There is no cure for the general condition of arthritis

Arthritis is an umbrella term for various conditions that cause joint pain

Arthritis isn’t one single disease, but rather a range of conditions that all lead back to the same outcome—joint pain. This American Academy of Orthopaedic Surgeons primer is a go-to resource for understanding what arthritis is, the most common types, and various treatment options depending on the underlying cause.

Five advancements in arthritis research

It is estimated that nearly 350 million people worldwide are currently suffering from arthritis. This resource explores five of the most promising recent advancements in arthritis research as scientists work towards improved treatments and continue the search for a cure.

Arthritis explained, with Dr. Nick Golinvaux

Arthritis, a condition affecting millions globally, is more than just joint pain—it’s a breakdown of cartilage that cushions bones, leading to stiffness, swelling, and discomfort. While often associated with aging, arthritis can affect people of all ages, especially after injuries. Though there’s no cure yet, treatments range from medication and physical therapy to surgical interventions like joint replacements.

Limb regeneration research may lead to treatments for arthritis

For scientists pursuing the cure for arthritis, the holy grail of discoveries lies in how to regrow healthy cartilage inside human joints. While this feat has so far resisted our best scientific attempts, there are plenty of other human tissues—such as the liver and fingertips—that will successfully regenerate.

Visualizing a joint under attack from rheumatoid arthritis

A particularly difficult arthritis subtype is rheumatoid arthritis, a painful condition provoking a vicious cycle of joint inflammation, destruction, and dysfunction. It begins with a misfiring of the patient’s own immune system—for unknown reasons, it identifies joint and cartilage cells as foreign, initiating an attack to eliminate the supposed "invaders."

Diagnosis and treatment of hip and knee osteoarthritis

Osteoarthritis is the most common type of arthritis, resulting from age-related degeneration of the soft cartilage lining between bones. As this layer breaks down, the normal smooth motion between bones is lost and the joint becomes painful.

Kangaroos evolved exceptionally thick knee cartilage to absorb shock

There is significant conflict in the medical field regarding chronic arthritis. Some advocate for keeping the joint as active as possible while others argue progressive overuse leads to worsening arthritis. To settle the score, scientists have looked outside the human population, discovering kangaroos rarely suffer from arthritis in their knees.

There's no definitive test for inflammation, or a baseline for what's considered normal

Existing tests can pick up proteins that indicate an immune response—in particular C-reactive protein, which the liver produces when the body's stressed—but that won't tell you why there's inflammation nor if it's chronic or acute inflammation. (Some users may experience a paywall.)

There's no cure for tinnitus, but sometimes it goes away on its own

Though there's no cure, treatments and management approaches can significantly reduce symptoms and improve quality of life. Hearing aids, sound generators, and other steps can help some people with this condition. But sometimes tinnitus resolves within hours or days for reasons that remain unclear.

Addressing lifestyle factors, which influence inflammation, can cure some chronic diseases

In this video, a physician claims that he reversed a patient's Type 2 diabetes in six weeks by addressing inflammation drivers such as diet. More broadly, he argues that society needs to better consider and address numerous disease factors that are modulated by inflammation, such as stress, sleep, diet, and movement.

Scleroderma, which causes skin to harden and scar, has no FDA-approved treatment

It's an autoimmune disease that disproportionately causes worse complications in African American people for unknown reasons. It causes the body to overproduce collagen after the immune system attacks the body's own connective tissue, leading to excess collagen deposits and restricted blood circulation as small blood vessels are damaged. It can damage various organs, including the lungs.

There are hundreds of subtypes of cancer, making a universal cure nearly impossible

Cancer is an umbrella term for over 200 different diseases, each with its own subtypes, genetic mutations, and behaviors. This diversity means that a treatment effective for one cancer type or patient may be ineffective for others. Moreover, as tumors grow, their cells accumulate different mutations, creating subclones with unique characteristics.

The disease no one survives (yet)

Creutzfeldt-Jakob disease is currently incurable and can cause one's death within months of symptoms appearing. It involves misfolded proteins that, for some reason yet unknown to science, aren't cleared by the brain as typical and instead trigger similar proteins to misfold. These malformed major prion proteins—prion being a portmanteau of protein and infection—clump inside nerve cells, blocking signals crucial to processes ranging from speaking to organ function.

Chronic lyme isn't a medically recognized diagnosis in conventional medicine

It describes a constellation of symptoms attributed to a persistent Lyme infection—meaning the bacteria have remained present even after antibiotics. It often occurs among people who have never received a positive test for Lyme. Doctors do recognize "post-treatment Lyme disease syndrome," however, which can include muscle and joint pain, fatigue, and cognitive difficulties after treatment for confirmed Lyme.

Unlike physical therapy, chiropractic lacks substantive, evidence-based support

Originating as a practice focused on removing blockages in the spine that impede the flow of mystical energy in the body, chiropractic has claimed to resolve many ailments, even those unrelated to the spine or skeletal system. However, no scientific studies have identified such blockages, and there are insufficient clinical trials supporting these treatments.

Schizophrenia is challenging to diagnose and treat

The disorder is diagnosed by a clinician who observes behaviors and medical history and may run additional tests to rule out other explanations for symptoms including physical injury or other mental health disorders. But, ultimately, it's largely a diagnosis of exclusion—since there is no definitive test for the disease. Antipsychotic medications can help control its symptoms for some patients, but there is no cure for schizophrenia.

Aspirin was the first synthesized anti-inflammatory drug

Once used by the ancient Sumarians—extracted from willow bark—but now synthesized in the lab, the active ingredient of this popular medication has been used to treat headaches and pain for thousands of years.

Why we don't have an answer for the common cold

Since a landmark study of the common cold in 1925, researchers have learned much more about the seasonal ailment. Despite continuous study, people still contract colds for similar periods of time at the same rate with the same symptoms, and there's no vaccine. This article explains how the many viral strains make it hard to control.

Continual sitting harms your health in a variety of ways

Prolonged inactivity, like sitting for long periods, slows metabolism, weakens muscles and bones, and impairs insulin function. When these negative changes persist over time, the cumulative result is an increased risk of cardiovascular disease, diabetes, and many cancers.

What is the most painful thing in the world?

Pain is famously difficult to quantify, and though our response to it may be subjective, most pain does have underlying objective causes. So what's the most painful thing of all? Many say childbirth, or a broken femur, but this article lays out one case for why, of all things, kidney stones may be the most painful experience. Prepare yourself to find out here.

Dementia describes progressive memory issues that impact daily activities

Although Alzheimer's disease is sometimes thought of synonymously with dementia, there are multiple types of dementia, which manifest in memory loss and other symptoms that make it challenging to perform daily tasks. These types include Lewy Body dementia, vascular dementia, and frontotemporal dementia. Parkinson's disease is not a form of dementia, but this movement disorder can sometimes develop into issues with memory and a formal diagnosis of dementia.

Overuse of opioids can lead to hypersensitivity to pain

Opioid misuse can lead opioid-induced hyperalgesia, where the body becomes increasingly sensitive to pain. The body produces its own opioids as a way to temporarily block pain signals. When met with external opioid use, the body ratchets up pain sensitivity to ensure it senses the pain necessary to trigger its own response.

Urushiol, the oily toxin in poison ivy, can remain allergenic on clothing for years

The substance can still cause rashes even after being on shoelaces, clothing, sleeping bags, boots, or other clothing for multiple years—some reports say five years on surfaces—so they all need to be washed after outdoor adventures with the plants.

Brain conditions and surgery can cause some individuals to feel no fear

Fear is a survival mechanism that originates in the brain's amygdala, triggering the body's fight-or-flight response. However, in modern society, without the same natural dangers, fear can lead to anxiety and mental health issues when unnecessarily triggered. Understanding individuals without fear may help identify new methods to treat anxiety disorders.

A licensed therapist shares advice for kindly addressing feelings of irritation in your relationship

All couples are bound to annoy each other, and it's often not caused by ill will. Reflecting on how and when to express pet peeves is important for ultimately building a connection and helping partners not feel attacked. While differences may not always be fully resolved, it can be helpful to discuss paths forward toward a compromise.

Poison ivy can cause rashes year-round since all parts of the plant contain urushiol, the oil that triggers our allergic response.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

Corals are themselves not coral reefs—the term refers to the tiny marine invertebrates that build the rigid reef.

Despite being favored by 87% of Americans, Congress does not have term limits.

See images of medical cases of firework injuries shared on this 'Instagram for doctors.' (Warning: Graphic content)

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

20,000 letters to the advice columnist 'Dear Abby' provide insight into prevailing sex, religion, and LGBTQ fears, anxieties, and concerns from the 1950s onward.

American dance legend Martha Graham, sometimes called 'the Picasso of dance,' refused to perform at the 1936 Olympics in Berlin and conceived the piece 'Chronicle' in response to the experience.

The price of gas is a composite made up of several different factors, with the federal gas tax making up less than 20% of what drivers pay at the pump.

Scientists can determine Earth's past climate conditions by analyzing air trapped in microscopic bubbles within ice cores—columns of compressed snow layers that build up over hundreds of thousands of years.

The word 'jazz' evolved from 'jasm,' 19th-century American slang for 'energy'

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

While the sun's gravity keeps the planets in orbit, their gravity also pulls on the sun, causing it and everything else in the solar system to orbit around a mutual balance point called the barycenter—the true center of the solar system.

Some renewable energy sources may weaken the resiliency of electric grids by removing outage buffers provided by coal- and natural gas-fired plants, which provide the system with more time to find a new power source if a plant goes down.

See how Budweiser's famous Clydesdales spend their days at Warm Springs Ranch, where roughly 70 to 80 of the beer brand's giant horses can be found at any given time.

'Grand Canyon of the Yellowstone,' a work by American painter Thomas Moran, inspired Congress to establish Yellowstone National Park.

Venture capital is a form of funding provided to early-stage companies with high growth potential, typically in exchange for an equity (or ownership) stake

Legendary architect Frank Lloyd Wright designed the SC Johnson headquarters in Wisconsin, aiming to make a cathedral-like workplace