IVF procedures fertilize eggs outside the body in a laboratory dish

A step-by-step overview of the IVF process

In-vitro fertilization involves a sequence of complex steps to move from egg production to birth. This include stimulating egg production in the ovaries, egg harvesting and fertilization outside the body, embryo culturing and transfer, and methods to support in and increase the likelihood of full-term pregnancy.

IVF was long considered controversial and ethically dubious

In spite of its wide acceptance as a form of reproductive assistance today, and its role in helping millions of people have children, in vitro fertilization was once considered a controversial threat to society. One magazine went as far as to describe the procedure as "the biggest threat since the atom bomb."

Follow an IVF procedure from lab to transplant

What happens once eggs are harvested from an ovary? How does an embryo form within a petri dish? This detailed video offers a glimpse of the transformations eggs experience as women age, and how sperm are injected into eggs in some forms of IVF treatment.

Calculate your chance of success for IVF treatments

The efficacy of in vitro fertilization procedures varies widely based on age, health history, genetics, and more. This CDC calculator provides an estimate of success rates based on your personal information, relying on thousands of reported outcomes across the US.

Scientific advances are unlocking a wide range of alternatives to IVF

From refined artificial insemination and microsurgical sperm extraction to experimental uterine transplants, scientific innovation is rapidly advancing potential fertilization technologies. But they come along with costly trials, some ethical dilemmas, regulatory issues, and more.

IVF is legal across America, but some worry that state bans could curtail this reproductive technology

This reproductive technology is available across the US, but if states take action to prohibit the discarding of unused embryos or pass related legislation, it could affect access to IVF. Laws prohibiting IVF or effectively outlawing the procedure by defining personhood as being conferred at the moment of conception have been under discussion in several states in recent years, including Ohio, Virginia, and Texas.

In vitro gametogenesis: using induced stem cells to fertilize eggs

Using stem cells from skin and mouth cells could save hopeful parents time and money and spare egg donors from significant amounts of discomfort throughout the process. There are potential consequences, not just for infertility treatment, but for the ability to create customized cells of any type.

The average number of IVF cycles before a viable pregnancy is 2.5

Health insurance often does not cover IVF treatment, and Medicaid coverage for fertility services differs by state. As a result, the cost of IVF is often unrealistic for low-income families.

The first successful IVF pregnancy was in the United Kingdom in 1978

Gynecologist Patrick Steptoe and his collaborator Robert Edwards, a biologist, attempted to fertilize a human egg cell in a petri dish 101 times before finally succeeding. This resulted in the birth of Louise Brown—at the time referred to as a "test tube" baby—in 1978, who was born into the spotlight.

About 250,000 patients accessed assisted reproductive technologies in 2022

In 2022, 251,542 patients tried assisted reproductive technologies—most commonly IVF—resulting in more than 98,000 infants. Those children represent around 2.6% of the babies born in the US.

Research studies can be conducted inside or outside of living samples

While "in vitro" experiments occur outside living organisms for cost-effectiveness, "in vivo" experiments take place inside them, providing real-life insights at a higher cost and with increased ethical concerns. Alternatively, "in silico" methods use computational simulations.

Australia legalized 3-parent IVF in 2022

It was the second country, after the UK, to legalize the procedure, which is still prohibited in the US. There are more than 300 rare mitochondrial diseases that can be passed from a mother to her offspring.

How two families navigated an unthinkable IVF mistake

The field offers hope to thousands of families annually, but it is also largely unregulated, and for a small number of parents, things can go terribly wrong.

Find fertility clinics and their success rates in your state

This database from the Centers for Disease Control and Prevention provides a searchable portal of fertility clinics across the US, with reported data on services, total procedures performed, and live births recorded for as recently as 2022.

Only about 0.0001% of sperm, on average, successfully reach the uterine cavity

We've evolved to make pregnancy a complex and difficult process. From the initial development of the blastocyst, to the energy and nutrients needed to grow a new human, our bodies are both fighting and supporting fetal development.

Without 3-parent IVF, women carrying faulty mitochondrial DNA have few options for children

Women who are carriers of mitochondrial diseases that wish to have children without those conditions cannot be biological parents without three-parent IVF. The alternatives are to adopt or have a child via egg donation.

Read about coral reef restoration efforts, from coral IVF and cryopreservation

Researchers have collected coral eggs and sperm from healthy reefs, grown baby corals in lab pools, and released them to help repopulate damaged or lost reefs. Devices such as Coralclip® help attach these corals to existing structures, promoting growth without the use of chemical bonding agents. Corals near extinction can be frozen using liquid nitrogen for future restoration efforts.

Infertility is often not discussed, forcing women and families to grieve privately

Watch this podcast discussion from Weill Cornell Medicine about the emotional journey of infertility for couples and individuals and hear advice about how to navigate the feelings of loss of control, grief, anger, and despair, including suggested tips for supporting individuals struggling with infertility.

Testosterone therapy can cause infertility, and has been explored as a contraceptive

Augmenting testosterone with testosterone hormone therapy suppresses sperm production, and the resulting infertility is permanent in some men. Though a high level of testosterone inside the testicles is essential for fertility, testosterone supplements suppress the production of the pituitary hormones that leads to that natural testosterone production in the testicles—causing infertility.

Most flu vaccines are still produced using chicken eggs

For decades, influenza vaccines have been made by growing viruses inside fertilized chicken eggs. Though newer methods using cell cultures or recombinant technology exist, egg-based production remains the primary global manufacturing process.

How freeze-drying leaves food with less than 4% of its original water content

In specialized equipment, foods are brought down to temperatures below freezing before a vacuum pump removes the air from the container, lowering the pressure around the food and the boiling temperature of water. Heaters beneath the food slowly raise its temperature above the now-reduced boiling point, causing the water to go from a frozen to a gaseous state.

The human body in 3D

Zygote Body is a free human anatomy tool that allows users to explore the intricacies of the human body in stunning detail. With the click of a mouse, users can isolate by body system or view anatomical structures from any angle. Check out this...

A visual database of pollens

Pollen is a powdery substance made up of small grains involved in the fertilization process of plants. There are thousands of types of pollens across the world, and you can see real images of them in this visual database.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Watch a tour of a battery manufacturing gigafactory

Inside Contemporary Amperex Technology Limited's facility, China's largest EV battery manufacturer uses slurry mixing, "jelly rolling," electrolyte injection, and other techniques and equipment to transform raw metals such as lithium and magnesium into approximately 2.2 million electrochemical cells daily.

Explore inside a mosquito factory where millions of mosquitoes are bred weekly

In Medellin, Colombia, scientists are infecting Aedes aegypti mosquitoes with Wolbachia, a bacterium that wouldn't otherwise infect the species, but does block its ability to transmit dengue, Zika, yellow fever, and chikungunya. In the wild, infected mosquitoes would breed with wild mosquitoes, pass down Wolbachia, and thus reduce disease transmission.

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

How fusion—which releases energy when two lighter atoms combine to form a heavier atom—differs from fission

An initial public offering or 'IPO' is the process of a private company becoming public by putting shares of the company on the stock market for purchase.

While the first exchange-traded fund (a 'basket' of different assets that can be bought and sold on a stock exchange) in the US only launched in 1993, the global ETF market has grown to more than $10T in the short time since.

Explore what it's like inside a patient isolation unit, used in situations such as treating a patient or suspected patient with Ebola.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

Coral polyps reproduce via broadcast spawning, where entire reefs simultaneously release reproductive cells for about one hour, once a year.

Objects can be 3D printed with light by projecting 2D computerized tomography (CT) scans onto rotating cylinders of resin, which solidify upon exposure.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

Planeterrellas create artificial auroras that mimic the atmospheric displays of light by setting up an electric field between two metal balls in a jar filled with a small amount of air.

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

The 1987 Nintendo video game 'Stadium Events' isn't known for being particularly fun, but its scarcity has made it a highly sought-after item that has sold for up to $35K at auction.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.

Children are now three times more likely to say they want to be a YouTuber when they grow up than an astronaut, with some even attending 'YouTube camps' that teach kids how to create content for the platform.

Use this tool to calculate the dollar value of your parental mental load, from meal planning to coordinating after-school care, then see resources that help generate solutions.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

Explore the archaeological treasures of Pompeii, the city buried under volcanic ash when Mount Vesuvius erupted in 79 CE.

In 1945, Surrealist artist Salvador Dalí and legendary animator Walt Disney began collaborating on a short film that was not completed until 2003, years after both men had died.

The Russia-Ukraine conflict is the largest ground war in Europe since World War II in terms of casualties, forces mobilized, and displacement of civilians.

In 2026, Finland was named the world's happiest country for the ninth consecutive year based on its wealth, social safety network, and high life expectancy, among other factors.