Watch what depression does to the brain

How depression affects the brain

Treatment for depression has historically hinged on the theory that the condition was caused by underactive or abnormal neurotransmitters, specifically serotonin and norepinephrine. This four-minute video by Yale Medicine details how these neurotransmitters didn't explain the symptoms of depression but, two other neurotransmitters involved in regulating mood and emotion did. GABA and glutamate, some of the brain's most plentiful neurotransmitters, may possibly be the source of depressive symptoms.

These areas of the brain are hard-hit in depression—but the changes are reversible

Depressed brains can have certain characteristic changes, including an overactive amygdala, reduced hippocampus size, and changes to the thalamus and neuromodulating chemicals in the brain.

Visualize the difference between a healthy brain and one with Alzheimer's

The brain has three main parts—the cerebrum, brain stem, and cerebellum—each combining to control the entirety of the body's operations. Alzheimer's progressively deteriorates the circuitry in these structures, resulting in what we see as the symptoms of the disease.

What’s with the teen brain, anyway

In this video NIDA explores the intriguing similarities between the processes of brain development and computer programming. This analogy helps us understand why toxic environmental factors like drugs, bullying, or lack of sleep strongly affect a teenager’s life The information provided by this video can empower your children or students with information they need make better decisions.

'Susan's Brain': what happens to the brain during addiction

This engaging animation from Harvard Online breaks down the neuroscience of addiction through the story of “Susan’s brain,” demonstrating how addictive substances hijack normal reward pathways. Through clear visual metaphors and approachable narration, it explains complex brain chemistry in understandable terms.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Menopause affects the brain in complex ways

Lisa Mosconi, a neuroscientist studying the impact of menopause on the brain, explains in this video how menopause directly impacts a woman's brain health and explores why this is an important and often overlooked area in menopause and women's aging healthcare discussions.

Can brain scans help with processing trauma?

MRIs and brain monitoring therapies are becoming increasingly popular for those looking to process trauma and address mental health conditions, including PTSD and depression. This article details how these therapies quantify mental health, giving users another way to measure and manage their mental and emotional needs through brain mapping and other methods.

Mixed reality technologies may help treat depression

A study led by a team from Stanford University showed that MR can help people with depression by providing pathways to engage in activities such as digital board games and dancing. Participants saw reduced symptoms of depression that made their overall treatment plans more successful.

Exercise improves brain blood flow, stimulates neural growth, and more

Exercise has dramatic effects on human biology, including reducing some of the long-term harms associated with chronic stress. Its effects are also pronounced in the brain, including improved memory retention, sleep, cognitive functioning, and more.

How do brain scans work?

There’s only one thing in our solar system sophisticated enough to study itself: the human brain. But this self-investigation is challenging because a living brain is shielded by skull, swaddled in tissue, and made up of billions of tiny cells. How do we study living brains without harming their owners? Two experts explain how the various techniques like EEGs, fMRIs, and PETs work in this TedEd talk.

A brain scientist's experience with a stroke

What happens when a leading brain scientist has a stroke of her own? Dr. Jill Bolte Taylor recounts moment by moment watching her brain function slow and then cease, followed by a prolonged recovery. Through this experience, she details what she learned about the phenomenon of stroke and how it has impacted her research ever since.

This is what happens inside your body when you're sick

This video details the biology of what happens inside the human body during illness.

Watch this 2021 video demonstrating a full brain death examination

This video and accompanying article in the peer-reviewed New England Journal of Medicine show the then-standard steps of a full brain death examination—demonstrating the process on a medical dummy to search for pain, blinking, eye movement, cough, gagging, or other forms of responsiveness. (May need to sign up for a free account to view.)

Explaining the physical connection between the gut and brain

This video overview from Duke University helps visualize the gut-brain axis—a physical connection of nerves running from the brain to digestive tract that acts as a physical and chemical link.

How science explains déjà vu

Take a fun look at the science explaining the odd experience of déjà vu, which some theories suggest is actually a sign of a healthy brain.

What sleep loss does to the brain

Proteins in the brain perform various critical functions, such as helping neurotransmitters function or enabling electrical activity in the organ. These proteins must fold in specific ways to perform their duties, similar to paper airplanes. Sleep deprivation contributes to the gathering of misfolded proteins that aren't shaped correctly for their roles and so accumulate in undesired spaces, such as in the gaps between neurons.

How to think yourself into health

Can the right thoughts lead to a stronger immune system? Neuroimmunologists like Hai Qi study how drugs targeting the brain, as well as thought exercises, can prompt stronger immune responses to infection. This six-minute video investigates the radical claims.

This is the human brain on the world's strongest psychedelic

Within seconds of inhaling a high dose of vaporized synthetic 5-MeO-DMT—a lab-produced substance that otherwise is naturally derived from the glands of the Colorado River toad—it induced slow brain waves. Such waves are typically associated with unconsciousness due to a coma or anesthesia, perhaps explaining why users describe feeling like everything falls away. The compound is currently in clinical trials for treating depression.

Explore this deep dive into how SSRIs work

This 101-style explainer on selective serotonin reuptake inhibitors explains how they work in the brain—complete with classroom-style whiteboard drawings. It covers common SSRIs, why someone might try this medication, and a deeper discussion about potential side effects.

What happens to your brain when you burn out?

You've probably heard of burnout, also known as the feeling of exhaustion that happens after a long period of being overwhelmed or stressed. It's often associated with work and careers, but other parts of life, like parenting, can cause burnout, too. Scientists are figuring out what happens, biochemically speaking, in the brain when burnout hits—and spoiler alert, it includes a neurotransmitter called glutamate. Watch this video to learn more.

Key tips for helping the depressed—including listening without judgment

Major depressive disorder is a clinical diagnosis and is not a lifestyle choice. Those who struggle with depression can express persistent feelings that are difficult to process and make sense of for friends and family. This guide walks through some counterintuitive perspectives, including resisting the urge to force a depressed person to do the things that would make them feel better.

A deeper walk through of the four stages of sleep

In this TED video, sleep expert Matthew Walker carefully breaks down the sleep stages along with a description of why each is important. He finishes the discussion by examining the consequences of altered or decreased sleep, and why seemingly small alterations in our sleep patterns can have outsized effects.

What is psychology? An overview

What is psychology and why should we study it? This short video from Macat explains how the subject has developed over the years and introduces some of the key thinkers and ideas.

What it feels like to live with dementia

This nine-minute short film attempts to answer what it feels like to fade into dementia, as memory, motor skills, and cognition steadily decline. This award-winning short film follows Jos, a married father who worked in hospitality, as he sinks into ,"what feels like a single day. Or is it years?"

CBT helps rewire the brain's false beliefs by challenging negative thoughts

Cognitive behavioral therapy identifies how specific situations can trigger distorted core beliefs—often formed early in life—that negatively shape thoughts and behavior. It frequently uses structured questioning that promotes self-reflection to uncover distorted thinking and guide people toward more balanced perspectives.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

See the evolution of Ebola vaccine and treatment development.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

Learn how your body is, scientifically, like a firework with its own slow, controlled burn.

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Crows are believed to have intelligence on par with a seven-year-old child and demonstrate complex behaviors, from problem-solving with tools to recognizing human faces.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Explore the history, structure, and species of Australia's Great Barrier Reef with this interactive journey narrated by Sir David Attenborough.

Watch how deep-sea mining equipment collects and processes polymetallic nodules—metal-rich, potato-shaped rocks—from the ocean floor and creates environmentally damaging plumes of sediments.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

In 1945, Surrealist artist Salvador Dalí and legendary animator Walt Disney began collaborating on a short film that was not completed until 2003, years after both men had died.

Netflix profits when you're not watching, and its movies are designed that way—read a detail-rich critical essay exposing lesser-known Netflix takes

According to the physics of black holes, our 4D reality may be a hologram—a projection of information coded on a 2D surface on the edge of the universe.

The first steps to rebuilding your credit score include getting to know exactly what's on your credit report and figuring out how far you are from the '700 club,' or 'good score' range.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

Watch this video that uses Lego bricks to explain how venture capital works.

Pure water does not conduct electricity because this flow of energy requires the movement of charged particles, and water is a neutral molecule.

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.