About 70% of the Human Genome Project's reference genome came from one donor

The Human Genome Project was forced to accelerate due to a private competitor

Despite a 15-year target when it began in 1990, the Human Genome Project faced competition from Celera Genomics when it entered the sequencing race in 1998. Celera's aim to complete the human genome in three years pressured the HGP to complete their sequencing several years ahead of schedule.

Explore the original goals of the Human Genome Project

The project goals emphasized DNA sequencing technologies and methods, which would lead to future treatments of genetic disorders. Exploring the project data's ethical and social implications was also considered.

An overview of the Human Genome Project

The Human Genome Project was a groundbreaking global scientific effort to sequence the genome of humans and several organisms used in scientific research. The sequenced genome was created by combining the DNA of 20 people from Buffalo, New York.

The $3B project scientists called 'junk'

In 1990, scientists set out to map all of human DNA. A $3B bet many called "junk." But the Human Genome Project's radical transparency and a race with a private company sped it to completion in just 13 years. Today, that once-contested map underpins nearly every breakthrough in genetics and personalized medicine.

All humans share 99.9% of the same DNA

Of the 3 billion base pairs that make up the human genome—the complete set of genetic material for the species—the diversity of humans is the result of variations in about 3 million molecular bases. The closest nonhuman genetic match is the chimp, with 98.8% similar genetics.

A student researcher working on the Human Genome Project shares their perspective

In a conversation with Ewan Birney, Director of the European Bio-informatics Institute, he discusses what it was like to be a PhD student working on the Human Genome Project in the months before the draft announcement and its impact on him and the field of genetics.

Only 2% of human DNA codes for proteins

The entire human genome contains about 20,000 protein-coding genes, with the rest having initially been categorized as "junk" DNA. However, research since 2003 suggests that this "dark genome" regulates how protein-coding genes are expressed in response to environmental factors encountered by cells.

The lack of diversity in DNA databases limits their applications

European ancestry dominates genetic research, hindering the usage of genetic databases for precision medicine for other groups, including African Americans, who face higher health risks due to genetic variants. Many Indigenous communities have also resisted genetic research due to past exploitation. (Some readers may experience a paywall.)

In 2025, researchers in the UK began working on developing artificial DNA

The Synthetic Human Genome Project aims to one day construct human DNA, molecule by molecule, in the hopes of creating disease-resistant cells and synthetic chromosomes for study. However, critics warn it may be misused to create enhanced or modified humans.

How uploading your consumer genetic testing could lead to a distant relative's arrest

This podcast includes a discussion about how law enforcement can compare DNA samples from a crime scene against voluntarily uploaded DNA on consumer genealogy databases to close cases. Investigators can and have cross-referenced a suspect's crime scene DNA with that of a suspect's relatives who happened to have chosen to upload their genetic information to an open-source genealogy database.

Gene therapy, a hope of the Human Genome Project, saves a baby's life

A baby with a rare genetic disorder received a bespoke gene-editing treatment using CRISPR technology. The case highlights the potential of personalized medicine for rare diseases, building on the foundation set by the Human Genome Project.

Here’s how different genetic disorders get passed on

The human genome is complex, as identified by the Human Genome Project. This article digs in to genetic disorders, the most common ones, and how they are diagnosed.

All publicly available DNA sequences are available at GenBank

The National Institutes of Health's database stores comprehensive, annotated DNA sequences as part of the International Nucleotide Sequence Database Collaboration. It encourages unrestricted data access within the scientific community while allowing submitters to retain intellectual property rights over their data.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

How to consider the ethics of 3-parent IVF, which is illegal in the US

Ethical concerns with this controversial procedure include that a little bit of a child's offspring would be from a third person and that the decisions made with this pregnancy will affect numerous generations, making a permanent change to the gene pool.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Why don't we synthesize blood?

We're trying. Scientists are currently working on creating viable synthetic blood, an alternative to the presently relied-upon donations that manage to fall short of demand. More than half of the world's nations struggle to meet their population's need for blood. This article details current and historical efforts to develop synthetic blood, a venture that started more than 400 years ago.

Six of history's most unethical human experiments, from deliberate flu exposure to withholding syphilis treatment

Some of the progress made in mental health treatment, vaccines, blood transfusions, and more came about before the advent of consent and ethics committees, resulting in serious physical and psychological harm that participants in studies were not even anticipating.

Scientists may have discovered why gene-edited pig kidneys are rejected in humans

In November 2025, researchers studying how a brain-dead donor’s body responded to the transplantation of a genetically engineered pig kidney, published that they’ve identified immune system reactions that may explain why these pig organs get rejected. What’s more, they were able to reverse the rejections with an already available drug combination and the kidney functioned well. They also pinpointed a way to detect a potential rejection up to five days sooner.

Scientists can suck animal DNA from the air

A look at how researchers filtered the air around two zoos and identified genetic material from dozens of species, a technique that could help track and conserve wildlife.

Only allowing three recipients causes the Nobel Prize to overlook team discoveries

While science has grown more inclusive and collaborative, the Nobel Prize system still struggles with outdated practices, such as secrecy and a rigid limit on awardees. This restriction sidelines many deserving scientists, especially in complex projects like the human genome or gravitational waves.

In 2023, at least 6 people were charged with stealing body parts

A recent case involving alleged trafficking in stolen human body parts charged that there was a nationwide network of individuals who bought and sold human remains. The charges alleged, among other things, that from 2018 through 2022, the manager of the morgue at Harvard Medical School's Anatomical Gifts Program stole organs and other parts of cadavers that had been donated for medical research and education. In late 2025, that Harvard morgue manager was sentenced to 96 months in prison.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

The average cell's DNA is damaged thousands of times daily

In the case of radiation-induced distortions in a DNA strand, specialized proteins can cut out entire segments and rebuild them using the second strand as a complementary template. If both DNA strands are completely severed, proteins interlace undamaged DNA with the severed DNA and rebuild both using complementary base pairing.

Trials ongoing for a 99% accurate, AI-powered blood test

The UK's National Health Service has launched a trial for a blood test that can detect a dozen types of cancers with just ten drops of blood. An AI tool looks for genetic material known to be released by tumors, allowing for cancer detection before tumors are large enough to be imaged.

The ABCs and FAQs on GMOs from the WHO.

GMOs (or genetically modified organisms) are a subject of great debate in the food world…but how come? GMOs are organisms whose genetic materials have been altered in a way that does not occur naturally in order to create a product that has a...

You can sign up to donate your organs at this website

A single person who chooses to donate their organs upon death can provide organs for as many as eight people. You can sign up to become an organ donor or update your donation status information at this website, or you can typically sign up at your state's Department of Motor Vehicles. Many states allow individuals to declare which tissues and organs you consent to donate (i.e. organs, eyes, and skin tissue). It's recommended to discuss your decision with your family so they are aware of your wishes.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Human-to-human transmission of hantavirus remains extremely rare, so the 2026 hantavirus cruise ship outbreak doesn't mean we're facing a COVID-style pandemic risk.

Up to a million Girl Scouts sell about 200 million cookie boxes every spring, generating $800 million, largely because refusing a child is frowned upon

US housing costs have risen by roughly 175% between 1991 and 2026—but a growing number of Gen Zers are becoming homeowners anyway. In 2025, 4% of homebuyers were Gen Z, up from 3% the year before.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Hear 50 years of iconic hip-hop samples, the genre's foundational looped tracks

Art theft is the third-largest source of criminal revenues worldwide, thanks in part to the subjective nature of valuing a work of art.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

When you complete a CAPTCHA on a website to prove you are human, you may be unknowingly training algorithms for self-driving cars, whose systems require training data to help identify crosswalks, bicycles, and other outdoor objects.

See 33 images that became central to huge scandals, including a young Charles and Camilla, Michael Jackson's baby on a hotel balcony, and Hugh Grant's mugshot.

Prince's sexually explicit 1984 track 'Darling Nikki' attracted the ire of the Parents Music Resource Center, an advocacy group that inspired the Parental Advisory sticker, even though the song ends with a Christian message.

Despite being favored by 87% of Americans, Congress does not have term limits.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

Domino's Pizza's 30-minute delivery guarantee was responsible for the chain's 1980s surge, but it was discontinued after the company was found liable for delivery driver accidents.

Double world record holder Hunter Ewen helped conquer his fear of balloons, called globophobia, by training to win Guinness World Record titles for balloon inflation.

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

Netflix profits when you're not watching, and its movies are designed that way—read a detail-rich critical essay exposing lesser-known Netflix takes

Venture capital is a form of funding provided to early-stage companies with high growth potential, typically in exchange for an equity (or ownership) stake

Brandi Chastain, the star of the 1999 US victory over China in the 1999 Women's World Cup, was a last-second choice to take the penalty kick that sealed the victory.

The price of gas is a composite made up of several different factors, with the federal gas tax making up less than 20% of what drivers pay at the pump.