Kangaroos evolved exceptionally thick knee cartilage to absorb shock

Anatomy of a healthy knee joint

To understand arthritis, study a normal joint. Where two bones come together, each is lined by a cartilage cap. These bones are linked together by strong ligaments. The inner juncture is lined by a joint capsule (synovial membrane) containing lubricating joint fluid between the two surfaces, allowing for near-frictionless motion.

Limb regeneration research may lead to treatments for arthritis

For scientists pursuing the cure for arthritis, the holy grail of discoveries lies in how to regrow healthy cartilage inside human joints. While this feat has so far resisted our best scientific attempts, there are plenty of other human tissues—such as the liver and fingertips—that will successfully regenerate.

Visualizing a joint under attack from rheumatoid arthritis

A particularly difficult arthritis subtype is rheumatoid arthritis, a painful condition provoking a vicious cycle of joint inflammation, destruction, and dysfunction. It begins with a misfiring of the patient’s own immune system—for unknown reasons, it identifies joint and cartilage cells as foreign, initiating an attack to eliminate the supposed "invaders."

Diagnosis and treatment of hip and knee osteoarthritis

Osteoarthritis is the most common type of arthritis, resulting from age-related degeneration of the soft cartilage lining between bones. As this layer breaks down, the normal smooth motion between bones is lost and the joint becomes painful.

Arthritis explained, with Dr. Nick Golinvaux

Arthritis, a condition affecting millions globally, is more than just joint pain—it’s a breakdown of cartilage that cushions bones, leading to stiffness, swelling, and discomfort. While often associated with aging, arthritis can affect people of all ages, especially after injuries. Though there’s no cure yet, treatments range from medication and physical therapy to surgical interventions like joint replacements.

Five advancements in arthritis research

It is estimated that nearly 350 million people worldwide are currently suffering from arthritis. This resource explores five of the most promising recent advancements in arthritis research as scientists work towards improved treatments and continue the search for a cure.

Real surgical footage reveals what arthritis looks like up close

Arthritis is a painful condition of human joints that often results from the loss or breakdown of the soft cartilage padding that naturally exists between bones. This video shows footage from an actual knee surgery that beautifully demonstrates the difference between normal cartilage and the degenerative cartilage seen in osteoarthritis.

Dinosaurs suffered from cancer, arthritis, and infections seen in modern animals

Using CT scans and advanced pathology techniques, paleopathologists have identified respiratory illnesses, malignant osteosarcoma, and other diseases in dinosaurs. The research has helped show how many of these ailments are not exclusively modern phenomena.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

The collapse of gas bubbles in the joint synovial fluid causes 'cracking' knuckles

The human population can be divided into two categories: those who crack their knuckles and those who don't. Do you know the technical term for this phenomenon is "tribonucleation?" What actually happens inside a knuckle when it pops? This visual explainer breaks down finger joint popping in real time.

Large animals like giraffes and elephants have evolved unique cancer defenses

One may expect the larger an animal is, the more likely it is to develop cancer—simply because there are more cells and more chances for a dangerous mutation. However, some large animals show cancer rates almost 10 times lower than humans—a phenomenon known as Peto's Paradox.

Why don't giraffes get hypertension?

The average blood pressure of a giraffe is about double that of a human, yet they don't suffer from the symptoms of high blood pressure that humans do: stiffening of the left heart ventricle, shortness of breath, fatigue, or swollen legs and ankles. This article explains how giraffes have evolved to have the "biological equivalent of support stockings."

Some dinosaurs evolved night vision and acute hearing for nocturnal hunting

Paleontologists analyzed the fossilized eye and ear structures of 16 theropods, finding that some had owl-like hearing and huge pupils. These characteristics are consistent with modern-day nocturnal species, including nightjars and geckos.

Zoo animals have developed allergies, too

Although scientists do not know if allergies manifest among wild animals—and if animals can survive with them—in a zoo setting, veterinarians have observed zoo animals with common allergy symptoms, including itchiness, crusty skin, and runny eyes. Veterinarians have identified Asian elephants with pollen allergies and at least one jaguar with an allergy to fleas.

Why you have to airlift rhinos upside down

Conservationists in Namibia have found that airlifting rhinos upside down is actually better for their health than lying them down on stretchers. A study by Cornell University found that rhinos have higher blood oxygen levels when upside down, which is critical for their survival during transport. The upside-down position also allows the rhino's spine to relax, which can help to prevent injuries. This new finding could revolutionize the way that rhinos are moved.

What we know about aurochs, the ancestors of modern cattle

The relationship between humans and cattle is invaluable and longstanding. Evidence suggests cattle's wild, larger, and now-extinct ancestors, the aurochs, were also linked to early humans. Similarly valuable for their milk and labor power, yet significantly more threatening due to their size, aggression, and speed, auroch domestication was slow and complex. Discover new information about the fascinating ancestors of modern cows and the potential of re-introducing the species with selective breeding.

Collagen supplements have become a multibillion-dollar industry

Beginning in our 20s, the amount of this protein in our skin, muscles, and connective tissue declines. But independent, high-quality studies—like those that are double-blind—have not yet shown a significant association between their use and evidence of it improving skin elasticity, reducing wrinkles, or combating hair loss. Some collagen supplements do seem to help with joint pain and knee function, but NPR cautions that studies on that purpose are industry-funded.

In the 1930s, three Australian soldiers were sent to fight emus with machine guns—and lost

As part of a post-WWI initiative to turn veterans into farmers, soldiers were given plots of land. After emus were found damaging the farmland, three men were sent to handle the flightless birds. These men ended up losing to the second-largest bird species in the world and potentially exacerbating crop losses by sending swaths of the birds running and trampling over wheat.

Humans won't develop more than 5 fingers because it would impact too many body parts

All modern animals have five or fewer digits on each of their limbs. Roughly 348 million years ago, at least two species had eight: the Ichthyostega and the Acanthostega. According to Dollo's law, complex evolved features are very unlikely to recur in evolution. Researchers believe humans won't develop more than five digits because it would impact other body parts too much.

Strengthening your butt muscles can help protect against running injuries

More than 28 million people may go running in the US every week, yet people often get hurt—especially with knee injuries—and this podcast explores the science on what happens to our bodies when we run and the effects on our muscles and joints. It also discusses safety tips, including the need to only add more distance to your runs in tiny increments, and that strengthening glute muscles via single-leg glute bridges may be particularly protective against injuries.

Scientists now know why wombats poop cubes

For years, scientists have been wondering why wombat poop is cube-shaped (yes, really). Now, they say they have got to the bottom of the mystery.

Mice were able to regenerate retinal cells in the lab—a breakthrough for mammals

Using gene therapy, a team of Korean researchers has enabled retinal regeneration in mice by blocking the intercellular transfer of a single inhibitory protein. This 2025 finding creates a new potential direction for treating retinal diseases. The work, which is still in animal studies, is projected to enter early-stage clinical trials in the next few years.

Optimal human functioning requires movement

There is now ample evidence to back the centuries-old hypothesis that exercise is critical to human health. This review article explores the latest discoveries in exercise science, including how exercise is intrinsic to maintaining our organ systems throughout life.

How trauma gets ‘under the skin’

A study examining the muscle function of older adults who have at least one adverse childhood experience (ACE) suggests that trauma digs itself into muscle cells. Participants who reported childhood trauma were found to have lower maximum levels of cellular energy than people who reported fewer or no ACEs. Such compromised mitochondrial function "doesn't bode well," as it relates to a variety of health and age-related outcomes.

Ticks are extremely hard to kill

These arachnids can transmit more than a dozen diseases to humans, and they're very resilient: Some can survive extreme heat and cold, live for years without a blood meal, and even survive multiple days underwater.

Gladiators followed a mostly vegetarian, high-calcium diet

Analysis of skeletons from a gladiator cemetery at Ephesus by researchers at the Medical University of Vienna found little meat consumption but unusually high calcium levels—likely from drinking wood ash mixed with water to promote weight gain and protect vital organs.

Tattoos remain visible on your skin thanks to immune cells called macrophages

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Poison ivy is in the same family as mangoes, cashews, and pistachios—and they all produce oily urushiol in their raw, unprocessed state—but they are typically prepared in ways to avoid causing human discomfort.

Crows are believed to have intelligence on par with a seven-year-old child and demonstrate complex behaviors, from problem-solving with tools to recognizing human faces.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Fear or disgust related to clusters of holes and cracks, called trypophobia, may stem from evolutionary processes to help us avoid pathogens.

Coral reefs get their colors from zooxanthellae—microorganisms that line corals' digestive tracts and provide them with sugars in exchange for a home within this protective tissue.

Explore the history, structure, and species of Australia's Great Barrier Reef with this interactive journey narrated by Sir David Attenborough.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

SpongeBob exemplifies Aristotle's philosophy for living well because he understands that happiness doesn't come from external factors like money, recognition, or power.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

20,000 letters to the advice columnist 'Dear Abby' provide insight into prevailing sex, religion, and LGBTQ fears, anxieties, and concerns from the 1950s onward.

NBA superstar Victor Wembanyama spent the 2025 summer training with monks in central China to enhance his body and mind.

See how Budweiser's famous Clydesdales spend their days at Warm Springs Ranch, where roughly 70 to 80 of the beer brand's giant horses can be found at any given time.

Legendary architect Frank Lloyd Wright designed the SC Johnson headquarters in Wisconsin, aiming to make a cathedral-like workplace

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

'Silent' fireworks have gained more interest in recent years as a quieter celebratory option.