Scleroderma, which causes skin to harden and scar, has no FDA-approved treatment

Early research suggests CAR-T therapy might treat scleroderma, reducing skin thickening

Clinical data from a couple patients in 2025 indicated that one experimental CAR-T therapy called rese-cel was able to genetically reprogram T cells to eliminate certain problematic immune B cells that were causing the condition. The therapy reduced skin thickening and allowed the patients to halt using immunosuppressive medications and steroids.

Sclerosis is the technical term for the lesions or plaques that form without myelin

In the absence of myelin, the body forms scar tissue called sclerosis. That scar tissue hampers nerve's abilities to transmit nerve impulses, essentially acting as a roadblock to speedy communication.

Chronic inflammation can cause cellular damage and could lead to cancer

Over time, this cellular defense system can inadvertently damage cells and tissues when it's in this heightened alarm mode over a prolonged period. This occurs because, when immune cells are sent somewhere without a true target, they may attack healthy cells and tissues.

Laser skin treatments can promote the production of collagen

Skin resurfacing vaporizes the top layer of skin to reveal healthier, new skin, while collagen can give the skin structure and elasticity. Such procedures treat scars and burns, but may leave light spots on the skin.

Black Americans with diabetes have amputation rates three times higher than average

Annually, 130,000 US diabetics undergo amputations due to complications from diabetes, with many patients located in low-income and uninsured neighborhoods. More than half of US diabetics who lose lower limbs are not subject to pre-surgery angiograms, imaging that shows blood flow blockages to determine if (and where) amputation is necessary.

The US FDA issued a 2025 warning about BPC-157 and other popular peptides

BPC-157, which mimics a naturally occurring gut peptide involved in soft tissue repair, has been marketed for various regenerative properties. But the FDA warned in July 2025 that it doesn't have enough data to assess its safety in humans and that such products may also pose risks related to contamination.

Caucasians are at the greatest risk of developing macular degeneration

A 2016 analysis across ethnic groups found, among other things, that white participants had the highest incidence of the disease, followed by Chinese, Hispanic, and Black participants. This study did not answer why that may be the case.

Rheumatoid arthritis affects about 1% of the population

Rheumatoid arthritis is an autoimmune condition leading to breakdown and inflammation of multiple joints throughout the body. This academic article provides an updated deep dive into our current cellular understanding of rheumatoid arthritis, how it is diagnosed, and the variety of medications available for treating this painful condition.

Black mold isn’t more worrisome than other colors of mold

Black mold typically refers to Stachybotrys chartarum, a mold that commonly appears in damp or water-damaged areas of the home. Black mold—and other molds—won’t typically make otherwise healthy people ill, and all molds should be treated the same with respect to health risks and removal. If you have mold allergies, mold can cause an allergic response, and it can trigger asthma attacks for people with asthma. If you have a compromised immune system, then black mold exposure can also cause a fungal infection in your airways or elsewhere in the body.

The resurgence of Black lung disease in coal miners

Black lung disease is a preventable condition long associated with coal miners who regularly breathe in toxic coal dust. Simple workplace safety procedures make the disease entirely preventable, but cases are rising. Due to lax enforcement of rules, miners in Central Appalachia are increasingly diagnosed with cases stemming from silica dust inhalation.

How trauma gets ‘under the skin’

A study examining the muscle function of older adults who have at least one adverse childhood experience (ACE) suggests that trauma digs itself into muscle cells. Participants who reported childhood trauma were found to have lower maximum levels of cellular energy than people who reported fewer or no ACEs. Such compromised mitochondrial function "doesn't bode well," as it relates to a variety of health and age-related outcomes.

Nonwhite Lyme patients tend to be diagnosed later and have more severe disease

Peer-reviewed research published in 2025 from Pfizer—a pharmaceutical company working on a candidate vaccine for Lyme disease—examined Lyme data from more than 150,000 Medicare and Medicaid beneficiaries and found that Black patients, as compared to white beneficiaries, were more likely to have disease that had spread further throughout the body at the time of care. The difference, the scientists wrote, may be partly due to difficulties recognizing the characteristic rash on darker-colored skin.

Drug-resistant staph infection is one of the deadliest superbugs

Methicillin-resistant Staphylococcus aureus (MRSA)—the superbug version of staph infection—is responsible for more deaths than any other superbug, killing more than 120,000 people globally each year. The bug is leading cause of hospital infections, and is harmless on the skin but causes severe symptoms once inside the body.

Sickle cell trait can put people at elevated risk of heat-related illness

This hereditary blood disorder affects the shape and function of red blood cells. A US military study found that among recruits the incidence rate of exertional heat-related illness was 48% higher among those who had sickle cell trait as compared to those without. Easing into intense exercise and gradually increasing exertional frequency and intensity is recommended.

Immunosuppressants enable organ transplants, but come with severe side effects

This drug cocktail helps to lower your body's natural response to attack a transplanted organ. Such medications usually need to be taken for a lifetime after receiving an organ and can come with serious side effects including high blood pressure, diabetes, increased risk of some cancers, and high cholesterol, among others.

Collagen supplements typically come from animal sources like fish, pigs, or cattle

Eating collagen-rich foods won't lead to more collagen in the body because your digestive system breaks down consumed collagen into amino acids. Instead, eating a healthy diet of proteins and greens helps your body to produce collagen. Collagen supplements derived from animal skin and bones are typically sold in a prebroken-down peptide formulation called hydrolyzed collagen so they can be absorbed through the gut into the bloodstream.

Ebola infects and disables immune cells, triggering a cascade of events that leads to small blood clots throughout the body, weakening blood vessels and interrupting blood flow to key organs.

Tattoo inks are largely unregulated by the FDA

With hundreds of ink manufacturers, all unregulated by the FDA, it’s hard to determine the exact ingredients in tattoo inks. Some pigments may contain carcinogenic chemicals, such as heavy metals and aromatic hydrocarbons, or even bacterial contaminants. Red ink often causes allergic reactions and may even contain lead or mercury.

Why vascular dementia develops

This type of dementia, the second most common form after Alzheimer's, develops due to microscopic bleeds and blood vessel blockages in the brain. The condition isn't curable but medications to help with blood clotting and high blood pressure are part of a suite of interventions designed to minimize damage to the brain.

The disease no one survives (yet)

Creutzfeldt-Jakob disease is currently incurable and can cause one's death within months of symptoms appearing. It involves misfolded proteins that, for some reason yet unknown to science, aren't cleared by the brain as typical and instead trigger similar proteins to misfold. These malformed major prion proteins—prion being a portmanteau of protein and infection—clump inside nerve cells, blocking signals crucial to processes ranging from speaking to organ function.

Does our fear of Alzheimer's create stigma around its treatment?

Surveys suggest our fear of Alzheimer's as a disease outranks that of heart disease and cancer. This piece argues our fear of aging and the slipping away of our mental capacities make it more difficult to treat Alzheimer's compassionately.

Secondary complications from measles in children range across the whole body

The most serious effects of a measles infection, particularly in young children, come from its attack on the immune system. This leaves the whole body vulnerable to follow-on diseases, with some of the most serious including respiratory conditions, encephalitis, and more.

American medical organizations rescind recognition of diagnosis cited in police custody deaths

American medical organizations have rescinded their recognition of a syndrome whose theory stemmed from discredited research. This article explores the history and implications of "excited delirium syndrome," a medical condition that can reportedly...

Lack of Vitamin D seems to be one major factor fueling MS risk

Researchers believe that a combination of factors can elevate MS risk, including a lack of vitamin D exposure in different locales, genetic history, cigarette smoke exposure, and Epstein-Barr virus infection.

Pollen and other allergens that are inhaled rarely cause anaphylaxis

Food allergies, insect stings, medications, and latex exposure are the main causes of the life-threatening allergic response called anaphylaxis. To reverse this severe reaction, a patient must typically receive an injection of epinephrine, otherwise known as adrenaline, a hormone that can relax some of the body’s muscles and increase heart rate, among other effects. Pollen allergies typically fuel a more localized reaction that isn’t as severe.

Tattoos remain visible on your skin thanks to immune cells called macrophages

Humanity's reduced body hair slows down wound healing

Cuts to human skin take twice as long to heal compared to chimps and other mammals. Scientists argue this is due to the reduced number of hair follicles on human bodies. Hair follicles contain stem cells which help repair skin cells faster, so as humanity shed its hair over time, so to speak, it also slowed its wound healing.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

Poison ivy's characteristic rash is caused by an allergic response to an oily compound in the plant called urushiol.

See images of medical cases of firework injuries shared on this 'Instagram for doctors.' (Warning: Graphic content)

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

About 12.5% of US adults experience a phobia in their lifetime, a diagnosis that hinges on the intense fear interfering with daily life and persisting for at least six months.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

US consumers collectively owe more than $1T to credit card companies—almost as much as they owe in auto loans.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Despite being favored by 87% of Americans, Congress does not have term limits.

The American Society of Civil Engineers' infrastructure report card gave the US a C in 2025, its highest grade since the project launched in 1998.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

American dance legend Martha Graham, sometimes called 'the Picasso of dance,' refused to perform at the 1936 Olympics in Berlin and conceived the piece 'Chronicle' in response to the experience.

Massive 3D printers have been used to build homes by stacking layers of 'concrete toothpaste,' a fire-resistant material that effectively insulates against outside noise.

The distributor behind 'Rocky Horror' pulled the film from its scheduled national release, believing it would be a failure, though it eventually amassed a dedicated fanbase through midnight showings, a trend that continues over 50 years later.