CDC does not require docs to report hand, foot, and mouth cases which makes tracking difficult

See Virginia's spike in HFMD cases in 2025

The state's own tracking showed a significant jump in HFMD cases in July 2025 as compared to the prior few years, and that more people were visiting the emergency room and urgent care centers for the disease, but epidemiologists could not explain why the numbers were so high.

Adults usually have some immunity to HFM Disease—but can still spread it

In 2025, certain eastern states including Virginia and West Virginia reported a sizable uptick in their HFMD cases, particularly in their schools and daycare centers, though the reason for the larger outbreaks remains unknown. When adults or teens get the disease, their symptoms are usually mild or even asymptomatic. Still, they may pass the disease between people, too. (Some users may encounter a paywall.)

Environmental conditions, shifting immunity, and viral strain could help explain 2025 spike

The surge in HFMD in the summer and early fall of 2025 in the mid-Atlantic could be the result of a confluence of factors, including a more virulent strain of disease-causing virus, good environmental conditions for the virus to spread—hot, humd—and a potential immunity gap among kids due to milder HFMD outbreaks the previous year.

Hand, foot, and mouth is usually seasonal—peaking in summer—but not always

This painful, contagious disease most commonly has outbreaks in summer and early fall in the US because the enteroviruses that cause disease can most readily survive and be transmitted in warmer, humid conditions. It can still show up throughout the year, however.

There are more than 200,000 cases of HFMD annually, and there's no cure

The highly contagious disease is caused by several viruses and it primarily affects little kids. It causes red spots in and around the mouth, hands, feet, and even the buttocks. They often become painful water-filled blisters that can burst and cause small ulcers. Eating and drinking is uncomfortable for about a week so patients need to be careful not to become dehydrated.

HFMD was first reported in 1957 in New Zealand

The first clinical report involved eight kids with the characteristic sores in New Zealand, and then in the years that followed there were dozens more cases there and also reports of outbreaks in England and Scotland, among other settings, including the US.

At least 7 eastern college campuses experienced surprisingly large HFMD outbreaks in 2018

The outbreaks at the college level caused a particularly nasty set of symptoms, including the usual blisters in the mouth and on the hands and feet—but also affected the genitals. They surprised health officials who weren't sure why so many young adults were being sickened, including more than 120 kids at Johns Hopkins University. The disease also caused outbreaks at campuses including Princeton, Dartmouth, West Virginia University, Lehigh University, Wesleyan University in Connecticut, and Mars Hill University in North Carolina.

Current US measles outbreak data from the CDC

This data portal from the Centers for Disease Control and Prevention tracks current cases, hospitalizations, and deaths from measles. A 2025 outbreak in Texas and New Mexico drove US cases to their highest levels since the early 1990s.

Hand, foot, and mouth disease spreads easily—including via fomites

The common ailment spreads through respiratory droplets, touching infected secretions like poop, but also by touching virus-laden fomites, which are contaminated objects such as doorknobs or toys.

In 2012, a virus that causes HFMD may have killed dozens of kids in Asia

More than 50 young children in Cambodia died in spring 2012 for unknown reasons, but laboratory testing of samples available from a limited number of those children came back positive for Enterovirus 71. That virus, which can cause HFMD, is known to cause severe complications among some people who contract the disease. But health officials concluded that poor baseline health and then incorrect treatment using steroids helped exacerbate their condition, helping lead to the deaths.

10 locally acquired malaria cases were reported in the US in 2023—a surprise

The cases, reported in Florida, Texas, Maryland, and Arkansas, broke a 20-year streak since there had been no reported locally acquired mosquito-transmitted malaria in the country since 2003, when there was a case in Florida.

'Tomato flu' outbreak in India turned out to be HFMD

An illness initially dubbed "tomato flu" in 2022 that sickened children in Kerala, India, with symptoms typical of hand, foot, and mouth disease turned out to be that—not a new ailment. A letter published in the prestigious journal The Lancet had initially described the illness as "a new virus" but at least some of the children ultimately tested positive for one of the viruses that causes HFMD, so it wasn't a new condition after all. (Some users may encounter a paywall.)

See MS prevalence by region in the United States

This map underscores that people in the northeastern United States have more cases of the disease as compared to the south, west, and midwest. On an individual level, these numbers may still differ based on genetic makeup and other factors irrespective of where people live.

There were more than 20 reported cruise ship outbreaks in 2025

A cruise ship outbreak is officially considered an outbreak when 3% or more of the people aboard a ship report being sick with gastrointestinal illness. It happens often enough that the US Centers for Disease Control and Prevention has a whole program just related to tracking such foodborne illness outbreaks.

This real-time tracking of the hantavirus cruise ship outbreak in May 2026 offers a unique glimpse into the global reach of the outbreak and whether the virus sickened passengers and their communities around the world.

Find out how prevalent the flu is at this current moment

Updated weekly, this USAFacts resource shares current data from the CDC detailing how many cases of influenza and other flu-like illnesses accounted for doctor's visits. Monitor the spread of respiratory illness during flu season with this handy resource and prepare accordingly.

Search Lyme disease incidence in your county

The searchable database at the bottom of this webpage allows users to check the reported incidence of Lyme disease in US counties and Canadian health regions. In 2022, for example, Baltimore County in Maryland had a rate of about 34 probable and confirmed cases per 100,000 people. Arlington, County in Virginia was less than half of that for the same time period.

A heatmap showing the drop in infectious diseases post-vaccine deployment

The number of infected people, measured over 70-some years and across all 50 states and the District of Columbia, declined significantly after vaccines were introduced.

See when the last case of wild poliovirus was found in each country

This chart shows when wild polio cases were last reported in each country worldwide. Beyond wild poliovirus, rare outbreaks can occur related to mutated strains of oral polio vaccine.

The 2026 Ebola outbreak is hampered by a lack of vaccine against the species of the virus, heightening the need for rapid tests to aid in disease control

Clinics in the Democratic Republic of Congo saw patients with Ebola symptoms months before the disease was identified. The identification lag was due to inadequate diagnostics that could not accurately or quickly identify the virus's myriad species. Contact tracing and better diagnostics will be required to tamp down the outbreak.

The 2026 Ebola outbreak is hampered by a lack of vaccine against the species of the virus, heightening the need for rapid tests to aid in disease control.

Maryland required cholera researchers to fly a yellow warning flag—signifying quarantine dangers in the 1970s

University of Maryland Hospital researchers intentionally infected volunteers with the cholera bacterium in the late 1970s to further their understanding of the disease. They proceeded with this work following the recommendation of a US government panel. (Some users may encounter a paywall.)

Leprosy symptoms may appear 20 years after infection, so contact tracing isn't possible

The standard approach for tracking disease transmission isn't realistic for this disease because symptoms may take decades to manifest. As a result, disease transmission is still not fully understood.

Reporting food poisoning aids in limiting outbreaks

If you suspect you were sickened by meat or poultry or by other food products (or your pet was sickened), the US has different voluntary online reporting forms and hotlines you can call. There’s even one for concerns about potentially contaminated pet food products. If you were potentially sickened at a restaurant, however, you report that directly to state and local health departments, not the federal government.

Fungal diseases cost the US around $19B annually

Estimates derived from health insurance claims, death certificates, and hospitalization data suggest that fungus is a significant medical issue. Each year, fungal diseases kill some 7,300 people—roughly the same number of deaths attributed to motor vehicles striking pedestrians. Around 130,000 people are hospitalized with fungal diseases, and the total national cost from fungal diseases is estimated to be about $19B—a figure that roughly matches Jamaica's entire gross domestic product.

In the 19th century, ice-cream-related illnesses were somewhat regular in America

Ice cream was a popular dessert, but it was also a dangerous one, with numerous reports of vomiting, diarrhea, and—in some cases—death. Historians argue this was likely due to vendors' poor hygienic practices.

Penicillin ended scarlet fever’s deadly threat to children

Between 1840 and 1883, scarlet fever was among the leading causes of childhood death in the United States, with case fatality rates ranging from 15% to 30%. Today, thanks to antibiotics like penicillin, the mortality rate is below 1%.

Fireworks-related ER visits are on the rise—in 2024, they increased by 52% as compared to the prior year.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Between 10 million and 50 million people in the US develop rashes from poison ivy, poison sumac, and poison oak each year.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

An investigation suggests a Scottish island became awash in forever chemicals via seafoam and seaspray—raising questions about what that means for the safety of other coastal areas.

Some researchers have labeled nomophobia, the fear of being without your phone, as 'the phobia of the 21st century.'

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

The American Society of Civil Engineers' infrastructure report card gave the US a C in 2025, its highest grade since the project launched in 1998.

The original copy of the Declaration of Independence is not a pristine document, and even features a smudged anonymous handprint in the bottom left corner.

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

View the ten deadliest tornadoes in US history.

The United States is one of only around two dozen countries with a fully federal system of government, in which power is divided between national and state governments.

Up to a million Girl Scouts sell about 200 million cookie boxes every spring, generating $800 million, largely because refusing a child is frowned upon

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

Many legends about George Washington, including his supposed wooden teeth and the story of cutting down the cherry tree, lack evidence.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Mid-century modern graphic designers, known for their bright colors and bold lines in advertising, also found success with children's books.

20,000 letters to the advice columnist 'Dear Abby' provide insight into prevailing sex, religion, and LGBTQ fears, anxieties, and concerns from the 1950s onward.

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

'Saturday Night Fever,' the 1977 film that introduced disco to the mainstream, was based on a fabricated magazine story.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

While El Niño moves warm Pacific Ocean waters east along the equator, La Niña moves them west, shifting where rainfall will become more common for months.