Polio is currently circulating in only two countries but it remains difficult to eradicate

Only one strain of wild poliovirus continues to infect humans

Three strains of polio used to regularly infect humans, but two of the strains were declared eradicated in 2015 and 2019, respectively. In 2019, world health leaders estimated complete polio eradication—if achieved—would save $14B by 2050.

See when the last case of wild poliovirus was found in each country

This chart shows when wild polio cases were last reported in each country worldwide. Beyond wild poliovirus, rare outbreaks can occur related to mutated strains of oral polio vaccine.

Most polio cases today are vaccine-derived rather than naturally occuring

Weakened, live virus vaccines—which aren't offered in the US—carry a risk of virus being shed in the stool. Rarely, the shed virus mutates and leads to vaccine-derived polio infections. Most recent polio cases are genetically linked to those vaccines. As shown in this graphic, there are typically hundreds of vaccine-derived polio cases annually.

Needle-free polio vaccines were offered in Afghanistan for the first time in 2026

Fear of needles has been one barrier to eradicating polio in Afghanistan. Vaccinators are now using a needle-free jet injector to deliver the vaccine through the skin—an approach that's previously been used in other locations. The inoculation includes the inactivated virus vaccine (the vaccine without any live virus in it).

See the polio cases that occur worldwide each year by region

Worldwide, the number of cases of polio reported each year from 1980 to 2024 has declined. This graphic depicts regional trends and declines by year.

Humans are the only known reservoir of poliovirus

The virus has not been found in any other species, which makes humans the only known reservoir for polio. In laboratory settings, nonhuman primates have also been infected with the virus, but there's no evidence that they contract the virus in nature.

Inactivated polio virus vaccine is the only one offered in the US—it contains no live virus

Inactivated polio virus vaccines cannot cause illness because the virus isn't alive. It's been the only polio inoculation offered in the United States since 2000 and provides almost complete protection

Polio commonly spreads when virus-laden feces gets into our mouths

This highly infectious disease is transmitted from one person to another, mainly when we eat virus-laden poop particles. Less frequently, contaminated food or water can transmit the virus, or people can be infected via respiratory droplets (from coughing or sneezing).

The COVID-19 pandemic led to a decrease in immunizations in the US and worldwide

Public health funds and resources that were diverted to COVID-19 response reduced efforts to combat polio and vaccinations for polio and other diseases declined during the pandemic, putting more people at risk for polio.

Approximately 70% of all polio infections in children are asymptomatic

Most polio infections are asymptomatic or appear with only flu-like symptoms. Infected individuals can still shed the virus in their stool and mucus for days or weeks

View this timeline of polio milestones and vaccine development

Polio has a long history in art and medicine, dating back centuries. It includes a representation of an apparent polio survivor with a shriveled leg in ancient Egyptian art. See milestones in the history of polio in this timeline.

Post-polio syndrome occurs decades after infection but isn't contagious

Affecting adults who contracted polio as children, this disorder can occur 15 to 40 years later, leading to slow, irreversible muscle weakening. Some research estimates that between 25% and 40% of polio survivors go on to develop this condition.

Variola: the second-deadliest virus on Earth

Because it was declared eradicated in 1980, many forget smallpox is one of history's deadliest diseases—in its final century, it's estimated to have claimed 500 million lives. This 11-minute video from production studio Kurzgesagt takes a look at...

A fake vaccine campaign was used to locate Osama bin Laden, fueling vaccine distrust

As part of the intelligence operation to find bin Laden in Pakistan, the US Central Intelligence Agency recruited a Pakistani doctor who ran a fake hepatitis B vaccine campaign and obtained DNA samples from bin Laden. News of this fake campaign fueled further distrust of healthcare workers, attacks on them, and stymied efforts to vaccinate against polio in the region.

Three Ebola species are responsible for most large outbreaks of the disease, yet the only approved Ebola vaccine is known to work against just one of them.

Malaria vaccines are not routine because they have limited effectiveness

Both of the currently recommended malaria vaccines have limited effectiveness, require multiple doses, and provide protection for only a short period of time. One, approved by the World Health Organization in 2021, is only about 30% effective, requires four doses, and protection fades within months. The other requires three shots, and some research indicates it is 75% effective for a year.

A look at the 2025 measles outbreak in West Texas and surrounding areas

A measles outbreak in the summer of 2025 ultimately led to more than 900 cases and the deaths of two young children. The highly contagious virus requires vaccination rates near 95% to achieve herd immunity—the Texas outbreak spread through areas of significant mistrust of vaccines, including the area’s Mennonite community.

We're in the middle of a decadeslong cholera pandemic

In 1961, the world's seventh recorded cholera pandemic started in South Asia, and it has continued through the decades. India and Bangladesh are at particular risk. This pandemic is driven partly by conflict, population displacement, extreme weather, and poor water infrastructure.

Iceland, the last mosquito-free country, detected them in 2025

Recently several of the mosquito species Culiseta annulata were documented in Iceland—the last country that had not yet seen them, underscoring that climate change is shifting the bugs' patterns. Mosquitoes can hide out in human structures to survive icy temperatures. The bugs are now known to live everywhere except the continent of Antarctica.

Foot-and-mouth disease, which affects animals, has been eradicated in many locations

The disease, which causes fevers and painful blistering in the mouth, muzzle, snout, teats, and feet—somewhat similar to hand, foot, and mouth disease in people—is transmitted via contact with infected animals or their fluids or eating infected foods or meat. Though it primarily affects cloven-hoofed animals, it's also been known to sicken camels and even elephants.

The 2026 Ebola outbreak is hampered by a lack of vaccine against the species of the virus, heightening the need for rapid tests to aid in disease control

Clinics in the Democratic Republic of Congo saw patients with Ebola symptoms months before the disease was identified. The identification lag was due to inadequate diagnostics that could not accurately or quickly identify the virus's myriad species. Contact tracing and better diagnostics will be required to tamp down the outbreak.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

California condors have been vaccinated against West Nile to protect their limited population

The condors became endangered in the 20th century primarily due to lead poisoning from consuming animals shot with lead bullet fragments inside them, so condors in captivity and in the wild are vaccinated against diseases including highly pathogenic avian flu and West Nile.

A podcast unpacking Pakistan’s political turmoil

Pakistan has been immersed in political crises for over 20 years. Despite being one of the world’s few nuclear powers, Pakistan’s internal instability has caused experts to question whether the country is, in fact, a failed state. Deep divisions...

Treating black fever can result in a complication that spreads the deadly disease

Black fever, a deadly parasitic disease second only to malaria, threatens more than 1 billion people across more than 83 countries. Also known as kala-azar or visceral leishmaniasis, the disease is caused by parasites that spread through sandfly...

The rare exoplanets orbiting distant pulsars

Pulsars are ridiculously volatile, massive, and super-dense. These objects are spread out around the universe, and their spinning magnetic fields blast out radioactive pulses. Rarely, some have planets orbiting them. There's not much hope for life there—pulsars emit regular deadly radiation—but they're still fascinating from a scientific perspective. This article further explores these amazing exoplanets.

86% of the world's 12,321 nuclear warheads are held by just two countries

As of early 2026, the US and Russia together control about 86% of the world's more than 12,000 nuclear warheads—over 9,600 in military stockpiles. None of the seven other nuclear nations holds more than 600.

The United States is one of only around two dozen countries with a fully federal system of government, in which power is divided between national and state governments.

One of the most famous portraits ever taken is 'Afghan Girl' (1984) by Steve McCurry, yet the subject Sharbat Gula went much of her life without being identified or benefitting from the image's success.

Lesser-known phobias include turophobia, or the fear of cheese, and nomophobia, the fear of being without your cell phone.

In 2026, Finland was named the world's happiest country for the ninth consecutive year based on its wealth, social safety network, and high life expectancy, among other factors.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

11 people died from firework injuries in the US in 2024.

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

In 2009, the nation was gripped by the story of a missing young boy who was believed to be floating over Colorado in a homemade balloon, until it was revealed that he was at home the whole time.

The Russia-Ukraine conflict is the largest ground war in Europe since World War II in terms of casualties, forces mobilized, and displacement of civilians.

Iran's Revolutionary Guard Corps is independent of Iran's regular army and is one of the most powerful and influential military-political organizations in the Middle East.

Take a 3D tour of the Hajj, Islam's annual pilgrimage to Mecca, undertaken by over 1.5 million Muslims.

Planarian flatworms are small, aquatic worms with exceptional regenerative capabilities. When cut, the worms can regenerate multiple bodies in a matter of weeks.

Electrical grids worldwide must double their power delivery capacity by 2050 to meet surging demand from AI and electric vehicles.

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

Pure water does not conduct electricity because this flow of energy requires the movement of charged particles, and water is a neutral molecule.

While El Niño moves warm Pacific Ocean waters east along the equator, La Niña moves them west, shifting where rainfall will become more common for months.

Volcanoes 'die' when their supply of magma runs out, if they are shifted away from their underlying magma reservoir, or if they get clogged by collapsing or their magma cooling back into rock.

Children are now three times more likely to say they want to be a YouTuber when they grow up than an astronaut, with some even attending 'YouTube camps' that teach kids how to create content for the platform.

The 1987 Nintendo video game 'Stadium Events' isn't known for being particularly fun, but its scarcity has made it a highly sought-after item that has sold for up to $35K at auction.