Within months of a landmark 2002 study that indicated HRT harms, sales dropped by about half

27% of US menopausal women used estrogen in 1999, but by 2020 that number was under 5%

The fallout of studies in the early 2000s linking hormone therapy for menopause and elevated cancer, stroke, and other health risks meant that even decades later—yet before the FDA removed its black box warning in 2025—use of HRT remained extremely uncommon. (Some users may experience a paywall.)

FDA has removed black box warnings from HRT for menopause

The agency removed the label in 2025, reversing its 2003 decision to warn women about HRT's links to stroke risk, developing cancer, and heart disease. Years of accumulating research have found that the risks had been overstated and unnecessarily deterred hormone therapy use. The agency still warns against using certain estrogen-alone products, however, due to elevated endometrial cancer risk.

HRT for menopause may not help with mental health or sleep says a large 2026 analysis

A recent analysis investigating the effects of menopause and HRT use on mental health, cognition, and brain health suggested HRT did little or nothing to aid with mental health and sleep. But the researchers caution that, among other data gaps, they didn't have information on which HRT formulations were used among their nearly 125,000 participants, so results may have varied by drug treatment.

HRT patches are popular partly because they have lower blood clotting risks than oral estradiol

Women taking estradiol for menopause or perimenopause are sometimes told oral HRT is not an option for them because it increases blood clot risks. But a large analysis in 2019 concluded that other forms of the HRT, such as the patch, creams, and gel, do not.

Premarin was the bestselling drug in the US in 1992

The drug, derived from the urine or pregnant mares, raised ethical and animal welfare concerns, but also became wildly popular until the Women's Health Initiative study findings in 2002 (which have since been largely disproved). In the 1990s, Premarin was used to treat menopause symptoms and also to protect against osteoporosis and heart disease among older women.

There are multiple HRT options to treat menopause and perimenopause symptoms

This lengthy video features a board-certified OB/GYN based in Texas who provides a thorough overview of the different formulations for HRT, used to treat symptoms including hot flashes, vaginal dryness, and mood swings, and the pros and cons of each. She also discusses modern synthetic options versus the older formulation extracted from the urine of confined pregnant horses.

It's never too late to start hormone replacement therapy for menopause symptoms

This board-certified gynecologist discusses how it's ideal to start estradiol as soon as possible after menopause to maximize its benefits, but that if older women have healthy hearts they can still start these medications later, in consultation with their doctors, and the products could be useful if women are continuing to suffer from symptoms of menopause or want to fight bone loss.

MS Drugs reduce inflammation, helping reduce relapses and slow disease progression

Disease-Modifying Drugs calm the body's inflammatory response to help stave off relapses—when new or existing MS symptoms show up for a day or longer. Avoiding smoking, exercising, reducing stress via mindfulness, checking for vitamin D deficiencies, drinking more water and eating well, all can slow disease progression. [The jury's still out on if HRT around the time of menopause may reduce dementia risk](https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(25)00122-9/fulltext) Estrogen can reduce inflammation and support neural growth in the brain, and some research has suggested that beginning hormone replacement therapy around menopause—versus later in life—reduces Alzheimer's disease risk. Still, a recent systematic review concluded that taking HRT didn't affect dementia risk, regardless of when women started taking it, so the science remains unsettled.

Health problems are being misdiagnosed as perimenopause symptoms

Symptoms of menopause and perimenopause (the premenopause period) can be varied enough that clinicians dismiss them in patients in their mid-30s and onward as just a symptom of hormone level change. In this story, a woman's itching was dismissed as a hormonal change, but after two years and 11 separate doctor consultations, was diagnosed as cancer. (Some users may experience a paywall.)

Late-onset menopause lowers osteoporosis risks, but heightens the risks for certain cancers

Defined as when a woman starts to experience perimenopause after age 55, this delayed menopause onset is linked to elevated risk of developing breast, ovarian, and uterine cancers.

The term 'low T' was coined in 2002, recasting testosterone therapy and elevating demand

The marketing shift and accompanying awareness campaigns, both by the company behind the first testosterone product approved by the FDA, changed the landscape for testosterone product demand. Testosterone is often considered low when it's below 300 nanograms per deciliter of blood. (Some users may experience a paywall.)

Heatstroke treatment guidelines were built almost exclusively on research in men

Protocols for the standard treatment recommendation for heatstroke—whole-body cold water immersion—were built based on studies almost entirely in men. The research wasn't replicated in women, who typically cool faster than men during cold water immersion, raising questions about standard protocol safety for women, due to the risk of overcooling.

Stroke risk doubles each decade after age 55

While age is the greatest risk factor, genetics, diet, and overall health play a prominent role in determining individual stroke risk. Prevention focuses heavily on modifiable risk factors. High blood pressure is the single most important controllable risk factor, contributing to both types of stroke.

How Western psychedelics research fell to the wayside

Psychedelics' modern era began when LSD was discovered in the 1930s. By the 1950s, clinical trials were underway. US user experimentation outside of medical settings (and high-profile violence, like the Manson murders) inspired negative attitudes toward psychedelics, leading to use restrictions that prohibited companies from patenting psychedelic compounds. This strangled psychedelics' profitability until the 1990s when the government loosened its grip and psychedelics research began seeing a resurgence.

Yes, you can die from a broken heart

Researchers reviewed the health records of about 200,000 people diagnosed with broken heart syndrome from 2016 to 2020 and the death rate was 6.5%—with men's deaths roughly doubling that of women.

Kava, kratom, St. John's Wort, and green tea extract present health concerns

Consumer Reports, which tests supplements for safety, urges consumers to avoid these four supplements due to safety warnings from researchers and public health authorities.

Heat-related deaths may have climbed by more than 50% over 20 years

Between 2000 and 2009 one study suggests annual heat deaths averaged around 2,670, but between 2010 and 2020 that figure was likely more than 4,000. Researchers studied 54 million death records from the contiguous US and created mathematical models to arrive at these figures, noting that a combination of aging populations and climate change drove that increase.

Why young women experience the most workplace ageism

While one might assume that older women face the most unfair treatment due to age in the workplace, some research from McKinsey & Co. suggests otherwise. The consulting firm found that while ageism impacts older women and men at similar rates, women in their 20s and 30s report much higher instances of ageism than both older women and their young, male colleagues. Learn more from the research here.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

The HPV vaccine reduces cervical cancer rates by 90% or more

Cervical cancer is the fourth most common cancer in women globally. Almost all cases (99%) are linked to infection with high-risk human papillomaviruses. However, cervical cancer is both treatable and preventable—and we may be able to prevent most cases through vaccination.

Most adults don't need a daily vitamin, and it won't extend your life

A 20-year study by the National Cancer Institute involving almost 400,000 people found that daily multivitamins did not help people live longer. In some cases, these vitamins also increased the risk of death. Although some subpopulations—such as those with documented vitamin deficiencies and pregnant individuals—should take vitamins, daily multivitamins should not be taken uniformly by adults. Instead, patients should discuss vitamins with their clinicians and consider baseline vitamin testing before starting vitamin regimens.

HRW explores women’s rights around the world

Human Rights Watch’s page documents human rights violations around the world affecting women and girls. The international women’s rights movement has made great strides over many years, but women and girls around the world continue to face...

When people stopped using GLP-1, they regained two-thirds of the weight back

Research from 2022 found that when people stopped using the injectable form of the medication, they regained up to two-thirds of lost weight within a year. The finding suggests ongoing treatment will be required for weight loss.

This 2022 study is one of the findings that prompted WHO to label aspartame as 'possibly carcinogenic'

This French study analyzed online periodic self-reported food journals from more than 100,000 people for a median of almost eight years and linked aspartame consumption to a roughly 15% increased cancer risk. It found that the people who consumed higher levels of aspartame had elevated cancer numbers—particularly breast and obesity-related cancers.

Marriage is experiencing a general decline

Marriage has taken drastically different forms than in the past. The transformation of marriage from a form of economic dependency for women to an equal partnership has forged demographic shifts. Richard Reeves, author of "Of Boys and Men," explains how economic and educational factors have potentially destabilized partnerships and changed patterns of “marriageability” for middle- and lower-class men.

Review the health effects of living near oil refineries, including increased respiratory risks

An analysis of 54 studies published between 1977 and 2024 in 15 international regions found evidence that proximity to refineries increased the risks of leukemia, asthma, bronchitis, and respiratory symptoms. Several studies also identified worse cardiovascular function in children and adults living near refineries, alongside other acute and chronic health impacts.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Human-to-human transmission of hantavirus remains extremely rare, so the 2026 hantavirus cruise ship outbreak doesn't mean we're facing a COVID-style pandemic risk.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

US housing costs have risen by roughly 175% between 1991 and 2026—but a growing number of Gen Zers are becoming homeowners anyway. In 2025, 4% of homebuyers were Gen Z, up from 3% the year before.

11 people died from firework injuries in the US in 2024.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

When a Paris department store hesitated to sell Estée Lauder's perfume, she 'accidentally' broke a bottle, causing the smell to spread throughout the store and shoppers to start asking to buy the scent.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

While the first exchange-traded fund (a 'basket' of different assets that can be bought and sold on a stock exchange) in the US only launched in 1993, the global ETF market has grown to more than $10T in the short time since.

70 years ago today, city officials in Santa Cruz, California, banned rock 'n' roll to protect its youth from corruption after witnessing a 'provocative' concert the night before.

20,000 letters to the advice columnist 'Dear Abby' provide insight into prevailing sex, religion, and LGBTQ fears, anxieties, and concerns from the 1950s onward.

See 33 images that became central to huge scandals, including a young Charles and Camilla, Michael Jackson's baby on a hotel balcony, and Hugh Grant's mugshot.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.

Domino's Pizza's 30-minute delivery guarantee was responsible for the chain's 1980s surge, but it was discontinued after the company was found liable for delivery driver accidents.

Poison ivy can cause rashes year-round since all parts of the plant contain urushiol, the oil that triggers our allergic response.

Brandi Chastain, the star of the 1999 US victory over China in the 1999 Women's World Cup, was a last-second choice to take the penalty kick that sealed the victory.

The United States has had a tumultuous relationship with Cuba since its 1959 revolution, highlighted by a nuclear crisis and a decades-long trade embargo.

Take a 3D tour of the Hajj, Islam's annual pilgrimage to Mecca, undertaken by more than 1.5 million Muslims each year.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

Some coin denominations have ridges etched on their sides, partly to prevent counterfeiting, in a practice called 'reeding.'

After the Boston Tea Party, colonists switched to coffee, which became the main morning drink for revolutionaries.