Physiological changes to the brain on LSD can be captured via MRI

Researchers recently took an unprecedented look at the neural effects of psychedelics

According to analysis published in 2026 that looked at more than 500 brain scans pooled from 267 people who took psychedelics, the drugs increase connectivity between different brain regions within minutes of taking them, including transmodal networks (tied to thinking) and unimodal networks (involved in visual and sensory perception).

Only a fraction of LSD reaches the brain, but it concentrates in key regions

When taken, LSD is absorbed quickly (often within an hour of ingestion) and exerts its effects primarily by binding to serotonin receptors. While only a small amount enters the brain, it's active in regions controlling the visual and auditory senses, potentially driving its psychedelic effects. The drug doesn't linger in the body, and is typically undetectable within a day.

Psychedelics set off a flurry of brain activity that may permanently alter it

The brain seems to experience a sharp increase in communication between areas that generally don't interact. New research suggests a thin, sheet-like gray matter structure tucked deep within the brain, between the insular cortex and striatum, may be the key to this change. The area is centrally located and home to many of the receptors that psychedelics target, potentially rewiring the brain and rewriting thought patterns.

Psychedelic drugs are having a scientific renaissance

After decades of repression, psychedelic research is making a resurgence. Hear from a host of experts in this 20-minute video on what that could mean for the future of mental health. The current science on psychedelics believes LSD can cause a particular brain network to quiet or deactivate.

How four types of psychedelics affect the brain

Brain imaging shows that ayahuasca, MDMA, DMT, and psilocybin profoundly affect neural activity, giving rise to higher states of introspection and consciousness. This article details exactly how each of these drugs physically affects the brain and what that means for mental health treatment. Some of these drugs quiet the brain or trigger the release of neurochemicals associated with mood regulation and learning.

An overview of modern clinical research on LSD

Researchers have determined that LSD, taken in a medical setting, decreases anxiety related to "life-threatening disease," reduces brain reactivity to fearful faces, increases the meaning and emotional response derived from music, and more. No complications of LSD administration have been observed in medical settings, though acute adverse effects, including exhaustion, nausea, and difficulty concentrating.

How can octopuses and MDMA help scientists understand the human brain?

Research shows that psychedelics may induce something called "critical periods" in the adult brain, which can make our brains more open to learning and changing, like they once were back in early childhood. Psychedelics similarly change how social creatures like octopuses behave, which demonstrates that these animals could help us better understand our own neurobiology.

Studies of psychedelic use may help shed light on the nature of consciousness

The nature of consciousness—what it is, where it comes from, and how it manifests as moment-to-moment experience—remains under debate by scientists. Recent studies show psychedelics were found to boost low-frequency brain signals known as delta waves, a behavior also seen during dream states.

Widespread use of LSD sparked a counter-cultural artistic movement in the 1960s

The trippy visuals often associated with LSD flourished in the 1960s as the drug became more widespread. Psychedelic design, defined by its undulating text and graphics, ultimately grew beyond just visuals, spawning psychedelia, a term that includes art, music, and cultural experiences based on psychedelic experiences.

LSD was discovered accidentally after its inventor touched his face and hallucinated

Unlike many drugs, the first time a human ever tripped on acid was recorded first-hand by a scientist. Swiss chemist Albert Hofmann, curious about the "not unpleasant intoxicated-like condition" that overcame him after an accidental exposure, set up a rigorous experiment to test the drug's effects on himself.

This is the human brain on the world's strongest psychedelic

Within seconds of inhaling a high dose of vaporized synthetic 5-MeO-DMT—a lab-produced substance that otherwise is naturally derived from the glands of the Colorado River toad—it induced slow brain waves. Such waves are typically associated with unconsciousness due to a coma or anesthesia, perhaps explaining why users describe feeling like everything falls away. The compound is currently in clinical trials for treating depression.

How to make LSD

Lysergic acid diethylamide, often shortened to LSD, comes from ergot, a parasitic fungus that can be found in grains. Chemists rearrange the fungus' chemical structure or the structure of an ergot derivative through complex chemical reactions, transforming it into the hallucinogenic bicycle-shaped LSD crystal. Due to the partially synthetic drug's criminalization, many of the details of modern LSD crafting honed by "underground chemists" are kept secret.

Psychedelic compounds: a visual library

However psychedelic experiences manifest, they all begin with the presence of psychoactive compounds. Learn about their various chemical compositions in this structural library of psychedelic compounds. Clicking on an entry will take readers to a new page where they can learn about the chemistry and pharmacology of each compound, as well as the drug's possible applications.

An LSD scientist's role in a US mind control project

Within a decade of LSD's discovery, the US government had launched a secret initiative involving hypnosis and hallucinogens. LSD researcher Louis Jolyon West conducted experiments for the CIA's MKUltra project, which focused on the potential of mind control. He later took part in a criminal trial that hinged on testimony whose sourcing was seemingly inspired by MKUltra experiments. This article explores light shed by West's personal archive.

The evolution of dream science—from interpretation to advanced brain imaging

In the mid-1900s, dream scientists would tape study participants' eyes open, wait for them to fall asleep, and attempt to influence their dreams by shaking, tickling, and more. Now, advanced techniques like MRIs have shed new light on what’s happening in the brain as we sleep.

Chronic drug use can cause neurological changes in the brain

Neuroscientist Judy Grisel breaks down the biology of addiction, examining how drugs hijack the brain’s natural reward system and create lasting neural changes. The physiological and neurological impacts of chronic drug use require a multifaceted treatment approach.

Can brain scans help with processing trauma?

MRIs and brain monitoring therapies are becoming increasingly popular for those looking to process trauma and address mental health conditions, including PTSD and depression. This article details how these therapies quantify mental health, giving users another way to measure and manage their mental and emotional needs through brain mapping and other methods.

Can music alter your memories?

You’re familiar with music’s ability to transport you to a past experience, but new research suggests that music can even alter how you remember your past experiences. A team of psychology researchers and music experts recently published a study that demonstrates how music can help shift our emotional recollection of a memory. Read to learn more about the study’s findings and how it could influence therapy practices.

A brain scientist's experience with a stroke

What happens when a leading brain scientist has a stroke of her own? Dr. Jill Bolte Taylor recounts moment by moment watching her brain function slow and then cease, followed by a prolonged recovery. Through this experience, she details what she learned about the phenomenon of stroke and how it has impacted her research ever since.

In 1970, Pittsburgh's Dock Ellis threw a no-hitter on LSD

It was the 174th no-hitter in MLB history, but the only one where the pitcher claimed to be high at the time. This animated video uses Ellis’ own comments from a 2008 NPR interview where he described why he took LSD that morning and the difficulty of pitching while tripping.

Like fingerprints, brain anatomy is unique too

Researchers have discovered that a combination of experiences and genetic factors shape the anatomy of the human brain. They found even quick experiences affect the brain’s genetic makeup, which—over time—means every person develops a completely unique brain anatomy. While brain imaging could be used to identify individuals, it remains much more expensive than fingerprinting for now. Read to found out more about this study from the University of Zurich.

Sharp wave ripples in the brain tag experiences for long-term memory storage

These ripples were known to quickly replay neuronal sequences during sleep for consolidation. While awake, they help the brain prioritize memories to remember, and their disruption can impair memory formation.

Visualizing a synaesthetic soundscape

Artist Michal Levy has chromesthesia, a subtype of synesthesia in which sounds and music trigger involuntary associations with and sensations of color. This condition gives Levy a unique artistic perspective and ability to interact with and interpret music. In this short animation, Levy tries to capture her audiovisual experience of 'Giant Steps," considered a landmark composition in jazz history by musician John Coltrane.

The science of optical illusions

The human brain has developed cognitive shortcuts to help us navigate in a world where our visual senses are constantly bombarded of information. But these shortcuts can also be exploited, tricking the brain into telling us something is happening when it really isn't. This short video unpacks the neuroscience behind some of the most common (but perplexing) optical illusions.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

The overview effect is a cognitive shift experienced when viewing Earth from space

Astronauts regularly report profound realizations after seeing Earth from space for the first time, sometimes prompting significant philosophical changes, including a greater awareness of the interconnectedness and fragility of life.

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

See the most iconic photos from four decades of LIFE magazine

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Objects can be 3D printed with light by projecting 2D computerized tomography (CT) scans onto rotating cylinders of resin, which solidify upon exposure.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

Fish populations in the Great Barrier Reef have increased after installing waterproof speakers on the ocean floor that played recordings of sounds from healthy coral reefs.

See how fireworks are made and learn how metals like magnesium and copper are responsible for different colors.

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

Hear 50 years of iconic hip-hop samples, the genre's foundational looped tracks

Scientists can determine Earth's past climate conditions by analyzing air trapped in microscopic bubbles within ice cores—columns of compressed snow layers that build up over hundreds of thousands of years.

Explore the known asteroids, comets, and spacecraft involved in asteroid studies within our solar system with 'Eyes on Asteroids,' a 3D visualization from NASA.

The first horror movie is believed to be George Méliès' 1986 short 'The Haunted Castle,' which pioneered the use of special effects

A 2019 Facebook event called on attendees to "Storm Area 51, They Can't Stop All of Us," resulting in countless memes, the creation of a music festival, and eventually the arrests of those who did try to approach the area.

See the evolution of Ebola vaccine and treatment development.

An initial public offering or 'IPO' is the process of a private company becoming public by putting shares of the company on the stock market for purchase.

Graffiti dates back to at least ancient Pompeii, where citizens scrawled messages to one another on public walls

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

This poison ivy knowledge quiz—accompanied by photos of the plant's varied forms—may help you identify this common rash-inducing growth.

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

The deadliest aspect of volcanic eruptions is often not lava, but pyroclastic flows—avalanches of ash, gas, and rock that can move more than half the speed of sound.