More than 5 million Americans have more than one autoimmune disease

Learn about the more than 100 known autoimmune diseases

Explore this resource with summaries and related resources for the dozens of autoimmune diseases defined in the medical literature. Many of these disease write-ups also have interviews with a patient with the disorder—offering a personal take about challenges, advice, and lifestyle effects.

Many patients with psoriasis develop other autoimmune diseases, too

A small study published in 2024 found that nearly three-quarters of patients with psoriasis—a condition in which the body attacks healthy skin cells—also developed autoimmune disorders including thyroid diseases, connective tissue diseases, and more, suggesting such connections between these autoimmune disorders warrant further exploration.

Rheumatoid arthritis affects about 1% of the population

Rheumatoid arthritis is an autoimmune condition leading to breakdown and inflammation of multiple joints throughout the body. This academic article provides an updated deep dive into our current cellular understanding of rheumatoid arthritis, how it is diagnosed, and the variety of medications available for treating this painful condition.

Arthritis affects almost 60 million Americans

Arthritis refers to a range of conditions resulting in joint pain that currently affects nearly 60 million people in the United States alone. This resource from the Centers for Disease Control and Prevention explores the basics of arthritis and provides resources for understanding its near-universal impact on our population.

Why are women more likely to suffer autoimmune diseases than men?

A majority of Americans with autoimmune diseases have more than one X chromosome, a typical marker of the female biological sex, according to a study published in February of 2024. During fetal development, cells side with one X chromosome over the other, preventing the overproduction of X-chromosome-specific proteins and shutting down the twin chromosome. This article explores how this X-chromosome inactivation can lead to autoimmune disorders by generating antibodies to the body's own tissues.

Autoimmune diseases affect between 5% and 10% of people worldwide, but their causes remain unknown

Autoantibodies—which attack the body—may be detectable in the body years before a patient develops symptoms, but some people may have detectable levels yet never go on to develop an autoimmune disease. This video discusses this and other unsolved mysteries with autoimmune disease.

Autoimmune disorders are one of the top 10 killers of young and middle-aged women

Studies in the US and the UK, though conducted decades ago, have underscored that autoimmune diseases, when grouped together, are a top killer of women.

How autoimmune diseases, which attack your own tissues and cells, work in the body

These diseases remain some of medicine's thorniest problems because the immune system can mistakenly attack almost any tissue in the body, resulting in myriad diseases, including lupus (numerous tissues affected), Hashimoto's (thyroid), and MS (the nervous system).

Autoimmune disease prevalence and incidence are on the rise—but no one knows why

Researchers theorize that environmental factors, including shifts to less healthy diets, air pollution, infections, stress, climate change, and exposures to xenobiotics—substances like pesticides, plastics, and toxins that incite immune responses—may all be fueling epigenetic changes to our bodies that make people's immune responses go awry.

Roughly 1 in every 4,300 individuals in the US has mitochondrial disease

Roughly 1,000 to 4,000 kids are born with these conditions each year in the US though many of the diseases are fatal. Mitochondrial disorders often affect the organs that require the most energy, including the heart, brain, and muscles.

One in 10 adults worldwide has diabetes

As of 2021, diabetes claimed at least 6.7 million lives and continues to kill one person every five seconds. Nearly one in two adults with diabetes don't know they have the condition, which is expected to increase in prevalence from 537 million in 2021, to 783 million in 2045.

Roughly 1 in 125 people have autism spectrum disorder globally

The disorder has been increasingly diagnosed as its definition has grown broader and as clinicians have become more adept at identifying it—with some estimates suggesting the figures are much higher. These figures include people across the spectrum, some of whom live mostly independent lives, while others require life-long care and assistance.

More than 1 in 7 people worldwide have had Lyme disease

Research published in 2022 suggests that 14.5% of the world's population has contracted Lyme disease. Researchers arrived at that estimate by analyzing the presence of Lyme disease antibodies (indicating prior infection) across 89 studies conducted between January 1984 and December 2021. The works collectively included blood samples from more than 150,000 people. (Some user may encounter a paywall.)

GLP-1s are netting interest for treating autoimmune diseases, but are considered experimental

Already used to treat type 2 diabetes, the novel medications are showing some early promise in experimental studies at reducing inflammation and treating autoimmune conditions including rheumatoid arthritis and inflammatory bowel conditions. But researchers caution that side effects are still under investigation—rarely the medication has caused lupus, an autoimmune disease.

More than 90% of America’s food allergies are triggered by 9 foods

Milk, egg, peanut, tree nuts, soy, wheat, fish, shellfish and most recently, sesame, are recognized as the most common food allergies in the US. Together, they are responsible for at least 90% of the serious food allergy responses in the country.

Breast, prostate, and lung cancer are the most common forms of the disease

Close to 1.8 million cases of cancer are diagnosed each year in the US, with more than 600,000 deaths (about 0.2% of the total population). This visualization tool offers a searchable database of aggregate statistics on common cancers by gender, race, state, and other demographic information.

1 in 10 US adults are taking medication for depression

A US government report indicates that about 10% of US adults took prescription medication for this disorder in 2023. Women, at 15.3%, were more than twice as likely to take one of these medications than the 7.4% of men.

Bipolar disorder, which is characterized by extreme mood swings, affects nearly 3% of the US population

There are two types of this disorder. Bipolar 1 features a significant manic episode—abnormally elevated mood and frantic energy—followed by repeated depression, while Bipolar 2 vacillates between depressive episodes and hypomania, a milder form of mania, but not a full mania. Listen to this podcast as experts explain the condition.

Scleroderma, which causes skin to harden and scar, has no FDA-approved treatment

It's an autoimmune disease that disproportionately causes worse complications in African American people for unknown reasons. It causes the body to overproduce collagen after the immune system attacks the body's own connective tissue, leading to excess collagen deposits and restricted blood circulation as small blood vessels are damaged. It can damage various organs, including the lungs.

Roughly 43 million Americans hold a cumulative $1.6T in federal student debt

About 43 million Americans hold a cumulative $1.6T in federal student debt. That's more than the country's combined credit card balance, according to data from in the first quarter of the year 2024.

Millions of aging Americans are facing dementia or cognitive impairment—alone

An estimated 4.3 million people aged 55 or older who have cognitive impairment or dementia live alone in the US. The individuals facing these challenges are more likely to be women, people of color, and to generally be poorer and less educated than other older adults who are also living alone.

Between 10 million and 50 million people in the US develop rashes from poison ivy, poison sumac, and poison oak each year.

Around 32% of American adults have at least one tattoo

Tattoos have waxed and waned in popularity over the centuries, depending upon the social standing of their wearers. Throughout US history, they were often considered taboo. However, growing acceptance of tattoos means they’re more visible in the public eye.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Why car insurance rates are skyrocketing

The average annual premium for auto insurance coverage in the US rose 26% in 2024, and rates are only expected to increase. The rate hikes aren’t simply a result of more people getting into crashes. This video explores how a lack of trained auto mechanics, a tighter supply of used vehicles, record healthcare bills, and litigation are contributing to higher monthly insurance bills.

US consumers collectively owe more than $1T to credit card companies—almost as much as they owe in auto loans.

The average American likely doesn’t notice how many ads they’re targets of per day

The average American is targeted with roughly 5,000 ads each day—but the conscious mind likely isn’t capable of recalling the majority of those. Even still, many consumers have reported ad fatigue due to the near-constant onslaught of ads.

Every Thanksgiving, Americans eat over 40 million turkeys

That's 50% of all whole turkeys sold in the US in a given year. (Most of the remaining 50% are purchased for Christmas.)

About 12.5% of US adults experience a phobia in their lifetime, a diagnosis that hinges on the intense fear interfering with daily life and persisting for at least six months.

The United States is one of only around two dozen countries with a fully federal system of government, in which power is divided between national and state governments.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

11 people died from firework injuries in the US in 2024.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Tattoos remain visible on your skin thanks to immune cells called macrophages

44% of Americans say they pray at least once a day—discover how your state's religiosity stacks up against the rest of the country.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

Calculate how much of your tax dollars go to each federal program based on your income, filing status, and number of children

See how each of the more than two million known species relates to each other—and to common ancestors—in this zoomable tree of life.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Meet the 56 signers of the Declaration of Independence—most of whom didn't put pen to paper until August 2, 1776—and see their original signatures.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

This site reaches millions of visitors who are tired of AI chatbots and seeking human connection. Pretend to be an AI chatbot and ask questions, provide answers, and draw for people in real time.

The Nasdaq's 'Magnificent 7' companies are responsible for roughly 40% of the Nasdaq 100 index's gains, while the remaining 93 companies account for the other 60%.

Three Ebola species are responsible for most large outbreaks of the disease, yet the only approved Ebola vaccine is known to work against just one of them.

Radioactive elements can introduce software errors because the ionizing radiation they produce can detach electrons from atoms, and computer code relies on the distribution of electrons.

The Russia-Ukraine conflict is the largest ground war in Europe since World War II in terms of casualties, forces mobilized, and displacement of civilians.

'Shogun,' a 1980s TV series, helped popularize sushi in the US by stimulating an American interest in Japanese culture.