Psychedelic drugs are having a scientific renaissance

How Western psychedelics research fell to the wayside

Psychedelics' modern era began when LSD was discovered in the 1930s. By the 1950s, clinical trials were underway. US user experimentation outside of medical settings (and high-profile violence, like the Manson murders) inspired negative attitudes toward psychedelics, leading to use restrictions that prohibited companies from patenting psychedelic compounds. This strangled psychedelics' profitability until the 1990s when the government loosened its grip and psychedelics research began seeing a resurgence.

Psychedelic side effects, including worsening mental health for some patients, give pause

This article explores whether the therapeutic potential of psychedelic drug use is really as good as current research suggests. Scientists are exploring its applications for conditions ranging from the existential crisis that can accompany terminal diagnoses to chronic mental health conditions, including anxiety and PTSD.

How psychedelics can potentially reinvent learning

Critical periods, discovered in the early 20th century, describe a period when someone is incredibly sensitive to their environment, and any information learned can stick with them for life. Some researchers argue these states can be "reopened" via psychedelics, which put the mind into a malleable state that can potentially be used to treat conditions ranging from lazy eyes to PTSD.

LSD fueled a countercultural movement before evolving into a potential therapeutic

As the use of recreational psychedelics became common, authorities were quick to claim LSD had lasting adverse effects, criminalizing the drug and halting scientific study for decades. Over time, LSD's reputation shifted from a potential source of enlightenment to a dangerous drug that could dim a person's future, and back to a possible therapeutic compound.

The commercial and therapeutic potential of psychedelics

A 2006 study into the potential therapeutic benefits of psychedelics sparked a renewed interest in the field of psychedelic research, a development that has cascaded into commercialized ventures and experiences. This article details how growing research into the psychological benefits of psychedelics is matched by the rise of anecdotal reports, book deals, businesses, and corporate claims seeking to capitalize on psychedelic potential.

Researchers recently took an unprecedented look at the neural effects of psychedelics

According to analysis published in 2026 that looked at more than 500 brain scans pooled from 267 people who took psychedelics, the drugs increase connectivity between different brain regions within minutes of taking them, including transmodal networks (tied to thinking) and unimodal networks (involved in visual and sensory perception).

Psychedelics are being fast-tracked for research after a 2026 executive order

Many such compounds (including LSD, psilocybin, and more) are classified as Schedule I drugs—illegal to possess and federally regarded as having no medical use. Researchers say such restrictions have created significant hurdles for formal clinical trials. With this executive order, the FDA will enable work particularly focused on depression, PTSD, and alcohol use disorder.

Psychedelics interact with neurotransmitter systems to alter one's perception

LSD, psilocybin, and MDMA can suppress the brain's default mode network and enhance connectivity. Research shows that, when paired with therapy, psychedelics may help treat mental health conditions, including depression, addiction, and PTSD.

The neurobiology of meaningfulness: the benefits of psychedelics

Psychedelics produce powerful emotions in its users, including a profound sense of meaningfulness. The philosopher William James called this sense "noetic" in the late 19th century, but for decades researchers avoided studying the effects of such drugs on the brain. However, the recent resurgence in psychedelic research has heightened interest in the relationship between this noetic sense resulting from the therapeutic use of drugs. Learn what researchers have found out here.

Studies of psychedelic use may help shed light on the nature of consciousness

The nature of consciousness—what it is, where it comes from, and how it manifests as moment-to-moment experience—remains under debate by scientists. Recent studies show psychedelics were found to boost low-frequency brain signals known as delta waves, a behavior also seen during dream states.

Physiological changes to the brain on LSD can be captured via MRI

Psychedelics like LSD often take users on novel experiences that can result in lasting shifts in perspective and behavior. See how LSD affects brain activity in this video that details how scientists visually captured the psychedelic's effect for the first time.

Widespread use of LSD sparked a counter-cultural artistic movement in the 1960s

The trippy visuals often associated with LSD flourished in the 1960s as the drug became more widespread. Psychedelic design, defined by its undulating text and graphics, ultimately grew beyond just visuals, spawning psychedelia, a term that includes art, music, and cultural experiences based on psychedelic experiences.

LSD-like drugs may inspire new antidepressants

LSD and psilocybin have shown promise as antidepressants. Using a virtual library of similar chemical compounds, researchers determined via animal studies that two molecules inspired by LSD have antidepressant effects without any associated hallucinogenic experience. These molecules were found to be 40 times more potent than the common antidepressant fluoxetine, also known as Prozac, with antidepressant effects lasting up to 21 days.

An overview of modern clinical research on LSD

Researchers have determined that LSD, taken in a medical setting, decreases anxiety related to "life-threatening disease," reduces brain reactivity to fearful faces, increases the meaning and emotional response derived from music, and more. No complications of LSD administration have been observed in medical settings, though acute adverse effects, including exhaustion, nausea, and difficulty concentrating.

People with schizophrenia are excluded from psychedelic research

Individuals with this mental health condition are routinely eliminated from any psychedelic research due to concerns about triggering or worsening psychosis. Yet there is little high-quality research in this area, raising questions about if further research into this question is warranted as interest grows in using psychedelics for therapeutic purposes.

How to avoid a 'bad trip' advice includes relaxing your mind if you experience scary things and not fighting the feeling

In this video, Michael Pollan, author of "This Is Your Mind On Plants," underscores the gaps in existing understanding about the substances and recommends only taking guided experiences, for safety and help. He tackles how psychedelics work, explains microdosing and psychedelic risks, how the substances could be used to treat addiction, and the history of psychedelic stigma.

Psychedelic compounds: a visual library

However psychedelic experiences manifest, they all begin with the presence of psychoactive compounds. Learn about their various chemical compositions in this structural library of psychedelic compounds. Clicking on an entry will take readers to a new page where they can learn about the chemistry and pharmacology of each compound, as well as the drug's possible applications.

Are psychedelics legal in your state?

The answer is usually more complicated than a simple yes or no. This resource includes a state-by-state and international breakdown of current psychedelics legislation and reform. As of November 2023, psychedelics are fully illegal in 18 states, though there still may be religious or medical exemptions depending on the drug in question. Legislation reform and decriminalization efforts are ongoing.

The psychedelic playlist inspired by a Johns Hopkins experiment

Dating back to 1967, the playlist is over seven hours long and organized in such a manner as to echo users’ experiences as their trips rise, crest, and fall. According to the initial creator of the playlist, the music is a “nonverbal support system” that keeps users from prematurely returning to normal consciousness.

Accounts of near-death experiences share similarities with hallucinogens

This short film explores human experiences of dying, blending personal reflections with scientific insight. It aims to illuminate the emotional, psychological, and physiological aspects of that final transition, and draws out similarities of psychedlic drug use and accounts of near-death experiences.

How a dose of MDMA transformed a white supremacist

A man leading a faction of the US white nationalist movement took part in a psychedelic trial on the pleasantness of social touch and came away from it with his beliefs reportedly upended. He left researchers a note on a form, stating, "this experience has helped me sort out a debilitating personal issue. Google my name. I now know what I need to do."

American medical organizations rescind recognition of diagnosis cited in police custody deaths

American medical organizations have rescinded their recognition of a syndrome whose theory stemmed from discredited research. This article explores the history and implications of "excited delirium syndrome," a medical condition that can reportedly...

The science behind ghosts, explored

Every culture has them—restless spirits, haunted houses, things that go bump in the night. But why do we believe in ghosts? Psychologist and skeptic Dr. Chris French joins host Sony Kassam to explore the science behind the supernatural, from sleep paralysis and hallucinations to the brain’s pattern-making instincts.

'1440 Explores,' Episode 2: Why We Drink and What It Does to US

Alcohol is the world's most popular drug—a molecule that can calm or excite and bond communities or tear them apart. We trace alcohol's journey from ancient rituals to modern hangovers, uncover how it shaped civilizations, and dive into the neuroscience of how it affects your brain and body. With insights from leading experts, we ask: Given all that we know, why do humans continue to drink?

The fantasy-based tabletop role-playing game 'Dungeons and Dragons' has seen a renaissance in the last few years

It's becoming mainstream after being relegated to the dorks for decades. LinkedIn cofounder Reid Hoffman has contemplated the role the game played in his own formation as a person and a business leader.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Fish populations in the Great Barrier Reef have increased after installing waterproof speakers on the ocean floor that played recordings of sounds from healthy coral reefs.

Learn how your body is, scientifically, like a firework with its own slow, controlled burn.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Fast-casual restaurant Chili's is experiencing a resurgence, with its parent company recently reporting a nearly 32% increase in sales, thanks to passionate Gen Z fans on TikTok.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

See the evolution of Ebola vaccine and treatment development.

Hear 50 years of iconic hip-hop samples, the genre's foundational looped tracks

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

The Mona Lisa's celebrity status and repeated restorations have obscured what made the painting so revolutionary for its time

The distributor behind 'Rocky Horror' pulled the film from its scheduled national release, believing it would be a failure, though it eventually amassed a dedicated fanbase through midnight showings, a trend that continues over 50 years later.

A 2019 Facebook event called on attendees to "Storm Area 51, They Can't Stop All of Us," resulting in countless memes, the creation of a music festival, and eventually the arrests of those who did try to approach the area.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

Jimmy Carter signed a 1978 bill that legalized home brewing, a move credited with kick-starting the craft beer industry.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

The name 'Silicon Valley' arose from the founding of Shockley Semiconductor Laboratory in Fairchild Semiconductor in 1956-57, founded near Stanford University in Palo Alto