European diseases killed a massive share of the Native American population

Europeans' arrival to America brought disease to Indigenous populations

Indigenous people lived in the Americas for centuries before the arrival of the first Europeans in the 15th century. Their arrival was disastrous for Native tribes; in addition to being enslaved and losing their land, they had no natural immunity to the diseases brought by colonists. Eventually, up to 95% of the Native American population was killed by illnesses including typhus, chickenpox, and cholera, an event now known as the Great Dying.

European colonization dramatically reshaped Native American life

As European settlers expanded across North America, Native Americans faced displacement, violence, and forced negotiations. Colonial powers used trade relationships, treaties, and military force to reshape Indigenous communities and claim their territories.

More than 300 distinct Native American languages existed at the time of European contact

Indigenous North America exhibited vast linguistic diversity, with over 300 languages spanning dozens of unrelated language families. This variety reflected centuries of distinct cultural development across the continent's many nations and regions.

In 2023, Native Americans had the lowest life expectancy at birth among all racial and ethnic groups

Native Americans and Alaska Natives face significant health disparities linked to chronic underinvestment in reservation health infrastructure, poverty, and multigenerational psychological harm—often called historical or inherited trauma.

The US government ran boarding schools designed to erase Native American identity

From the late 19th century into the 20th century, the federal government sent Native children to boarding schools under the philosophy of "kill the Indian, save the man." Children were forbidden from speaking their languages or practicing their cultures, and many endured abuse.

Native Americans were not granted US citizenship until 1924

The Indian Citizenship Act granted citizenship to all Native Americans born in the US, more than 130 years after the Constitution's ratification. Even then, some states continued to deny Native Americans the right to vote for decades.

Indigenous women are murdered at 10 times the rate of all other ethnicities in the US

Murder is the third-leading cause of death among Indigenous women, who are also 2.5 times more likely to experience violence than any other group. More than 4 in 5 Indigenous women have experienced violence in their lifetime.

The Trail of Tears killed thousands of Native Americans forced from their homelands

After the Indian Removal Act passed, the US Army marched the Cherokee and other nations hundreds of miles to the designated "Indian Territory" in present-day Oklahoma. Thousands died from starvation and disease along the way.

Native American tribes still are waiting for museums to return the remains of their ancestors

The remains of more than 100,000 Native Americans are held by prestigious US institutions, despite a 1990 law meant to return them to tribal nations. Here’s how their ancestors were stolen—and how tribes are working to get them back.

The Dawes Act of 1887 broke up communally held tribal lands

Sometimes called the General Allotment Act, the Dawes Act divided reservation land into individual plots assigned to Native Americans, while "surplus" land was sold to white settlers. The policy led to Native tribes losing roughly 90 million acres, about two-thirds of their remaining land.

The share of the immigrant population in the US peaked at nearly 16% in January 2025

In January 2025, the US reached a historic high of 53.3 million immigrants—nearly 16% of the population. By June of that year, the number had fallen by more than a million, ending 50 years of continuous growth in the immigrant population.

Why the 1918 flu killed between 50 and 100 million people

The 1918–1920 flu pandemic (once called, incorrectly, the Spanish flu) killed quickly and in huge numbers, with estimates of the global death toll ranging from 50 to 100 million people. Several factors contributed to the high mortality rate: lack of antibiotics, the global disruption of World War I, and more.

The Wampanoag collaborated with the Pilgrims in order to survive

Decades of violence and disease brought by European settlers had devastated local tribes. Up to 75% of the Wampanoag people had been eliminated, leading them to sign the peace treaty to preserve those who remained.

The US Army massacred close to 300 Lakota men, women, and children at Wounded Knee in 1890

Fearing the Ghost Dance—a spiritual movement spreading across starving reservations—the Army surrounded a Lakota encampment at Wounded Knee Creek, South Dakota. When a shot was fired during an attempted disarmament, it sparked chaos, and soldiers killed nearly 300 people.

See MS prevalence by region in the United States

This map underscores that people in the northeastern United States have more cases of the disease as compared to the south, west, and midwest. On an individual level, these numbers may still differ based on genetic makeup and other factors irrespective of where people live.

Native Americans developed pottery and religion, and experienced population growth during the Woodland period

Between 500 B.C.E. and 1100 C.E., Indigenous peoples produced pottery and practiced animism, a spiritual worldview in which animals, plants, and natural forces are believed to possess sacred power. They moved seasonally to make the most of available resources.

Why genetic similarities between humans suggest a past near-extinction event

Researchers have found that low genetic diversity among humans—even those on opposite sides of the planet—may result from a breeding population of as few as 1,280 adults, estimated to have existed 930,000 years ago. This genetic bottleneck may have resulted from a near-extinction or from a small population of human ancestors, from which we all descend, that broke off from a larger population.

The Civil War was the deadliest conflict in American history

Between 1861 and 1865, an estimated 620,000 to 750,000 soldiers died from battle and disease—more than in all other US wars combined.

Nearly 5,500 crows died during four months in 1999 from West Nile in NYC

Subsequent testing made clear the disease at that point was 100% fatal to crows. From 1999 to 2004, millions of birds died as West Nile spread across North America, but the virus fortunately became less virulent as it moved westward.

From 1970 to 2017, invasive species have caused $1.28T in damage globally

The costliest species were the Asian tiger and yellow fever mosquitoes ($149B), which arrived in the US from Asia and sub-Saharan Africa, respectively. The bulk of their damage came from their transmission of diseases such as Zika, chikungunya, and dengue. (Some readers may experience a paywall.)

Native, wild bees are at much greater risk of extinction than honey bees

It is estimated that there are more honey bees, which often compete with native bees for resources, on the planet than at any point in human history. Meanwhile, 40% of invertebrate pollinator species, including wild bees and butterflies, face extinction in the coming decades.

Heat-related deaths may have climbed by more than 50% over 20 years

Between 2000 and 2009 one study suggests annual heat deaths averaged around 2,670, but between 2010 and 2020 that figure was likely more than 4,000. Researchers studied 54 million death records from the contiguous US and created mathematical models to arrive at these figures, noting that a combination of aging populations and climate change drove that increase.

Hear how the Black Death reshaped Europe's economy

The Black Death killed tens of millions across Europe, but the labor shortages that followed shifted economic power. With fewer workers available, survivors demanded higher wages and better conditions—sparking what historians call a medieval “Golden Age of Labor.”

Explore why Americans are drinking less alcohol

US alcohol consumption fell 5% in 2025, with beer and wine leading the decline. Economists point to tighter budgets and less face-to-face socializing overall, while younger Americans are increasingly choosing not to drink.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

How the California wildfires are impacting wildlife

The deadly 2025 Eaton and Palisades Fires in California have devastated neighborhoods, forested canyons and chaparral—a type of shrubland. In addition to taking dozens of human lives and displacing thousands, the fires destroyed countless habitats and displaced many species. See the unfortunate effects of the flames on wildlife populations, including birds, snakes, wildcats, and fish.

11 people died from firework injuries in the US in 2024.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

View the ten deadliest tornadoes in US history.

Cultural norms about how to handle the bodies of loved ones in communities in West Africa have hampered Ebola responses.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

Explore an interactive map of battles from the American Revolution, along with detailed summaries of each engagement

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

See a 3D reconstruction of Tenochtitlan, the Aztec capital that was home to an estimated population of 200,000 to 400,000.

Human-to-human transmission of hantavirus remains extremely rare, so the 2026 hantavirus cruise ship outbreak doesn't mean we're facing a COVID-style pandemic risk.

US consumers collectively owe more than $1T to credit card companies—almost as much as they owe in auto loans.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

The United States has had a tumultuous relationship with Cuba since its 1959 revolution, highlighted by a nuclear crisis and a decades-long trade embargo.

The United States is one of only around two dozen countries with a fully federal system of government, in which power is divided between national and state governments.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

The Russia-Ukraine conflict is the largest ground war in Europe since World War II in terms of casualties, forces mobilized, and displacement of civilians.

After NASA's Voyager 1 captured Earth as a single pixel as it left the solar system in 1990, astronomer Carl Sagan used the image to reflect on humanity's fragility and the responsibility to protect 'the only world we've ever known.'

See how each of the more than two million known species relates to each other—and to common ancestors—in this zoomable tree of life.

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

Poison ivy's rash-causing compound is found in the plant's roots, stem, and leaves—so coming into contact with any part of the plant can lead to rashes for the 85% of people who are allergic to it.

While El Niño moves warm Pacific Ocean waters east along the equator, La Niña moves them west, shifting where rainfall will become more common for months.

'Grand Canyon of the Yellowstone,' a work by American painter Thomas Moran, inspired Congress to establish Yellowstone National Park.

Many legends about George Washington, including his supposed wooden teeth and the story of cutting down the cherry tree, lack evidence.