Visualizing a joint under attack from rheumatoid arthritis

Rheumatoid arthritis occurs when the immune system attacks cells within joints

Rheumatoid arthritis is a specific type of arthritis that occurs when the body's immune system attacks normal cells within the connective tissues of the joint and degrades them. This sets off a painful cycle of inflammation and joint destruction that often requires lifelong medication to control.

Rheumatoid arthritis affects about 1% of the population

Rheumatoid arthritis is an autoimmune condition leading to breakdown and inflammation of multiple joints throughout the body. This academic article provides an updated deep dive into our current cellular understanding of rheumatoid arthritis, how it is diagnosed, and the variety of medications available for treating this painful condition.

Real surgical footage reveals what arthritis looks like up close

Arthritis is a painful condition of human joints that often results from the loss or breakdown of the soft cartilage padding that naturally exists between bones. This video shows footage from an actual knee surgery that beautifully demonstrates the difference between normal cartilage and the degenerative cartilage seen in osteoarthritis.

Anatomy of a healthy knee joint

To understand arthritis, study a normal joint. Where two bones come together, each is lined by a cartilage cap. These bones are linked together by strong ligaments. The inner juncture is lined by a joint capsule (synovial membrane) containing lubricating joint fluid between the two surfaces, allowing for near-frictionless motion.

Arthritis explained, with Dr. Nick Golinvaux

Arthritis, a condition affecting millions globally, is more than just joint pain—it’s a breakdown of cartilage that cushions bones, leading to stiffness, swelling, and discomfort. While often associated with aging, arthritis can affect people of all ages, especially after injuries. Though there’s no cure yet, treatments range from medication and physical therapy to surgical interventions like joint replacements.

Arthritis affects almost 60 million Americans

Arthritis refers to a range of conditions resulting in joint pain that currently affects nearly 60 million people in the United States alone. This resource from the Centers for Disease Control and Prevention explores the basics of arthritis and provides resources for understanding its near-universal impact on our population.

Research links the gut microbiome and rheumatoid arthritis

Arthritis is a potentially disabling joint condition that currently affects nearly one in five adults across the globe. Doctors still don't know what causes rheumatoid arthritis, but the answer may be partly determined by chemicals produced by bacteria in the gut.

Kangaroos evolved exceptionally thick knee cartilage to absorb shock

There is significant conflict in the medical field regarding chronic arthritis. Some advocate for keeping the joint as active as possible while others argue progressive overuse leads to worsening arthritis. To settle the score, scientists have looked outside the human population, discovering kangaroos rarely suffer from arthritis in their knees.

There is no cure for the general condition of arthritis

While there are innumerable conditions ultimately leading to the joint pain we collectively term "arthritis," one common pathway is progressive inflammation and joint damage many years after an injury.

Limb regeneration research may lead to treatments for arthritis

For scientists pursuing the cure for arthritis, the holy grail of discoveries lies in how to regrow healthy cartilage inside human joints. While this feat has so far resisted our best scientific attempts, there are plenty of other human tissues—such as the liver and fingertips—that will successfully regenerate.

The collapse of gas bubbles in the joint synovial fluid causes 'cracking' knuckles

The human population can be divided into two categories: those who crack their knuckles and those who don't. Do you know the technical term for this phenomenon is "tribonucleation?" What actually happens inside a knuckle when it pops? This visual explainer breaks down finger joint popping in real time.

An interactive dive into the immune system

Our bodies are equipped with an incredible system able to fight off invasive pathogens to protect us from illness. The complicated system includes lymph nodes, the spleen, bone marrow, and even the tonsils. But this same system can turn against itself, a condition known as autoimmune disorders. Follow along with this thorough, engaging explainer on the human body's defense system.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Visualize the difference between a healthy brain and one with Alzheimer's

The brain has three main parts—the cerebrum, brain stem, and cerebellum—each combining to control the entirety of the body's operations. Alzheimer's progressively deteriorates the circuitry in these structures, resulting in what we see as the symptoms of the disease.

A man with organ failure used AI to speed discovery of his miracle drug

David Fajgenbaum had a few months to live after a diagnosis with a rare form of Castleman's disease. By studying his blood, medical records, and broader literature, he was able to identify the cause of his condition and a treatment. He's been in total relapse for ten years.

Multiple sclerosis means 'many scars'

That's a reference to the scarring or lesions that occur in the brain, spinal cord, and elsewhere whenever the immune system has a flare-up. The immune system attacks the myelin because it incorrectly responds as if it's a threat, damaging the body's ability to transmit electrical signals effectively from areas of the body to the brain.

Visualize how CRISPR works at the molecular level

CRISPR is a revolutionary gene-editing technology already making a real-world impact in helping to treat several diseases and conditions. This simulation provides a microscopic view to help easily visualize the complex science.

There's no definitive test for inflammation, or a baseline for what's considered normal

Existing tests can pick up proteins that indicate an immune response—in particular C-reactive protein, which the liver produces when the body's stressed—but that won't tell you why there's inflammation nor if it's chronic or acute inflammation. (Some users may experience a paywall.)

Visualizing a synaesthetic soundscape

Artist Michal Levy has chromesthesia, a subtype of synesthesia in which sounds and music trigger involuntary associations with and sensations of color. This condition gives Levy a unique artistic perspective and ability to interact with and interpret music. In this short animation, Levy tries to capture her audiovisual experience of 'Giant Steps," considered a landmark composition in jazz history by musician John Coltrane.

Visualizing cyberattacks by country

Cyber crime is expected to cost the global economy trillions per year by 2025. This data illustration showcases the countries with the most severe cyber attacks from 2006-2020.

See images of medical cases of firework injuries shared on this 'Instagram for doctors.' (Warning: Graphic content)

Wet macular degeneration affects 10%-15% of those with macular degeneration

This form of molecular degeneration refers to when excess blood vessels form in the back of the eye and damage the macula. If someone with this condition looks at straight lines, they will typically appear wavy or crooked.

See images of medical cases of firework injuries shared on this 'Instagram for doctors'

Included photos include scans of missing or damaged digits, a chunk of missing flesh, a facial injury from a homemade firework in a glass bottle that exploded in the patient's hand before it was thrown, and an injury where a patient's finger bone flew into someone's leg.

A visualization of mycoremediation, where fungi extract toxic and radioactive pollutants from soil

As organisms such as mushrooms grow, they develop large networks of root-like structures called mycelium that spread underground and release enzymes that break down contaminants. By absorbing these chemicals, fungi limit the damage caused by these toxins and localize them within the organism for easier collection and disposal.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Explore this interactive visualization of the IVF journey as a parent or child

This step-by-step graphic takes the viewer through different challenges and stages of the IVF journey, from a parent's and a child's perspective, including a parent's struggle when other families become pregnant around them, even as IVF is not working for their family.

Erythema migrans rash is common in Lyme—but it often doesn't look like a bull's-eye

The US Centers for Disease Control and Prevention states that this rash occurs in roughly 70% or more of Lyme disease patients, and typically occurs at the site of a tick bite. The rash may expand slowly over several days and feel warm to the touch, but it's rarely itchy or painful. As it grows, areas of it may clear—creating a target or "bull's-eye" appearance.

Fear or disgust related to clusters of holes and cracks, called trypophobia, may stem from evolutionary processes to help us avoid pathogens.

Poison ivy's characteristic rash is caused by an allergic response to an oily compound in the plant called urushiol.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Particle accelerators have been used to reveal detailed ant anatomy

Using a synchrotron facility at the Karlsruhe Institute of Technology in Germany, a pair of X-ray beams swept across about 2,200 ant specimens to create over 200 terabytes of projection images from multiple angles. The images were compiled into micrometer-resolution 3D reconstructions of 792 species, which are freely accessible on the Antscan platform.

Tattoos remain visible on your skin thanks to immune cells called macrophages

Watch how viruses like Ebola can spill over from animals to humans—and vice-versa.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Explore the animals that populate the depths of the ocean, from fish and coral in the first few hundred feet, all the way down to the bottom of the Mariana Trench.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

Explore chaos in this simulation of two double pendulums, where small differences in the release angles produce wildly different outcomes.

Explore an interactive map of battles from the American Revolution, along with detailed summaries of each engagement

Legendary architect Frank Lloyd Wright designed the SC Johnson headquarters in Wisconsin, aiming to make a cathedral-like workplace

Objects can be 3D printed with light by projecting 2D computerized tomography (CT) scans onto rotating cylinders of resin, which solidify upon exposure.

All rainbows are 'raincircles' caused by water droplets separating white sunlight into a spectrum of colors, but Earth's surface blocks the bottom half of the circle from our line of sight.

American dance legend Martha Graham, sometimes called 'the Picasso of dance,' refused to perform at the 1936 Olympics in Berlin and conceived the piece 'Chronicle' in response to the experience.

The word 'jazz' evolved from 'jasm,' 19th-century American slang for 'energy'

Iran's Revolutionary Guard Corps is independent of Iran's regular army and is one of the most powerful and influential military-political organizations in the Middle East.

Art theft is the third-largest source of criminal revenues worldwide, thanks in part to the subjective nature of valuing a work of art.

Search a massive database of over 4 decades of clues from the TV quiz show 'Jeopardy!'

'Grand Canyon of the Yellowstone,' a work by American painter Thomas Moran, inspired Congress to establish Yellowstone National Park.