Explore the biology of pain and why the experience of pain may differ widely from one person to another.

Learn about the point of the physical and emotional experience of pain, which has three broad categories that help determine treatment approaches.

Theories vary on why we love to eat spicy food—even when it hurts.

The science of fear

The Hidden Brain podcast team explores the science of fear by traveling to a haunted house curated by a scientist to investigate what scares us, and why some people enjoy this sensation more than others.

Watch what depression does to the brain

This video explores the neurobiology of depression and why unraveling the complexities of this disease and its etiology will potentially improve treatments. Effective depression treatment, as this video highlights, can eventually make a depressed brain look like a healthy one on brain scans.

We hear because soundwaves are converted into electrochemical signals in our ears

This science teacher video systematically walks through the biology of the outer, middle, and inner ear. The explanation starts with the auricle, an external part that funnels sound through the auditory canal, and the tympanic membrane (the ear drum), which vibrates when sounds hit it. Beyond that, as the video details, is the eustachian tube, which is connected to the back of our throats and allows air to pass in and out to equalize ear pressure.

Researchers have investigated the benefits of extreme pain rituals, exploring how and why we engage in these events when humans generally naturally avoid pain and perceive it as a negative experience.

The subjectivity of pain means that one person's kidney stones may be another's childbirth, but most sources of pain do have objective, underlying causes.

Explaining the physical connection between the gut and brain

This video overview from Duke University helps visualize the gut-brain axis—a physical connection of nerves running from the brain to digestive tract that acts as a physical and chemical link.

The brains of people who experience frisson have unique neural pathways

A small 2016 study aimed to investigate the behavioral and neural differences between 10 individuals who experience goose bumps when listening to music and 10 who typically don’t. Scientists reported that individuals experiencing musical chills had greater white matter connectivity in specific auditory, emotional, and social processing areas of the brain.

How brain cells carry information

At any moment, there is an electrical storm coursing through your body. Discover how chemical reactions create an electric current that drives our responses to everything from hot pans to a mother’s caress.

The neuroscience of heartbreak

An analysis of functional MRIs revealed a difficult fact: the active brain areas of people experiencing heartbreak were very similar to those actively in love. This is a major reason why people in the middle of rejection can't accept the reality of their loss. This article breaks down the various changes in neurotransmitters and neural pathways for those enduring that universal experience, heartbreak.

This is what happens inside your body when you're sick

This video details the biology of what happens inside the human body during illness.

Your favorite music can minimize physical pain, according to a 2025 study on how music can bring solace and address pain.

Take a deep dive into the neuron

Neurons are the basic unit of the brain and nervous system—electrically excitable cells that sends signals throughout the body. They can communicate with each other, fire in sequence, and conspire to do everything from drive body movement to help form memories. Check out this intro-level overview to learn more about their structure and how they work.

Why the human brain loves opioids

When opioids enter the brain, they dock in receptors, blocking electrical pulses such as those that communicate pain. They also trigger the release of dopamine, a neurotransmitter tied to motivation and associated with stress relief.

Accounts of near-death experiences share similarities with hallucinogens

This short film explores human experiences of dying, blending personal reflections with scientific insight. It aims to illuminate the emotional, psychological, and physiological aspects of that final transition, and draws out similarities of psychedlic drug use and accounts of near-death experiences.

Itching is caused by stimulated nerve cells in the skin

Scratching produces low-level pain signals to the brain, distracting from the itch. Scratching also releases serotonin, a neurotransmitter that creates a happy sensation, which resets the itch signal. This can cause a cyclical itch-scratch cycle.

What is a migraine attack like?

Are you one of the lucky people who've never experienced a migraine? Take the neurological condition for a whirl in this virtual experience sponsored by Excedrin, a pain relief medication brand. This 360º video is less than two minutes long and shows a snippet of an oncoming migraine suffered by a pastry chef.

How the brain's somatosensory system translates touch into an experience

When humans perceive touch, that information is sent to the thalamus and then onward to the primary somatosensory cortex, the part of the brain that receives sensory inputs.

When common sounds become disturbing

Misophonia causes certain sounds to feel violating, triggering a "very visceral kind of experience" filled with extremely unpleasant emotions, including annoyance, anger, and disgust. A 2017 study found that people with misophonia have elevated activity in the brain's anterior insula—a region associated with interoception, emotional processing, and behavioral responses—when exposed to trigger sounds. Ongoing research suggests trigger sound context affects the severity and manifestation of the condition.

Phantom limb pain may often match the pain or contortion of the injury that led to the limb loss.

The research that led to sour

Scientists are trying to figure out if there are unique receptors that respond to the molecules that make up flavors we associate with calcium, blood, batteries, and other items that often escape dinner menus. Taste researcher Dr. Danielle Reed says the minimum evidence for a taste category typically involves identifying dedicated receptors and then removing them to show the taste vanishes.

Learn how your body is, scientifically, like a firework with its own slow, controlled burn

This NPR video makes clear that there are surprising similarities between how our bodies and fireworks function. Fireworks and our bodies are both packed with carbon atoms, and have controlled releases of energy that create heat—keeping the human body warm or fueling fireworks' heat, respectively. What's more, the human body even emits a tiny bit of light somewhat similar to fireworks—though it's not visible to the human eye.

Learn about the various types of patience and how to cultivate them

Baylor University professor of psychology and neuroscience, Sarah Schnitker, PhD, discusses why patience is not uniform and can vary across contexts and circumstances for the same individual. She also discusses where in human development patience first arises, the health impacts of impatience, and how strategies for regulating emotions can mitigate impatience.

Each part of the human body experiences aging differently

With global average life expectancy cresting at 73 years, understanding how the body ages is imperative to effective medical treatment and maintaining a desired quality of life. This 13-minute video dives into how the body and its organs age "from head to toe."

Listen to an amputee describe what it was like in the aftermath of his partial foot amputation and how his chronic, extreme pain fueled his depression and his decision to attempt to alleviate the pain with the radical surgery.

Why the nature of consciousness is such a difficult problem

David Chalmers is one of the leading philosophers of consciousness. In this video, he outlines some of the major questions in this field, including the "hard problem of consciousness," which seeks to find neural correlate for every conscious experience.

Hear examples of what tinnitus can sound like to those suffering from it.

Humans experience the world subjectively. What does that mean for scientific research?

When you close your eyes, do you see static or colorful patterns or an "intrinsic grey" known as Eigengrau in German? This variation of our internal experiences is just the tip of the iceberg, one that scientists are increasingly studying and...

Real surgical footage reveals what arthritis looks like up close

Arthritis is a painful condition of human joints that often results from the loss or breakdown of the soft cartilage padding that naturally exists between bones. This video shows footage from an actual knee surgery that beautifully demonstrates the difference between normal cartilage and the degenerative cartilage seen in osteoarthritis.

The science of optical illusions

The human brain has developed cognitive shortcuts to help us navigate in a world where our visual senses are constantly bombarded of information. But these shortcuts can also be exploited, tricking the brain into telling us something is happening when it really isn't. This short video unpacks the neuroscience behind some of the most common (but perplexing) optical illusions.

Humans likely cannot tickle themselves because there's no element of surprise

Unraveling the neural mechanisms of tickling—formally called gargalesis—is an area of active research, but a leading theory about why we can't tickle ourselves is that the brain's somatosensory cortex processes self-touch differently than it does external touch. The cerebellum already anticipated what was going to happen when you move your hand for self-touch, limiting the effectiveness of a self-tickle.

Engineer explains VR at five levels of complexity

While its possible to grab a virtual reality headset and hop into an immersive world with little effort, a significant amount of technical and biological science has gone into creating the effect of a 3D world. This video breaks down the technology in five layers of increasing complexity.

Do trees feel pain?

Trees don’t have nerves or brains. But when they’re wounded, they send underground and airborne warnings to other trees.

What is psychoanalysis?

This nine-minute video, the first of a four-part series, seeks to answer the questions: what is psychoanalysis, and is it weird? The answer to the latter question is overwhelmingly yes. The answer to the first question is a bit...

The biology of stress in your body

Stress is a normal human response that has evolved over millions of years to handle changes or threats in our environment. This article is a helpful overview of the biological basics of this response. While it is not harmful to our physiology in the acute setting, chronic stress can lead to damaging changes in the human body over many years.

Emotional crying is an important and cathartic process

Though babies don't initially produce tears when they cry, this podcast discusses how humans are hardwired to cry throughout life. Most crying research relies on self-reporting of crying and emotions. This podcast notes that there aren't neuroimaging studies of crying—they're quite expensive to complete. As a result, the brain precursors and processes during a bout of crying remain understudied.

The psychology of narcissism

It's not just an insult: Narcissistic personality disorder impacts thousands of people—and there are ways to get better. Here's a short video explaining it.

What is it like to be a bee?

Scientists have long known the intimate features of bee anatomy: six limbs, five eyes, lots of hair, a long, tasteless tube -like tongue, and wings that stroke close to 12,000 times a minute. But getting inside the mind or consciousness of a...

She can't feel pain, hunger, or danger

Olivia Farnsworth, born with a rare chromosome 6p deletion, may be the only person known to lack pain, hunger, and fear responses. This overview explores her unique condition, the incredible incidents that revealed it, and how scientists hope her case could unlock new insights into human survival and sensory systems.

Dive into the ocean's hottest water to explore hydrothermal vents

What can live at temperatures of 700 degrees Fahrenheit under skull crushing pressure with zero sunlight? Meet the animals living in the most extreme conditions on Earth in this four-minute video.

See why food poisoning makes you feel nauseous

Scroll through these illustrations to learn what’s happening behind the scenes with bacterial foodborne illnesses, including why we sometimes vomit and how the body reacts to toxins secreted by bacteria.

The science behind why some noises have color names

Different noise colors (white, brown, pink, blue) have been proven to affect mood and focus. An audiologist explains that these sounds are named after specific light wave frequencies. While individual preferences vary, certain noises consistently impact sleep, stress reduction, cognitive performance, and problem-solving. The article highlights how these sounds can enhance productivity, relaxation, and even gaming experiences.

Doctors ignored women's pain as a nurse replaced their fentanyl with saline

This five-part podcast series, produced by Serial Productions, focuses on the experiences of women undergoing fertility treatments at a Yale clinic where a nurse secretly replaced pain medication with saline solution. This led to women experiencing excruciating pain during procedures, but the clinic downplayed or ignored their complaints.

How do vaccines work? Watch this brief 101

Watch this under-3-minute video explaining how vaccines use the body's immune system to prepare our bodies against viral and bacterial threats to our health.

We may be using Q-tips in our ears—even when we shouldn't—because they can stimulate pleasure nerves

People continue to use Q-tips inside their ears even though we know it's risky. Some clinicians suggest that beyond the desire to get water out, this may be because the nerve bundle called the vagus nerve, which spans from the brain to the large intestine, can be stimulated that way, causing a pleasurable sensation in other body parts including the heart, belly, or genitals.

Finding delight through your five senses

Digging into your immediate senses is shown to benefit your overall psychological well-being, from the happy memories evoked by familiar scents or through the transformative power of birdsong. This episode from the Science of Happiness podcast highlights insights from Gretchen Rubin, an author who has written books on the importance of engaging your senses for a happy life.

Is life all about pleasure? Debating the Experience Machine

If you could plug into an Experience Machine that gave you total pleasure all the time, would you do it? Philosopher Robert Nozick thinks you wouldn't, using this as evidence against hedonism, the view that life is all about pleasure. Explore the nuances of the argument and counterarguments with this accessible article.

Twin studies helped scientists understand why mosquitoes like some of us more than others

A combination of carbon dioxide output, skin chemistry, genetic factors, hormones, and clothing choice can make us particularly vulnerable to mosquito bites. Watch how mosquitoes responded to one man in the video versus his wife, a research approach typically conducted with identical and fraternal twins to test mosquito attractiveness.

Meet the 12 cranial nerves

Your cranial nerves are a set of 12 paired nerves in your brain. They help your brain and body communicate senses, movement or both.