Variola: the second-deadliest virus on Earth

Marburg virus, related to Ebola, is also extremely deadly

Discovered nine years before Ebola, Marburg is part of the same filovirus family. While this virus is less contagious, it can still be deadly. Currently, no vaccines exist against this disease. (Some users may encounter a paywall.)

Only one strain of wild poliovirus continues to infect humans

Three strains of polio used to regularly infect humans, but two of the strains were declared eradicated in 2015 and 2019, respectively. In 2019, world health leaders estimated complete polio eradication—if achieved—would save $14B by 2050.

Marburg virus, related to Ebola, is also extremely deadly, and has no available vaccine.

Vector-borne diseases kill more than 700,000 people globally each year—and are growing

The diseases with the greatest potential to spread widely aren't the ones that quickly kill human hosts. Instead, the best hosts or reservoirs for vector-borne diseases would be chronically ill over the long term, increasing the likelihood that the pathogen could be transmitted to others.

Live virus vaccines predated polio—that's how we vaccinate against smallpox

Since 1796, smallpox vaccines have used a live poxvirus related to smallpox. Yellow fever vaccines have used a live weakened form of the virus responsible for yellow fever since 1937.

Since 1600, the longest stretch without an outbreak that killed 10,000 was four years

We think of pandemics as unlikely events, but disease outbreaks are surprisingly common. Over the past 400 years, the longest stretch without an outbreak that killed at least 10,000 people was just four years. The next pandemic can't be precisely known, so experts and policymakers focus on preparation.

The measles vaccine has saved an estimated 94 million lives since its introduction

Measles killed an estimated 2.6 million people globally in 1980, after the development of a vaccine but before its widespread dissemination. By 2014, that figure had dropped to an estimated 73,000.

Diphtheria was once a leading childhood killer before antibiotics and vaccines

In 18th- and 19th-century outbreaks, some New England families lost as many as eight children to diphtheria, and fatality rates in hospitals often topped 60%. The invention of antitoxins, penicillin, and vaccines dramatically reduced deaths.

Explore 3D models of some of the most dangerous viruses

Everyone has come in contact with common viruses—typically something like influenza (the common flu)—but sometimes they encounter more dangerous strains. While we're familiar with the symptoms that manifest, it wasn't until the advent of advanced microscopy that scientists could pin down the exact structure and behavior of various viruses.

What if we killed every mosquito on Earth?

Mosquitoes aren't just annoying, they're deadly. they're also responsible for an estimated 725,000 deaths worldwide, every year. Would it be so bad if we found a way to wipe them out completely? Real scientists have gamed out this hypothetical scenario, concluding it actually wouldn't be that bad. This five-minute video breaks down one way this could happen.

Watch how viruses like Ebola can spill over from animals to humans—and vice-versa.

Measles reached global transmission during the 15th- and 16th-century Columbian exchange

Devastating diseases like smallpox, influenza, measles, and other viruses were largely introduced into the Western Hemisphere beginning with the 1492 arrival of Christopher Columbus and the ensuing age of exploration.

How the 1918 pandemic spurred developments in virology and vaccines

This article provides an in-depth historical account of the 1918 Spanish Flu pandemic, including its impact on the global population and how its occurrence spurred significant advancements in the study of viruses—laying the groundwork for the...

Every virus is classified into 7 groups based on genetic differences

Viruses infecting humans have been named based on symptoms ("chickenpox") or the location or animal in which they were first discovered ("Bolivian Haemorrhagic Fever" and "Monkeypox"). For clarity among scientists and to reduce stigma, virologists classify the 15,000 known viruses (270 of which infect humans) by their basic genetic material.

Explore demonstrations of hundreds of viruses and other malware in action

On their YouTube channel, Malware historian Daniel White has documented what happens when various types of malware—mostly from the 1980s and 90s—run on a computer or Nokia cell phone. The demonstrations were safely conducted within virtual machines—older operating systems run within contained windows of modern software, resembling a picture-in-picture setup.

View the 10 biggest volcanic eruptions in recorded history

The Mount Tambora eruption in 1815 was the deadliest and released so much sun-blocking ash and gas that 1816 became known as “the year without summer.” The resulting global food shortages are estimated to have killed over 71,000 people.

The bubonic plague spread in three waves over 600 years

The Black Death refers to the first wave of the plague, which swept through Europe in the 14th century and killed 25 to 50 million people. Caused by the bacterium Yersinia pestis carried by fleas (often on rats), the human toll was roughly one-third of Europe's population at the time.

Influenza infects up to a billion people worldwide each year

The World Health Organization estimates that seasonal influenza causes about 1B cases annually, including 3 to 5M severe illnesses and between 290,000 to 650,000 deaths.

See how cholera spreads in a community

This animated video offers a comprehensive look at how cholera spreads. It makes clear why it's so difficult to stamp out this disease in communities around the world. It also details what steps can help control cholera.

'Our greatest responsibility is to be good ancestors.'

- Polio vaccine developer Jonas Salk (1914–1995)

How do vaccines work? Watch this brief 101

Watch this under-3-minute video explaining how vaccines use the body's immune system to prepare our bodies against viral and bacterial threats to our health.

The HPV vaccine reduces cervical cancer rates by 90% or more

Cervical cancer is the fourth most common cancer in women globally. Almost all cases (99%) are linked to infection with high-risk human papillomaviruses. However, cervical cancer is both treatable and preventable—and we may be able to prevent most cases through vaccination.

See the differences between chickenpox and hand, foot, and mouth

This helpful explainer breaks down the differences between these two contagious, viral diseases, which both present with fevers and sores. It includes photos of the sores that are characteristic of both diseases, showing how they have appeared across different skin tones to better inform people looking for information about their own loved one's symptoms.

Foot-and-mouth disease, which affects animals, has been eradicated in many locations

The disease, which causes fevers and painful blistering in the mouth, muzzle, snout, teats, and feet—somewhat similar to hand, foot, and mouth disease in people—is transmitted via contact with infected animals or their fluids or eating infected foods or meat. Though it primarily affects cloven-hoofed animals, it's also been known to sicken camels and even elephants.

One in 10 adults worldwide has diabetes

As of 2021, diabetes claimed at least 6.7 million lives and continues to kill one person every five seconds. Nearly one in two adults with diabetes don't know they have the condition, which is expected to increase in prevalence from 537 million in 2021, to 783 million in 2045.

How many people died in WWII?

Fallen.io, a short animated data-driven documentary about war and peace, explores the harrowing statistics of World War II and sizes up its numbers to other wars in history, including recent conflicts. Watch and click through this interactive documentary to learn more.

How the most famous Ebola book, The Hot Zone, which sold 3.5 million copies and was translated into 30 languages, got aspects of the disease so wrong.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

There have been five mass extinction events in Earth’s history

Each extinction event has resulted in the loss of at least 70% of Earth’s species at the time of the event, often due to significant changes in global temperatures. The most recent event occurred 66 million years ago and wiped out all non-avian dinosaurs.

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

View the ten deadliest tornadoes in US history.

This real-time tracking of the hantavirus cruise ship outbreak in May 2026 offers a unique glimpse into the global reach of the outbreak and whether the virus sickened passengers and their communities around the world.

The deadliest aspect of volcanic eruptions is often not lava, but pyroclastic flows—avalanches of ash, gas, and rock that can move more than half the speed of sound.

In 2019, a laptop loaded with six of the worst malware in history and described as 'an exhibit of historical weaponry' sold for $1.3M.

After NASA's Voyager 1 captured Earth as a single pixel as it left the solar system in 1990, astronomer Carl Sagan used the image to reflect on humanity's fragility and the responsibility to protect 'the only world we've ever known.'

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

The Russia-Ukraine conflict is the largest ground war in Europe since World War II in casualties, forces mobilized, and displacement of civilians.

Urushiol, the oily toxin in poison ivy, can remain allergenic on clothing for years.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

See images of medical cases of firework injuries shared on this 'Instagram for doctors.' (Warning: Graphic content)

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Lesser-known phobias include turophobia, or the fear of cheese, and nomophobia, the fear of being without your cell phone.

The Mona Lisa's celebrity status and repeated restorations have obscured what made the painting so revolutionary for its time

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Explore fun facts from the USPS, including unique post office buildings, a stamp that traveled past Pluto, and more.

Watch contemporary footage covering the US-backed Shah of Iran fleeing the country in the face of the 1979 Iranian Revolution

The boiling temperature of water decreases with increasing elevation because the molecules need less energy to overcome the lower atmospheric pressure associated with thinner air.

The most expensive ad of all time was for Chanel No. 5 perfume and cost roughly $33M to produce in 2004—about $57M in today's dollars.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.