America had a national leprosarium—a leper colony—in Louisiana until 1999

Read an account of what life was like in America's national leprosarium—its leper colony

José Ramirez Jr. shares an account of his eight years at the 300-acre national leprosarium in Carville, Louisiana, from 1968 through the mid-1970s. Mostly staffed by nuns with nursing degrees, this facility was home to hundreds of people at a time, and it's also the site where they were required to be buried.

In 1865, Hawaii's king authorized forcible removal, quarantining of those with leprosy

King Kamehameha V authorized the removal of anyone with leprosy symptoms and for them to be placed in a medical facility later maintained by the Catholic Church on Moloka'i, Hawaii's fifth largest island. Patients weren't allowed to transfer to other medical facilities until 1969.

Up to 225 cases of leprosy in the US are diagnosed each year

Most cases in the US are imported, meaning someone was infected in a country where it was more common. Since symptoms can sometimes take decades to appear, tracing the origin of the disease can be hard.

Listen to what it was like living as a medieval leper

This podcast uses paleopathological and anthropological findings to reconstruct what it was like for people diagnosed with leprosy in medieval times on the Eurasian continent. If a town lacked a leprosarium—an isolated leper asylum or colony—or the suspected leper was a foreigner or a Jew, which would make them ineligible for leprosarium admission, they'd be expelled.

Louisiana has parishes instead of counties

Louisiana is the only US state that uses parishes rather than counties as its primary local government unit. The distinction traces back to the state's French and Spanish Catholic colonial heritage.

Watch how doctors examine leprosy patients for signs of vision impairment

Clinicians must screen for symptoms of eye and vision damage in leprosy patients, including loss of sensation, reduced blink reflex, and inability to close or keep the eyes closed.

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

Louisiana's 'Cancer Alley' has cancer rates 50% above the national average

Due to its proximity to Gulf oil production, an 85-mile stretch of highway linking Baton Rogue, Louisiana, and New Orleans is home to 25% of the country's petrochemical manufacturing. It's also one of the most polluted regions of the US, with cancer rates at 50% above average.

A French Army surgeon discovered that malaria is a parasitic disease in 1880—but scientists were initially skeptical

Charles Louis Alphonse Laveran won the Nobel Prize for his work "on the role played by protozoa" in causing diseases. His work included discovering and reporting the malaria-causing parasite in the blood of a patient suffering from malaria.

Grosse Île, the quarantine island of the Port of Quebec

As tens of thousands of Irish emigrated to North America to escape the Great Famine in the mid-19th century, many port cities set up quarantine areas amid an epidemic of cholera. In Quebec City on the St. Lawrence River, one island became a mass graveyard where over 3,000 Irish immigrants died over a decade as they waited in quarantine. Listen to the history here.

The peer support movement may date back to 18th century France

At the Bicêtre Hospital, an asylum near Paris, Jean-Baptiste Pussin (who had previously been a patient but later led the hospital administration) tried to hire as many staff as possible from among recovered patients. Chief physician Philippe Pinel found these individuals to be kinder than other staff and "averse from active cruelty" which was common at the time. This approach allowed the facility to move away from shackling patients and other violent methods.

Private education offered an alternative for Black Americans

The early public school system was ostensibly designed for all Americans, but it was also racially segregated, offering substandard schools for Black Americans. Some private schools were founded to combat that problem, including St. Frances Academy in Baltimore, the United States' oldest predominantly Black Catholic high school.

The most haunted locations in the US

This TimeOut guide presents some of the most notorious places in the United States, profiling the creepy histories of Eastern State Penitentiary in Philadelphia, the Waverly Hills Sanitorium in Louisville, Kentucky, and the lingering effects of the witch trials in Salem, Massachusetts.

The first recorded American Mardi Gras was in Alabama

French explorers observed celebrations in what would become the United States in the late 1600s, but the first recognized modern American Mardi Gras took place in Mobile, Alabama, on New Year's Eve, running from 1830 into 1831. By 1840, the town had incorporated costumes, masks, and themes into its parade. After the Civil War, Mobile's Mardi Gras was moved to the more traditional date of Fat Tuesday. By 1850, a group from Mobile migrated to New Orleans, bringing the city's traditions with it.

In 1939, baseball star Lou Gehrig delivered his 'Luckiest Man' speech after retiring due to a health condition

Gehrig's diagnosis of amyotrophic lateral sclerosis, a disease that now bears his name, forced him to retire early. Weeks later, he spoke with gratitude and stated, "For the past two weeks, you have been reading about a bad break. Yet today I consider myself the luckiest man on the face of the earth." Gehrig died at the age of 37, about two years later.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Gambling funded America's early expansion

In the colonial era, lotteries were viewed as a voluntary tax to help fund infrastructure and capital projects. The idea came from Europe, which had used lotteries dating back to the 16th century. The image below is from a Massachusetts lottery in 1758.

How the National Science Foundation helped cement the use of American Sign Language

Before the 1960s, deaf students were taught to read lips and pronounce words without signing, which was not considered a true language. After noticing that students nonetheless signed when communicating, American linguist William Stokoe conducted NSF-funded research that showed that signing met the definition of oral languages, thus establishing ASL.

Meriwether Lewis grew up in the same neighborhood as Jefferson

Hailing from Jefferson’s Albemarle County neighborhood in Virginia, Lewis was a trusted aide and former Army officer. After leading the Corps of Discovery, he became Louisiana Territory governor in 1806, dying three years later under mysterious circumstances.

What's the role of forced prison labor in a land where slavery is illegal?

Companies across the South profited off the forced labor of people in prison after the Civil War. This hourlong investigative podcast episode explores the role forced (and often unpaid) prison labor has played in the US since slavery was abolished.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

The Love Canal disaster exposed the dangers of buried toxic waste

In the late 1970s, residents of Niagara Falls, New York, discovered their neighborhood was built atop 20,000 tons of chemical waste. Leaking toxins caused illness and birth defects, sparking nationwide outrage and leading to the creation of the EPA's Superfund cleanup program in 1980.

Most Americans are now dying at home, reversing 20th century trends

For most of the 21st and 20th centuries most Americans died in hospital settings. But in 2016, home-based deaths overtook hospitals; most Americans are now dying at home, likely fueled by individual preferences to die at home or to receive at-home palliative care.

How Los Angeles got its palm trees

Los Angeles is known for its warm weather and palm trees, but the latter haven't always been part of the landscape. As Hollywood's movie industry grew, so did the number of palm trees. As this article points out, most of the city's palm trees were planted in the 1930s through an unemployment relief program.

The first glasshouse was constructed in 1931

The Maison de Verre in Paris was built to house a doctor's office on the ground level and an apartment upstairs. Unlike the typical model that would follow, this glass house exposed very little of the home's interior.

Explore what it's like inside a patient isolation unit, used in situations such as treating a patient or suspected patient with Ebola.

The 1965 Immigration and Nationality Act abolished national-origin quotas and transformed the demographics of America

Following decades of citizens pressing for reform, President Johnson signed legislation abolishing national-origin quotas, enabling increased immigration from Asia and Africa. The LBJ Presidential Library features photos, videos, audio clips, and text from the 1965 signing ceremony.

In the 1960s, Virginia became home to the first emergency department in the US

It was a 450-square-foot basement room with four stretchers staffed by four doctors inside Alexandria Hospital, in Alexandria, Virginia. Patients there were charged $5 per visit. The first emergency medicine residency followed in 1970, in Cincinnati.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

This real-time tracking of the hantavirus cruise ship outbreak in May 2026 offers a unique glimpse into the global reach of the outbreak and whether the virus sickened passengers and their communities around the world.

Hear about the 250-year history of the United States Postal Service, complete with some of its strangest deliveries, important innovations, and the figures that made it an American institution.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

20,000 letters to the advice columnist 'Dear Abby' provide insight into prevailing sex, religion, and LGBTQ fears, anxieties, and concerns from the 1950s onward.

During the French Revolution, a botanist's letter asking about "dear Rhus" (poison ivy) was intercepted, leading authorities to suspect he was conspiring with the Russians.

Despite being favored by 87% of Americans, Congress does not have term limits.

44% of Americans say they pray at least once a day—discover how your state's religiosity stacks up against the rest of the country.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

When a Paris department store hesitated to sell Estée Lauder's perfume, she 'accidentally' broke a bottle, causing the smell to spread throughout the store and shoppers to start asking to buy the scent.

See how Budweiser's famous Clydesdales spend their days at Warm Springs Ranch, where roughly 70 to 80 of the beer brand's giant horses can be found at any given time.

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

Explore an interactive map of battles from the American Revolution, along with detailed summaries of each engagement

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Apollo astronauts left items in the moon's 'toss zone,' including golf balls, family photos, and bags of human waste, to make room for lunar rocks.

In 2009, the nation was gripped by the story of a missing young boy who was believed to be floating over Colorado in a homemade balloon, until it was revealed that he was at home the whole time.

Legendary architect Frank Lloyd Wright designed the SC Johnson headquarters in Wisconsin, aiming to make a cathedral-like workplace