America's top causes of death are heart disease, cancer, accidents, and stroke

Explore the gap in what Americans die from versus news coverage on death causes

Top killers like heart disease, stroke, and liver disease, though they represent a significant burden nationally, are not often extensively covered in the media.

Visualizing cause of death over time in America

As people age, their life expectancy decreases, but the timing and speed of this decline have evolved over the years. Check out this chart which shows the shift in various causes of death of Americans over the last few decades. Data from the...

Explore more statistics about cancer

The American Cancer Society's Cancer Statistics Center estimates there will be more than 2 million new cancer cases and almost 620,000 cancer deaths in the US during the course of 2025. Breast, prostate, and lung cancers remain the most prevalent. This interactive tool provides detailed statistics on cancer incidence, mortality, and survival rates, allowing users to explore data by state, cancer type, demographics, and risk factors.

Heatstroke deaths may be massively undercounted—perhaps by a factor of 10

One often-cited average estimate of annual American heat deaths—roughly 1,200 per year—is based on death certificate data, but it may be a significant undercount because heat kills through cardiovascular, kidney, and respiratory causes that are more likely to be cited on those documents. (Separate analysis that looked at data from 1999 to 2023 found that the highest number, in 2023, was 2325.)

Traumatic brain injury is a leading cause of brain death—and TBIs are trending up

Traumatic brain injury-related deaths have generally increased between 2000 and 2023, growing from roughly 49,000 to more than 68,000 in 2023. Firearm-related suicide is the most common cause of TBI-related deaths in the US, according to the Centers for Disease Control and Prevention. People also experience TBIs from falls, motor vehicle crashes, or assaults.

Estimates suggest inactivity contributes to 6% of deaths worldwide

The World Health Organization identifies physical inactivity as the fourth leading modifiable risk factor for global mortality, just behind hypertension, tobacco use, and high blood glucose. Latest estimates are that inactivity contributes to 6% of deaths and significantly increases the burden of chronic diseases like heart disease, diabetes, and cancer.

Heat is the leading cause of death in natural disasters

Floods are a distant second, followed by hurricanes. That's according to data reported by the National Oceanic and Atmospheric Administration.

11 people died from firework injuries in the US in 2024.

More than 4,000 people died from cholera in 2023

This global health threat sickened more than half a million people in 2023 and killed 4,007 people. That's a 71% increase in deaths as compared to a year earlier. (Report only offered in PDF format.)

How Alzheimer’s disease becomes fatal

Despite more than 100,000 people with Alzheimer's dying each year, the specific cause of death is not the disease itself. Often, secondary diseases arise from complications with the disease, including pneumonia, severe falls, malnutrition, or infection. Read more about the range of complications caused by Alzheimer’s here.

Murder rates spiked in the US after COVID-19, and then declined in 2023

Criminologist and former investigator Jillian Peterson says whether a murder is solved in the US is nearly up to the flip of a coin, with the clearance rate for murder cases being about 50%. The US, which has more guns than citizens, has about roughly five gun homicides per 100,000 residents, resulting in the 28th-highest rate of deaths from gun violence compared to the rest of the world.

The Civil War was the deadliest conflict in American history

Between 1861 and 1865, an estimated 620,000 to 750,000 soldiers died from battle and disease—more than in all other US wars combined.

The US had about 155.4 million emergency room visits in 2022

Of those emergency incidents, the largest share of patients were between the ages of 25 and 44 and were in the southern part of the US. More than 43 million of the visits involved injuries, including poisonings.

Ranking America's healthiest and unhealthiest cities

Compiling data from the 180 most populated cities in the US, WalletHub evaluated which of those metros are the healthiest using 43 health indicators, from the average cost of a medical visit to total vaccination rates.

Sepsis is the leading cause of death in hospitals

Sepsis is the result of an overly aggressive immune system trying to combat infection, triggering inflammation throughout the body. After it begins, each passing hour increases the risk of death by 4% to 9%, and an estimated 350,000 people die from the condition in the US each year.

In 2024, the US had more organ transplants than ever before—besting the 2023 record

More than 48,000 organ transplants were performed in 2024, and about 46,630 were performed in 2023. These record highs are illustrated here as part of data from 1988 to partway through 2025. Kidneys, livers, and the heart remain the most common transplanted organs. (Some users may encounter a paywall.)

Mosquitoes top the ranking of the world's deadliest animals

Mosquitos kill about 760,000 people every year. The vast majority of those deaths are caused by malaria, which is transmitted and spread by the Anopheles mosquito. The second-place deadliest animal title goes to snakes, with an estimated human death toll of around 100,000 annually.

America's financial burden from dementia in 2025 was $781 billion

That figure, calculated by researchers at the University of Southern California, includes medical and long-term care costs, unpaid family and friend caretaking, lost productivity for patients and their families, and the economic loss in quality of life for patients and their families. In 2025, they estimate there were 5.6 million people living with dementia.

Low cell division rates in heart cells make heart cancer particularly rare

The heart's location in the chest also offers protection from external cancer-causing factors. The disease affects about 3 in every 10,000 people, though most cases arise from metastasis from other body parts.

Autoimmune disorders are one of the top 10 killers of young and middle-aged women

Studies in the US and the UK, though conducted decades ago, have underscored that autoimmune diseases, when grouped together, are a top killer of women.

What issues Americans are prioritizing in 2022

Inflation, Crime, and Abortion—see a breakdown of voter preferences by age, race, and gender, along with what topics are top of mind for Americans.

Most common jobs in the US

Most US government organizations list roughly 500 primary occupations that most Americans fall into, such as teachers and cashiers. Using data from the 2018 through 2022 American Community Survey, these graphics break down the most common jobs in the US by age, gender, and more. See the graphics here.

Arthritis affects almost 60 million Americans

Arthritis refers to a range of conditions resulting in joint pain that currently affects nearly 60 million people in the United States alone. This resource from the Centers for Disease Control and Prevention explores the basics of arthritis and provides resources for understanding its near-universal impact on our population.

The average American contributed nearly $6,000 to a 401(k) account in 2023

That's an increase over the previous year—and roughly 8% of their total income. When employer contributions are factored in, the total average contribution to 401(k) accounts rose to $8,618 in 2023, up from $8,362 in 2022 and $8,236 in 2021.

This year's highest-paid dead celebrities

Forbes unveiled the list of 13 highest-paid dead celebrities. For the first time ever, the top five people in Forbes 2022 list of highest paid dead celebrities, have made more than $100 million each

Daylight Saving Time is linked to a rise in heart attacks and strokes

Losing an hour of sleep with seasonal time changes is not good for our health and it’s linked to risks for the first couple days of Daylight Saving Time, including a short-term rise in heart attacks and strokes. Scientists theorize these elevated risks are linked to the disruption to the body’s circadian rhythm.

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

View the ten deadliest tornadoes in US history.

US consumers collectively owe more than $1T to credit card companies—almost as much as they owe in auto loans.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

The American Society of Civil Engineers' infrastructure report card gave the US a C in 2025, its highest grade since the project launched in 1998.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

This real-time tracking of the hantavirus cruise ship outbreak in May 2026 offers a unique glimpse into the global reach of the outbreak and whether the virus sickened passengers and their communities around the world.

44% of Americans say they pray at least once a day—discover how your state's religiosity stacks up against the rest of the country.

Three Ebola species are responsible for most large outbreaks of the disease, yet the only approved Ebola vaccine is known to work against just one of them.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

In 2026, Finland was named the world's happiest country for the ninth consecutive year based on its wealth, social safety network, and high life expectancy, among other factors.

A Yale student wrote a profound essay about the consulting industry's influence on elite college students that was published in a book of her writing after she died in a post-graduation car accident.

The US Constitution is widely regarded as the longest-standing written national constitution still in force—see how it has influenced rights worldwide.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

The United States has had a tumultuous relationship with Cuba since its 1959 revolution, highlighted by a nuclear crisis and a decades-long trade embargo.

See the most iconic photos from four decades of LIFE magazine

Dozens of S&P 500 stocks, including Coca-Cola and Walmart—known as the dividend aristocrats—have increased dividends every year for 25 years

Explore an interactive map of battles from the American Revolution, along with detailed summaries of each engagement

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Lesser-known phobias include turophobia, or the fear of cheese, and nomophobia, the fear of being without your cell phone.

Neutron stars, the remains of some massive stars after they explode in a supernova, are the densest directly observable objects in the universe.

The boiling temperature of water decreases with increasing elevation because the molecules need less energy to overcome the lower atmospheric pressure associated with thinner air.