the year before.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

20,000 letters to the advice columnist 'Dear Abby' provide insight into prevailing sex, religion, and LGBTQ fears, anxieties, and concerns from the 1950s onward.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

Play the role of a student in a game where you try to navigate college and remain debt-free, selecting different income levels, high school experience, race, ethnicity, and more.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Children are now three times more likely to say they want to be a YouTuber when they grow up than an astronaut, with some even attending 'YouTube camps' that teach kids how to create content for the platform.

Iran's Revolutionary Guard Corps is independent of Iran's regular army and is one of the most powerful and influential military-political organizations in the Middle East.

Poison ivy will likely become both larger and more resilient due to climate change.

Objects can be 3D printed with light by projecting 2D computerized tomography (CT) scans onto rotating cylinders of resin, which solidify upon exposure.

Hedge funds, the private investment firms that trade a wide swath of financial assets, make money by imposing steep fees on investors and from the fund's investment performance.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Take a 3D tour of the Hajj, Islam's annual pilgrimage to Mecca, undertaken by over 1.5 million Muslims.

Brandi Chastain, the star of the 1999 US victory over China in the 1999 Women's World Cup, was a last-second choice to take the penalty kick that sealed the victory.

Shooting stars, or meteors, are fragments of asteroids and comets that burn up as they enter Earth's atmosphere, creating streaks in the sky called meteor showers.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

See how Budweiser's famous Clydesdales spend their days at Warm Springs Ranch, where roughly 70 to 80 of the beer brand's giant horses can be found at any given time.

The United States has had a tumultuous relationship with Cuba since its 1959 revolution, highlighted by a nuclear crisis and a decades-long trade embargo.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.