Interface device implanted into ALS patients restored some of their abilities

Brain-reading devices are helping paralyzed people to touch

In clinical trials, implanted brain-computer interfaces are allowing dozens of individuals with paralysis to control prosthetics that are restoring a range of skills, including drinking coffee and feeding oneself. One area of related prosthetic research is creating a synthetic sense of touch—coupling the brain implant with pressure sensors in prosthetic robotic fingertips to enable an approximation of a sense of touch.

Using AI to restore speech 30 years after a stroke

Through a novel surgical procedure involving electrodes implanted in the brain, along with the help of artificial intelligence, a stroke patient is regaining her ability to speak. This technology converts her thoughts into speech through a digital avatar, allowing her to verbally express herself for the first time in decades.

How ALS (Lou Gehrig’s Disease) might work, and what scientists are learning about it

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the nerve cells (neurons) controlling muscle movement. As the motor neurons degenerate, they stop sending signals to the muscles, causing progressive muscle weakness and, eventually, death. This three-minute animation focuses on the mechanisms within the motor neurons that cause them to degenerate. By understanding these mechanisms, researchers hope to one day find a cure for ALS.

The first neural devices were cochlear implants, designed to treat hearing loss

Neural interfaces connect with our nervous system to restore or enhance abilities, such as hearing or movement. These neuroprostheses have enabled the restoration of mobility, communication, and activities of daily living that might otherwise require a caregiver.

An essay exploring how living day-to-day with a brain implant helps restore a sense of identity

Companies like Neuralink are experimenting with volunteers who have lost control over their bodies. Many of the program's participants claim the most significant benefit from the tool is the ability to perform simple, mundane tasks, such as playing video games or shaking hands, rather than more obvious milestones like walking or eating. This essay explores what it's like, day to day, to use a brain implant.

Deep brain stimulation helps manage movement in patients with neurological disorders

DBS is a surgical procedure that uses implanted electrodes to send electrical signals to targeted areas in the brain, interrupting abnormal neural activity. It may be implemented when medications lose effectiveness or cause disruptive side effects.

Implanted neurotechnology can leave users vulnerable when manufacturers go under

Despite providing relief from neurological conditions, patients are left stranded when the companies that make these devices shut down. The lack of regulation means patients often face technical failure, insurance battles, or risky surgeries to maintain their quality of life.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

In a first, eye prosthesis has restored sight to macular generation patients

In a clinical trial, 27 of 32 participants with advanced macular degeneration regained enough vision to read books, food labels, and subway signs about a year after receiving a prosthetic retina device. This is the first device to restore functional vision to patients with incurable vision loss, though in this case they can only see in black and white, with no shades in between.

A man with organ failure used AI to speed discovery of his miracle drug

David Fajgenbaum had a few months to live after a diagnosis with a rare form of Castleman's disease. By studying his blood, medical records, and broader literature, he was able to identify the cause of his condition and a treatment. He's been in total relapse for ten years.

Remylination is a huge focus for treatment—especially among older adults

Our ability to build new myelin sheaths for nerves degrades with age. There have been research advances boosting cells that support these processes and clear away debris from degraded myelin, but not yet any medications to boost myelination itself, which would aid nerve signaling and preserve nerve function.

The man who turned his leg into a hotspot

Biohacker Michael Laufer recently had a 512GB drive implanted in his leg, which can store data, stream music or movies, and power a hot spot and mesh network. It's called the PegLeg, and WIRED's Daniel Oberhaus spoke with Laufer about the device and the field of biohacking.

Defying the odds, Stephen Hawking outlived his ALS diagnosis by over 50 years

When diagnosed with ALS, Stephen Hawking was given two years to live. However, he survived with the progressive neurodegenerative disease for over 50 years, highlighting the disease's variability and complexity.

The Armamentarium is a set of new gene therapy tools to fight brain diseases

Research from 29 universities and institutions across North America has resulted in the development of 1,000 tools that provide large-scale, cell-type specific targeting for the first time. These tools may be used to alter the activity of brain cells to address some neurological diseases and sleep disorders.

Prosthetics and orthotics have been 3D printed to improve the lives of animals

Shells for hermit crabs, wheelchairs for guinea pigs and dogs, and horseshoes for improved running performance have been created using 3D printers. Other artificial body parts made using this technology include a jaw for a loggerhead turtle, a beak for a toucan, and a tail for an American alligator.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

Misfired motor signals may explain why many people with schizophrenia hear voices

Up to 80% of schizophrenia patients may have auditory hallucinations. Recent research concluded that this symptom may be from misfired motor signals that feed into each other, essentially failing to suppress certain sensory neural activities and that resulting overexcitment fuels hallucinations. The finding suggests that, one day, magnetic pulses might be used to stimulate specific nerves to better regulate the errant signals and reduce or stop hallucinations. (Some users may encounter a paywall.)

The iron lung—a simple mechanical ventilator—was first used to treat polio

These breathing devices, developed in the late 1920s at Harvard, were used to treat polio patients with breathing difficulties. Watch this video describing how these negative pressure devices work.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Patient H.M. revealed that the hippocampus was responsible for memory formation

Henry Molaison became a landmark case in psychology after surgery removed large portions of his hippocampus, leaving him unable to form new memories. Upon his death, Molaison's brain was sliced into 2,401 sections and digitized for research.

Apple's latest invention

Apple may be working on a robotic smart lamp. Internally called ELEGNT, it's designed to respond to music, display emotion through movement, and even serve up reminders. A new research paper details how it could work—though Apple hasn't officially confirmed a release.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

Help scientists at LIGO train AI to resolve glitches in observational data

Volunteers are provided with visual representations of signal abnormalities at various frequencies and tasked with categorizing them based on reference examples. Progressing through the tool unlocks more difficult images and additional features. Categorized images will be used to train machine learning algorithms for automated future classification.

Large language models struggle to play video games, despite coding them easily

As of 2025, given clear tasks, specific feedback, and test results to learn from, LLMs have been successful at coding simple video games that resemble pre-existing ones. However, given the variety of games, the lack of training datasets, and the need for spatial awareness, which LLMs find challenging, some of these models experience greater difficulty navigating and "winning" games.

CAR-T is showing promise for treating lupus—previously thought to be incurable

A small number of lupus patients have remained in complete remission for years after undergoing an experimental CAR-T cell therapy that seems to eliminate enough B cells to fuel a "deep reset" of the immune system. CAR-T therapy is also being used experimentally to treat MS, myositis, and other autoimmune disorders. (Some users may experience a paywall.)

The Lazarus Effect is when a heart begins beating on its own after declared death

Formally called autoresuscitation, this rare phenomenon occurs when someone is declared dead following a cardiac arrest but their heart beats again without help—making it seem like the person came back to life. Doctors don't know the exact cause.

How Alzheimer's caregivers get pulled into their loved one's reality

Caregivers, most often children and spouses, do not just witness a family member's cognitive decline—they also often become drawn into it, navigating a world in which the typical rules of time, order, or logical continuity may not apply.

When people stopped using GLP-1, they regained two-thirds of the weight back

Research from 2022 found that when people stopped using the injectable form of the medication, they regained up to two-thirds of lost weight within a year. The finding suggests ongoing treatment will be required for weight loss.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Genetically modified viruses can help construct battery electrodes

MIT scientists' modifications caused the viruses to attract conductive materials, such as gold ions, which the viruses self-assembled into nanowires that could be used in batteries. These components allow batteries to be thinner and flexible enough to be constructed into new shapes.

A vending machine run with Anthropic's AI went out of business after it was convinced to give away items for free and sell a video game console.

Learn how monoclonal antibodies, which mimic the body's antibodies, can fight diseases like Ebola.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

When you complete a CAPTCHA on a website to prove you are human, you may be unknowingly training algorithms for self-driving cars, whose systems require training data to help identify crosswalks, bicycles, and other outdoor objects.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Electrical grids worldwide must double their power delivery capacity by 2050 to meet surging demand from AI and electric vehicles.

English mathematician Ada Lovelace wrote the first computer algorithm a century before computers existed and hypothesized that computing devices would one day be able to compose music—foreseeing the generative AI systems of today.

Fish populations in the Great Barrier Reef have increased after installing waterproof speakers on the ocean floor that played recordings of sounds from healthy coral reefs.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.

This real-time tracking of the hantavirus cruise ship outbreak in May 2026 offers a unique glimpse into the global reach of the outbreak and whether the virus sickened passengers and their communities around the world.

The American Society of Civil Engineers' infrastructure report card gave the US a C in 2025, its highest grade since the project launched in 1998.

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

See images of medical cases of firework injuries shared on this 'Instagram for doctors.' (Warning: Graphic content)

Planeterrellas create artificial auroras that mimic the atmospheric displays of light by setting up an electric field between two metal balls in a jar filled with a small amount of air.

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

In 1945, Surrealist artist Salvador Dalí and legendary animator Walt Disney began collaborating on a short film that was not completed until 2003, years after both men had died.