IVF is legal across America, but some worry that state bans could curtail this reproductive technology

How to consider the ethics of 3-parent IVF, which is illegal in the US

Ethical concerns with this controversial procedure include that a little bit of a child's offspring would be from a third person and that the decisions made with this pregnancy will affect numerous generations, making a permanent change to the gene pool.

A 2024 court ruling has had ripple effects for frozen embryos

The Alabama Supreme Court's 2024 ruling that embryos created through IVF are legally children has had a chilling effect on the fertility industry. A few centers for reproductive assistance paused egg fertilization, and others are questioning where the legal argument will lead. The decision has some surprising implications for the future of IVF technology, including techniques that haven't yet been invented.

IVF was long considered controversial and ethically dubious

In spite of its wide acceptance as a form of reproductive assistance today, and its role in helping millions of people have children, in vitro fertilization was once considered a controversial threat to society. One magazine went as far as to describe the procedure as "the biggest threat since the atom bomb."

Four frozen embryos in the US were created via 3-parent IVF technique

Columbia University researchers created four embryos using mitochondrial replacement therapy for four female patients who didn't want to pass on mitochondrial diseases to their children. Yet US law restricts the researchers from implanting the embryos so they remain frozen. (Some users may encounter a paywall.)

Scientific advances are unlocking a wide range of alternatives to IVF

From refined artificial insemination and microsurgical sperm extraction to experimental uterine transplants, scientific innovation is rapidly advancing potential fertilization technologies. But they come along with costly trials, some ethical dilemmas, regulatory issues, and more.

IVF procedures fertilize eggs outside the body in a laboratory dish

In vitro fertilization is a complex and expensive set of procedures that potential parents dealing with infertility or genetic disorders may turn to when other methods are unavailable. IVF births account for 2% to 3% of all live births in the US annually.

Australia legalized 3-parent IVF in 2022

It was the second country, after the UK, to legalize the procedure, which is still prohibited in the US. There are more than 300 rare mitochondrial diseases that can be passed from a mother to her offspring.

About 250,000 patients accessed assisted reproductive technologies in 2022

In 2022, 251,542 patients tried assisted reproductive technologies—most commonly IVF—resulting in more than 98,000 infants. Those children represent around 2.6% of the babies born in the US.

Selecting an embryo based on polygenic score is illegal in the UK, Israel, and swaths of Europe

Though their use for embryo selection is illegal in many locations, private clinics in the US may offer polygenic scores to inform embryo selection. The US Food and Drug Administration has not banned their use—instead the tests are regulated like supplements, meaning they are not regulated before they come to market but consumers can file complaints and then the agency may take action.

How two families navigated an unthinkable IVF mistake

The field offers hope to thousands of families annually, but it is also largely unregulated, and for a small number of parents, things can go terribly wrong.

The average number of IVF cycles before a viable pregnancy is 2.5

Health insurance often does not cover IVF treatment, and Medicaid coverage for fertility services differs by state. As a result, the cost of IVF is often unrealistic for low-income families.

The US FDA recently tried to regulate the expanded prenatal genetic tests

The agency proposed a new rule in 2023 to make it explicit that these types of tests are devices under existing law and clarify that that the agency could move to regulate them. They finalized a regulatory change in 2024 that added the words "including when the manufacturer of these products is a laboratory" to an existing law, but a federal district court vacated that edit in March 2025—returning the law to as it was before.

US federal researchers are blocked from putting certain human cells in animals

In 2015, US policymakers put a halt to any government-funded work that would insert human stem cells into animals. The reasoning was that human cells might spread through the animal's body and perhaps to its brain, blurring the line between humans and nonhumans. The ban remains in place today even as gene-edited pig parts are being placed in humans.

Privacy advocates warn menstrual cycle apps could put women at legal risk in certain states

Smartphone apps that women may use to track their menstrual cycle and identify times of peak ovulation are not covered by data privacy laws. Included data could potentially be used against women during prosecution in states with abortion restrictions.

France once had a reproduction czar to help midwives deliver babies

Much ado is made about falling marriage and birth rates worldwide, and how they might affect tax bases, retirement funds, and social standing. But this isn’t the first time marriage, and subsequently reproduction, have fallen out of favor. Some countries have resorted to drastic measures to restore the tarnished state of these hallowed institutions.

More than 40 states have passed versions of the Uniform Declaration of Death Act

The 1981 model law, now enacted in most states, is the legal basis for death in the US. There have been many efforts to amend this law, citing the need for more transparency to improve trust between families and the medical profession, though none have moved forward. Alterations to the law could have implications for organ donations and removing life support.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

You can draft a will designed to block AI resurrection—but the request may be ignored

Ars Technica spoke with legal experts about how—and if—people could design their wills to prevent AI resurrection. Though this is not yet a common request, one lawyer suggested that people worried about living on in an AI format can draft a power of attorney and a will that prevents those in charge of one's estate from submitting any texts, voice, image, writings, or other personal information to any AI tools.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Despite originating in America, happy hour isn’t allowed in every state

States including Vermont, Massachusetts, and Utah started banning the discount drinking practice after anti-drunk driving advocacy entered the mainstream. This article has more details about happy hour bans across the United States.

States are increasingly using preemption laws to override local decisions

Preemption laws enable state legislatures to prevent cities and counties from enacting their own rules on issues like minimum wage, gun control, and housing. Their use has increased significantly in recent years.

Trump's H-1B fee hike could reshape US industries and global talent flows

Analysts warn the new H-1B fee could trigger labor shortages in tech, medicine, and universities; push firms to offshore more work; and drive skilled Indian workers and students toward other countries—weakening America's innovation edge.

Ibogaine, a psychedelic substance, can be used to treat mental illness

Although the substance is banned in the US, it's legal in Mexico. Americans who have traveled there for treatment, including the NFL's Braden Smith, say the drug helps deal with conditions like obsessive-compulsive disorder.

This American Life explored Ohio's gerrymandering battle

In 2022, Ohio lawmakers repeatedly drew congressional districts that the state Supreme Court ruled unconstitutional. This defiance violated a voter-approved reform intended to prohibit partisan gerrymandering.

Browse a list of the most important scientific breakthroughs from each state

Although scientific discoveries involve experimentation, analysis, and collaborations among many individuals across a variety of locations, some observations, advancements, and breakthroughs have their origins in facilities within the US. These include the polio vaccine in Pennsylvania, the breathalyzer in Indiana, the observation of Pluto in Arizona, and the invention of nylon and Teflon in Delaware. (Some readers may experience a paywall.)

Interracial and same-sex marriages have both been illegal at certain times during US history

June 12 marks Loving Day, the date when interracial marriage was legalized in 1967. A brave Virginia couple fought back against anti-miscegenation laws, which were finally struck down by the Supreme Court. The Court also ruled for the protection of same-sex marriages in 2015.

Supporters of payday loans say banning them would harm low-income Americans

Many argue for a federal policy that would cap interest rates for these loans, but payday lenders say that would make it impossible for them to make money, effectively forcing them to close up shop. As a result, some argue that the policy would prevent low-income, unbanked, and traditionally high-risk borrowers from accessing credit when they need it. (Some users may experience a paywall.)

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

See this overview of the firework rules across all 50 states, ranging from a complete ban on non-professional fireworks in Massachusetts to states with more lax rules like Indiana.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

The US Constitution is widely regarded as the longest-standing written national constitution still in force—see how it has influenced rights worldwide.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

How fusion—which releases energy when two lighter atoms combine to form a heavier atom—differs from fission

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

Electrical grids worldwide must double their power delivery capacity by 2050 to meet surging demand from AI and electric vehicles.

44% of Americans say they pray at least once a day—discover how your state's religiosity stacks up against the rest of the country.

Cultural norms about how to handle the bodies of loved ones in communities in West Africa have hampered Ebola responses.

Venture capital is a form of funding provided to early-stage companies with high growth potential, typically in exchange for an equity (or ownership) stake

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

20,000 letters to the advice columnist 'Dear Abby' provide insight into prevailing sex, religion, and LGBTQ fears, anxieties, and concerns from the 1950s onward.

Jimmy Carter signed a 1978 bill that legalized home brewing, a move credited with kick-starting the craft beer industry.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

A vending machine run with Anthropic's AI went out of business after it was convinced to give away items for free and sell a video game console.

Calculate how much of your tax dollars go to each federal program based on your income, filing status, and number of children

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

The distributor behind 'Rocky Horror' pulled the film from its scheduled national release, believing it would be a failure, though it eventually amassed a dedicated fanbase through midnight showings, a trend that continues over 50 years later.