Living donations most commonly involve a kidney or part of a liver

Transplant organs don't always last a lifetime—that's where retransplants come in

How long a transplanted organ lasts depends on a variety of factors including the type of organ and the health of the recipient. Sometimes organs can last many decades, but other times people may need retransplants, which means another transplant following a previous one. Retransplants are most common with kidneys.

Organ donation isn't usually logistically possible if you die at home

Since organs need to be well-preserved for organ donation, with oxygen flowing through the body, internal organs often aren't viable for organ donation if someone dies at home. But some tissues—like eye corneas and skin tissue—may still be donated since they remain usable for a longer period without oxygen flow.

Brain death is a top source of organ donation

Brain death is a significant source of organ donations because patients declared brain dead and hooked up to intensive care unit machines will still have oxygen flowing to organs like the heart, lungs, and kidneys—preserving those organs.

In 2024, the US had more organ transplants than ever before—besting the 2023 record

More than 48,000 organ transplants were performed in 2024, and about 46,630 were performed in 2023. These record highs are illustrated here as part of data from 1988 to partway through 2025. Kidneys, livers, and the heart remain the most common transplanted organs. (Some users may encounter a paywall.)

'Donation after circulatory death' is on the rise

This occurs when a patient in a coma is on life support and family members agree to donate the organs. Watch this video about a 2025 New York Times investigation that identified 12 instances across nine states of bungled or premature attempts to retrieve organs from people whose families had authorized withdrawal of life support.

You can sign up to donate your organs at this website

A single person who chooses to donate their organs upon death can provide organs for as many as eight people. You can sign up to become an organ donor or update your donation status information at this website, or you can typically sign up at your state's Department of Motor Vehicles. Many states allow individuals to declare which tissues and organs you consent to donate (i.e. organs, eyes, and skin tissue). It's recommended to discuss your decision with your family so they are aware of your wishes.

The first successful organ transplant was performed in 1954

The successful kidney transplant procedure, at what's now-called Brigham and and Women's Hospital, ushered in a new medical era and gave hope to patients with organ failure. The recipient, 23-year-old Richard Herrick, lived eight more years after receiving the donated organ from his living twin brother, Ronald.

Donated hearts remain viable three times longer now with new tech

Advances in organ perfusion systems have significantly lengthened the amount of time donated hearts can remain viable for transplant, expanding the possibilities for donor organs to wider geographic areas. "Heart in a box" devices, developed in recent years, enable effective oxygen flow in the donor heart during transport, which means that hearts can now travel farther to potential recipients and still be in good condition.

Thousands of donated human kidneys are thrown away annually

Ten donated kidneys are thrown away daily even though thousands of people are awaiting a kidney transplant. Listen to a kidney doctor and a 2012 economics Nobel laureate discuss why this happens and how the organ transplantation system may be improved. Transplant centers are penalized for low transplant survival rates, they note, and that contributes to why hospitals may decide certain organs are just too risky to use.

Organ transplants can come with a price tag of more than $2M without insurance

According to 2025 report data that was graphically represented by Statista, average costs for organ transplants can be as steep as $2.3M for a double lung transplant and $1.9M for a heart. These figures are based on what was actually charged to insurance companies—not what individual patients paid. Following the actual transplant there are also additional costs associated with the procedure, including lifelong immunosuppressant drugs.

Artificial intelligence may improve organ donation systems—and even organ health

Mayo Clinic transplant experts suggest that artificial intelligence could potentially improve organ donation systems in several ways, including better identifying patients most at risk for organ rejection, enhancing donor-recipient matching, and helping to avoid organ transplant needs by identifying health issues earlier.

Which organs can you live without?

While there are some organs (such as the heart) that people simply can’t live without, there are other organs that can be removed without a huge impact. Patients who have their appendix removed, for example, experience no changes to their daily...

A clinical trial is underway in 2026 to help kidney transplant recipients avoid a lifetime of immunosuppressing drugs

This later-stage clinical trial, in Chicago and Taiwan, evaluates the efficacy and safety of a new cellular therapy that may be swapped in for immunosuppressing drugs among kidney transplant recipients. The study randomizes people to either receive standard immunosuppressants or this cellular therapy and fewer immunosuppressants. It only includes kidney transplant recipients receiving organs from live donors so transplant surgery timing won't hinge on the unpredictable schedule of performing surgery and follow-up care when a donor dies.

Several years after the English law changed, organ donation rates haven't improved

A 2024 analysis found that several years after England changed its organ donation system to an opt-out donation system there was no improvement to the country's organ donation rates, perhaps highlighting the need for better understanding and education around the law.

A living will is a legal document spelling out your medical wishes for emergency care

This legal document makes it explicit if you want medical interventions in the event of an emergency, including CPR, feeding tubes, ventilator assistance to push air into your lungs to help you breathe, and more. Talking with your doctor about this is covered by Medicare.

Watch this video letter (via Facebook) from a kidney recipient to his donor

A kidney recipient named Justin reads a letter he wrote to his deceased donor about how the person's generous kidney donation saved his parents from having to watch him suffer and his brother from having the pressure of perhaps being his only shot at a life-saving transplant.

A revocable living trust is the most common type of trust

With a revocable trust, the grantor can alter or dissolve the trust at any time. A living trust, is one that the grantor creates during their lifetime (as compared to a “testamentary” trust, which a grantor establishes in their will to be read after death).

Organoids: 3D organs grown from stem cells in the lab

An organoid is a three-dimensional construct composed of multiple cell types that originate from stem cells that can simulate the architecture and functionality of native organs. One big benefit of these lab-grown organs is that drug candidates can be tested in model systems without needing live patients.

A first-of-its-kind clinical trial taps livers from gene-edited pigs to clean blood

The experimental dialysis-like treatment from United Therapeutics, eGenesis, and OrganOx, is designed to help people with liver failure. The therapy, which involves attaching the modified pig liver externally, filters a patient’s blood so their own livers can temporarily rest and perhaps heal.

Bone marrow transplants were the first successful type of stem cell therapies

Bone marrow contains two types of stem cells: Skeletal (develop into bone, cartilage, and more) and hematopoietic, which create new blood cells. The latter are critical in bone marrow transplants, and give the recipient the ability to create healthy blood cells to fight diseases like leukemia.

How much your blood really costs

In the US, donating plasma twice a week can earn you $400 a month. But this system only works by targeting people who need the money most. Plasma clinics are placed in low-income zip codes, and frequent donation may increase health risks.

Research studies can be conducted inside or outside of living samples

While "in vitro" experiments occur outside living organisms for cost-effectiveness, "in vivo" experiments take place inside them, providing real-life insights at a higher cost and with increased ethical concerns. Alternatively, "in silico" methods use computational simulations.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Helping support others in older age linked to longer life

Analysis of findings from a long-term study of older couples first interviewed in 1987 and then followed for the next five years found that individuals who lend support to friends, neighbors, and relatives live longer. Non-helpers were more than twice as likely to die as helpers during the five-year period. That's even after controlling for factors including age, gender, and physical and mental health.

Different types of endowments, explained

​This Investopedia article provides a comprehensive overview of financial endowments—donations made to nonprofit institutions like universities, museums, or hospitals. It explains how endowments are structured, the various types (such as restricted and quasi-endowments), and how they are managed to support an institution's mission over time.

A 'death benefit' can replace lost income, pay for a funeral, or leave a legacy

Those beneficiaries are usually family members. In exchange, the policyholder pays a monthly fee for coverage. It’s normally used to cover the life of a financial provider.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Planarian flatworms are small, aquatic worms with exceptional regenerative capabilities. When cut, the worms can regenerate multiple bodies in a matter of weeks.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

See how each of the more than two million known species relates to each other—and to common ancestors—in this zoomable tree of life.

Art theft is the third-largest source of criminal revenues worldwide, thanks in part to the subjective nature of valuing a work of art.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Apollo astronauts left items in the moon's 'toss zone,' including golf balls, family photos, and bags of human waste, to make room for lunar rocks.

Salvador Dalí believed he was his own dead brother, who had died nine months before he was born

Watch the cumbersome, but necessary, precautions healthcare workers must take to care for and protect themselves while caring for Ebola patients.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

Objects can be 3D printed with light by projecting 2D computerized tomography (CT) scans onto rotating cylinders of resin, which solidify upon exposure.

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

An initial public offering or 'IPO' is the process of a private company becoming public by putting shares of the company on the stock market for purchase.

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

A Yale student wrote a profound essay about the consulting industry's influence on elite college students that was published in a book of her writing after she died in a post-graduation car accident.

Dozens of S&P 500 stocks, including Coca-Cola and Walmart—known as the dividend aristocrats—have increased dividends every year for 25 years

Most of the observable universe's volume consists of voids and supervoids—enormous regions of space with little to no galaxies, stars, or light.

The US Constitution is widely regarded as the longest-standing written national constitution still in force—see how it has influenced rights worldwide.