NSF-funded research into matching algorithms improved the success of organ transplants

Artificial intelligence may improve organ donation systems—and even organ health

Mayo Clinic transplant experts suggest that artificial intelligence could potentially improve organ donation systems in several ways, including better identifying patients most at risk for organ rejection, enhancing donor-recipient matching, and helping to avoid organ transplant needs by identifying health issues earlier.

The first successful organ transplant was performed in 1954

The successful kidney transplant procedure, at what's now-called Brigham and and Women's Hospital, ushered in a new medical era and gave hope to patients with organ failure. The recipient, 23-year-old Richard Herrick, lived eight more years after receiving the donated organ from his living twin brother, Ronald.

3 US maps illustrate transplants, donors, and organ waitlist additions—by state

National UNOS tracking data feeds into these US maps that record all the transplants, donors, and waitlist additions in the last 12 months. California, for example, had the most transplantations in 2025—totaling about 5,200—but it also has the longest waiting list, with more than 20,000 additions in that same period.

Thousands of donated human kidneys are thrown away annually

Ten donated kidneys are thrown away daily even though thousands of people are awaiting a kidney transplant. Listen to a kidney doctor and a 2012 economics Nobel laureate discuss why this happens and how the organ transplantation system may be improved. Transplant centers are penalized for low transplant survival rates, they note, and that contributes to why hospitals may decide certain organs are just too risky to use.

A clinical trial is underway in 2026 to help kidney transplant recipients avoid a lifetime of immunosuppressing drugs

This later-stage clinical trial, in Chicago and Taiwan, evaluates the efficacy and safety of a new cellular therapy that may be swapped in for immunosuppressing drugs among kidney transplant recipients. The study randomizes people to either receive standard immunosuppressants or this cellular therapy and fewer immunosuppressants. It only includes kidney transplant recipients receiving organs from live donors so transplant surgery timing won't hinge on the unpredictable schedule of performing surgery and follow-up care when a donor dies.

Living donations most commonly involve a kidney or part of a liver

In 2023, more than 6,900 transplants were made possible thanks to living donors. Living donation is when a living person donates an organ or part of an organ—usually one of their two kidneys or part of the liver, since that organ can regenerate in a healthy person. Much more rarely, living donors donate other organs. Living donations often occur when someone wants to ensure a loved one has certainty that they will quickly receive a needed organ.

Transplanted organs can be rejected by the body immediately, months after transplant, or slowly over years

Organ rejection remains a huge challenge for organ transplant recipients. Rejection occurs when a recipient's immune system identifies a transplanted organ as foreign and attacks it. Recipient-donor screening processes try to match antigens to help reduce this risk.

Organ transplants can come with a price tag of more than $2M without insurance

According to 2025 report data that was graphically represented by Statista, average costs for organ transplants can be as steep as $2.3M for a double lung transplant and $1.9M for a heart. These figures are based on what was actually charged to insurance companies—not what individual patients paid. Following the actual transplant there are also additional costs associated with the procedure, including lifelong immunosuppressant drugs.

Scientists may have discovered why gene-edited pig kidneys are rejected in humans

In November 2025, researchers studying how a brain-dead donor’s body responded to the transplantation of a genetically engineered pig kidney, published that they’ve identified immune system reactions that may explain why these pig organs get rejected. What’s more, they were able to reverse the rejections with an already available drug combination and the kidney functioned well. They also pinpointed a way to detect a potential rejection up to five days sooner.

As of 2025, perfect synthetic replication of natural organs remains elusive

Advancements such as 3D printing muscles, performing vaginal reconstruction with colon tissue, and growing organs in a lab have shown promise, but artificial options and transplanting substitutions continue to exhibit functional and performance limitations compared to their natural equivalents.

How heart transplants work

Heart transplants require an old heart to be removed and a new one to be installed without killing the patient. How does that work? In this easy-to-understand five-minute video, learn each step of the intricate process, from donor matching to the preservative solution a heart is doused in while it is transported.

Cross-species transplantation has been attempted in medicine for more than 300 years

Early reported xenotransplantation attempts included 17th century efforts in France to transfuse blood from animals into humans. The poor results prompted France to issue a xenotransplantation ban. In the 19th century, researchers tried animal-to-human skin grafts from species including sheep, rabbits, dogs, cats, rats, chickens, and pigeons.

Traffic flow can be improved through research into card shuffling

Card-shuffling mathematics has been applied to solving problems in biology to estimate the evolutionary distance between organisms and in computer science to determine the optimal distribution of files and folders in databases.

Genetic drug matching, called pharmacogenomics, can help avoid dangerous drug reactions

Certain gene variants can affect how quickly or slowly medications are broken down in the body, affecting drug effectiveness and the risk of drugs failing. Such testing is often not covered by insurance companies though research indicates if these tests were performed for more than six drugs across the US population, avoided ailments would likely climb into the hundreds of thousands. (Some users may encounter a paywall.)

Mitochondrial DNA swapping can occur before or after fertilization

Mitochondrial replacement therapy can be conducted with four different techniques, with varying genetic material transferred depending on the approach. Maternal spindle transfer, one common method, involves transplanting the nuclear DNA from a mother into an unfertilized egg from a donor. The donor egg is then fertilized and implanted into the mother's uterus using in vitro fertilization. Another major approach, pronuclear transfer, does the genetic swapping after the mother's egg has already been fertilized. This order of operations may be uncomfortable for some individuals, but the success rate with this technique is higher.

How Nobel Prize-winning research unraveled why the immune system doesn't always attack itself

The 2025 Nobel Prize was awarded to scientists who discovered how immune system soldiers are typically stopped from attacking healthy tissue. The work furthered autoimmune understanding and cancer therapies.

Stem cell therapies

Stem cells' special attributes interest researchers developing new therapeutic tools for a variety of health problems. Much of this research is done with support from the National Institutes of Health (NIH). This page offers a snapshot of research programs funded by the NIH and the health problems those programs focus on.

Generally, NBA basketball teams whose players touch each other more win more games

This 2010 research finding underscores the importance of touch in promoting trust, bonding, and cooperation, thereby apparently improving team success. Touch also promotes cooperation in other settings: In a separate "prisoner's dilemma" study, when the experimenter gently touched some participants with a quick pat on the back, the touched individuals were more likely to cooperate and share with their partner.

Researchers are exploring neural links between Alzheimer's and autism

Recent DNA sequencing and molecular biology studies suggest that similarities in genes, neural circuitry and patterns of disease warrant further exploration to potentially better understand both conditions and how to treat them. (Some users may encounter a paywall.)

Understanding the causes, effects, and prevalence of algorithmic bias

Found in search engines, hiring and college admissions tools, facial recognition systems, and other software, algorithms act on the rules they are programmed with, which may be authored by individuals unaware of their own biases. Algorithms based on limited, incomplete, or inaccurate data are more likely to inherit and propagate existing biases.

Neuralink brain implants have enabled a paralyzed person to play video games

As one of twelve test subjects in Neuralink's PRIME study, Rob Greiner's implant translates his brain's activity into digital commands for the 'Battlefield 6' game. He can now also design 3D models and 3D-print objects using his thoughts.

Netflix's recommendation algorithm was born from a $1M competition

In 2006, Netflix launched an open competition for data science teams to develop approaches to outperform its recommendation algorithm. Three years later, the prize was awarded after a group of competitors merged, developing a solution that beat Netflix's internal algorithm by more than 10%. Today, recommendations are based on what users watch, particularly via bingeing.

The matchmakers serving the elite of Silicon Valley

If members of the wealthy elite want to find romance, they often choose expensive match-making services rather than dating apps. These services can cost $150,000 for each match, and providers are experts in dealing with the unique social dynamics caused by being wealthy and the unusual egos such wealth can bring. This article explores this hidden cultural phenomenon.

About 250,000 patients accessed assisted reproductive technologies in 2022

In 2022, 251,542 patients tried assisted reproductive technologies—most commonly IVF—resulting in more than 98,000 infants. Those children represent around 2.6% of the babies born in the US.

Before ChatGPT, OpenAI Five beat esports world champions

The bot won two back-to-back Dota 2 matches and developed a new skill of working as a teammate with humans, even though it had only been trained to beat other bots.

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

This site reaches millions of visitors who are tired of AI chatbots and seeking human connection. Pretend to be an AI chatbot and ask questions, provide answers, and draw for people in real time.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Learn how monoclonal antibodies, which mimic the body's antibodies, can fight diseases like Ebola.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Play the role of a student in a game where you try to navigate college and remain debt-free, selecting different income levels, high school experience, race, ethnicity, and more.

See how each of the more than two million known species relates to each other—and to common ancestors—in this zoomable tree of life.

The term 'algorithm' originated from the Latinized name of al-Khwārizmī, a 9th-century mathematician whose works introduced Arabic numerals and the decimal-based numeral system to Europe and whose treatise 'Al-Jabr' gave algebra its name.

The history of many kitchen appliances involves unexpected discoveries and applications, including wartime radar turned hamster defroster and replacing an 'ice king' with heat-stealing boxes.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

While the first exchange-traded fund (a 'basket' of different assets that can be bought and sold on a stock exchange) in the US only launched in 1993, the global ETF market has grown to more than $10T in the short time since.

The 1987 Nintendo video game 'Stadium Events' isn't known for being particularly fun, but its scarcity has made it a highly sought-after item that has sold for up to $35K at auction.

Up to a million Girl Scouts sell about 200 million cookie boxes every spring, generating $800 million, largely because refusing a child is frowned upon

Watch this video that uses Lego bricks to explain how venture capital works.

Art theft is the third-largest source of criminal revenues worldwide, thanks in part to the subjective nature of valuing a work of art.

Objects can be 3D printed with light by projecting 2D computerized tomography (CT) scans onto rotating cylinders of resin, which solidify upon exposure.

Watch how deep-sea mining equipment collects and processes polymetallic nodules—metal-rich, potato-shaped rocks—from the ocean floor and creates environmentally damaging plumes of sediments.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

The Brothers Grimm were lawyers before they were storytellers, but became interested in fairy tales as they began investigating how rules and customs had been passed down through cultures.