Global xenotransplantation market may already be valued at more than $13B

Organ transplants can come with a price tag of more than $2M without insurance

According to 2025 report data that was graphically represented by Statista, average costs for organ transplants can be as steep as $2.3M for a double lung transplant and $1.9M for a heart. These figures are based on what was actually charged to insurance companies—not what individual patients paid. Following the actual transplant there are also additional costs associated with the procedure, including lifelong immunosuppressant drugs.

In 2024, the US had more organ transplants than ever before—besting the 2023 record

More than 48,000 organ transplants were performed in 2024, and about 46,630 were performed in 2023. These record highs are illustrated here as part of data from 1988 to partway through 2025. Kidneys, livers, and the heart remain the most common transplanted organs. (Some users may encounter a paywall.)

Xenotransplants are an experimental last resort for the terminally ill

David Bennett Sr., the world’s first genetically modified pig heart transplant recipient, explained his reasoning to his University of Maryland Medical Center care team in 2022 regarding why he accepted a pig organ: He was dying and ineligible for a human heart transplant so this was a last-ditch effort, he said. He died two months after receiving the heart.

3 US maps illustrate transplants, donors, and organ waitlist additions—by state

National UNOS tracking data feeds into these US maps that record all the transplants, donors, and waitlist additions in the last 12 months. California, for example, had the most transplantations in 2025—totaling about 5,200—but it also has the longest waiting list, with more than 20,000 additions in that same period.

Cross-species transplantation has been attempted in medicine for more than 300 years

Early reported xenotransplantation attempts included 17th century efforts in France to transfuse blood from animals into humans. The poor results prompted France to issue a xenotransplantation ban. In the 19th century, researchers tried animal-to-human skin grafts from species including sheep, rabbits, dogs, cats, rats, chickens, and pigeons.

Transplant organs don't always last a lifetime—that's where retransplants come in

How long a transplanted organ lasts depends on a variety of factors including the type of organ and the health of the recipient. Sometimes organs can last many decades, but other times people may need retransplants, which means another transplant following a previous one. Retransplants are most common with kidneys.

Thousands of donated human kidneys are thrown away annually

Ten donated kidneys are thrown away daily even though thousands of people are awaiting a kidney transplant. Listen to a kidney doctor and a 2012 economics Nobel laureate discuss why this happens and how the organ transplantation system may be improved. Transplant centers are penalized for low transplant survival rates, they note, and that contributes to why hospitals may decide certain organs are just too risky to use.

NSF-funded research into matching algorithms improved the success of organ transplants

Investigations in game theory, including concepts focused on creating mutually beneficial partnerships—matching theory—led to the design of computer systems that efficiently matched kidney recipients and live donors, resulting in higher-quality matches. By 2019, these matching algorithms were used for multi-organ exchanges.

The plasma-selling industry is expected to reach $50B by the end of the decade

About 55% of your blood volume is plasma, the liquid part of blood created from water, proteins, minerals, and salts absorbed through the digestive tract. This 49-minute podcast episode explores the business of plasma—part of a global industry expected to be worth $50B by 2029.

In 2023, at least 6 people were charged with stealing body parts

A recent case involving alleged trafficking in stolen human body parts charged that there was a nationwide network of individuals who bought and sold human remains. The charges alleged, among other things, that from 2018 through 2022, the manager of the morgue at Harvard Medical School's Anatomical Gifts Program stole organs and other parts of cadavers that had been donated for medical research and education. In late 2025, that Harvard morgue manager was sentenced to 96 months in prison.

Extending the worldwide lifespan by one healthy year is worth $38T

This econometric study attempts to estimate the economic value of increasing the global healthy lifespan by one year—and to answer the question of whether it is better to extend lifespans or slow the rate of healthy aging.

Organoids: 3D organs grown from stem cells in the lab

An organoid is a three-dimensional construct composed of multiple cell types that originate from stem cells that can simulate the architecture and functionality of native organs. One big benefit of these lab-grown organs is that drug candidates can be tested in model systems without needing live patients.

Christmas trees are a $6B global industry

In the US, the real tree industry is valued at $2B, the reflection of nearly 30 million trees sold annually at an average profit of about $10 per tree. While each tree takes about 8 years to mature, their artificial counterparts can be made much more quickly, mostly in China, valued at over $1B as of 2020.

The potential for weight loss drugs to transform the economy

In 2023, Americans spent more than $50B on weight loss drugs, a number expected to triple by the end of the decade. However, because of the wide range of obesity-linked health issues, widespread adoption of the treatments could transform the wider economy.

Inhalers, antihistamines, immunotherapy, and more have made allergies a multimillion-dollar market

Market research suggests that the allergies market will continue to grow in the years ahead as the number of allergy diagnoses increases, identifying new patients. Areas of growth include the increasing interest in immunotherapies designed to retrain the immune system through regular exposure to potential allergens via injections and under-the-tongue medical formulations, among other approaches.

The global horse market is worth about $400B

In this podcast episode from a new series on horses, Freakonomics explores the market around buying and selling some of the world's top sport horses, and the nebulous forces that make them so valuable.

Hormone and peptide compounds imported from China soared in 2025

US customs data indicates that these imports doubled to $328M in the first three quarters of 2025, from $164M in the same period of 2024. The imports include GLPs, among other products. (Some users may experience a paywall.)

New eye implant clinical trial recruiting in 2026

University of Southern California researchers have launched a phase 2b clinical trial of a stem cell implant designed to restore vision in people with advanced dry macular degeneration. Patients will be randomized to receive the stem cell implant or a simulated procedure and placebo implant. This type of larger, second-stage clinical trial is designed to confirm efficacy and dosing and to look for side effects. It's one of the stages that precedes the US Food & Drug Administration approval of a device.

The $3B project scientists called 'junk'

In 1990, scientists set out to map all of human DNA. A $3B bet many called "junk." But the Human Genome Project's radical transparency and a race with a private company sped it to completion in just 13 years. Today, that once-contested map underpins nearly every breakthrough in genetics and personalized medicine.

The global consulting industry was worth roughly $710B in 2023

From 2017 to 2021, the consulting firm McKinsey took in $77M in consulting contracts with just the US Food and Drug Administration alone.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

See a ranking of the world's most valuable brands

Evaluating a brand's value involves evaluating investments in marketing, the strength of the brand, and even the company's performance. Technology companies represent most of the global economy's brand value. As of 2026, Apple has the most valuable brand in the world at $608B.

The trans-Atlantic slave trade brought over 10 million enslaved people to the Americas

During the Atlantic slave trade (1526-1867), about 12.5 million Africans were forced onto ships; only 10.7 million survived to reach the Americas. Fewer than 400,000 arrived in what became the United States—the rest were taken to the Caribbean or Latin America.

How to consider the ethics of 3-parent IVF, which is illegal in the US

Ethical concerns with this controversial procedure include that a little bit of a child's offspring would be from a third person and that the decisions made with this pregnancy will affect numerous generations, making a permanent change to the gene pool.

From 1970 to 2017, invasive species have caused $1.28T in damage globally

The costliest species were the Asian tiger and yellow fever mosquitoes ($149B), which arrived in the US from Asia and sub-Saharan Africa, respectively. The bulk of their damage came from their transmission of diseases such as Zika, chikungunya, and dengue. (Some readers may experience a paywall.)

Global trade volume is roughly 45 times what it was when the General Agreement on Tariffs and Trade was founded

Since 1950, world trade values have grown nearly 410 times, mainly due to the successive tariff reductions negotiated under GATT and the WTO.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

While the first exchange-traded fund (a 'basket' of different assets that can be bought and sold on a stock exchange) in the US only launched in 1993, the global ETF market has grown to more than $10T in the short time since.

SpaceX's S-1 or 'prospectus' revealed many previously unknown details about the company, including its unprofitability despite doing $18.7B in revenue in 2025, exactly how many voting shares Elon Musk will have in the company (roughly 85%), and more.

The US dollar is the most widely circulated currency in the world, and is involved in nearly 90% of global transactions

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

This real-time tracking of the hantavirus cruise ship outbreak in May 2026 offers a unique glimpse into the global reach of the outbreak and whether the virus sickened passengers and their communities around the world.

Art theft is the third-largest source of criminal revenues worldwide, thanks in part to the subjective nature of valuing a work of art.

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

See how each of the more than two million known species relates to each other—and to common ancestors—in this zoomable tree of life.

Electrical grids worldwide must double their power delivery capacity by 2050 to meet surging demand from AI and electric vehicles.

US housing costs have risen by roughly 175% between 1991 and 2026—but a growing number of Gen Zers are becoming homeowners anyway. In 2025, 4% of homebuyers were Gen Z, up from 3% the year before.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

Up to a million Girl Scouts sell about 200 million cookie boxes every spring, generating $800 million, largely because refusing a child is frowned upon

Stanford built a Google Maps for the Roman Empire, revealing how much it cost to travel in the ancient world

The 1987 Nintendo video game 'Stadium Events' isn't known for being particularly fun, but its scarcity has made it a highly sought-after item that has sold for up to $35K at auction.

Use this calculator to find the dollar value of your mental load, from meal planning to coordinating after-school care for your children.

Before humans, the Soviet Union and the United States sent animals—including apes, dogs, and cats—to space during the Space Race.

NBA superstar Victor Wembanyama spent the 2025 summer training with monks in central China to enhance his body and mind.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

The Russia-Ukraine conflict is the largest ground war in Europe since World War II in terms of casualties, forces mobilized, and displacement of civilians.

A 2019 Facebook event called on attendees to "Storm Area 51, They Can't Stop All of Us," resulting in countless memes, the creation of a music festival, and eventually the arrests of those who did try to approach the area.