More than 200 drug trials for Alzheimer's have failed or been abandoned since 2010

Early-onset Alzheimer's can appear as early as age 30

Drugs recently approved to slow the progression of Alzheimer's appear to work best when administered as early as possible. Early stages are marked by a low buildup of tau, a protein experts believe clumps into misfolded, neuron-disrupting tangles once clusters of another protein—amyloid beta—have already started causing damage.

Scientists are reevaluating the causes of Alzheimer's beyond the amyloid hypothesis

The cause of Alzheimer's disease has been debated for decades. The amyloid cascade hypothesis—where plaques build up in the brain, triggering neurodegeneration—has long been the leading theory. But after a number of failed drug trials, researchers are beginning to reevaluate various culprits. [Untreated hearing loss is linked with dementia risk](https://www.thelancet.com/article/S0140-6736(20)30367-6/fulltext) Hearing loss does not cause dementia, but it does increase the risk of developing dementia and research suggests that people who wear hearing aids for age-related hearing loss also maintain better brain function than those who don't.

There are two FDA-approved blood tests that may detect early Alzheimer's disease

Yet the tests are only recommended for those who have symptoms of dementia, and are not definitive on their own. False positives are a concern with these new tests, which detect biomarkers that may indicate the presence of brain proteins linked to the disease. This podcast explores the state of research on the disease and concerns about regulators taking jobs at pharmaceutical and biotech companies, which may influence their approach to approvals. It also dives into an investigation about the data underpinning one experimental Alzheimer's drug.

How Alzheimer’s disease becomes fatal

Despite more than 100,000 people with Alzheimer's dying each year, the specific cause of death is not the disease itself. Often, secondary diseases arise from complications with the disease, including pneumonia, severe falls, malnutrition, or infection. Read more about the range of complications caused by Alzheimer’s here.

Does our fear of Alzheimer's create stigma around its treatment?

Surveys suggest our fear of Alzheimer's as a disease outranks that of heart disease and cancer. This piece argues our fear of aging and the slipping away of our mental capacities make it more difficult to treat Alzheimer's compassionately.

A top Alzheimer's researcher was accused of faking results

In 2021, an investigation revealed photo manipulation in images from a seminal 2006 paper by researcher Sylvain Lesné on the role of amyloid plaques in progressive Alzheimer's disease. The revelation rocked the field, leaving many wondering whether they had tried to build on fabricated results. (Some users may experience a paywall.)

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Chronic drug use can cause neurological changes in the brain

Neuroscientist Judy Grisel breaks down the biology of addiction, examining how drugs hijack the brain’s natural reward system and create lasting neural changes. The physiological and neurological impacts of chronic drug use require a multifaceted treatment approach.

There are more than 1,400 listed clinical trials for macular degeneration

The US database of clinical trials listed more than 1,400 macular degeneration trials in early 2026. That doesn't mean every trial is recruiting, but it does indicate there is significant interest in this medical condition.

DBS effectiveness in treating addiction remains uncertain amid inconsistent results

Critics argue that deep brain stimulation should be considered a last resort and not a scalable solution, given its high costs and trials limited to small samples. However, it has helped some patients manage severe opioid use disorder when conventional methods didn’t work.

Advanced drugs are closing in on cancer's deadliest mutations

The protein KRAS, mutated in many cancers, was deemed ‘undruggable’. Now scientists are hoping to save lives with a batch of new compounds that target it.

Companies developing new weight loss drugs

In recent years, weight loss drugs made a tremendous amount of money for Novo Nordisk and Eli Lilly. Other companies are developing new drugs to break into the market. This piece is a concise overview of companies creating and testing new drugs, how far along they are, and what Novo Nordisk and Eli Lilly are doing to compete with these emerging rivals.

It can take 10 to 15 years and more than $1B to develop a new antibiotic.

Why don't we just develop new antibiotics? In part, it's a complex scientific challenge, but market incentives also play a significant role. It can be time consuming, expensive, and most notably, we should use as little as possible to avoid driving further antibiotic resistance.

A new daily MS pill is seeking regulatory approval in 2026

In clinical trials, Roche's fenebrutinib showed promise treating primary progressive MS and doubling relapse-free time in patients with relapsing MS as compared to existing treatment. But some liver damage and two possible drug-related deaths in the trials may make it difficult for the drug to net approval. (Some users may encounter a paywall.)

Dementia caregiver training programs exist—but they aren't common

Comprehensive dementia care programs go beyond offering support to caregivers. They train people on how to modify their homes, communicate with their loved ones with dementia, and cope with the stress of caregiving, among other skills. Yet despite evidence showing their effectiveness and the economic benefit of avoiding unnecessary emergency room visits, these programs are often poorly funded and difficult to find.

How Alzheimer's disease affected one family as symptoms progressed

News program 60 Minutes interviewed a couple navigating aging and Alzheimer's over a 10-year period to illustrate the effects of the disease on their lives.

Antidepressants alone may fail to help an estimated one-third to one-half of depressed patients

There are three major categories of antidepressants—tricyclic antidepressants, monoamine oxidate inhibitors, and selective serotonin reuptake inhibitors. This podcast notes these first-line depression drugs are not effective for many patients and may also come with concerning side effects. Other therapeutic approaches—either in combination with medication or as an alternative—include therapy, meditation, and consistent exercise.

Timeline of cancer research milestones

While cancer remains incurable, there's been so much progress in its treatment over the last two decades. Nature provides an abridged history of milestones and major triumphs in cancer research and treatment. Start in the year 2000, and see how much has changed in the first quarter of the new millennium

Remylination is a huge focus for treatment—especially among older adults

Our ability to build new myelin sheaths for nerves degrades with age. There have been research advances boosting cells that support these processes and clear away debris from degraded myelin, but not yet any medications to boost myelination itself, which would aid nerve signaling and preserve nerve function.

How Western psychedelics research fell to the wayside

Psychedelics' modern era began when LSD was discovered in the 1930s. By the 1950s, clinical trials were underway. US user experimentation outside of medical settings (and high-profile violence, like the Manson murders) inspired negative attitudes toward psychedelics, leading to use restrictions that prohibited companies from patenting psychedelic compounds. This strangled psychedelics' profitability until the 1990s when the government loosened its grip and psychedelics research began seeing a resurgence.

Alcoholics Anonymous leads to increased abstinence compared with other treatments

That's according to a 2020 meta-review of 27 studies. This large analysis found that Alcoholics Anonymous had between 22 and 37 percent abstinence numbers as compared to other treatments that had figures of about 15 to 25 percent. AA was founded in 1935, in Ohio, and depends on peer connections and consistent meeting availability. (Some users may experience a paywall.)

See the evolution of Ebola vaccine and treatment development

The recently approved vaccine and treatments against Ebola are the result of many years of investments and have reshaped how the world addresses Ebola outbreaks. Four drugs were tested in the midst of the 2014 outbreak. Two proved to be so effective the clinical trial ended early. The vaccine proved effective during the 2018-2020 outbreak in the DRC.

Efforts to create disease-sniffing capabilities for phones still can't match dogs

In this video, a scientist explains why dogs remain leaders in olfactory capabilities, outpacing technology. Scientists have attempted to create artificial "e-noses" for phones to detect early signs of disease, but so far they have not been successful.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

The Armamentarium is a set of new gene therapy tools to fight brain diseases

Research from 29 universities and institutions across North America has resulted in the development of 1,000 tools that provide large-scale, cell-type specific targeting for the first time. These tools may be used to alter the activity of brain cells to address some neurological diseases and sleep disorders.

Autism research has faced significant cuts under Trump

One of the largest areas of halted research was at the Department of Education where its Institute of Education Sciences had studies underway focused on developing and evaluating school-based interventions for students with autism. DOE was significantly cut back as part of federal government layoffs.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

See the evolution of Ebola vaccine and treatment development.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

US intelligence allegedly pursued more than 600 schemes to assassinate Cuban revolutionary Fidel Castro.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

In 1945, Surrealist artist Salvador Dalí and legendary animator Walt Disney began collaborating on a short film that was not completed until 2003, years after both men had died.

Despite being favored by 87% of Americans, Congress does not have term limits.

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

Roughly 43 million US borrowers owe roughly $1.7T in student debt, the second-largest source of consumer debt behind mortgages.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

20,000 letters to the advice columnist 'Dear Abby' provide insight into prevailing sex, religion, and LGBTQ fears, anxieties, and concerns from the 1950s onward.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

A vending machine run with Anthropic's AI went out of business after it was convinced to give away items for free and sell a video game console.

Search a massive database of over 4 decades of clues from the TV quiz show 'Jeopardy!'

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

The most expensive ad of all time was for Chanel No. 5 perfume and cost roughly $33M to produce in 2004—about $57M in today's dollars.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

In 1984, Operation Smash Hit intentionally crashed a 239-ton train into a nuclear waste canister at 100 miles per hour to prove the canister's safety, which remained completely intact and lost just 0.29 of its 100 pounds of pressure.

Art theft is the third-largest source of criminal revenues worldwide, thanks in part to the subjective nature of valuing a work of art.

A 2019 Facebook event called on attendees to "Storm Area 51, They Can't Stop All of Us," resulting in countless memes, the creation of a music festival, and eventually the arrests of those who did try to approach the area.

Explore the known asteroids, comets, and spacecraft involved in asteroid studies within our solar system with 'Eyes on Asteroids,' a 3D visualization from NASA.