Read an account of what life was like in America's national leprosarium—its leper colony

America had a national leprosarium—a leper colony—in Louisiana until 1999

Public health officials forcibly sent those diagnosed with leprosy to the Louisiana Leper Home in Carville, first founded in 1894. Listen to an interview about this site, its evolution, and how its residents advocated for themselves—including regaining the right to vote.

Read excerpted accounts from some of the 8,000 residents with leprosy on Moloka'i

Accounts preserved by the Kalaupapa National Historical Park describe how residents felt about being sent to live in this remote location and knowing they would never be allowed to leave. In 2012, 20 residents with the disease continued to voluntarily live in the area.

Listen to what it was like living as a medieval leper

This podcast uses paleopathological and anthropological findings to reconstruct what it was like for people diagnosed with leprosy in medieval times on the Eurasian continent. If a town lacked a leprosarium—an isolated leper asylum or colony—or the suspected leper was a foreigner or a Jew, which would make them ineligible for leprosarium admission, they'd be expelled.

Leprosy bacteria replicate extremely slowly—only once every two weeks

Mycobacterium leprae has a long incubation period and a very slow replication rate, taking roughly 12 to 14 days to make a copy of itself and divide. In contrast, bacteria like E. coli can replicate in about 20 minutes in ideal conditions. Someone can be infected for years without experiencing any symptoms. This also makes the disease difficult to treat. This video describes the knowns—and unknowns—about this infectious bacterium.

Grosse Île, the quarantine island of the Port of Quebec

As tens of thousands of Irish emigrated to North America to escape the Great Famine in the mid-19th century, many port cities set up quarantine areas amid an epidemic of cholera. In Quebec City on the St. Lawrence River, one island became a mass graveyard where over 3,000 Irish immigrants died over a decade as they waited in quarantine. Listen to the history here.

What was life like as a slave in the US?

Over 2,500 former slaves were interviewed by writers and journalists in the late 1930s as part of the US Federal Writer's Project. The collection recorded images and firsthand verbal accounts of life as a slave, eight of which are highlighted in this article at the Library of Congress. See the humanity in each of these individuals with their firsthand accounts.

Explore what it's like Inside a patient isolation unit

Containing a contagious disease like Ebola requires strict protective measures. There are several specialized medical wards to contain deadly infectious diseases at hospitals across the U.S. Emory University has one such unit, where 4 patients were treated during the 2014 outbreak.

Explore what it's like inside a patient isolation unit, used in situations such as treating a patient or suspected patient with Ebola.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Camus contracted tuberculosis as a teenager

There was still little understanding of treatment for the disease at the time; for most people, a tuberculosis diagnosis was a death sentence. The 17-year-old Camus was quarantined in his uncle's house, where he grew into an avid reader. Scholars note that the experience would inform his later work, including his 1947 novel "The Plague."

The peer support movement may date back to 18th century France

At the Bicêtre Hospital, an asylum near Paris, Jean-Baptiste Pussin (who had previously been a patient but later led the hospital administration) tried to hire as many staff as possible from among recovered patients. Chief physician Philippe Pinel found these individuals to be kinder than other staff and "averse from active cruelty" which was common at the time. This approach allowed the facility to move away from shackling patients and other violent methods.

Explore the components of the linear particle accelerator at Los Alamos

Located at the site of bomb design and development for the Manhattan Project, LANSCE features an injector system for hydrogen ions, a series of tanks with alternating electric fields for proton acceleration, and an isotope production facility that creates radioisotopes for medical treatments.

Hear the story of a doctor who decided to flee Cuba with his family in 1963

In this StoryCorps conversation, Gustavo Mestas reflects on leaving the island with his family in 1963 and the difficult transition that followed—from treating patients in Cuba to picking tomatoes and cleaning motels while rebuilding a life in the US.

Read a firsthand account of a participant in the first Biosphere 2 mission

The first crew of “Biospherians” spent four months growing their own wheat and awaiting the ripening of tomatoes, onions, and peppers to make their own pizza. They also raised their own livestock, including chickens, pigs, and two goats named Milky Way and Stardust.

After being diagnosed with lupus, O'Connor moved to her family's Georgia farm

In 1950, O'Connor began feeling ill and returned to Georgia, where she was diagnosed with lupus, the same disease that killed her father when O'Connor was just 15. After the diagnosis, O'Connor and her mother moved to Andalusia, the family farm north of Milledgeville, Georgia.

Arlington National Cemetery was built on land seized from Robert E. Lee's family during the Civil War

Established in 1864 on a plantation once owned by Lee's wife, Arlington now spans 639 acres and is home to more than 400,000 veterans and their eligible dependents. The cemetery conducts as many as 27 funerals every weekday.

Leonard Knight built a folk art landmark in the California badlands

Slab City is an unofficial off-the-grid community on the site of a decommissioned Marine Corps base in the Southern California desert. Knight began constructing his enormous and colorful "Salvation Mountain" in 1984. In 2000, it was designated "a folk art site worthy of preservation and protection."

Before launching his cereal company, John Harvey Kellogg promoted natural food at a sanitarium

Kellogg was the director of the Battle Creek Sanitarium, a health resort in Michigan, where he served patients vegetarian dishes, including early experiments with meat substitutes. Kellogg espoused a philosophy of "Biologic Living," which suggested consuming natural food would lead to "racial hygiene" for white Americans, a tenet of the eugenics movement.

When America's deadliest serial killer went undetected

Samuel Little, who, for years, washed in and out of the justice system on violent charges eroded into lesser offenses, ultimately admitted to killing 93 people, mostly women, over more than 30 years. He tended to target those on the fringes of society—runaways, drug users, sex workers—people whose deaths were more likely to go unnoticed, he remarked, referring to them as fruits to be plucked at will.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

This Indiana medical school encouraged students to get to know their cadavers' families

The school's anatomy professor instructed medical students to think of the cadavers they worked with as their "first patients"—using their names to acknowledge that this was a person and to exchange letters with the cadaver's family members if they agreed to participate. At the conclusion of the course, families were invited to a lab-based memorial service.

Integration of Latino players in MLB

The Senators’ spectacular losing record obscures one of the most important stories in baseball history: the club’s role in integrating Latino players into the major leagues

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Interred Japanese Americans wrote satirical poetry

Senryu is a Japanese poetic form that is similar to the haiku, though its aim is often satirical and its composition is often collaborative. At California’s Tule Lake Segregation Center, interred citizens met to write senryu together, often composing verse that criticized their surroundings.

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

Loyola's 98-year-old team chaplain became a beloved figure during the 2018 tournament

Sister Jean became an international celebrity in 2018 when she cheered Loyola Chicago's Ramblers to the Final Four at age 98, inspiring bobbleheads and merchandise before passing away in October 2025 at 106.

People in certain states can now work remotely from prison

Prisoners in Maine can now use their laptops in their cells—not only for academic classes and homework, but also to work remotely for employers outside of the prison. One person in prison working as a software engineer was paid at least a six-figure salary.

Permanent staff at NPS dropped nearly a quarter in 2025

Despite record-level visitation in recent years, NPS staffing reductions have affected maintenance, scientific research, and search-and-rescue operations most acutely, functions visitors don't typically see. According to the NPCA, some visitor centers have reduced hours, lifeguard positions have gone unfilled, and rangers report covering multiple roles simultaneously.

Atari buried hundreds of thousands of video games in the New Mexico desert

The video game industry crashed in 1983, leaving the company with an enormous inventory. Looking to offload the excess, the company secretly had 800,000 cartridges buried in the desert in Alamogordo, New Mexico. For decades, the story was believed to be an urban legend, but documentary filmmakers pursued the story and, in 2014, unearthed the games.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

The Ramones' 'Pet Sematary,' the theme song for the Stephen King novel of the same name, was written while the band was admiring the writer's collection of horror memorabilia.

Hear about the 250-year history of the United States Postal Service, complete with some of its strangest deliveries, important innovations, and the figures that made it an American institution.

20,000 letters to the advice columnist 'Dear Abby' provide insight into prevailing sex, religion, and LGBTQ fears, anxieties, and concerns from the 1950s onward.

See the most iconic photos from four decades of LIFE magazine

Explore the archaeological treasures of Pompeii, the city buried under volcanic ash when Mount Vesuvius erupted in 79 CE.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

Apollo astronauts left items in the moon's 'toss zone,' including golf balls, family photos, and bags of human waste, to make room for lunar rocks.

During the French Revolution, a botanist's letter asking about "dear Rhus" (poison ivy) was intercepted, leading authorities to suspect he was conspiring with the Russians.

Legendary architect Frank Lloyd Wright designed the SC Johnson headquarters in Wisconsin, aiming to make a cathedral-like workplace

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Existentialist writer Jean-Paul Sartre coined the famous phrase 'Hell is—other people' in his play 'No Exit'

See how Budweiser's famous Clydesdales spend their days at Warm Springs Ranch, where roughly 70 to 80 of the beer brand's giant horses can be found at any given time.

44% of Americans say they pray at least once a day—discover how your state's religiosity stacks up against the rest of the country.

Learn how to read a prospectus, the juicy document that any company must file with the SEC before going public.

In 2019, a laptop loaded with six of the worst malware in history and described as 'an exhibit of historical weaponry' sold for $1.3M.