Gene therapy is restoring hearing among kids with genetic deafness

Gene therapy, a hope of the Human Genome Project, saves a baby's life

A baby with a rare genetic disorder received a bespoke gene-editing treatment using CRISPR technology. The case highlights the potential of personalized medicine for rare diseases, building on the foundation set by the Human Genome Project.

Gene therapy treats a disease by editing its DNA source

This modification is typically performed by viruses, which are naturally skilled at entering cells but have their disease-causing component removed before delivery. Once inside, cells can use the inserted genetic material to produce more helpful proteins, fewer harmful ones, or create new proteins.

Usher Syndrome, a rare genetic disorder, causes progressive hearing and vision loss

People with one of the subtypes of this condition have a genetic mutation that starves cells in the inner ear and the retina of proteins required for detecting sound and light. Gene therapy in animals has seemed like a promising treatment for the condition.

Cochlear implants are raising questions about deaf identity and culture

The rise of cochlear implants, which are usually covered by insurance and can enable hearing for many patients, raises questions about what it means to be deaf, the effects on deaf individuals learning American Sign Language, and about deaf culture. Watch this video that discusses the controversies and spotlights a little girl who hears for the first time with her cochlear implant.

More than 90% of American deaf children are born to hearing parents

The National Institute on Deafness and Other Communication Disorders have collated top statistics about hearing loss in the US including differences by age, racial groups, and other factors.

The first neural devices were cochlear implants, designed to treat hearing loss

Neural interfaces connect with our nervous system to restore or enhance abilities, such as hearing or movement. These neuroprostheses have enabled the restoration of mobility, communication, and activities of daily living that might otherwise require a caregiver.

Mice were able to regenerate retinal cells in the lab—a breakthrough for mammals

Using gene therapy, a team of Korean researchers has enabled retinal regeneration in mice by blocking the intercellular transfer of a single inhibitory protein. This 2025 finding creates a new potential direction for treating retinal diseases. The work, which is still in animal studies, is projected to enter early-stage clinical trials in the next few years.

An ear doctor with hearing loss seeks to help those with hearing loss enjoy music

Alex Chern, an ear doctor who has hearing loss himself, dreams of restoring the ability to experience "all the richness and the beauty of the sound of music" for patients—not just functional hearing. Hearing aids amplify sound waves and aren't designed to work well with music that may have varied pitch and volume. Chern is studying how hearing loss and engaging with music may affect cognitive decline.

See worldwide hearing loss by age group and country

This 2023 data from the Institute for Health Metrics and Evaluation shows the estimated number of people with complete hearing loss in different age groups per 100,000 people in the population. Individuals aged 70 or older make up the largest group with this type of hearing deficit.

If hearing is damaged, the brain may amplify remaining sounds, perhaps causing tinnitus

Recent mouse brain and ear imaging revealed that the creature compensates for hearing loss by sending signals to the cochlea in the inner ear. This triggers nerve fibers in the inner ear to increase volume and become more sensitive. Learning about these boosted-sensitivity messages from the brain to the cochlea—if they're similar in humans—might help explain tinnitus and fuel experimental approaches to turn down that sensitivity.

A first-of-its-kind clinical trial taps livers from gene-edited pigs to clean blood

The experimental dialysis-like treatment from United Therapeutics, eGenesis, and OrganOx, is designed to help people with liver failure. The therapy, which involves attaching the modified pig liver externally, filters a patient’s blood so their own livers can temporarily rest and perhaps heal.

OTC hearing aids are now available in the US and cheaper than prescription ones

The devices, available in recent years, are typically more affordable than prescription ones and are intended for people with mild to moderate hearing loss, yet surveys suggest people often don't feel comfortable choosing one on their own. The nonprofit Consumer Reports ranked available OTC options to help patients navigate the market.

There's no cure for tinnitus, but sometimes it goes away on its own

Though there's no cure, treatments and management approaches can significantly reduce symptoms and improve quality of life. Hearing aids, sound generators, and other steps can help some people with this condition. But sometimes tinnitus resolves within hours or days for reasons that remain unclear.

Big Ocean is breaking barriers as the world's first deaf K-pop boy band

The three-person boy band—whose members have different levels of hearing loss—use light systems, vibrations, and a mix of Korean and American Sign Languages, as well as International Sign (which isn't a whole language), to communicate and keep their dance routines in sync. In this interview, a band member with partial hearing describes their challenges.

Genetic tests aren't always actionable, which is one reason genetic counselors are so vital

This podcast interview with a Harvard Medical School professor focused on cancer genetics and prevention discusses the specifics of genetic testing and insights and the challenges of processing the outcomes of the testing and what may be actionable—or not.

Pediatricians look for a list of behaviors to signal typical hearing development

These markers of typical hearing development among infants and toddlers include turning head to sound sources within the first five months of life, babbling by about 11 months, and trying to imitate simple words by 17 months of age.

See this 201-level explanation about mitochondria and mitochondrial replacement therapy

This 2022 academic presentation from Stanford University's Dr. Gregory Enns offers a detailed overview about mitochondrial therapy approaches. Enns, a pediatric geneticist, explains how well-functioning mitochondria support the human body.

Most custom earmolds for in-ear hearing aids are made using 3D printing

The technology has also been utilized for behind-the-ear and receiver-in-canal hearing aids, allowing for the creation of structures tailored to the patient's anatomy for enhanced effectiveness. 3D printing has also been used to print retinal eye cells and custom eyeglass frames.

How the National Science Foundation helped cement the use of American Sign Language

Before the 1960s, deaf students were taught to read lips and pronounce words without signing, which was not considered a true language. After noticing that students nonetheless signed when communicating, American linguist William Stokoe conducted NSF-funded research that showed that signing met the definition of oral languages, thus establishing ASL.

Carrier screening enables individuals without symptoms to see if they carry a gene for disease

Some conditions are autosomal recessive—meaning a person may carry a gene for that condition, but not have symptoms. Cystic fibrosis, sickle cell disease, and Tay-Sachs disease are examples of autosomal recessive diseases in which a person must inherit two copies of a nonfunctioning gene—one from each parent—to develop disease.

Gender-affirming hormone therapy cues changes similar to puberty

When HRT is part of gender affirmation care, people receive regular doses of estrogen or testosterone to alter hormone levels to more closely align with those of cis individuals of that biological sex. HRT may affect voice pitch, body hair, bone density, and more. Many of those changes are not reversible with the cessation of therapy, though the effects may diminish.

Fish populations in the Great Barrier Reef have increased after installing waterproof speakers on the ocean floor that played recordings of sounds from healthy coral reefs.

Hereditary hyperosmia is the official term for being a super-smeller

Some sniffers with this rare trait may be more sensitive to pleasant smells, while others may be more attuned to unpleasant scents. Some research suggests that certain genetic mutations are associated with a heightened sense of smell.

Scientists identify hundreds of genes responsible for OCD

Researchers analyzed the DNA of more than 53,000 people with OCD and identified 30 areas in the genome linked to the disease, containing 249 genes of interest. Of those, several were linked to other brain disorders, paving the way for genetic treatments of various mental illnesses.

Fish populations in the Great Barrier Reef have increased after installing waterproof speakers on the ocean floor that played recordings of sounds from healthy coral reefs.

If kids have ear tubes, over-the-counter ear drop solutions to clear buildup shouldn't be used

Mixes of acetic acid or alcohol to help speed water evaporation in the ears shouldn't be placed into children's ears if they have a hole in the eardrum or if they had ear tubes inserted—hollow cylinders made of plastic or metal that are inserted into the eardrum by a doctor to help drain fluid and improve airflow in the middle ear. Alcohol or acids can cause irritation to the middle ear and intense pain as they pass through the hole or tube.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

'Silent' fireworks have gained more interest in recent years as a quieter celebratory option.

US housing costs have risen by roughly 175% between 1991 and 2026—but a growing number of Gen Zers are becoming homeowners anyway. In 2025, 4% of homebuyers were Gen Z, up from 3% the year before.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Hedge funds, the private investment firms that trade a wide swath of financial assets, make money by imposing steep fees on investors and from the fund's investment performance.

Up to a million Girl Scouts sell about 200 million cookie boxes every spring, generating $800 million, largely because refusing a child is frowned upon

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

Hear 50 years of iconic hip-hop samples, the genre's foundational looped tracks

For centuries, Niagara Falls has been a magnet for daredevils seeking to conquer one of nature's most powerful wonders, with its 200-foot drop and water rushing at 32 feet per second with 280 tons of force.

Pure water does not conduct electricity because this flow of energy requires the movement of charged particles, and water is a neutral molecule.

The Brothers Grimm were lawyers before they were storytellers, but became interested in fairy tales as they began investigating how rules and customs had been passed down through cultures.

Play the role of a student in a game where you try to navigate college and remain debt-free, selecting different income levels, high school experience, race, ethnicity, and more.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.