FDA removed its cardiovascular risk warning on testosterone products in 2025

FDA has removed black box warnings from HRT for menopause

The agency removed the label in 2025, reversing its 2003 decision to warn women about HRT's links to stroke risk, developing cancer, and heart disease. Years of accumulating research have found that the risks had been overstated and unnecessarily deterred hormone therapy use. The agency still warns against using certain estrogen-alone products, however, due to elevated endometrial cancer risk.

The term 'low T' was coined in 2002, recasting testosterone therapy and elevating demand

The marketing shift and accompanying awareness campaigns, both by the company behind the first testosterone product approved by the FDA, changed the landscape for testosterone product demand. Testosterone is often considered low when it's below 300 nanograms per deciliter of blood. (Some users may experience a paywall.)

Testosterone prescriptions remain very low overall

Though demand for an injectable formulation of testosterone roughly doubled between 2019 and 2025, testosterone prescriptions still remain very uncommon—adding up to less than 2 per 100,000 prescriptions in 2025.

Testosterone therapy can cause infertility, and has been explored as a contraceptive

Augmenting testosterone with testosterone hormone therapy suppresses sperm production, and the resulting infertility is permanent in some men. Though a high level of testosterone inside the testicles is essential for fertility, testosterone supplements suppress the production of the pituitary hormones that leads to that natural testosterone production in the testicles—causing infertility.

The US FDA recently tried to regulate the expanded prenatal genetic tests

The agency proposed a new rule in 2023 to make it explicit that these types of tests are devices under existing law and clarify that that the agency could move to regulate them. They finalized a regulatory change in 2024 that added the words "including when the manufacturer of these products is a laboratory" to an existing law, but a federal district court vacated that edit in March 2025—returning the law to as it was before.

The US FDA issued a 2025 warning about BPC-157 and other popular peptides

BPC-157, which mimics a naturally occurring gut peptide involved in soft tissue repair, has been marketed for various regenerative properties. But the FDA warned in July 2025 that it doesn't have enough data to assess its safety in humans and that such products may also pose risks related to contamination.

As of 2025, extensive research studies do not support fears about seed oils

Across human trials, seed oils have not been shown to increase rates of disease or inflammation, with a study of over 800 Swedish men finding that higher seed oil diets were linked to living longer. Reviews of these trials found better health outcomes when saturated fats were replaced with seed oils.

Supplements often have issues with impurities, toxins, and inaccurate labels

Consumer Reports' tests of more than 20 supplement powders and shakes in 2025 found that more than two-thirds of them contain unsafe levels of lead. Some contained 10 times the amount of lead that's considered acceptable to ingest in a day. The levels they found, in some cases, were even higher than when they tested the products 15 years earlier.

Gender-affirming hormone therapy cues changes similar to puberty

When HRT is part of gender affirmation care, people receive regular doses of estrogen or testosterone to alter hormone levels to more closely align with those of cis individuals of that biological sex. HRT may affect voice pitch, body hair, bone density, and more. Many of those changes are not reversible with the cessation of therapy, though the effects may diminish.

A new daily MS pill is seeking regulatory approval in 2026

In clinical trials, Roche's fenebrutinib showed promise treating primary progressive MS and doubling relapse-free time in patients with relapsing MS as compared to existing treatment. But some liver damage and two possible drug-related deaths in the trials may make it difficult for the drug to net approval. (Some users may encounter a paywall.)

There are two FDA-approved blood tests that may detect early Alzheimer's disease

Yet the tests are only recommended for those who have symptoms of dementia, and are not definitive on their own. False positives are a concern with these new tests, which detect biomarkers that may indicate the presence of brain proteins linked to the disease. This podcast explores the state of research on the disease and concerns about regulators taking jobs at pharmaceutical and biotech companies, which may influence their approach to approvals. It also dives into an investigation about the data underpinning one experimental Alzheimer's drug.

Stroke risk doubles each decade after age 55

While age is the greatest risk factor, genetics, diet, and overall health play a prominent role in determining individual stroke risk. Prevention focuses heavily on modifiable risk factors. High blood pressure is the single most important controllable risk factor, contributing to both types of stroke.

A clinical trial is underway in 2026 to help kidney transplant recipients avoid a lifetime of immunosuppressing drugs

This later-stage clinical trial, in Chicago and Taiwan, evaluates the efficacy and safety of a new cellular therapy that may be swapped in for immunosuppressing drugs among kidney transplant recipients. The study randomizes people to either receive standard immunosuppressants or this cellular therapy and fewer immunosuppressants. It only includes kidney transplant recipients receiving organs from live donors so transplant surgery timing won't hinge on the unpredictable schedule of performing surgery and follow-up care when a donor dies.

At-home genetic testing results commonly led users to healthier lifestyles

Italian research that aimed to investigate what people do longer-term after receiving direct-to-consumer genetic test results indicated that whether the results were positive or negative, people tended to adopt a healthier diet after receiving the results, and they'd still maintained it a year after receiving their results. Some users also reported an overall reduction in stress over their health concerns. (Some users may encounter a paywall.)

The government has said Title IX does not protect transgender athletes or apply to athlete pay

In early 2025, President Donald Trump signed an executive order banning transgender women from college athletics, suggesting the move was in line with Title IX compliance. A week later, the Department of Education said Title IX does not require equitable distribution of name, image, and likeness payments to athletes. Both instances reverse former President Joe Biden’s interpretations of the law.

CTE is a major threat to NFL players

A week before Super Bowl LVII, Boston University released findings from a study diagnosing 91.7% of former NFL players in their 376-person study with chronic traumatic encephalopathy. It was a stark comparison to the less than 1% of CTE diagnosis in non-football players.

Biotech ETFs allow investors to gain exposure to multiple promising companies in the industry

Biotech ETFs offer a diversified alternative to purchasing an individual biotech stock and gambling on whether an individual company’s clinical trial yields the next blockbuster cancer treatment or an absolute flop. This list of the top biotech ETFs in 2025 can help you learn more about them.

The last remaining US-Russia nuclear arms treaty expired in February 2026

The New START treaty, which capped US and Russian strategic warheads at 1,550 each, expired on Feb. 5, 2026. Without formal limits, fears of a renewed arms race are rising, as both nations could deploy more weapons while follow-on talks continue.

Vitamins can slow macular degeneration

Research published in 2022 affirmed that vitamin formulations containing vitamins C and E, copper, zinc, lutein, and zeaxanthin—but no beta carotene—can enhance eye health and slow the progression of macular degeneration.

Healthy adults should perform 'progressive resistance training'

That's the recommendation in March 2026 from the American College of Sports Medicine. They reviewed existing studies on the topic and concluded that resistance training with progressively more weight and repetitions improves muscle strength, size, power, endurance, gait speed, balance, and more.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

The potential for weight loss drugs to transform the economy

In 2023, Americans spent more than $50B on weight loss drugs, a number expected to triple by the end of the decade. However, because of the wide range of obesity-linked health issues, widespread adoption of the treatments could transform the wider economy.

The WHO’s guidance on 5G, radiation, and health

5G is the latest wireless mobile phone technology, first widely deployed in 2019. 5G is expected to increase performance and a wide range of new applications, including strengthening e-Health (telemedicine, remote surveillance, and telesurgery).

After a tragic 3 decades, F1 created better safety measures

The first three decades of Formula One saw 41 drivers die in competition; since 1980, only 11 have perished. The reduction is due in large part to better safety measures. This article highlights every safety improvement made by year since F1 started, and describes the accidents or deaths that led to the rule changes.

Prostate cancer is both manageable and the second-deadliest cancer for men

One in 44 men in the US will die from prostate cancer, while one in eight will be diagnosed with it. Commonly viewed as the safest cancer to have, screenings can save lives—but they can also cause complications for otherwise benign cases of the disease.

Michael Sveda discovered cyclamate by accident

When this lab researcher brought his hands to his lips to smoke his cigarette in 1937, he tasted something sweet, which he called cyclamate. It was quickly used in diet sodas, but it was banned from the US in 1969 after being linked to rodent bladder cancer in lab experiments.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

While the first exchange-traded fund (a 'basket' of different assets that can be bought and sold on a stock exchange) in the US only launched in 1993, the global ETF market has grown to more than $10T in the short time since.

An Ebola vaccine was developed during the 2018 west African Ebola outbreak, but the 2026 Ebola outbreak is with a different species of the virus, not the one that the vaccine is approved to treat.

11 people died from firework injuries in the US in 2024.

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

US housing costs have risen by roughly 175% between 1991 and 2026—but a growing number of Gen Zers are becoming homeowners anyway. In 2025, 4% of homebuyers were Gen Z, up from 3% the year before.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Urushiol, the oily toxin in poison ivy, can remain allergenic on clothing for years.

The distributor behind 'Rocky Horror' pulled the film from its scheduled national release, believing it would be a failure, though it eventually amassed a dedicated fanbase through midnight showings, a trend that continues over 50 years later.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

20,000 letters to the advice columnist 'Dear Abby' provide insight into prevailing sex, religion, and LGBTQ fears, anxieties, and concerns from the 1950s onward.

In 2026, Finland was named the world's happiest country for the ninth consecutive year based on its wealth, social safety network, and high life expectancy, among other factors.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

The United States has had a tumultuous relationship with Cuba since its 1959 revolution, highlighted by a nuclear crisis and a decades-long trade embargo.

Prince's sexually explicit 1984 track 'Darling Nikki' attracted the ire of the Parents Music Resource Center, an advocacy group that inspired the Parental Advisory sticker, even though the song ends with a Christian message.

Despite being favored by 87% of Americans, Congress does not have term limits.

When caught in the mouths of cardinal fish, seed shrimp release glowing, bioluminescent chemicals, which alert predators of the cardinal fish, prompting the shrimp's ejection.

In 2025, four executives from large tech companies were given positions in the US Army Reserves—including Palantir Chief Technology Officer Shyam Sankar, which reinforced Palantir's ties with the US military and its role as a leading defense partner.

The identity of the Tank Man in the iconic photo from the 1989 Tiananmen Square protests remains unknown and was possibly killed.

The most expensive ad of all time was for Chanel No. 5 perfume and cost roughly $33M to produce in 2004—about $57M in today's dollars.

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.