There are more than 200,000 cases of HFMD annually, and there's no cure

Although rare, HFMD can spreads in pools due to poor bathroom hygiene

In pools with inadequate levels of chlorine, this disease can spread via the poop-to-mouth route, though this isn't one of the most common ways the disease is transmitted. People can become infected by swallowing contaminated pool water after little kids (or their parents) don't do an adequate job removing virus-laden feces from the child before the child enters the water.

In 2012, a virus that causes HFMD may have killed dozens of kids in Asia

More than 50 young children in Cambodia died in spring 2012 for unknown reasons, but laboratory testing of samples available from a limited number of those children came back positive for Enterovirus 71. That virus, which can cause HFMD, is known to cause severe complications among some people who contract the disease. But health officials concluded that poor baseline health and then incorrect treatment using steroids helped exacerbate their condition, helping lead to the deaths.

Adults usually have some immunity to HFM Disease—but can still spread it

In 2025, certain eastern states including Virginia and West Virginia reported a sizable uptick in their HFMD cases, particularly in their schools and daycare centers, though the reason for the larger outbreaks remains unknown. When adults or teens get the disease, their symptoms are usually mild or even asymptomatic. Still, they may pass the disease between people, too. (Some users may encounter a paywall.)

CDC does not require docs to report hand, foot, and mouth cases which makes tracking difficult

Mid-Atlantic states saw a surge of hand, foot, and mouth disease in 2025 for as-yet unknown reasons. Virginia, Maryland, and New Jersey, reported elevated outbreak numbers in 2025 as compared to other recent years, but since the US Centers for Disease Control and Prevention does not require mandatory reporting of positive HFMD cases—unlike strictly notifiable diseases like measles—it's hard to truly know the extent of the outbreaks and how significant the caseload is as compared to prior years across the region or country.

At least 7 eastern college campuses experienced surprisingly large HFMD outbreaks in 2018

The outbreaks at the college level caused a particularly nasty set of symptoms, including the usual blisters in the mouth and on the hands and feet—but also affected the genitals. They surprised health officials who weren't sure why so many young adults were being sickened, including more than 120 kids at Johns Hopkins University. The disease also caused outbreaks at campuses including Princeton, Dartmouth, West Virginia University, Lehigh University, Wesleyan University in Connecticut, and Mars Hill University in North Carolina.

HFMD was first reported in 1957 in New Zealand

The first clinical report involved eight kids with the characteristic sores in New Zealand, and then in the years that followed there were dozens more cases there and also reports of outbreaks in England and Scotland, among other settings, including the US.

HFMD symptoms typically begin to show up 3-6 days after exposure

Fever is often the first symptom and then painful sores may develop a day or two later. Coxsackie A16 is currently the most common enterovirus that leads to the disease, though there are several other enteroviruses that can cause it as well.

Hand, foot, and mouth is usually seasonal—peaking in summer—but not always

This painful, contagious disease most commonly has outbreaks in summer and early fall in the US because the enteroviruses that cause disease can most readily survive and be transmitted in warmer, humid conditions. It can still show up throughout the year, however.

See Virginia's spike in HFMD cases in 2025

The state's own tracking showed a significant jump in HFMD cases in July 2025 as compared to the prior few years, and that more people were visiting the emergency room and urgent care centers for the disease, but epidemiologists could not explain why the numbers were so high.

'Tomato flu' outbreak in India turned out to be HFMD

An illness initially dubbed "tomato flu" in 2022 that sickened children in Kerala, India, with symptoms typical of hand, foot, and mouth disease turned out to be that—not a new ailment. A letter published in the prestigious journal The Lancet had initially described the illness as "a new virus" but at least some of the children ultimately tested positive for one of the viruses that causes HFMD, so it wasn't a new condition after all. (Some users may encounter a paywall.)

HFMD can survive on surfaces for days at a time

That's why the virus can be transmitted via fomites—surfaces that have virus on them like doorknobs, kids toys, etc. These viruses are resilient—they are often even resistant to freezing (and are frequently stored at freezing temperatures in lab settings).

The similarly named foot-and-mouth disease doesn't affect humans, unlike HFMD

Though the names are similar, foot-and-mouth disease—also known as hoof-and-mouth disease—exclusively affects animals, primarily those with hooves, such as cattle, sheep, pigs, goats, and even giraffes. It doesn't sicken humans, though both this disease and hand, foot, and mouth disease do come from the same family of viruses—Picornaviridae.

See the differences between chickenpox and hand, foot, and mouth

This helpful explainer breaks down the differences between these two contagious, viral diseases, which both present with fevers and sores. It includes photos of the sores that are characteristic of both diseases, showing how they have appeared across different skin tones to better inform people looking for information about their own loved one's symptoms.

Herpangina is a related disease that also has characteristic sores in the mouth and throat

This painful condition is also caused by several viruses in the enterovirus family. The condition typically has early symptoms including a fever and sore throat, in addition to the sores. Herpangina is often mistaken for strep throat, but there's no cure for herpangina and patients typically have symptoms for about a week.

Dengue is sometimes called 'breakbone fever' because it's so painful

Though this mosquito-transmitted disease can be asymptomatic, in more severe cases patients experience high fever, muscle spasms, and joint pain. The experience can be so excruciating that it feels like the patient's bones are broken, thus the nickname of breakbone fever. It's the world's fastest spreading tropical disease.

1 in 6 Americans get food poisoning each year

The US federal government estimates there are about 48 million cases of foodborne illness in the country annually, resulting in as many as 3,000 deaths and 128,000 hospitalizations. Food poisoning puts those with weakened immune systems, the elderly, pregnant people, and young children at particularly high risk. This chart of common disease-causing pathogens highlights common threats and details about them, including likely food sources.

The flu is a contagious respiratory illness caused by influenza viruses

Unlike the common cold, influenza attacks suddenly with fever, body aches, and fatigue. Seasonal strains circulate worldwide, infecting up to a billion people each year and causing hundreds of thousands of deaths despite vaccines and treatments.

Measles attacks the body’s immune system, leaving it vulnerable to secondary complications

A measles infection begins in the lungs, where it hijacks cells known as macrophages and begins to replicate itself. It then uses a Trojan horse method to enter the lymph nodes, where it attacks vulnerable T and B cells. Symptoms include fever and rashes.

Erythema migrans rash is common in Lyme—but it often doesn't look like a bull's-eye

The US Centers for Disease Control and Prevention states that this rash occurs in roughly 70% or more of Lyme disease patients, and typically occurs at the site of a tick bite. The rash may expand slowly over several days and feel warm to the touch, but it's rarely itchy or painful. As it grows, areas of it may clear—creating a target or "bull's-eye" appearance.

Marburg virus, related to Ebola, is also extremely deadly, and has no available vaccine.

Penicillin ended scarlet fever’s deadly threat to children

Between 1840 and 1883, scarlet fever was among the leading causes of childhood death in the United States, with case fatality rates ranging from 15% to 30%. Today, thanks to antibiotics like penicillin, the mortality rate is below 1%.

Candida auris spreads easily in healthcare facilities and causes high death rates

This fungus has spread rapidly in healthcare settings since the first US case was reported in 2016, and it has grown increasingly resistant to echinocandins, the antifungal medicine most commonly used to treat it. Often, it’s resistant to multiple antifungal drugs, contributing to its high death toll. It can most readily infect those with invasive medical devices like intravenous catheters and those with frequent or long-duration stays in healthcare facilities.

This real-time tracking of the hantavirus cruise ship outbreak in May 2026 offers a unique glimpse into the global reach of the outbreak and whether the virus sickened passengers and their communities around the world.

Ringworm is caused by a fungus, not a worm

Ringworm, formally known as tinea and known for its red circular rash, is responsible for about 325 million infections at any given time—comprising roughly half the world’s fungal skin infection burden. It’s caused by a type of fungus called a dermatophyte, which also causes athlete’s foot and jock itch. Doctors typically prescribe antifungal tablets or powders to stamp out these fungal invaders.

There's no cure for Ménière's disease, only medications to reduce frequency of attacks

Ménière's disease is an inner ear problem that can cause vertigo and hearing loss. Most of the time, Ménière's disease affects only one ear.

What exactly are hiccups?

If you don’t know a surefire cure for hiccups, it’s not really a surprise—while there are some known facts about this funny affliction, a surprising amount remains a mystery. Doctors believe that a round of hiccups usually either comes from...

Breaking down various tongue disorders, from infections to genetics

Taste is one of our fundamental senses, but can be impeded by a wide variety of conditions including glossitis, angioedema, and black hairy tongue. Most are characterized by their color, shape, and sometimes change in function. Causes range from vitamin or mineral deficiencies to fluid accumulation, fungal infection, or more.

Firework or sparkler burns, even if they cover a relatively small area of skin, can significantly affect our range of motion.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Poison ivy's characteristic rash is caused by an allergic response to an oily compound in the plant called urushiol.

About 12.5% of US adults experience a phobia in their lifetime, a diagnosis that hinges on the intense fear interfering with daily life and persisting for at least six months.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

Mid-century modern graphic designers, known for their bright colors and bold lines in advertising, also found success with children's books.

Planarian flatworms are small, aquatic worms with exceptional regenerative capabilities. When cut, the worms can regenerate multiple bodies in a matter of weeks.

All rainbows are 'raincircles' caused by water droplets separating white sunlight into a spectrum of colors, but Earth's surface blocks the bottom half of the circle from our line of sight.

Coral reefs get their colors from zooxanthellae—microorganisms that line corals' digestive tracts and provide them with sugars in exchange for a home within this protective tissue.

Fast-casual restaurant Chili's is experiencing a resurgence, with its parent company recently reporting a nearly 32% increase in sales, thanks to passionate Gen Z fans on TikTok.

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

Pure water does not conduct electricity because this flow of energy requires the movement of charged particles, and water is a neutral molecule.

Hedge funds, the private investment firms that trade a wide swath of financial assets, make money by imposing steep fees on investors and from the fund's investment performance.

The 1987 Nintendo video game 'Stadium Events' isn't known for being particularly fun, but its scarcity has made it a highly sought-after item that has sold for up to $35K at auction.

In 2009, the nation was gripped by the story of a missing young boy who was believed to be floating over Colorado in a homemade balloon, until it was revealed that he was at home the whole time.

Volcanoes 'die' when their supply of magma runs out, if they are shifted away from their underlying magma reservoir, or if they get clogged by collapsing or their magma cooling back into rock.

The United States is one of only around two dozen countries with a fully federal system of government, in which power is divided between national and state governments.

For centuries, Niagara Falls has been a magnet for daredevils seeking to conquer one of nature's most powerful wonders, with its 200-foot drop and water rushing at 32 feet per second with 280 tons of force.

While El Niño moves warm Pacific Ocean waters east along the equator, La Niña moves them west, shifting where rainfall will become more common for months.

The original copy of the Declaration of Independence is not a pristine document, and even features a smudged anonymous handprint in the bottom left corner.