Arthritis affects almost 60 million Americans

Arthritis is an umbrella term for various conditions that cause joint pain

Arthritis isn’t one single disease, but rather a range of conditions that all lead back to the same outcome—joint pain. This American Academy of Orthopaedic Surgeons primer is a go-to resource for understanding what arthritis is, the most common types, and various treatment options depending on the underlying cause.

Rheumatoid arthritis affects about 1% of the population

Rheumatoid arthritis is an autoimmune condition leading to breakdown and inflammation of multiple joints throughout the body. This academic article provides an updated deep dive into our current cellular understanding of rheumatoid arthritis, how it is diagnosed, and the variety of medications available for treating this painful condition.

Five advancements in arthritis research

It is estimated that nearly 350 million people worldwide are currently suffering from arthritis. This resource explores five of the most promising recent advancements in arthritis research as scientists work towards improved treatments and continue the search for a cure.

Arthritis explained, with Dr. Nick Golinvaux

Arthritis, a condition affecting millions globally, is more than just joint pain—it’s a breakdown of cartilage that cushions bones, leading to stiffness, swelling, and discomfort. While often associated with aging, arthritis can affect people of all ages, especially after injuries. Though there’s no cure yet, treatments range from medication and physical therapy to surgical interventions like joint replacements.

More than 5 million Americans have more than one autoimmune disease

Overall, about 4.6% of the US population—15 million people—have an autoimmune condition. Some common examples include rheumatoid arthritis, psoriasis, type 1 diabetes, Grave's disease, and autoimmune thyroiditis.

The most common type of arthritis is osteoarthritis, or age-related cartilage loss

The most common form of arthritis is osteoarthritis. It's caused by cartilage loss within our joints as we age. This article is formatted specifically for patients. It provides easily digestible information on our most evidence-based understanding of osteoarthritis causes, symptoms, and treatments.

Visualizing a joint under attack from rheumatoid arthritis

A particularly difficult arthritis subtype is rheumatoid arthritis, a painful condition provoking a vicious cycle of joint inflammation, destruction, and dysfunction. It begins with a misfiring of the patient’s own immune system—for unknown reasons, it identifies joint and cartilage cells as foreign, initiating an attack to eliminate the supposed "invaders."

There is no cure for the general condition of arthritis

While there are innumerable conditions ultimately leading to the joint pain we collectively term "arthritis," one common pathway is progressive inflammation and joint damage many years after an injury.

Research links the gut microbiome and rheumatoid arthritis

Arthritis is a potentially disabling joint condition that currently affects nearly one in five adults across the globe. Doctors still don't know what causes rheumatoid arthritis, but the answer may be partly determined by chemicals produced by bacteria in the gut.

Over 28% of US adults use yoga for pain management

According to a 2022 study, 28.8% of adults used yoga as a way to manage pain. That's a significant uptick from 2002, when only 11.2% did. The most used approach was chiropractic, which 85.7% used.

Visualizing obesity rates across the US

Nearly 70% of adults in the US are either overweight or obese, rates that have tripled over the last 60 years. Severe cases have risen tenfold during this period. Factors like location, income level, and demographics contribute to various obesity levels across the US. Visualize the statistics with this article and chart series.

Black Americans with diabetes have amputation rates three times higher than average

Annually, 130,000 US diabetics undergo amputations due to complications from diabetes, with many patients located in low-income and uninsured neighborhoods. More than half of US diabetics who lose lower limbs are not subject to pre-surgery angiograms, imaging that shows blood flow blockages to determine if (and where) amputation is necessary.

America's financial burden from dementia in 2025 was $781 billion

That figure, calculated by researchers at the University of Southern California, includes medical and long-term care costs, unpaid family and friend caretaking, lost productivity for patients and their families, and the economic loss in quality of life for patients and their families. In 2025, they estimate there were 5.6 million people living with dementia.

America's top causes of death are heart disease, cancer, accidents, and stroke

Heart disease killed more than 680,000 people in 2023 and cancer killed around 613,000 people that year. Both causes of death are far above the next leading cause of death—accidents, which numbered around 223,000. Provisional data for 2024 indicates the leading causes of death remained the same.

Breaking down the knee's anatomy

The human knee is a remarkably complex structure carrying the full weight of the body throughout a person’s life while allowing a number of complex twists, flexes, and extensions. It's also one of the body's biggest weaknesses—the location of chronic pain and replacement surgeries for millions of Americans.

Age-related macular degeneration is the primary cause of blindness in older Americans

Around 20 million Americans suffer from macular degeneration, and it's the leading cause of blindness in older Americans. Risk factors for age-related macular degeneration include aging, genetics, smoking, hypertension, obesity, and diet.

Alcohol use disorder is the most common addiction in the US

This comprehensive overview from the Addiction Center uses recent data from SAMHSA’s National Survey to examine the 10 most common substance dependencies in the United States. It ranks addictions from alcohol (affecting 28.3 million Americans) to barbiturates, while highlighting key trends, risks, and societal impacts.

How many Americans receive government assistance?

In 2022, nearly half of all American children—and roughly one in three Americans overall—were enrolled in at least one government assistance program. Those programs provide support for people who cannot afford healthcare, food, housing, or other needs. Find out more about the number of Americans receiving government assistance here.

Someone suffers from a stroke every 40 seconds

Every 40 seconds, someone in the US experiences a stroke—and every minute without treatment destroys millions of brain cells. This explainer breaks down the two main types of strokes, their risk factors, and how early detection could change outcomes in the future.

Addressing lifestyle factors, which influence inflammation, can cure some chronic diseases

In this video, a physician claims that he reversed a patient's Type 2 diabetes in six weeks by addressing inflammation drivers such as diet. More broadly, he argues that society needs to better consider and address numerous disease factors that are modulated by inflammation, such as stress, sleep, diet, and movement.

Roughly 70 million Americans have 401(k) plans

Ted Benna, a rural benefits consultant, proposed a reinterpretation of a small tweak to the Internal Revenue Code in 1980. This led to a fundamental transformation of how American workers plan for retirement.

Scleroderma, which causes skin to harden and scar, has no FDA-approved treatment

It's an autoimmune disease that disproportionately causes worse complications in African American people for unknown reasons. It causes the body to overproduce collagen after the immune system attacks the body's own connective tissue, leading to excess collagen deposits and restricted blood circulation as small blood vessels are damaged. It can damage various organs, including the lungs.

European diseases killed a massive share of the Native American population

After Western contact, epidemic diseases devastated Indigenous communities. By 1920, the Native American population of the US had fallen to roughly 270,000, compared with an estimated 1.2 to 18 million at the time of European arrival.

30% of Americans make New Year's resolutions

The practice is more popular among younger people: In a Pew Research Center study, nearly half of people under 30 reported making at least one resolution. The majority of Americans (of all ages) who didn’t make resolutions said they simply don’t like the tradition.

Between 10 million and 50 million people in the US develop rashes from poison ivy, poison sumac, and poison oak each year.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

Search Lyme disease incidence in your county

The searchable database at the bottom of this webpage allows users to check the reported incidence of Lyme disease in US counties and Canadian health regions. In 2022, for example, Baltimore County in Maryland had a rate of about 34 probable and confirmed cases per 100,000 people. Arlington, County in Virginia was less than half of that for the same time period.

About 12.5% of US adults experience a phobia in their lifetime, a diagnosis that hinges on the intense fear interfering with daily life and persisting for at least six months.

US consumers collectively owe more than $1T to credit card companies—almost as much as they owe in auto loans.

44% of Americans say they pray at least once a day—discover how your state's religiosity stacks up against the rest of the country.

Fireworks-related ER visits are on the rise—in 2024, they increased by 52% as compared to the prior year.

Calculate how much of your tax dollars go to each federal program based on your income, filing status, and number of children

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

20,000 letters to the advice columnist 'Dear Abby' provide insight into prevailing sex, religion, and LGBTQ fears, anxieties, and concerns from the 1950s onward.

See how each of the more than two million known species relates to each other—and to common ancestors—in this zoomable tree of life.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

Despite being favored by 87% of Americans, Congress does not have term limits.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Explore an interactive map of battles from the American Revolution, along with detailed summaries of each engagement

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

The US dollar is the most widely circulated currency in the world, and is involved in nearly 90% of global transactions

US housing costs have risen by roughly 175% between 1991 and 2026—but a growing number of Gen Zers are becoming homeowners anyway. In 2025, 4% of homebuyers were Gen Z, up from 3% the year before.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

View the ten deadliest tornadoes in US history.

The word 'jazz' evolved from 'jasm,' 19th-century American slang for 'energy'

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

Three Ebola species are responsible for most large outbreaks of the disease, yet the only approved Ebola vaccine is known to work against just one of them.

Art theft is the third-largest source of criminal revenues worldwide, thanks in part to the subjective nature of valuing a work of art.