Foot-and-mouth disease, which affects animals, has been eradicated in many locations

The similarly named foot-and-mouth disease doesn't affect humans, unlike HFMD

Though the names are similar, foot-and-mouth disease—also known as hoof-and-mouth disease—exclusively affects animals, primarily those with hooves, such as cattle, sheep, pigs, goats, and even giraffes. It doesn't sicken humans, though both this disease and hand, foot, and mouth disease do come from the same family of viruses—Picornaviridae.

Hand, foot, and mouth disease spreads easily—including via fomites

The common ailment spreads through respiratory droplets, touching infected secretions like poop, but also by touching virus-laden fomites, which are contaminated objects such as doorknobs or toys.

There are more than 200,000 cases of HFMD annually, and there's no cure

The highly contagious disease is caused by several viruses and it primarily affects little kids. It causes red spots in and around the mouth, hands, feet, and even the buttocks. They often become painful water-filled blisters that can burst and cause small ulcers. Eating and drinking is uncomfortable for about a week so patients need to be careful not to become dehydrated.

Animal-to-human pathogens constitute 75% of emerging infectious diseases

Zoonotic diseases encompass more than 200 diseases transmitted from animals to humans, wherein humans are usually accidental hosts. Ranging from rabies to HIV to monkeypox, this overview lists some of the most common viral threats.

HFMD was first reported in 1957 in New Zealand

The first clinical report involved eight kids with the characteristic sores in New Zealand, and then in the years that followed there were dozens more cases there and also reports of outbreaks in England and Scotland, among other settings, including the US.

Horses can—rarely—get West Nile, too

The animals can contract the virus via infected mosquito bites, but for horses there are four vaccines available. Though West Nile's often asymptomatic or mild in horses, the disease can sometimes be deadly, killing via severe neurological inflammation. There are no reported instances of people becoming sickened by infected horses or vice-versa.

Watch how viruses like Ebola can spill over from animals to humans—and vice-versa.

Yes, many animals get malaria—not just humans

Birds, rodents, monkeys, lizards, bats, apes, and livestock are among the species that can become infected with malaria. Infected animals' symptoms often resemble those of humans, including fever, lethargy, loss of appetite and difficulty breathing. Birds will also have ruffled feathers and drooped heads.

'Sloth fever' is an emerging health threat, especially to pregnant women

This disease, caused by the Oropouche virus, is found in animals including sloths, primates, and birds. It primarily spreads through the bite of midges—insects commonly called "no-see-ums." It's endemic to the Amazon region, but US travelers are increasingly contracting it internationally.

The Chinese market for donkey hides has created a new source of diseases

Since 1992, China’s donkey population has dropped more than 80 percent. This report examines how China’s booming demand for a traditional medicine known as e-jiao, made from collagen from donkey hides, is leading to the slaughter of 6 million African donkeys annually, and providing a new source for zoonotic diseases.

Marburg virus, related to Ebola, is also extremely deadly

Discovered nine years before Ebola, Marburg is part of the same filovirus family. While this virus is less contagious, it can still be deadly. Currently, no vaccines exist against this disease. (Some users may encounter a paywall.)

Marburg virus, related to Ebola, is also extremely deadly, and has no available vaccine.

Zoo animals have developed allergies, too

Although scientists do not know if allergies manifest among wild animals—and if animals can survive with them—in a zoo setting, veterinarians have observed zoo animals with common allergy symptoms, including itchiness, crusty skin, and runny eyes. Veterinarians have identified Asian elephants with pollen allergies and at least one jaguar with an allergy to fleas.

People can—and have—contracted leprosy from armadillos

A 2011 study linked multiple human cases to the handling of armadillos or the consumption of their meat. The research couldn't document direct transmission, but did find that the animals and humans shared the same exact strain of the disease.

Bird Flu is spreading—what does that mean for us and other species?

The rapid global spread of H5N1 bird flu—from remote Antarctic islands to US farms—shows how animal spillover, driven by human activity and ecological disruption, is accelerating pandemic risk across species long before sustained human transmission begins.

Treating black fever can result in a complication that spreads the deadly disease

Black fever, a deadly parasitic disease second only to malaria, threatens more than 1 billion people across more than 83 countries. Also known as kala-azar or visceral leishmaniasis, the disease is caused by parasites that spread through sandfly...

Polio is currently circulating in only two countries but it remains difficult to eradicate

Wild polio virus is only endemic in two places. Afghanistan and Pakistan are the last two countries with naturally occurring polio cases. Vaccination campaigns have been plagued by misinformation, Taliban bans on vaccines, distrust of public health workers, and violence, including the killing of vaccinators.

Measles was declared eliminated in the US in 2000

Following a decades-long vaccination campaign, health officials declared victory over measles. This formal definition does not mean limited outbreaks no longer occur, but that ongoing endemic transmission for longer than 12 months has been prevented.

Some animals have little or no bacterial populations in their gut

Gut microbiomes are essential to human health, but many animals have a much smaller, transient, or even nonexistent microbiome. The discoveries have advanced our understanding of the evolution of the human microbiome.

Mycotoxins are toxic compounds produced by fungi—some show up in food

About a quarter of the world’s agricultural products are contaminated with mycotoxins. Some of these compounds can cause serious health problems, including cancer, so the US government has set up monitoring programs to detect them in our food and in animal feed. Humans can become ill if they eat contaminated food, but also if they ingest products from animals that had previously consumed these toxic compounds, such as milk from a cow that ate contaminated corn.

Human-to-human transmission of hantavirus remains extremely rare, so the 2026 hantavirus cruise ship outbreak doesn't mean we're facing a COVID-style pandemic risk.

Ebola species have historically been named after where they were discovered, stigmatizing residents who live there, including Bundibugyo, in Uganda.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

Watch wild elephants 'mourn' their dead

Wild elephants in Samburu National Reserve in northern Kenya visited their dead matriarch's body weeks after her death and displayed behaviors that researchers are hesitant to call "mourning" though they do believe the animals are displaying a specific reaction in response to the death. The video shows elephants using their trunks to touch and explore the carcass while standing in place for extended periods, which is uncommon for the animals.

Yellow fever sidelined more US troops than enemy fire during the Spanish-American War

The disease, transmitted by the Aedes aegypti mosquito, sickened more than 2,000 soldiers. Fewer than 400 American soldiers died in the 1898 war.

Georges Cuvier used his knowledge of anatomy to prove extinction had occurred

Extinction had been viewed as impossible because a divine plan for the world would not rationally involve the loss of any of God’s creations. However, mammoth and mastodon bones differed from elephants’, and it seemed impossible that such creatures could be hiding elsewhere on Earth.

Ringworm is caused by a fungus, not a worm

Ringworm, formally known as tinea and known for its red circular rash, is responsible for about 325 million infections at any given time—comprising roughly half the world’s fungal skin infection burden. It’s caused by a type of fungus called a dermatophyte, which also causes athlete’s foot and jock itch. Doctors typically prescribe antifungal tablets or powders to stamp out these fungal invaders.

Cow tongue was once a Thanksgiving delicacy

Cow feet and tongue were sometimes included in mincemeat pies—a popular 18th-century dish. Josefa Hale, who inspired Lincoln to declare Thanksgiving a holiday, said they were “indispensable; but [hoped] this rich, expensive, and exceedingly unhealthy diet will be used very sparingly...”

'Shoofly pie' was named after a molasses named after a mule named after a song

Although most people assumed the sweet dessert earned its name for its ability to attract flies, etymologists believe it can be traced back to a molasses brand named after a boxing mule (Shoofly the mule), who was named after a song ("Shoofly Don't Bother Me") that was a play on slang of the time.

Inside the world's largest two-headed calf collection

The Two-Headed Calf MOOseum in San Francisco contains 50 taxidermied cow heads, all of which are paired with another one. They are the result of rare genetic mutations called polycephaly, that is, two-headedness. The museum is run by punk musician Henry Rosenthal, who first became captivated by the rare phenomenon in his 20s. Learn more about the exhibit here.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Poison ivy is in the same family as mangoes, cashews, and pistachios—and they all produce oily urushiol in their raw, unprocessed state—but they are typically prepared in ways to avoid causing human discomfort.

Lesser-known phobias include turophobia, or the fear of cheese, and nomophobia, the fear of being without your cell phone.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

See how Budweiser's famous Clydesdales spend their days at Warm Springs Ranch, where roughly 70 to 80 of the beer brand's giant horses can be found at any given time.

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

See images of medical cases of firework injuries shared on this 'Instagram for doctors.' (Warning: Graphic content)

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

Famed poet TS Eliot rejected the manuscript for George Orwell's political fable 'Animal Farm,' writing that its criticism of authoritarianism was not 'the right point of view.'

Coral polyps reproduce via broadcast spawning, where entire reefs simultaneously release reproductive cells for about one hour, once a year.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

One of the most famous portraits ever taken is 'Afghan Girl' (1984) by Steve McCurry, yet the subject Sharbat Gula went much of her life without being identified or benefitting from the image's success.

The distributor behind 'Rocky Horror' pulled the film from its scheduled national release, believing it would be a failure, though it eventually amassed a dedicated fanbase through midnight showings, a trend that continues over 50 years later.

While El Niño moves warm Pacific Ocean waters east along the equator, La Niña moves them west, shifting where rainfall will become more common for months.

The US first hosted the World Cup in 1994, a tournament that lives in soccer infamy for its poor planning and the murder of Colombian player Andres Escobar, who'd accidentally scored on his own net.

NBA superstar Victor Wembanyama spent the 2025 summer training with monks in central China to enhance his body and mind.

In 2026, Finland was named the world's happiest country for the ninth consecutive year based on its wealth, social safety network, and high life expectancy, among other factors.