How to consider the ethics of 3-parent IVF, which is illegal in the US

IVF is legal across America, but some worry that state bans could curtail this reproductive technology

This reproductive technology is available across the US, but if states take action to prohibit the discarding of unused embryos or pass related legislation, it could affect access to IVF. Laws prohibiting IVF or effectively outlawing the procedure by defining personhood as being conferred at the moment of conception have been under discussion in several states in recent years, including Ohio, Virginia, and Texas.

Four frozen embryos in the US were created via 3-parent IVF technique

Columbia University researchers created four embryos using mitochondrial replacement therapy for four female patients who didn't want to pass on mitochondrial diseases to their children. Yet US law restricts the researchers from implanting the embryos so they remain frozen. (Some users may encounter a paywall.)

IVF was long considered controversial and ethically dubious

In spite of its wide acceptance as a form of reproductive assistance today, and its role in helping millions of people have children, in vitro fertilization was once considered a controversial threat to society. One magazine went as far as to describe the procedure as "the biggest threat since the atom bomb."

Australia legalized 3-parent IVF in 2022

It was the second country, after the UK, to legalize the procedure, which is still prohibited in the US. There are more than 300 rare mitochondrial diseases that can be passed from a mother to her offspring.

3-parent baby technique fuels worries of future 'designer babies'

Some critics of this approach worry that any genetic manipulation will both culturally and technologically normalize the idea of "designer babies"—embryos that are manipulated or selected based on physiological characteristics including height, eye color, athletic ability, and intelligence.

Selecting an embryo based on polygenic score is illegal in the UK, Israel, and swaths of Europe

Though their use for embryo selection is illegal in many locations, private clinics in the US may offer polygenic scores to inform embryo selection. The US Food and Drug Administration has not banned their use—instead the tests are regulated like supplements, meaning they are not regulated before they come to market but consumers can file complaints and then the agency may take action.

Scientific advances are unlocking a wide range of alternatives to IVF

From refined artificial insemination and microsurgical sperm extraction to experimental uterine transplants, scientific innovation is rapidly advancing potential fertilization technologies. But they come along with costly trials, some ethical dilemmas, regulatory issues, and more.

A 2024 court ruling has had ripple effects for frozen embryos

The Alabama Supreme Court's 2024 ruling that embryos created through IVF are legally children has had a chilling effect on the fertility industry. A few centers for reproductive assistance paused egg fertilization, and others are questioning where the legal argument will lead. The decision has some surprising implications for the future of IVF technology, including techniques that haven't yet been invented.

Without 3-parent IVF, women carrying faulty mitochondrial DNA have few options for children

Women who are carriers of mitochondrial diseases that wish to have children without those conditions cannot be biological parents without three-parent IVF. The alternatives are to adopt or have a child via egg donation.

How two families navigated an unthinkable IVF mistake

The field offers hope to thousands of families annually, but it is also largely unregulated, and for a small number of parents, things can go terribly wrong.

In vitro gametogenesis: using induced stem cells to fertilize eggs

Using stem cells from skin and mouth cells could save hopeful parents time and money and spare egg donors from significant amounts of discomfort throughout the process. There are potential consequences, not just for infertility treatment, but for the ability to create customized cells of any type.

About 250,000 patients accessed assisted reproductive technologies in 2022

In 2022, 251,542 patients tried assisted reproductive technologies—most commonly IVF—resulting in more than 98,000 infants. Those children represent around 2.6% of the babies born in the US.

The science and ethics of artificial wombs

Artificial wombs may be able to help preterm babies survive their early entry into the world and possibly curb the long-term adverse health effects associated with such premature birth. This article dives into the current ethics and science behind artificial wombs and ectogenesis, which is when a fetus develops in artificial conditions.

Triplet birth numbers are dropping—and that may be a good thing

Pregnancies involving three kids or more have dropped 62% from 1998 to 2023, a trend that the Centers for Disease Control and Prevention links to fewer embryo transfers during assisted reproduction procedures—a transition prompted by more refined techniques and technical advances. Though multiple births can occur naturally, often pregnancies involving multiple births have been the result of efforts to ensure pregnancy success by transferring multiple embryos.

US federal researchers are blocked from putting certain human cells in animals

In 2015, US policymakers put a halt to any government-funded work that would insert human stem cells into animals. The reasoning was that human cells might spread through the animal's body and perhaps to its brain, blurring the line between humans and nonhumans. The ban remains in place today even as gene-edited pig parts are being placed in humans.

The average number of IVF cycles before a viable pregnancy is 2.5

Health insurance often does not cover IVF treatment, and Medicaid coverage for fertility services differs by state. As a result, the cost of IVF is often unrealistic for low-income families.

Fertility treatments linked to increased risk of cancer among offspring

Recent research has explored potential links between increased childhood cancer occurrence, particularly leukemia, and assisted reproductive technology (ART). Though some studies have detected this type of association, researchers caution that it remains unclear if ART itself, fertility drugs, underlying infertility of the parents, or other unknown factors may explain any increased cancer numbers among ART-conceived children. Overall, the incidence of cancer in children, regardless of conception method, is very low.

About 70% of the Human Genome Project's reference genome came from one donor

Volunteers who donated blood to the Human Genome Project consented to using no more than 10% of their DNA, raising questions about the project's legality. Listen to how pressure from a private competitor may have driven officials to ignore ethical standards.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

A poll from May 2025 found that a majority of Americans oppose ending birthright citizenship

As legal challenges progressed, a May 2025 NPR/Ipsos poll showed fewer than one-third of Americans supported eliminating birthright citizenship, despite broader public backing for other immigration restrictions.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

An anthropologist analyzes the Japanese movement against having children

Broadly known as anti-natalism, the philosophical stance against having children stems from a variety of factors. In Japan, it arises amid low fertility rates, economic pressures, and ethical concerns. This essay explores the reasons some Japanese embrace the philosophy.

Imagining how genetics works in 'Harry Potter' and how muggle-born Hermione is a witch

Dr. Robert Pyatt, director of Sanford Health’s medical genetics lab, talks through real-world genetics scenarios in the Harry Potter series, from the Weasley's red hair and freckles to why Hermione, a witch, could be born to "muggle"—or nonmagical—parents.

Psychedelic therapy's ethical guidelines (or lack thereof)

With a checkered history of misconduct, how will psychedelic-assisted therapists be held accountable in the emerging legal field? This article explores the nascent field's need for ethical guidelines and clear protection of patient rights when therapeutic breakthroughs teeter "on the edge of consent."

The risks of bioremediation, from intermediate products to ecological disruption

A step in the series of complex biochemical reactions involved in the implemented bioremediation process may produce dangerous molecules—sometimes more toxic than the initial pollutants—that require ongoing monitoring to ensure optimal conditions for processing these intermediates toward the eventual, safe outputs. Introducing non-native nutrients or species, including GMOs, may alter existing food webs and gene pools.

Global xenotransplantation market may already be valued at more than $13B

With more than 100,000 people on the waiting list for organs at any given time in the United States, there's a known demand for organ transplants. Some estimates put the value of the global xenotransplantation market above $13B in recent years—and project the market to continue growing.

'Human composting' is an eco-friendly burial method legal in only a few states

Formally known as natural human organ reduction, this process relies on the same principles as standard composting and breaks down the body over many weeks, turning it into a type of soil. It's currently only legal in a handful of states.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

The tragic Pulitzer Prize-winning image 'The Vulture and the Little Girl' (1993) generated controversy, raised concerns about ethics in photography, and eventually led to the photographer's death.

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

The Brothers Grimm were lawyers before they were storytellers, but became interested in fairy tales as they began investigating how rules and customs had been passed down through cultures.

Up to a million Girl Scouts sell about 200 million cookie boxes every spring, generating $800 million, largely because refusing a child is frowned upon

The US Constitution is widely regarded as the longest-standing written national constitution still in force—see how it has influenced rights worldwide.

Watch the cumbersome, but necessary, precautions healthcare workers must take to care for and protect themselves while caring for Ebola patients.

Massive 3D printers have been used to build homes by stacking layers of 'concrete toothpaste,' a fire-resistant material that effectively insulates against outside noise.

Art theft is the third-largest source of criminal revenues worldwide, thanks in part to the subjective nature of valuing a work of art.

An initial public offering or 'IPO' is the process of a private company becoming public by putting shares of the company on the stock market for purchase.

An investigation suggests a Scottish island became awash in forever chemicals via seafoam and seaspray—raising questions about what that means for the safety of other coastal areas.

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See this overview of the firework rules across all 50 states, ranging from a complete ban on non-professional fireworks in Massachusetts to states with more lax rules like Indiana.

Prince's sexually explicit 1984 track 'Darling Nikki' attracted the ire of the Parents Music Resource Center, an advocacy group that inspired the Parental Advisory sticker, even though the song ends with a Christian message.

How fusion—which releases energy when two lighter atoms combine to form a heavier atom—differs from fission

The US first hosted the World Cup in 1994, a tournament that lives in soccer infamy for its poor planning and the murder of Colombian player Andres Escobar, who'd accidentally scored on his own net.

Explore fun facts from the USPS, including unique post office buildings, a stamp that traveled past Pluto, and more.